1WQA,2F7L


Conserved Protein Domain Family
PGM_like1

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cd03087: PGM_like1 
Click on image for an interactive view with Cn3D
This archaeal PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100089
View PSSM: cd03087
Aligned: 43 rows
Threshold Bit Score: 468.974
Threshold Setting Gi: 118431870
Created: 21-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #  #                                                                        
1WQA_A         4 LFGTFGVRGIAne-kiTPEFAMKIGMAFGTLlkregrkkpLVVVGRDTRVSGEMLKEALISGLLSVGCDVIDVGIAPTPA 82  Pyrococcus hori...
NP_147143      6 LFGTDGVRGVIgs-elTPEFVLRLARAIGAYfgr----gsRILVGRDTRSGGELFEGLVAAGLAFEGVEVHLAGTLPTPA 80  Aeropyrum perni...
YP_001435474   4 LFGTDGVRGITne-gmTPELAMKVAQAACTWlg-----ggKVLVGRDVRYGGDMLVSAVLAGLSSCGCEPYYAGLVPTPA 77  Ignicoccus hosp...
YP_001541501   7 LFGTNGVRLEFtkgnyDPGFLVKLAGAVATYvn-----agDVLLGFDVRVTSLPLVGVLYGVLSMYGINVDVIGPLPTPI 81  Caldivirga maqu...
10581623       3 VFGSSGTRGVAne-elTPGFVLRVAKAAGSVwr-----adRVAVARDTRTTGRMLENAAVAGLQSIGVDVDRLGVVPTPA 76  Halobacterium s...
YP_331302      3 VFGSSGVRGVVge-klTPPFVGRVAAAAATVld-----adTMAVARDTRTSGQLFADAAASALAAVGCSVARLGVVPTPG 76  Natronomonas ph...
YP_656811      3 LFGSSGTRGVVge-giTPELVLQVAKAAGTVwe-----anQAIIARDTRTSSQSFVNAAVSGLTSVGIDVIRLGVTPTPS 76  Haloquadratum w...
NP_279859     11 LFGTAGIRGDAve-tvTPQLALAVGTAAATTapg---dtpEFVVSRDGRETGPALIAAVTAGLAAGGARVIRGGVLPTPA 86  Halobacterium s...
YP_184190      3 LFGTAGIRGTLwe-kvTPELAMKVGMAVGTYks------gKALVGRDGRTSSVMLKNAMISGLLSTGMEVLDADLIPTPA 75  Thermococcus ko...
NP_148606      7 LFGTAGIRGRYlr-kvTPLLAYQVGLALAGYvgs----ggSIVVAHDVRTTSPLLASMAASGVMAGGVDAILVGQVPLPA 81  Aeropyrum perni...
Feature 1                          ###       #                                                   
1WQA_A        83 VQWATKHfnadGGAVITASHNPPEYNGIKLLEpNGMGLKKEREAIVEELFFKedfd-rakWYEIGe-VRRED---IIKPY 157 Pyrococcus hori...
NP_147143     81 LQLYVRDhgydAGVMVTASHNPPEYNGIKVVGgDGVEVPRDVEEGIEALFWEgkfs-tveWRSVAgqPKRVHd--AVDYY 157 Aeropyrum perni...
YP_001435474  78 LQYAVPRlgydMGIMVTASHNPPQYNGVKVIGsNGVEVPRDAEREIEEIIFEnkvr-rvpYYEVKe-AKREGr--VLDVY 153 Ignicoccus hosp...
YP_001541501  82 HQYLTKAwgyrAGIMVTASHNPPHYNGIKLMDsNGVEVSRRVEEEVETIFFNgryketvdYRDIGa-VRFINveeGLRDY 160 Caldivirga maqu...
10581623      77 TQAYAERag-vPAVMVTASHNPSQYNGVKLVGsDGVELAVADLERVERAFTTeqfd-naaWDGVGa-DREVAs--AGRDY 151 Halobacterium s...
YP_331302     77 AQAYADRtg-rPVVMITASHNPPAYNGVKLVGgDGTELPRATLETIEDRLLAedfd-lvgYDAVGssTRIPD---APETY 151 Natronomonas ph...
YP_656811     77 VVHYAGEtd-rPGIVITASHNPPEYNGVKLIGeTGVEIGVEGLERIEACVLNedft-pasWDNIGs-ITRTEt--VNTEY 151 Haloquadratum w...
NP_279859     87 LAYASRGr---RGIQVTASHNPPSDNGIKLFA-DGREYDSDAERAIETRVAAdte--yaaWAEWGs-AESAT---VRPDY 156 Halobacterium s...
YP_184190     76 LAWGTRKla-dAGVMITASHNPPTDNGVKVFNgDGTEFYVEQERGLEEIIFSgnfr-karWDEIKp-VRNVE---VIPDY 149 Thermococcus ko...
