2DKC,1KFQ,1TUO,1WQA,2DKD,2FKM,2FUV,2H4L


Conserved Protein Domain Family
phosphohexomutase

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cd03084: phosphohexomutase 
Click on image for an interactive view with Cn3D
The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). These enzymes play important and diverse roles in carbohydrate metabolism in organisms from bacteria to humans. Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100086
View PSSM: cd03084
Aligned: 13 rows
Threshold Bit Score: 309.287
Threshold Setting Gi: 18655891
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2DKC_A; Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) binds GlcNAc-6-Phosphate and Zn phosphate; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2DKD_A; Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) binds GlcNAc-1-Phosphate and Zn phosphate; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2FKM_X; Pseudomonas aeruginosa PMM/PGM binds alpha-D-glucose 1,6-bisphosphate
    View structure with Cn3D
  • Structure:2H4L_X; Pseudomonas aeruginosa PMM/PGM binds ribose 1-phosphate
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       # #  #                                                                        
2DKC_A     23 TYGTAGFRMKAdk-----ldYVTFTVGIIASLRskyl------------------------------------------- 54  Candida albicans
1KFQ_B     20 KPGTSGLRKKVsea---tqpNYLENFVQSIFNTlrkdelkpknvlfvggdgryfnrqaifsiirlayandisevhvgqag 96  Paramecium tetraur...
1TUO_A     13 RFGTEGFRGVIare---ftfATLHRLAEAYGRHllerggglvvvghdtrfladafaralsghl----------agmglkv 79  Thermus thermophilus
1WQA_A      4 LFGTFGVRGIAnek---itpEFAMKIGMAFGTLlkregrkkplvvvgrdtrvsgemlkealis---------gllsvgcd 71  Pyrococcus horikoshii
2DKD_A     23 TYGTAGFRMKAdk-----ldYVTFTVGIIASLRskyl------------------------------------------- 54  Candida albicans
2FKM_X     12 IFRAYDIRGVVgdt---ltaETAYWIGRAIGSEslargepcvavgrdgrlsgpelvkqliqg-----------lvdcgcq 77  Pseudomonas aerugi...
2FUV_A     44 KFGTSGHRGSAgrhs--fnePHILAIAQAIAEErakngitgpcyvgkdthalsepafisvlevlaan--gvdvivqenng 119 Salmonella typhimu...
2H4L_X     13 IFRAYDIRGVVgdt---ltaETAYWIGRAIGSEslargepcvavgrdgrlsgpelvkqliqg-----------lvdcgcq 78  Pseudomonas aerugi...
P31120      6 YFGTDGIRGRVgdap--itpDFVLKLGWAAGKVlarhgsrkiiigkdtrisgymlesaleag-----------laaagls 72  Escherichia coli K12
AAH10087   56 EFGTAGLRAAMgpgisrmndLTIIQTTQGFCRYlekqfsdlkqkgivisfdarahpssggssrrfarlaattfisqgipv 135 human
BAB74060  384 LFGQRGVQGLAnid---ispEFAVKLGAAYGSTlkpgakvtvsrdqrnvsrmvtrsliagl-------------msvgvd 447 Nostoc sp. PCC 7120
AAV74380   16 NFGTSGARGLVvdf----thNVCAAFTHAFLSViekhfkfdtvavaidnrpssfniaqacvf-----------aikqhgy 80  Escherichia coli
XP_640645   5 IRSISGVRGVVgadq--swtPTLVANHIIAFTQllesshynqnqkkivvgrdsrvsgpwfemitn------gslisrgyq 76  Dictyostelium disc...
Feature 1                                  ###           #                                    
2DKC_A     55 ------------------qgktVGVMITASHNPp----EDNGVKVVDplGSMLESSWEKYATDLANAspspsndsegekn 112 Candida albicans
1KFQ_B     97 lmstpasshyirkvneevgnciGGIILTASHNPggkehGDFGIKFNVrtGAPAPEDFTDQIYTHTTKikeyltvdyefek 176 Paramecium tetraur...
