1VHQ


Conserved Protein Domain Family
GATase1_ES1

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cd03133: GATase1_ES1 
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Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1
Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1. This group includes, proteins similar to ES1, Escherichia coli enhancing lycopene biosynthesis protein 2, Azospirillum brasilense iaaC and, human HES1. The catalytic triad typical of GATase1domains is not conserved in this GATase1-like domain. However, in common with GATase1domains a reactive cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. Zebrafish ES1 is expressed specifically in adult photoreceptor cells and appears to be a cytoplasmic protein. A. brasilense iaaC is involved in controlling IAA biosynthesis.
Statistics
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PSSM-Id: 153227
View PSSM: cd03133
Aligned: 22 rows
Threshold Bit Score: 289.137
Threshold Setting Gi: 56707776
Created: 27-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
conserved cys
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:conserved cys residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1VHQ_A         9 IGVILSGCGVYDGSEIHEAVLTLLAISRSGAQAVCFAPDKQQVDVINHltge-axtETRNVLIEAARITRGEIRPLaqad 87  Escherichia coli
NP_967561      4 IAVVLSGCGHRDGSEITESVSLLIGLHQAGAEVHCFAPDIQIPITNHInge--aqgEKRSLLTEAARIARGHIQSLdklh 81  Bdellovibrio ba...
EAN28957       5 IGVVLSGCGVYDGAEIHEATLTLYFLDKAGTKVVCMAPDKDQFHVVNHltgd-empERRNVRVESARIARGDVKRLdevk 83  Magnetococcus s...
YP_197882      8 AAVVLSGCGHLDGAEVREVVLSLLVLDQQEVEVKCFAPDINITQVVNHktte-avkEKRNVLVEAARVARSEICDLkeak 86  Wolbachia endos...
CAA68857      45 VALVLSGCGVYDGTEIHEASAILVHLSRGGAEVQIFAPDVPQMHVIDHtkgqpsegESRNVLTESARIARGKITDLanls 124 human
XP_693678      6 VALVLSGCGVYDGTEVHEASAIMVHLSRAGAEVTIFAPDVEMMHVVNHcegk-pvaDKRNVMQESARIARGDVTDLakld 84  zebrafish
AAH81203      39 VAVVLSGCGVFDGTEIHEASAILVHLSRAGAEVKMFAPDVPQMHVVDHskgq-psqESRNVLVESARLARGNITALsrln 117 African clawed ...
NP_001025969  36 VAVVLSGCGVYDGTEIHEASAILVHLSRGGAEVQMYAPDVPQMHVVDHskgqpaeaESRNVLVESARIARGKITNLaklt 115 chicken
XP_787091      6 VAVVLAGSGVYDGSEVHEASAVWVHLSRGGADVSFFAPDVPQMHVINHtkgepsenETRNVLVESARIARGKIAALsgls 85  purple urchin
YP_154338      3 CVVLLCGCGHMDGSEVRESVLVLLELDRLGVKFQCCAPDIQQHDVVNHasks-tenQTRNILAESARIARGEVISIervq 81  Anaplasma margi...
Feature 1                                                            #                           
1VHQ_A        88 aaelDALIVPGGFGAAKNLSNFASLGSECTVDRELKALAQAXHqAGKPLGFXXIAPAXLPKIFd-------fPLRLTIGt 160 Escherichia coli
NP_967561     82 akdfDAVVFPGGYGAAKNLSNWAEKGAQCEVNPDVKRVILEFHsASKPIGALCIAPVLVAKVLgd------kKVTVTIGd 155 Bdellovibrio ba...
EAN28957      84 atelDGLIIPGGFGMAKNLSTLAFDGANAQVDEDLVALVMAMHgAGKPIGALCITPAVLSKILae------rGVRLTIGn 157 Magnetococcus s...
YP_197882     87 aedfDMLVVPGGYGVAKNLSDLAEDKEVVTVIPEFERLVSEFFaTKKPIGAICISPAIIVSILssktskgesKIKVTIGd 166 Wolbachia endos...
CAA68857     125 aanhDAAIFPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHqAGKPIGLCCIAPVLAAKVLr--------GVEVTVGh 196 human
XP_693678     85 vsafDALIIPGGFGVAKNLSDWATKGKEYSITPQIDKVIKGFHqAKKPIGLCCISPVLAAKAIp--------GCELTVGh 156 zebrafish
AAH81203     118 vkehDAVIFPGGFGAAKNLSSFAVDGESFKVQPDVERVLTGFSkAKKPIGLCCIAPVLAAKVIp--------GVEVTVGq 189 African clawed ...
NP_001025969 116 tvdhDAVIFPGGFGAAKNLSTFAVDGKDCKVNREVERVLKDFHkAGKPIGLCCISPVLAAKVLs--------GAEVTVGh 187 chicken
XP_787091     86 sgnfDAVVFPGGFGAAKNLSDFAVNGAGCTVNTGVERVIKEFHkAKKPIGLCCISPVLAAKVIp--------GCSVTVGh 157 purple urchin
YP_154338     82 vhefDMLIVPGGFGVAKNFSNLVSQSGPVSVIDSVKGLIHQFHrARKAIGGVCIAPAVIAAALse-----lvKVKVTLGd 156 Anaplasma margi...
Feature 1                                                                               
1VHQ_A       161 d---------idTAEVLEEXGAEHVPCPVdDIVVDednkIVTTPAYXLAQNIaea-asGIDKLVSRVLVLA 221 Escherichia coli
NP_967561    156 d---------aaTAAEIEKTGAIHEECPVnDYITDreskVVTTPAYMYGDAKpnevfaGIFGLAHEIVEWA 217 Bdellovibrio bacteriovor...
EAN28957     158 d---------egTAEAIRNMGNTHVESGAeQIIIDeqnnVISSAAYMCAASIaea-gvGIEKLVAEVLKRA 218 Magnetococcus sp. MC-1
YP_197882    167 -----------dREKLIEKLGGEHIKCDTgLSIEDeehnVFSCSAYMRRDEStysvyqGIKHMIDSMVKKT 226 Wolbachia endosymbiont s...
CAA68857     197 eqeeggkwpyagTAEAMKALGAKHCVKEVvEAHVDqknkVVTTPAFMCETALhyi-hdGIGAMVRKVLELT 266 human
XP_693678    157 dkvck-mwpyaqVAQSMAELGCKHVNKHVgEVHVDtknkLVTTSAFMCNAPIhei-fdGLELMVADVLKLA 225 zebrafish
AAH81203     190 eeelggkwpyagTAKSISALGGKHCAKEVdEVHVDskcrVVTTPAFMGEAPLhqi-fdGIGAMVSGVLKLT 259 African clawed frog
NP_001025969 188 eeeeggkwpyagTAGAIKELGGKHCVKEVtEAHVDtknkVVTTPAFMCETELhni-fdGIGAMVKNVLKLT 257 chicken
XP_787091    158 dseeggrwpyagTAKAIQEMGSKHVNKDInEAHVDeenkIVTAPAFMCETKVhei-fdSVGSMVNGVLKLC 227 purple urchin
YP_154338    157 -----------dADGIISRCGGEHVVCPTdDFVADeknaVFSCSAYMRDDTLhrv-hlGIQKMVEGMVKFC 215 Anaplasma marginale str....

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