NP_148606     82 ASYSVVRsgskSGIMVTASHNPPWDNGIKIVDsRGMELTRSEEEELESIIEDgvegfladWNSVGi-LRIEKe--MLNYY 158 Aeropyrum perni...
Feature 1                                                                                        
1WQA_A       158 IEAIKSKVDveai----kkrKPFVVVDTSNGAGs-LTLPYLLRELGCKVITVNAQPDGYFpaRNPEPNEENLKEFMEIVK 232 Pyrococcus hori...
NP_147143    158 VNRVVENVSaftq----rggGERVVVDCGGGATs-FTTVEILKRLGARPIPLSCKPDPLFssRDPEPTPDTLGPAASLVR 232 Aeropyrum perni...
YP_001435474 154 IDGILADIDvqkv----knkEFKVVVDGANSVGs-LATPLVLRKLGAKVLCLNCNLDPSFpgRHPEPTPQSLEETSRAAV 228 Ignicoccus hosp...
YP_001541501 161 RDHLLSIINdepi----rrrGFRIVADFANSVNs-IALSYVLRGLNVKVYSINGHLDGEFpgRNPEPRPENLNVASRAVV 235 Caldivirga maqu...
10581623     152 RAQLSDAVDraai----aaaDLTVALDPGHGAGa-LTSPTFYRELGCDVVTVNAQPDGHFpgREPEPVREHLGDLGALVR 226 Halobacterium s...
YP_331302    152 VEELLDRLAtdglrerlaaaEPTVAIDPGNGAGc-VTSPRFFRELGCDVVTVNGQPDGHFpgRDPEPVADNLGSLRRLVR 230 Natronomonas ph...
YP_656811    152 VDKLLTALEqdgsreaiadaNLTVAIDPGHGAGc-LTSPQFFRKLGCDVVTVNATPDGHFpgRPSEPIASNLTALRSLVT 230 Haloquadratum w...
NP_279859    157 RAAVEAFARdhga----pldGTTVAVDCGNGVAa-VATPHVLRALGAHVVTLNANVDGHFpgRPSKPTPETVTDLREFVA 231 Halobacterium s...
YP_184190    150 INAVLDFVGhe--------tNLKVLYDGANGAGs-LVAPYLLREMGAKVLSVNAHVDGHFpgRKPEPRYENIAYLGKLVR 220 Thermococcus ko...
NP_148606    159 MEDIVARTAvdg------etSLSMAVDCANGAAsgVTPIVLRSIGVRRVYTFNCHPDGYFpgRHPEPRPDVLEPFIKSSS 232 Aeropyrum perni...
Feature 1                  # # ##                                        #                     ##
1WQA_A       233 ALgaDFGVAQDGDADRAVFIDENGRFIQGDKTFALVADAVlkek---gggLLVTTVATSNLLDDiakk-hgaKVMRTKVG 308 Pyrococcus hori...
NP_147143    233 SSgaVFGVGHDADGDRAIVIDDRGRVVWGDRSGALLAGFVaevglakgplKVYTGVSSSIVVEDylrp-rgiEVVWTPVG 311 Aeropyrum perni...
YP_001435474 229 AVgaDLIVAHDADADRAIIGDEAGEVHWGDRSGALLTEHLaekyp-hlpkRTFTGVSSSHIVVDgylrpkgiEVVWTPVG 307 Ignicoccus hosp...
YP_001541501 236 ESsaDFGVAYDGDGDRSLFIDEKGNVIWGDRTGTILALSMikn-----gdKVVTPVSSSVVVKWaveg-aggRVIWTRVG 309 Caldivirga maqu...
10581623     227 AAdaDVGIAHDGDADRAIFVDETGEYIEGDATLAALAEAElda-----gdTTVSAVNVSQRLVDvcdr-tgaTLELTPIG 300 Halobacterium s...
YP_331302    231 STdaDLGIAHDGDADRAMFVDETGSHIEGDAALAALADAElep-----gdAVVSAVNVSQRLVDvvad-adaELELTQIG 304 Natronomonas ph...
YP_656811    231 ASnaDIGIAHDGDADRAVFIDEQGKQIAGEASLAALAAAElds-----nsATVAAVNVSQRLVDvcnr-vgaTLELTPIG 304 Haloquadratum w...
NP_279859    232 TGdaAFGIAHDGDADRIVIVDGDGDIVHEDTIVAILADHYtrtsd-aadpVVVTTPNASGRIDDrvta-aggRVERVQLG 309 Halobacterium s...
YP_184190    221 ELgvDLAIAQDGDADRIAVFDEKGNYVDEDTVIALFAKLYveeh---gggTVVVSIDTGSRIDAvver-aggRVVRIPLG 296 Thermococcus ko...
