Conserved Protein Domain Family
GATase1_CobB

?
cd03130: GATase1_CobB 
Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase
Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase. CobB plays a role in cobalamin biosythesis catalyzing the conversion of cobyrinic acid to cobyrinic acid a,c-diamide. CobB belongs to the triad family of amidotransferases. Two of the three residues of the catalytic triad that are involved in glutamine binding, hydrolysis and transfer of the resulting ammonia to the acceptor substrate in other triad aminodotransferases are conserved in CobB.
Statistics
?
PSSM-Id: 153224
View PSSM: cd03130
Aligned: 55 rows
Threshold Bit Score: 206.679
Threshold Setting Gi: 53713794
Created: 22-Sep-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
catalytic triad
Feature 1:catalytic triad [active site]
Evidence:
  • Citation:PMID 8208731
  • Comment:catalytic triad based on similar proteins with structures
  • Comment:Conserved trio of residues critical for the catalytic function.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
CAC36214    258 IGILQDRVFQFYYPENLEALEFAgARLVRITSS-DSDLPdniDGLYIGGGFPETHLEILadnstlksaIRDRIEs----G 332 Thermodesulforha...
NP_939836   238 IALAGGPAFSFTYAEHVEMLSAAgATVVAFDPL-SEQLPq-cDGLIIPGGFPEEHCDVLeqr----adLKQQVCdviaqG 311 Corynebacterium ...
CAB59468    290 VAMASGAAFTFSYAEHTELLAAAgAEVVTFDPLrDEELPegtQGLVIGGGFPEVYASELsan----egLRKSVAelafsG 365 Streptomyces coe...
ZP_00549837 282 VAVAGGAAFTFGYPEHIELLTAAgADVVPVDPLrDETLPpgtDALIIGGGFPEEHVAALadnarlraeVAAFAAr----G 357 Frankia sp. CcI3
NP_875518   250 IAIAEDKAFHFRYPETKECLEELgINLIKWQITqDSPIPkqaKGLIIPGGFPEQFAEEIsqckrslnsIKEFLN-----N 324 Prochlorococcus ...
NP_893189   246 IVIAEDKIFHFQYPETRDFLDEIgIPLIPWSIFnNEEIPneaSSLIIPGGFPEKYAGHIsdsdkslksLREFRK-----K 320 Prochlorococcus ...
NP_217364   256 VAIAAGRAFTFGYAEHAEMLRAAgAEVVEFDPL-SETLPegtDAVVLPGGFPEQFTAELsan----dtVRRQINelaaaG 330 Mycobacterium tu...
YP_055148   261 VGMFAGRAFTFRYPETTEMLIAAgFRVVDVDPLtDRRLPdgiQGLYLGGGFPQMHATDLetnseladdVRSHAEa----G 336 Propionibacteriu...
AAL95168    251 IAIAQDRAFSFYYNDNIEFLEYMgFKVKYFSPLkDSKVPe-cDIIYLGGGYPENFAEELsnnkemfnsIRKNYEq----G 325 Fusobacterium nu...
YP_359625   245 VAYAFDKAFNFYYQEAIEYLRRSnAEVFAVSPLnDSDFPp-vDLLFLGGGYPELFARDLflnqkfiqnLKKKIQg----G 319 Carboxydothermus...
Feature 1             #                                                                         
CAC36214    333 MPVYAECGGLMYLSRGIisgk-rfypMVGIFPVDVEMcrkpqghgYGVGLVVAENPFWLKgt--wIKGHEFHYSRIsrfh 409 Thermodesulforha...
NP_939836   312 IPVHAECAGLLWLLSTLdg-----rpMLDVIPTHGAMgrrl-tlgYRDAVVVHDSVIYRAge--rVTGHEFHHTAIadsv 383 Corynebacterium ...
CAB59468    366 APVAAECAGLLYLCRELdg-----lpMCGVLDAAARMskrl-tlgYRDAVAVSDSALAVAgt--rMRGHEFHRTVVepga 437 Streptomyces coe...