1TUO_A     80 vllkgpvptpllsfavrhlkaaGGAMLTASHNPp----QYLGVKFKDatGGPIAQEEAKAIEALVPEearaleg------ 149 Thermus thermophilus
1WQA_A     72 vidvgiaptpavqwatkhfnadGGAVITASHNPp----EYNGIKLLEpnGMGLKKEREAIVEELFFKedfdrakwy---- 143 Pyrococcus horikoshii
2DKD_A     55 ------------------qgktVGVMITASHNPp----EDNGVKVVDplGSMLESSWEKYATDLANAspspsndsegekn 112 Candida albicans
2FKM_X     78 vsdvgmvptpvlyyaanvlegkSGVMLTGDHNPp----DYNGFKIVVa-GETLANEQIQALRERIEKndlasgv------ 146 Pseudomonas aerugi...
2FUV_A    120 ftptpavsnailvhnkkggplaDGIVITPSHNPp----EDGGIKYNPpnGGPADTNVTKVVEDRANAllagglqgvkris 195 Salmonella typhimu...
2H4L_X     79 vsdvgmvptpvlyyaanvlegkSGVMLTGXHNPp----DYNGFKIVVa-GETLANEQIQALRERIEKndlasgv------ 147 Pseudomonas aerugi...
P31120     73 alftgpmptpavayltrtfraeAGIVISASHNPf----YDNGIKFFSidGTKLPDAVEEAIEAEMEKeiscvdsae---- 144 Escherichia coli K12
AAH10087  136 ylfsditptpfvpftvshlklcAGIMITASHNPk----QDNGYKVYWdnGAQIISPHDKGISQAIEEnlepwpqawddsl 211 human
BAB74060  448 iqnldataipiartviptmgvaGGIHVRVHPDRa----DYILIEFMDhkGINISKAQEKKIEGAYFKedmrralthe--- 520 Nostoc sp. PCC 7120
AAV74380   81 gieyhgviptpalahysmqkniPCIMVTGSHIPf----DRNGLKFYRpdGEITKEDELAIVNSEYTFspvgvlphl---- 152 Escherichia coli
XP_640645  77 vihidiastptvqymvektkssGGIVITSSHNPi----EWNGLKFIGpdGLFIAPKECEILFSMADKpeefkfsgyd--- 149 Dictyostelium disc...
Feature 1                                                                                     
2DKC_A    113 slveviknlvsdlkidlsipanvviardsresspalsmatidgfqsvpntkyqdfglfttpelhyvtrtlndpdfgkpTE 192 Candida albicans
1KFQ_B    177 hinldqig--------------------------------------------------vykfegtrlekshfevkvvdTV 206 Paramecium tetraur...
1TUO_A    150 ------------------------------------------------------------------------ayetldLR 157 Thermus thermophilus
1WQA_A    144 ---------------------------------------------------------------------eigevrredII 154 Pyrococcus horikoshii
2DKD_A    113 slveviknlvsdlkidlsipanvviardsresspalsmatidgfqsvpntkyqdfglfttpelhyvtrtlndpdfgkpTE 192 Candida albicans
2FKM_X    147 -----------------------------------------------------------------------gsveqvdIL 155 Pseudomonas aerugi...
2FUV_A    196 l----------------------------------------------------------------daaxasghvkavdLV 211 Salmonella typhimu...
2H4L_X    148 -----------------------------------------------------------------------gsveqvdIL 156 Pseudomonas aerugi...
P31120    145 ---------------------------------------------------------------------lgkasrivdAA 155 Escherichia coli K12
AAH10087  212 -----------------------------------------------------------------idsspllhnpsasIN 226 human
BAB74060  521 ---------------------------------------------------------------------igdvaypsqVI 531 Nostoc sp. PCC 7120
AAV74380  153 ---------------------------------------------------------------------etssqgadcYL 163 Escherichia coli
XP_640645 150 --------------------------------------------------------------------qlgkiekcvdAN 161 Dictyostelium disc...
