Conserved Protein Domain Family
GATase1_AraC_ArgR_like

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cd03136: GATase1_AraC_ArgR_like 
AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain
A subgroup of AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to the Pseudomonas aeruginosa ArgR regulator. ArgR functions in the control of expression of certain genes of arginine biosynthesis and catabolism. AraC regulators are defined by a AraC-type helix-turn-helix DNA binding domain at their C-terminal. AraC family transcriptional regulators are widespread among bacteria and are involved in regulating diverse and important biological functions, including carbon metabolism, stress responses and virulence in different microorganisms. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with typical GATase1domains a reactive cys residue is found in some sequences in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.
Statistics
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PSSM-Id: 153230
View PSSM: cd03136
Aligned: 52 rows
Threshold Bit Score: 122.694
Threshold Setting Gi: 68556138
Created: 20-Oct-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
conserved cys
Feature 1:conserved cys residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
ZP_00621377  14 VDILLFDDFSGHCLANTVEPMRAANtlag---relYRWRFLSlnssrVVSSSGMEVtahaql---adcrgDMLAVMPSyn 87  Silicibacter sp....
NP_103473     5 FAFLLVRDFTLSPLSLFIDTLRLAGdegdrsrrieFDWEIVGerglpIRASCGVELlptkgi--gnpedfDNIVVVGGll 82  Mesorhizobium lo...
AAK89130     29 VAFLLADRFTLSAFANFVDVLRLAAdeadrsrpilCEWSVLSatlanVQSSCGVKVqpdtrl--idaghyDYIVVVGGli 106 Agrobacterium tu...
NP_252873    30 VGFLLLEHFSLPAFTQALDTLVTANlir----sesFAVSNFSlsgepVTSDLGLLIcpdlalasaalqglDLLVVCGGlr 105 Pseudomonas aeru...
AAL52796     25 VGIVVLPGFTLSALSLFLDPFRLAAddrdksrqirCAWKICTlsgdpVTSSSGMVIeptvpl--geidecDYVAVVGGll 102 Brucella meliten...
NP_745701     7 LLIMPLPDFALLPFGAFLDKLRFSAddedysqqryCSWMVAGlslepVPSSSGAVLqveaiadqldldlfDYLVVFGGrs 86  Pseudomonas puti...
YP_132804     7 FLLLPLPDFTMLPFGGFIDKLRFSAdnedysqqrhCGWQILGlksgtVTSSSSVSVevqvtpeqirfadyDYLVVFGCrs 86  Photobacterium p...
EAM36240      2 VGIFLWPRFPLLSLAGLCDALRHAAdlgdqsrqvrCTWTVLSatgepVASSCGVEVptlaaa--ssdcrfDYVAVIGGll 79  Polaromonas sp. ...
YP_299024    52 FGIVLLPNFTLTAFSGFVDMLRLSAddgdyskpvrCVWSVIGntlapVRASCGIQVapwetf--desepfDYVVVVGGll 129 Ralstonia eutrop...
YP_355018    13 IALILQDKFTIAAFSGFIDALRLAAddaaksrqirVAWKVFAqhrspVMASCGLRVatedgl--pvpedyDYIAICGGns 90  Rhodobacter spha...
Feature 1                                   #                                                   
ZP_00621377  88 fl--rhdtPETRRALRAAAmryrELAGLDTGPWLLAAAGLLDGRRATIHWDelerLAEAYPDidv----qrsRYVLDg-n 160 Silicibacter sp....
NP_103473    83 dtn-rslsSDKEVFLLRAAekgvPLTALCTGSFVLARYGLLDGYAAAVSWFhikdFRSQFPDvnah---adsLFSVDr-g 157 Mesorhizobium lo...
AAK89130    107 sdh-salpPEALRFLKDRAaagiPIVGLCTGVFILHEAGLLDGYRCCVSWFhrqdFLDRFDTvqmv---sdqIFVIDr-d 181 Agrobacterium tu...
NP_252873   106 tp--lrssAALREALQDVAsrgvALAGLWNGAWFLGDAGLLDGYRCCIHPEhraaLAEIARNsqv----tsdSYMVDr-d 178 Pseudomonas aeru...
AAL52796    103 aqy-rhsqQALIDLIKRADkrgkAVVGLCTAAFLLAEAGVLEDRNCCVSWFhrddFLELFDGytad---ttsLFHLSg-r 177 Brucella meliten...
NP_745701    87 amataalaPRYQALLRQAAkagvKLVGVDNGAFLLAACGLLQGHKVVVHWRheaeFRAAFPQlqll---reqLYCIDg-n 162 Pseudomonas puti...
YP_132804    87 arhaqqmaSSYKALLKQAAsfgvTLVTIDNACFMLAEAGLLKKNKVSVHWRhaqeFMAAYPDievr---teqLYCIDk-k 162 Photobacterium p...
EAM36240     80 pfm-ktadARGLKFLNQAAksgvPLIGICTGSFALAKHGFMEGRMACVHPFhvndWKEAFPElaft---tncDYVFDg-d 154 Polaromonas sp. ...
YP_299024   130 hsg-pqagPETLDFIRRAAgggaTIVGICTGVFALMRAGVLQGHRACVSWFhywdFMERFPSvdpnlliadrLFVIDr-r 207 Ralstonia eutrop...
YP_355018    91 fad-aapaPQLAQLIQRAHrarvGLLGICTGSFAIARAGLIGDRRFCIHWNvaepFKALFPRaqi----svdRIFIDegd 165 Rhodobacter spha...
Feature 1                                            
ZP_00621377 161 RITCTGALAAFDLMLERIGIAhGQALRLEVAALFMST 197 Silicibacter sp. TM1040
NP_103473   158 RSTCAGGTGAADLAGYFVSQFiGQKAAEKAAKILVLD 194 Mesorhizobium loti MAFF303099
AAK89130    182 RLTCSGGHGAAHLAAFLVERHvGQSAAIKSLNIMMID 218 Agrobacterium tumefaciens str. C58
NP_252873   179 RLTAASPTGAFNLALEWIARRhGRDLVEAVVDILAFE 215 Pseudomonas aeruginosa PAO1
AAL52796    178 HYTCAGGLGAAALALSIIQNEiSEELARKSASILLIP 214 Brucella melitensis 16M
NP_745701   163 RITCAGGTAAIDLAVALLSRAcGRTRALKGLADMLVD 199 Pseudomonas putida KT2440
YP_132804   163 RISCSGGSAAIDLAVELLTRHcGRTRAMKGLADMISI 199 Photobacterium profundum SS9
EAM36240    155 RITCAGGISIIELATELIRLHcGPDRAAKVVHQMTVT 191 Polaromonas sp. JS666
YP_299024   208 RITCSGGRASIDVAAAILLRHfDHATVQKALRILLVG 244 Ralstonia eutropha JMP134
YP_355018   166 VITCAGSTAAIDLALYLVMRHcGQDRAQQVMRHMMLS 202 Rhodobacter sphaeroides 2.4.1

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