Conserved Protein Domain Family
ManB

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cd03088: ManB 
ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In Mycobacterium tuberculosis, the causative agent of tuberculosis, PMM is involved in the biosynthesis of mannosylated lipoglycans that participate in the association of mycobacteria with host macrophage phagocytic receptors. ManB belongs to the the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100090
View PSSM: cd03088
Aligned: 29 rows
Threshold Bit Score: 601.113
Threshold Setting Gi: 84515086
Created: 21-Oct-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #  #                                                                        
AAV74380      16 NFGTSGARGLVVDFTHNVCAAFTHAFLSViekh---fkfdTVAVAIDNRPSSFNIAQACVFAIKQHGYGIEYHGVIPTPA 92  Escherichia coli
YP_170385     16 KFGTSGVRGLVSAMTDKICWLYTKAFIQFleqkysiakgtKIAIAHDLRESSPRITTVVIKAIIDSGHEPIYCGEIPSPA 95  Francisella tul...
1230581       14 AFGTSGVRALVENLTPKLCYAYAQAFLQQics-----natQVAVAIDLRPSSPDIACAMLKAAQDLNIDVVFCGALPTPA 88  Vibrio cholerae...
ZP_00629794   91 AFGTSGARGLVSALTDRVAHGYTQGFLHYlreigefapgtAVALAGDLRPSTPRILRACAQAIRDTGGQPVFCGHVPTPA 170 Paracoccus deni...
ZP_01451091   49 KFGTSGARGLATDMTDRVCYAYTTAFLHYleskgdirrgdEVAIAGDYRPSSPRIMNAVALAVRDGGFLPVNCGFIPTPA 128 Mariprofundus f...
ZP_00531722   10 KFGTSGARGLVADMTDRVCYAFASAFLQSvad-----daeTVLLGHDLRPSSPAIASACLSAVKDAGSRVVYAGALPTPA 84  Chlorobium phae...
YP_001603372  13 AFGTSGARGLVTAMTDAVCFAYTVGYLKHlatlgefspgtPVAVAGDLRPSTPRIVRACVAAIRSMRGEPVFCGFVPTPA 92  Gluconacetobact...
ZP_01875882   16 KFGTSGARGLATAMTDEVCYAYTLAFLTHlensnnikegsEVAIAGDLRPSSPRICAAVVKAVEDKGYLAVYSGEIASPA 95  Lentisphaera ar...
YP_001166175  22 PFGTSGVRGLASAMTDVLCHAYATAFLQYlrqigefapgdPVAIAGDLRESTPRILAACATAVRDCGGEVINCGRTPTPA 101 Novosphingobium...
YP_001258541   4 AFGTSGLRGESVDFTDNVCMVYVSAFLQHlshn---fsyeTVYVGADLRESSPKITISCYRAIELTGRRAIWAGNVPTPA 80  Brucella ovis A...
Feature 1                         ###       #                                                    
AAV74380      93 LAHYSMQKNIPCIMVTGSHIPFDRNGLKFYRPDGEITKEDELAIVNSEYTFspvgvlp---------------------- 150 Escherichia coli
YP_170385     96 VMLYGISNQIPSVMVTGSHIPEDRNGIKFNTPYGEVLKEDEEMIVSQTISIdesifdkngmfl----------------q 159 Francisella tul...
1230581       89 LAYFAMQNAMPSIMITGSHIPFDRNGFKFYTTTGEITKADELSIQNAPVSErssdfcla--------------------- 147 Vibrio cholerae...
ZP_00629794  171 LAHYAFGRAIPSLMVTGSHIPNDRNGIKFHRPGGEILKSDEAGMARQALALdparfgpdggl-----------------v 233 Paracoccus deni...
ZP_01451091  129 VACYAMARGQASIMVTGSHIPDDRNGIKFYKPTGEVLKPDEEAISRSEVKLparfgvagevlascfdddgeilpdsmegg 208 Mariprofundus f...
ZP_00531722   85 IAFYAEKRQAPAVVVTGSHIPFDRNGIKFYRADGEISKADEQAMMSASLDVpetvqpav--------------------- 143 Chlorobium phae...
YP_001603372  93 LCVHAFARGIPSLMVTGSHIPADRNGIKFNRAHGEFLKTDEAAMREQDVELpegwfdadgal-----------------a 155 Gluconacetobact...
ZP_01875882   96 VAYYGFSKTIPSVMVTGSHIPDDRNGIKYNTPLGEILKEDEQGIRAQEVTIpenvfddegffi----------------e 159 Lentisphaera ar...
YP_001166175 102 LAFRAIGRGMASIMVTGSHIPADRNGIKFYRPHGEVLKSDEAGIVSQVVKAgddrfgadggl-----------------l 164 Novosphingobium...
YP_001258541  81 LAAYAMARNAPAIMITGSHIPEAYNGIKFYRPDGEFLKDDEAPVRGLAEELlskvvdgqrs------------------- 141 Brucella ovis A...