Feature 1                                                                                     
2DKC_A    193 DGYYSKLAKSfqeiyticesnnekiDITIDAANGVGaPKIQELLEkylhkeisfTVVNGDYKqpn---------llNFDC 263 Candida albicans
1KFQ_B    207 QDYTQLMQKLfdfdllkglfsnkdfSFRFDGMHGVAgPYAKHIFGtllg-cskeSLLNCDPSedf--------gggHPDP 277 Paramecium tetraur...
1TUO_A    158 EAYFEALKAHldlkal----sgfsgVLYHDSMGGAGaGFLKGFLRhvgl-eipvRPIREEPHplf--------hgvNPEP 224 Thermus thermophilus
1WQA_A    155 KPYIEAIKSKvdveai----kkrkpFVVVDTSNGAGsLTLPYLLRelg---ckvITVNAQPDgyf--------parNPEP 219 Pyrococcus horikoshii
2DKD_A    193 DGYYSKLAKSfqeiyticesnnekiDITIDAANGVGaPKIQELLEkylhkeisfTVVNGDYKqpn---------llNFDC 263 Candida albicans
2FKM_X    156 PRYFKQIRDDiama--------kpmKVVVDCGNGVAgVIAPQLIEalg---csvIPLYCEVDgnf--------pnhHPDP 216 Pseudomonas aerugi...
2FUV_A    212 QPFVEGLADIvdxaai----qkaglTLGVDPLGGSGiEYWKRIAEhyk---lnlTLVNDQVDqtfrfxhldkdgaiRXDC 284 Salmonella typhimu...
2H4L_X    157 PRYFKQIRDDiama--------kpmKVVVDCGNGVAgVIAPQLIEalg---csvIPLYCEVDgnf--------pnhHPDP 217 Pseudomonas aerugi...
P31120    156 GRYIEFCKATfpnel-----slselKIVVDCANGATyHIAPNVLRelg---anvIAIGCEPNgv----------niNAEV 217 Escherichia coli K12
AAH10087  227 NDYFEDLKKYcfhrsv---nretkvKFVHTSVHGVGhSFVQSAFKafdlvppeaVPEQKDPDpefp-------tvkYPNP 296 human
BAB74060  532 DLYCTAFEKLlnvstl----nnsraKVVIDYVYAVSgAVLPQMLDkfg---adaVVLNASLNkn-----------aVTTT 593 Nostoc sp. PCC 7120
AAV74380  164 ERYVSLFYSDilk----------gkRIGVYEHSSAGrDLYASLFNqlg---aevISLGRSDEfv----------piDTEA 220 Escherichia coli
XP_640645 162 QQHVGAILSLafldisk--irerrfKVCLDSVNGAGgPIMSYLLTqln---cevIGINLETTgl----------faHTPE 226 Dictyostelium disc...
Feature 1                                      # # ##                                         
2DKC_A    264 gadyvKTNQKLPKNVkpv-------nnKLYASFDGDADRLICYYqnndnkfKLLDGDKLSTLFALFlqqlfkqid-ptki 335 Candida albicans
1KFQ_B    278 n---lTYAHDLVELLdihkkkdvgtvpQFGAACDGDADRNMILGr-----qFFVTPSDSLAVIAANanlif--------k 341 Paramecium tetraur...
1TUO_A    225 i---pKNLGVTLAVLgpe------tppSFAVATDGDADRVGVVLpg----gVFFNPHQVLTTLALYrfrk---------- 281 Thermus thermophilus
1WQA_A    220 n---eENLKEFMEIVkal-------gaDFGVAQDGDADRAVFIDen----gRFIQGDKTFALVADAvlke---------- 275 Pyrococcus horikoshii
2DKD_A    264 gadyvKTNQKLPKNVkpv-------nnKLYASFDGDADRLICYYqnndnkfKLLDGDKLSTLFALFlqqlfkqid-ptki 335 Candida albicans
2FKM_X    217 gk--pENLKDLIAKVkae-------naDLGLAFDGDGDRVGVVTnt----gTIIYPDRLLMLFAKDvvsr---------- 273 Pseudomonas aerugi...
