1FYE


Conserved Protein Domain Family
GAT1_Peptidase_E_like

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cd03129: GAT1_Peptidase_E_like 
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Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins
Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins. This group contains proteins similar to the aspartyl dipeptidases Salmonella typhimurium peptidase E and Xenopus laevis peptidase E and, extracellular cyanophycinases from Pseudomonas anguilliseptica BI (CphE) and Synechocystis sp. PCC 6803 CphB. In bacteria peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. Peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly. Cyanophycinases are intracellular exopeptidases which hydrolyze the polymer cyanophycin (multi L-arginyl-poly-L-aspartic acid) to the dipeptide beta-Asp-Arg. Peptidase E and cyanophycinases are thought to have a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad typical of GATase1 domains by having a Ser in place of the reactive Cys at the nucleophile elbow. Xenopus peptidase E is developmentally regulated in response to thyroid hormone and, it is thought to play a role in apoptosis during tail reabsorption.
Statistics
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PSSM-Id: 153223
View PSSM: cd03129
Aligned: 69 rows
Threshold Bit Score: 71.566
Threshold Setting Gi: 55980135
Created: 30-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic triad
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:active site nucleophile [active site]
Evidence:
  • Comment:Active site serine is located in a strand helix motif.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1FYE_A        3 LLLLSNStlpgkawleHALPLIANQLng--------------rrSAVFIPFAgvtq--twdEYTDKTAEVLAPL------ 60  Salmonella typhi...
NP_624606     3 FLLTASGlr-----neTLRDALRDMLgkpf-----------gsaNVVFVPTAsva----dpGDHGWVVADMNRLhglgw- 61  Streptomyces coe...
EAM75633     17 LLLTSAGlv-----naESCEALAALArrpl-----------aslAVAVVPTAanv----ipGDEGWFIADCVNLqrasf- 75  Kineococcus radi...
YP_118154     8 ILATSMGfhr---ardPWQPSPVFRLafdlag-------gpsrpRLCFVTTGtgd----rqTSIDAFYAAFDGT------ 67  Nocardia farcini...
ZP_00537888   3 LLLTSGGiq-----ndSQRRALVDLLgkpi-----------eeaHALCIPTAvygm-kegpYHAYLFITGTGSTpmcelg 65  Exiguobacterium ...
XP_829323    61 VRTIKGCfpgs-lpdaLNDMSVIDHIlsltgrfdegqaalastvNVVYVGTAvydipryreEYTKNFIARGCGIs----- 134 Trypanosoma brucei
ZP_00838429   3 MVLISDLnn------aASQAAITSVLspsvlnq-----gankstSLGYLASGhep----eqNYYLGTQQQYARL------ 61  Shewanella sp. PV-4
ZP_00383050   5 YFLTSNPllviekklnPNNKFIENLSenip-----------tlaKVLFVCSDp--------YSYELTDKFSEEMricf-- 63  Lactococcus lact...
CAJ02596     11 ACLAGSGhd------aFSEPVTIDHLlslvat------pktgvvSVAYVGTAtydlaesqtEQTSLLLQRGWTVrpi--- 75  Leishmania major
XP_815112    12 GFFAGSGld------aFGEPAVVDRVlmltglfdmekkvltapvHVAYIGTAvydiptykeRQTKWFVSRGCTVa----- 80  Trypanosoma cruzi
Feature 1                                                                                   #   
1FYE_A       61 -----GVNVTGIHrv-----------aDPLAAIEKAEIIIVGGGNTFQLLKESRErgLLAPMADRVk-rGALYIGWSAGA 123 Salmonella typhi...
NP_624606    62 -refdILELNGLPq------------qMVLDRLLHADVVYVEGGNHYHLARSITGngLVDGFLEALq--SRVYVGVSAGS 126 Streptomyces coe...
EAM75633     76 -aqvdLVDVSALEr------------eVWSARLEEADVLAVTGGDTTHLLHWLRRs-GLAATLPGLl-rERVYLGVSAGS 140 Kineococcus radi...
YP_118154    68 -----GVMTSHLAlfdk------pnmpNVTEHLHEQDVIWVDRGSVVNLLAVWRAh-GIDEILRDCwtrGVVMGGESAGS 135 Nocardia farcini...
ZP_00537888  66 fqsvgVLELTALPild---------esLWVPLVEQADVLLVNGGDPLFLNYWMKKs-GLADRLPSL---KAVYVGLSAGS 132 Exiguobacterium ...
XP_829323   135 ----eVCVAEARStgatpcaaatmvtpDQLQHLAEAHIILLPEGNTLFAIRRWEEt-GLDACLRASaarGVVLVGGGCCF 209 Trypanosoma brucei