NP_148606    233 ILgvQAFIAHDGDADRTALGVPGYGFVKQDLVIALLSWWKlre----rkgSVVVSVDVGIEVEEvvee-lggRIVRSRLG 307 Aeropyrum perni...
Feature 1        #                     # # #                                                     
1WQA_A       309 DLIVARAl-----yENNGTIGGEENGGVIFPeHVLGRDGAMTVAKVVEIFAksgkKFSELIDELPKYYQIKTKRHVeg-- 381 Pyrococcus hori...
NP_147143    312 APIIARAi-----lTQGGIAAFEENGGYMHPpHQYVRDGGMKAALLLAMLRatgeSLSSLLDRLPSYHPIKTKIPAs--- 383 Aeropyrum perni...
YP_001435474 308 SVVIAHEl-----iKRGGVSGFEENGGFMNPvHQPVRDGAMTAALFLEMLAqrgkRASELFSALPKAYAIKGKVYRg--- 379 Ignicoccus hosp...
YP_001541501 310 SVDVSHKv-----iEEGALCGFEDNGGFIWPkHHPVRDGVSTTLLMMKVLSeekaKLSELNARMPAMLTARERMEMsr-d 383 Caldivirga maqu...
10581623     301 STQIMTRireleaeGDHVPVAGEGNGGIIFPeYRMTRDGAYTGARFLELLAdg-tPASEVVAPYDDYHNVRVNVDYdtea 379 Halobacterium s...
YP_331302    305 STYLISRirklrreGTSVPVAGEGNGGIMFPdYRIARDGAYTAARFLALVAd--rPASDVVADYSGYAYLRANIEYdhpd 382 Natronomonas ph...
YP_656811    305 STNIITRiqelqksGVSVPVAGEGNGGIFFPkFRLVRDGAYIGAKFLRLICe--qPASSIIEPYTKYANARINIEHgsek 382 Haloquadratum w...
NP_279859    310 ALHEGIAaar--ddGGDVVFAAEPWKHIHTA-FGGWIDGVASAAVLSRLVAda-gGLAPLRDPVTERPYRKVSVDCpd-e 384 Halobacterium s...
YP_184190    297 QPHDGIK-------RYKAIFAAEPWKLVHPK-FGPWIDPFVTMGLLIKLIDen-gPLSELVKEIPTYYLKKANVLCpd-e 366 Thermococcus ko...
NP_148606    308 KIHEKLLq------EANAVLAAEPWKLIDPD-WGLWVDGVYQAALLAHISLatgkTPRELLDMLPYYPSARVSYVLggen 380 Aeropyrum perni...
Feature 1                                                  # ###    #                      
1WQA_A       382 dRHAIVNKVAEmarer----gytvdTTDGAKIIFED-GWVLVRASGTEPIIRIFSEAkSKEKAQEYLNLGIELL 450 Pyrococcus horikoshii
NP_147143    384 -REEALCAVEAvkqefq---germvTIDGVKVIGEG-YWVLVRPSGTEPVVRIMLEArSEEEARALFERVLRAV 452 Aeropyrum pernix K1
YP_001435474 380 eKEELRGLYEAlkskyq---dcqftEIDGLKVVCEN-FWFLVRPSGTEPVVRIMVEAtDPKKAKEVYSELESFV 449 Ignicoccus hospitalis...
YP_001541501 384 lAGKIVEALKGrnwg------geviTIDGLRVNYTD-SWFLVRPSGTENLLRVVIEAsSSDRFNTLRHEVMNSI 450 Caldivirga maquilinge...
10581623     380 qRGALLDAAEAralda----dadrtTIDGYRLDYGD-AWVLVRPSGTEPVVRIYAEStDHERAESLAEAFAADL 448 Halobacterium sp. NRC-1
YP_331302    383 eREAMLVAAEKvaeda----daeltTTDGYRLDYGD-AWVLVRPSGTEPLVRLYAEAgDRARAQTLLETFRDPM 451 Natronomonas pharaoni...
YP_656811    383 eLEALMRGAEEfaeea----dvtpnIIDGYRLDYDD-AWVLIRPSGTEPVVRVYAEAkEQTQAQTLADDAAGKL 451 Haloquadratum walsbyi...
NP_279859    385 kKAAVMDAVADrlpdah--pdadveTEYGVRLAFADgSWALVRPSGTEPYVRVYAESsDVDELVDAVTDVVAST 456 Halobacterium sp. NRC-1
YP_184190    367 yKAEVVRRAAEeverklsseikevlTISGFRIALNDgSWILIRPSGTEPKIRVVAEApTEKRRDELFEMAYSTV 440 Thermococcus kodakare...
NP_148606    381 eRDRLYEDVVEklshsltgnavrilPIDGVRIDYEDrSWLLFRKSGTEPKLRVYAQArEKERLVELLSRIHSMV 454 Aeropyrum pernix K1

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