Feature 1                                                                                        
AAV74380     151 ---hletssqGADCYLERYVSLFYSDiLKGKRIGVYEHSSAGRDLYASLFNQLGAEVISLGRSDEFVPIDTEAVSDEDRV 227 Escherichia coli
YP_170385    160 klelpepskqAYTQYIDRYVDFFPNNcLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVK 239 Francisella tul...
1230581      148 --alppvdlaASFLYQKRYTDLFLSTaLKGKRIGLYEHSGVGRDLITSILRQLGAEVISLDRTDTFVPIDTEAVSEADQQ 225 Vibrio cholerae...
ZP_00629794  234 daaplpepqdIQDGYLRRYLDFFGKDaLSGLVLGLYQHSAVGRDLIARILRALGAEVLPLGRSDRFIPVDTEALRPEDIE 313 Paracoccus deni...
ZP_01451091  209 cealphvntaAETEYIQRYLDFFPAGcLQGRKVGVYQHSSVDRDIMVAVFEGLGASVTALGRSLSFIPVDTEAIRPEDVQ 288 Mariprofundus f...
ZP_00531722  144 ---lpqkderAYQAYVARYLDFFGQGaLDGMTVGVYEHSSVARDVLRDILEGLGAQVMSLGRTDTFVPIDTEAVREEDAH 220 Chlorobium phae...
YP_001603372 156 iaadlpaitdVVPPFVARYRDFFGPDaLSGLTLGVYQHSAVGRDVLVDIVEALGGKAVPLGRMDSFIPVDTEAVRPEDAA 235 Gluconacetobact...
ZP_01875882  160 trelaticekAEEIYIKRYTNFFAPDtLAGLRLGVYEHSCVGRDTLKSIYQQLGAEVVGLGRSEKFIPVDTEAIRPEDVA 239 Lentisphaera ar...
YP_001166175 165 dpaplpevvdVSQDYIDRYVRHFGAGaLEGLTIGVYQHSAVGRDVLVRAVEALGGVAVPFGRSEQFLPVDTEAIRQEDIE 244 Novosphingobium...
YP_001258541 142 -vnlpapladVAEEYVSRSIGAFGRDtLAGMKIGIDLHSAVGRDILVRIFKGLGAEVYPFRRTENFVAVDTEALDPADIS 220 Brucella ovis A...
Feature 1                         # # ##                                 #                  ###  
AAV74380     228 LAREWSKKYNLDAIFSTDGDGDRPLVADENGEWLRGDILGLLTAIELNIKALAIPVSCNTAIEESNkfaSIQRTKIGSPY 307 Escherichia coli
YP_170385    240 LAKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLTAKYLQANVIVTPVSSNTVAEKIGyfsNVIRTKIGSPY 319 Francisella tul...
1230581      226 KAFAWSKEWALDAIVSTDGDADRPLISDENGLWLRGDVVGILVARFLQATHVATPVNANTALELANpnmFTKRTRIGSPY 305 Vibrio cholerae...
ZP_00629794  314 LARGWAAEHRLDAIVSTDGDSDRPLLADHRGEWLRGDILGLICARELGAKCVVTPVSSNTALELSGafaRTIRTRIGSPH 393 Paracoccus deni...
ZP_01451091  289 LASVWAEKGDFDCLVSADGDGDRPLISDEHGNWLRGDVAGILCARYLEATHVVTPVSSNSAVEKSNwfkQVARTRIGSPY 368 Mariprofundus f...
ZP_00531722  221 RARAWAKEHTFDAIVSTDGDGDRPLIGDEQGEWLRGDVVGILCAQFLRANVVVTPVSCNTAVEECGafdRVIRTRIGSPY 300 Chlorobium phae...
YP_001603372 236 LARDWAAAGTLDAILTTDGDSDRPLLADRAGNWLRGDVLGILAARFLNAAAVTTPVSSNTALELSGfakEVRRTRIGSPF 315 Gluconacetobact...
ZP_01875882  240 LAAQWAQESHFDAILSADGDCDRPLISDEKGQWLRGDVAGILCAQFLNADAVATPVSCNSAVELCEsfsVVKRTRIGSPY 319 Lentisphaera ar...
YP_001166175 245 LAAQWARSNKVDAIISTDGDSDRPLVADASGTWLRGDIVGLLCARAVGADIVVTPVSSNTVLELSGaapRVARTRIGSPY 324 Novosphingobium...
YP_001258541 221 RARTFIAEHGLDAVVSTDGDGDRPLVIDDQGRQVNGDTLGILTARYLRAKTVVTPLSTTSALEESGwfeNIHRTRIGSPY 300 Brucella ovis A...
Feature 1                                # # #                                                   
AAV74380     308 VIAAFadl------akQFDSVAGFEANGGFLLASDLqinDKELKSLPTRDAVLPALMLLIASRn--sTISQLINNLPQRF 379 Escherichia coli
YP_170385    320 VIAAMnel-----lsnNQNAVVGYEANGGFLLASDIckdDKTLKALPTRDAVIPMLAVMMLSInsnkTVSELLFDLPSRY 394 Francisella tul...