ZP_00838429  62 -----GMALSHYLdleq------gytqAGLDRLLNCQAIHLAGGDTFQFLAQVQKr-GLMAEFADYlnrGGILIGLSAGA 129 Shewanella sp. PV-4
ZP_00383050  64 --lssGFNFSEYKvldn------rniqEKHNIISEADVLILAGGHVPTQNQFFHEi-DLKSELKNS---DKVIIGFSAGS 131 Lactococcus lact...
CAJ02596     76 --qvaDPAVKAVNd------------sDVHFIQTAADIVLVSGGNTLYAVRRWEEt-GLAQLLKDAaarQVVLAGGSAGA 140 Leishmania major
XP_815112    81 -----EVRVADLSvpnt-------vdkEELEFLGKAHIVVVSGGNTLFAIRRWEEt-GLDVCLRAVavrGAVLAGGSAGA 147 Trypanosoma cruzi
Feature 1                                                                                       
1FYE_A      124 NLAcpt---------------irTTNDMPIVdp---------------------------------------------ng 143 Salmonella typhi...
NP_624606   127 MIFsr----------------nlTGHSADVIgdatdlh-----------------------------------vlgatsv 155 Streptomyces coe...
EAM75633    141 MVTgph---------------lrLSRSVQRApe----------------------------------------------d 159 Kineococcus radi...
YP_118154   136 LCWft----------------ggTTDSFGSMra----------------------------------------------f 153 Nocardia farcini...
ZP_00537888 133 MVLtp-----------------rIGHAFVEWtaph------------------------------------------ttt 153 Exiguobacterium ...
XP_829323   210 RAEhsdsanpktcaqymlsreneADSGQPVEmeegga-------------------------------------kweylc 252 Trypanosoma brucei
ZP_00838429 130 MLMtpsi------------acapLCGDENHLgl---------------------------------------------sd 152 Shewanella sp. PV-4
ZP_00383050 132 MNCaee---------------vyAQPDLEGEsisas----------------------------------------ykrf 156 Lactococcus lact...
CAJ02596    141 ICWft----------------sgHSDSADPAtylqpslkraalkmglipqd---------qiskteaeladlstswsyir 195 Leishmania major
XP_815112   148 ICWft----------------sgHSDSADPStyatamlraacgdtvakkdyddddgnakktskteqqqqqeedaswsyir 211 Trypanosoma cruzi
Feature 1                                                                                       
1FYE_A      144 FDALDLFPLQINPHFTnalpeghkgetREQRIRELLVVap-------elTVIGLPEgnwiqvs------ngqavlgGPNT 210 Salmonella typhi...
NP_624606   156 EPPFGLFDWYLKPHLYspd-----fpeRDDAWADRITAra-------dfPIYFIDDetavrvr------dgkadvvSEGR 217 Streptomyces coe...
EAM75633    160 TAGLGLVDFLVQPHLDsphf----psaREDAVRRAVAGfa--------hPTFALADgravlvd------ddevrvvGAGR 221 Kineococcus radi...
YP_118154   154 ADGLSLLPFSNAVHYSd----------RREHFRSCVAAge--------lPEGYTTEagaglhfagtecvgafadrkSAAA 215 Nocardia farcini...
ZP_00537888 154 DETLGLVEFSIFPHLDhell---pentLDEAVKWAADLt---------gPSYAIDDqtaiqvv------dgvvkviSEGH 215 Exiguobacterium ...
XP_829323   253 VHGLSVLPGIFCPQHSs----------RDATGLLLNESfskmlkrhpteRGIGVDCravlllmgdgryqvltianrEGRT 322 Trypanosoma brucei
ZP_00838429 153 LNGMGLLPYQFLPHSDlsdgg-valsvRAACLLEAASLae-------ypLILCGDEdavvat---------kaglrGFGQ 215 Shewanella sp. PV-4
ZP_00383050 157 LEGLGITKTQILPHYNli-------knDFLDGKKLFEEitysd--sfgkEFIALNDgsyiygddkhekiygeayliSDGR 227 Lactococcus lact...
CAJ02596    196 VRGLNILPGMLCPHFDvtqg---ngvrREEDFTKMLKRhp-------teRGIGVDNwallil---------kgdgtYESA 256 Leishmania major
XP_815112   212 VHGLGLLPGLLCPHYDmcet---ngvlREEDFDKMMKRhp-------teRGIGIDHwaav-------------vlpGDGT 268 Trypanosoma cruzi
Feature 1            
1FYE_A      211 TWVFK 215 Salmonella typhimurium
NP_624606   218 WRFHP 222 Streptomyces coelicolor A3(2)
EAM75633    222 HLVLP 226 Kineococcus radiotolerans SRS30216
YP_118154   216 YRVVR 220 Nocardia farcinica IFM 10152
ZP_00537888 216 WKRFD 220 Exiguobacterium sp. 255-15
XP_829323   323 ASVKD 327 Trypanosoma brucei
ZP_00838429 216 PLLFD 220 Shewanella sp. PV-4
ZP_00383050 228 IRAID 232 Lactococcus lactis subsp. cremoris SK11
CAJ02596    257 ALPGK 261 Leishmania major
XP_815112   269 YEVFS 273 Trypanosoma cruzi

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