2FUV_A    285 ss--eCAXAGLLALRdk---------fDLAFANDPDYDRHGIVTp-----aGLXNPNHYLAVAINYlfqhrp------lw 342 Salmonella typhimu...
2H4L_X    218 gk--pENLKDLIAKVkae-------naDLGLAFDGDGDRVGVVTnt----gTIIYPDRLLMLFAKDvvsr---------- 274 Pseudomonas aerugi...
P31120    218 g---aTDVRALQARVlae-------kaDLGIAFDGDGDRVIMVDhe----gNKVDGDQIMYIIAREglrqg--------- 274 Escherichia coli K12
AAH10087  297 ee--gKGVLTLSFALadk------tkaRIVLANDPDADRLAVAEkqdsgewRVFSGNELGALLGWWlftswkeknqdrsa 368 human
BAB74060  594 dr--eTLLTQLGHVVeal-------kaNFGVQVSANGEQLILVDe-----sGYPIRGELLTALMVDmilts--------- 650 Nostoc sp. PCC 7120
AAV74380  221 vs--dEDRVLAREWSkky-------nlDAIFSTDGDGDRPLVADen----gEWLRGDILGLLTAIEln------------ 275 Escherichia coli
XP_640645 227 pv--pSNLGQLCEMVvky-------kaDFGIAVDPDVDRCVFIDe-----hGKPLGEEYTLAMAVElvlgd--------c 284 Dictyostelium disc...
Feature 1               #                     ###                     # # #                   
2DKC_A    336 slniGVVQTAYANGSSTKyvedvlkiPVRCTPTGVKHLHHEaen-----fdiGVYFEANGHGTVIfnpeaekkifdykpn 410 Candida albicans
1KFQ_B    342 ngllGAARSMPTSGALDKvaak-ngiKLFETPTGWKFFGNLmda-----gliNLCGEESFGTGSNhi------------- 402 Paramecium tetraur...
1TUO_A    282 ghrgRAVKNFAVTWLLDRlger-lgfGVTTTPVGFKWIKEEflk-----gdcFIGGEESGGVGYPeh------------- 342 Thermus thermophilus
1WQA_A    276 kgggLLVTTVATSNLLDDiakk-hgaKVMRTKVGDLIVARAlye-----nngTIGGEENGGVIFPeh------------- 336 Pyrococcus horikoshii
2DKD_A    336 slniGVVQTAYANGSSTKyvedvlkiPVRCTPTGVKHLHHEaen-----fdiGVYFEANGHGTVIfnpeaekkifdykpn 410 Candida albicans
2FKM_X    274 npgaDIIFDVKCTRRLIAlisg-yggRPVMWKTGHSLIKKKmke-----tgaLLAGEMSGHVFFKerw------------ 335 Pseudomonas aerugi...
2FUV_A    343 gkdvAVGKTLVSSAXIDRvvnd-lgrKLVEVPVGFKWFVDGlfd-----gsfGFGGEESAGASFLrfdgt---------- 406 Salmonella typhimu...
2H4L_X    275 npgaDIIFDVKCTRRLIAlisg-yggRPVMWKTGHSLIKKKmke-----tgaLLAGEMSGHVFFKerw------------ 336 Pseudomonas aerugi...
P31120    275 qlrgGAVGTLMSNMGLELalkq-lgiPFARAKVGDRYVLEKmqe-----kgwRIGAENSGHVILLdk------------- 335 Escherichia coli K12
AAH10087  369 lkdtYMLSSTVSSKILRAialk-egfHFEETLTGFKWMGNRakqlidqgktvLFAFEEAIGYMCCpf------------- 434 human
BAB74060  651 nprgTVVVPVHASSAVEQvarr-hdgRIIRTKANATALMEAcqkn----pnvVLGGSGETGFIFPql------------- 712 Nostoc sp. PCC 7120
AAV74380  276 --ikALAIPVSCNTAIEEsnk---faSIQRTKIGSPYVIAAfadla-kqfdsVAGFEANGGFLLAsdlqind-------- 341 Escherichia coli
XP_640645 285 grrgNVCKNLSSSRAIDDickk-yesQVICAPVGEIQVAKKmqq-----vnaVIGGEGNGGVMLPdi------------- 345 Dictyostelium disc...