1230581      306 VIEAMqalalqattttGSPKVVGYEANGGFLVGNDMpcgLGMLNALPTRDAVLPILAVLCQSAqdglPISQLVDGLPARY 385 Vibrio cholerae...
ZP_00629794  394 VIAAMdea-----aceTLGPVCGYEANGGFLLGSEIvrdGRRLSALPTRDAVLPVVAVLAAAKa--rPLAELCADLPQRA 466 Paracoccus deni...
ZP_01451091  369 VIEAMdma-----vadGASSVVGYEANGGFLIATDIelhGKTLTALPTRDAVIVPVAILLLAIeggvSVGGLLDSLPQRF 443 Mariprofundus f...
ZP_00531722  301 VIAGMee-------agSDGVVVGYEANGGFLLGSDAvrnGKALDALPTRDAVLPIVALLCMVRelgcKVSELTDSLPKRY 373 Chlorobium phae...
YP_001603372 316 VVAAMtea-----aeaGLVPSVGYEANGGFLLASDVtryGRTLAALPTRDSVLPMICALVAAReqgrDLDALVATLPPRF 390 Gluconacetobact...
ZP_01875882  320 VIASMkea-----sasGSQMVVGYEANGGFLTNSDFkqgAKVLEALPTRDAAILHIALLVDAKkqgiKLSELVATLPARY 394 Lentisphaera ar...
YP_001166175 325 VIAAMmdaa----tadPSARVCGYEANGGFLLGTDVgegEGRLTALPTRDALLPIIAVVRAARq--rPLADILAELPPRF 398 Novosphingobium...
YP_001258541 301 VVVEMar--------aVAHPVVGFEANGGFLLGDDValkTGLLRRLPTRDAVLPAVAVLAQAKdqgmRLSEMVATLPSRF 372 Brucella ovis A...
Feature 1                                                                         # ###    #     
AAV74380     380 TWSDRVKNFPSDSSQQIIKNAISspnnffns-----lgyeslsCSSIDETDGARFTLNNGDIIHLRPSGNAPELRCYAEA 454 Escherichia coli
YP_170385    395 TASSKIDDFASEKSQEILKSILAgesdlldkii-sehfdgknsIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEA 473 Francisella tul...
1230581      386 TYSDRIQQVPTEFSQRLIKQLKEdsqqmqcfl--eatgveapsVDTVDETDGLRIHLSNYEIVHLRPSGNAPELRCYAES 463 Vibrio cholerae...
ZP_00629794  467 TFSDRLKDFPTRDAQAILAWLTSgseaesrarieaqfgalagrLGRIDQTDGLRMSFEDGAIIHLRPSGNAPELRLYTEA 546 Paracoccus deni...
ZP_01451091  444 SCSDRLKAFPTDIAQARIKALSSgdiatdkaaiealfgeqfgtVASINDTDGLRITFASEEVVHLRPSGNAPELRCYNEA 523 Mariprofundus f...
ZP_00531722  374 TASDRLQDFPTELSRSIIAGLQAapdeigal-----mapdagaAAAVDSTDGLRVTFANGDIVHLRPSGNAPELRCYAEA 448 Chlorobium phae...
YP_001603372 391 TLSDRLVEMPTAQSQAQIAKLGEdpeggaaal---gfteacgpLHHVDKTDGLRMIFANGEIIHLRPSGNAPELRVYVEA 467 Gluconacetobact...
ZP_01875882  395 TISDRLKEFPTERSQEKLKSFTSeggesriee---lfaqlsgsLASIDQTDGVRMTFDNKEVIHLRPSGNAPELRCYNEA 471 Lentisphaera ar...
YP_001166175 399 TFSDRVAEFPQAHSAALIAFLSTgpedaqlariarcfgeiaglPIGIDTTDGYRMTFADGSIIHFRPSGNAPELRCYTEA 478 Novosphingobium...
YP_001258541 373 MKADRVKEVPGDRAAPFLHAMETsqsfrsn------fspliaePEAISTVDGVRMAFANGDTVHFRQSGNAPEMRIYIET 446 Brucella ovis A...
Feature 1                      
AAV74380     455 SDENQAKQYVTNVL 468 Escherichia coli
YP_170385    474 ASDEQAKSLNQYCV 487 Francisella tularensis subsp. tularensis SCHU S4
1230581      464 SEMNRAKQIVELAL 477 Vibrio cholerae O139
ZP_00629794  547 ETEETARTLNARAL 560 Paracoccus denitrificans PD1222
ZP_01451091  524 ATEARAAEMNRICM 537 Mariprofundus ferrooxydans PV-1
ZP_00531722  449 DTAERAGRLCRECL 462 Chlorobium phaeobacteroides BS1
YP_001603372 468 DSPERADELLKTGL 481 Gluconacetobacter diazotrophicus PAl 5
ZP_01875882  472 DSEARAIELNRACI 485 Lentisphaera araneosa HTCC2155
YP_001166175 479 ETEAKARDLNARAL 492 Novosphingobium aromaticivorans DSM 12444
YP_001258541 447 DSAEKTDRMLSEFI 460 Brucella ovis ATCC 25840

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