ZP_00549837 358 GPVAAECAGLLYLARTLdg-----apMCGVLDVEAVMgprl-tlgYRSAIAAADSPLAAAgt--tVHAHEFHRTVLrppp 429 Frankia sp. CcI3
NP_875518   325 YPIYAECGGMLILGKSLsdtnekkfpMAGILPFNAKEgkl--kvgYRKLTAISNSLISNKgd--lINGHEFHRWKLding 400 Prochlorococcus ...
NP_893189   321 GFIYAECGGMMILGDLIkdenginhkMSGILPFKSKKsnl--svgYRYIKGLKDTPIIKQnq--tIRGHEFHYWEVer-- 394 Prochlorococcus ...
NP_217364   331 APVHAECAGLLYLVSELdg-----hpMCGVVAGSARFtqhl-klgYRDAVAVVDSALYSVge--rVVGHEFHRTAVtfad 402 Mycobacterium tu...
YP_055148   337 MPIVAECAGLLYLCRHLdg-----heMAGVLPMDAAMa------kRLTMGYRVATRDSIS-----VVGHEFHRTTTtpla 400 Propionibacteriu...
AAL95168    326 KNILAECGGFMYLSNGIeqiegkvyqMCGLVPCVVNMt------nRLDISRFGYILINNKndieiARGHEFHYSKLkavl 399 Fusobacterium nu...
YP_359625   320 LRVYAECGGFIYLTSGVkvke-qtypLTGILPGEMELtdklqglgYYRGKPVGGYLGKNFqk--eIWGHKFHYSTYtgpq 396 Carboxydothermus...
Feature 1                                                              # #                      
CAC36214    410 gsvs---------------fsvklkkGHGIIEQFDGMIYk------nCAAFYTHVHAVg--------------------n 448 Thermodesulforha...
NP_939836   384 vpgw---------------dsawgwrAWDGSPKVEGFVSg------nVHASYLHVHPAa--------------------v 422 Corynebacterium ...
CAB59468    438 ga-------------------apawgMRAPERRVEGFVEr------gVHASYLHTHWAa--------------------e 472 Streptomyces coe...
ZP_00549837 430 grap--------------cdprspspAHGAAGPPPGSSW--------VAAWWLPVPETaprpapgrvagggrrggqqaas 487 Frankia sp. CcI3
NP_875518   401 sndlditkkepmiqssmnlyspweirGWGIDTRQEGWSNk------nFHASWIHLHWAs--------------------s 454 Prochlorococcus ...
NP_893189   395 ------------------------asSEFDLKKNENHSQ--------LFSPWEIKSWEtkfkk------------egwsd 430 Prochlorococcus ...
NP_217364   403 syq-----------------pawvyqGQDVDDVRDGAVHs------gVHASYLHTHPAa--------------------t 439 Mycobacterium tu...
YP_055148   401 dldpaw----------hitmpdgtdrAEGALGDPAGLGRp------tIQASYLHLHWAg--------------------q 444 Propionibacteriu...
AAL95168    400 -----------------------edtRKFKAVKKDGRTWecifneknLYAGYPHIHFFg--------------------s 436 Fusobacterium nu...
YP_359625   397 dn-------------------payllQKNGREAFDGVARd------nIFASFLHLNFYg--------------------k 431 Carboxydothermus...
Feature 1               
CAC36214    449 DEWARRFV 456 Thermodesulforhabdus norvegica
NP_939836   423 PAAVRRFV 430 Corynebacterium diphtheriae NCTC 13129
CAB59468    473 PGVARRFV 480 Streptomyces coelicolor A3(2)
ZP_00549837 488 PWMSEGFV 495 Frankia sp. CcI3
NP_875518   455 PSILQNWS 462 Prochlorococcus marinus subsp. marinus str. CCMP1375
NP_893189   431 KKLHASWI 438 Prochlorococcus marinus subsp. pastoris str. CCMP1986
NP_217364   440 PGAVARFV 447 Mycobacterium tuberculosis H37Rv
YP_055148   445 PTQAAWFA 452 Propionibacterium acnes KPA171202
AAL95168    437 YKFIEEVF 444 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
YP_359625   432 ADLVKTLV 439 Carboxydothermus hydrogenoformans Z-2901

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap