1SOA,1J42,1PDW,1PE0,1PS4


Conserved Protein Domain Family
GATase1_DJ-1

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cd03135: GATase1_DJ-1 
Click on image for an interactive view with Cn3D
Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. DJ-1 is involved in multiple physiological processes including cancer, Parkinson's disease and male fertility. It is unclear how DJ-1 functions in these. DJ-1 has been shown to possess chaperone activity. DJ-1 is preferentially expressed in the testis and moderately in other tissues; it is induced together with genes involved in oxidative stress response. The Drosophila homologue (DJ-1A) plays an essential role in oxidative stress response and neuronal maintenance. Inhibition of DJ-1A function through RNAi, results in the cellular accumulation of reactive oxygen species, organismal hypersensitivity to oxidative stress, and dysfunction and degeneration of dopaminergic and photoreceptor neurons. DJ-1 has lacks enzymatic activity and the catalytic triad of typical GATase1 domains, however it does contain the highly conserved cysteine located at the nucelophile elbow region typical of these domains. This cysteine been proposed to be a site of regulation of DJ-1 activity by oxidation. DJ-1 is a dimeric enzyme.
Statistics
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PSSM-Id: 153229
View PSSM: cd03135
Aligned: 78 rows
Threshold Bit Score: 123.433
Threshold Setting Gi: 47459424
Created: 28-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
conserved cys
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:conserved cys residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1SOA_A        6 ALVILAKGA-EEMETVIPVDVMRRAg------------IKVTVAGLagkdpvqc---srdvvicpDASLedakkegpyDV 69  human
AAB96189     21 IAIIITQKT-NDLHATVPCFLWRKAr------------YAVDLISAeakasiml---emgihvrcDNTLsktn-fnqyTA 83  Mycoplasma pneum...
NP_072689     7 IVYPEMNDV-EYTNVMVVFSFIKTIq------------TTCYHHSLkkitas-------ngvvevNNIVntin-lsefDA 65  Mycoplasma genit...
NP_326306     3 LLTILHDQY-QDIEYSVVMSILDISk-----------tFDTMDVYNpdgqdriygqhktsyadvsVKDLskvs-hkdyDA 69  Mycoplasma pulmo...
NP_757456    11 IAIMCSIES-NDMDIVIPYDIWTRAg------------IIVETVSNekkksifl---qsgtkitcSEEIekvn-ldkfNA 73  Mycoplasma penet...
NP_757506     3 LLALTMSKF-QDLEMVALLSIFKASqk----------fERIDFYSPenlemvt-----gqfdianIKTIknfn-vndyDV 65  Mycoplasma penet...
YP_016286     3 LLTLVLDEF-QDIELINVNATLQRGnflekndfynphnKKVVTGQFni---------------anVNTItqin-endyDA 65  Mycoplasma mobil...
AAV27728      4 LLVILLDKF-QDIELTTFISLIKKAe------------IFTDIEFFnpknklvig-qfgvvsiqaHNHWksd----dfDA 65  Mycoplasma hyopn...
YP_278149     3 LLVIVDNNF-QDVELTTVVSILKRSq------------QFNKIAFYnpcsrkat---gqfeivkfNNLEtsvn-lkdyQA 65  Mycoplasma synov...
ZP_00868328   3 VLIAIPPEKfRDEELLIPVKKFQEAgvt--------yeLASTHVGVvmgvlgkk---akvnrtfeDVLLsgv---ddyYA 68  Methanospirillum...
Feature 1                                                #                                      
1SOA_A       70 VVLPGGnlGAQNLse-sAAVKEILKEQEnr----kgLIAAIXAGPTALLAh-eIGFGSKVTTH-PLAKDkmm-ngGHYTy 141 human
AAB96189     84 AFIPHG--NTTRLve-iDKLRKDLEKFVykpkgpmrWLFSSGNGACVLKEfdlIAPDQLVTVQ-NEKEMvkl-lgKNFIk 158 Mycoplasma pneum...
NP_072689    66 VYIPGGigATKHLdk-dEKLLKTINYFKvn----nlYLFAICDTPNVLFKhgiITKDEIYSSF-PNPNLvm---sENRSt 136 Mycoplasma genit...
NP_326306    70 IFILGGk-NVRRLad-dQKTLKFIKDFYts----gkDLFVLCFASNVLFDs-gIINEEKYVGY-PLQNQk----rGKNFt 137 Mycoplasma pulmo...
NP_757456    74 LYIPGGkgCQRLLtdrnERVINKIVKFAgde--gkkWLFTAGAASTVLAEl-gVLGNKKITTA-PGFEEkl---gKNYSd 146 Mycoplasma penet...
NP_757506    66 LYIPGGy-GATLLrq-sKKGIACVKEFIdn----dkWVIAICDAPNALADhnlIKEDQKYISWsSGDITd----sKRIKd 135 Mycoplasma penet...
YP_016286    66 IFIPGGk-AAQHLrk-dSKSLNLIESFIkk----nkIIIMICDAPNAIYEsnlLKKDIIFTSY-PVESIl----kLKPIq 134 Mycoplasma mobil...
AAV27728     66 VFIPGGf-AAQLFrk-dSKSIQLVSEFFaq----nkHIFAICDAPNAIFEl-kLAENYQFSSY-PNQHNs----kIRLRq 133 Mycoplasma hyopn...
YP_278149    66 VFVPGGk-ACFSFkd-nKEIIKKIRHFFdk----dkWVFAICDAPNALRYn-nLIKEQNYTSF-PSAWSkelrsnSNYQn 137 Mycoplasma synov...
ZP_00868328  69 LMIVGGp-GTQVHlwnnRHLIELVTIFNtr----qkVVAAIDNAPIVVAKa-gILKKKIATVA-PGLTVrem-mkEDAIi 140 Methanospirillum...
Feature 1                                       
1SOA_A      142 se-nrVEKDGLILTSRGPGTSfeFALAIVEAL 172 human
AAB96189    159 q---pVHVDKNIISCANSCGLtkFSFKVIEEL 187 Mycoplasma pneumoniae M129
NP_072689   137 a---kVTVANKLITARSAGCAleFATVIVCTF 165 Mycoplasma genitalium G37
NP_326306   138 et-igIVRDKNLFTGAGAFSSfeLGFTIVDHF 168 Mycoplasma pulmonis UAB CTIP
NP_757456   147 n---nIVVDKNFVSFKSPFHAfeFALLIVEKL 175 Mycoplasma penetrans HF-2
NP_757506   136 fn-thVYRSNKLITGRCPVVTldLAFYSLEVI 166 Mycoplasma penetrans HF-2
YP_016286   135 rnednVVYYKNFFSAKSAAFSieLGLKVIEVL 166 Mycoplasma mobile 163K
AAV27728    134 d--slVTIDRNYISARNAASSadFAFVVIEKL 163 Mycoplasma hyopneumoniae 232
YP_278149   138 k---gVVVFEKLITAKSSYYSqhLAFEIIRTL 166 Mycoplasma synoviae 53
ZP_00868328 141 qn-kpVVYKDRIVTAMGFEAAeeFASIIIKYE 171 Methanospirillum hungatei JF-1

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