Feature 1                                                                                     
2DKC_A    411 ndneakaikvlqnfsqlinqtVGDAISDLLAVLIVVHyl------klSPSDWDNeyt-----dlPNKL-VKVIvpdrsif 478 Candida albicans
1KFQ_B    403 --------------------rEKDGIWAVLAWLTILAhknkntdhfvTVEEIVTqywqq-fgrnYYSR-YDYEqvdsaga 460 Paramecium tetraur...
1TUO_A    343 -------------------lpERDGILTSLLLLESVAat------gkDLAEQFKevealtglthAYDR-LDLPlkapldl 396 Thermus thermophilus
1WQA_A    337 -------------------vlGRDGAMTVAKVVEIFAks------gkKFSELIDelp-----kyYQIK-TKRHvegdrha 385 Pyrococcus horikoshii
2DKD_A    411 ndneakaikvlqnfsqlinqtVGDAISDLLAVLIVVHyl------klSPSDWDNeyt-----dlPNKL-VKVIvpdrsif 478 Candida albicans
2FKM_X    336 -------------------fgFDDGIYSAARLLEILSqd------qrDSEHVFSafp-----sdISTPeINITvtedskf 385 Pseudomonas aerugi...
2FUV_A    407 -----------------pwstDKDGIIXCLLAAEITAvt------gkNPQEHYNelaar-fgapSYNR-LQASatsaqka 461 Salmonella typhimu...
2H4L_X    337 -------------------fgFDDGIYSAARLLEILSqd------qrDSEHVFSafp-----sdISTPeINITvtedskf 386 Pseudomonas aerugi...
P31120    336 -------------------ttTGDGIVAGLQVLAAMArn------hmSLHDLCSgmk-----mfPQIL-VNVRytagsgd 384 Escherichia coli K12
AAH10087  435 -------------------vlDKDGVSAAVISAELASflat---knlSLSQQLKaiy-----veYGYH-ITKAsyfichd 486 human
BAB74060  713 -------------------hpGFDSMFCIAKIIEMLTiq------erSLATVRSelp-----rvIYRT-HTIRcpwsakg 761 Nostoc sp. PCC 7120
AAV74380  342 --------------kelkslpTRDAVLPALMLLIASRn--------sTISQLINnlp-----qrFTWS-DRVKnfpsdss 393 Escherichia coli
XP_640645 346 -------------------hiGRDAPVAATLALQLMAnrys---qapSISKLKEtlp-----tyEIVK-LKAGiegldpd 397 Dictyostelium disc...
Feature 1                                                                            # ###    
2DKC_A    479 kttnaertlve--------------------------------------pkgmqdeidklvaqypnGRSFVRASGTe--- 517 Candida albicans
1KFQ_B    461 nkmmehlktkfqyfeqlkqgn-----------------kadiydyvdpvdqsvsknqgvrfvfgdgSRIIFRLSGTgsvg 523 Paramecium tetraur...
1TUO_A    397 tpfreprplag-------------------------------------ltpkgvdtldgvkwlyeeAWVLFRASGTe--- 436 Thermus thermophilus
1WQA_A    386 ivnkvaemare--------------------------------------rgytvdttdgakiifedGWVLVRASGTe--- 424 Pyrococcus horikoshii
2DKD_A    479 kttnaertlve--------------------------------------pkgmqdeidklvaqypnGRSFVRASGTe--- 517 Candida albicans
2FKM_X    386 aiiealqrdaq-------------------------------------wgegnittldgvrvdypkGWGLVRASNTt--- 425 Pseudomonas aerugi...
2FUV_A    462 alsklspexvsastlagd-----------------------pitarltaapgngasigglkvxtdnGWFAARPSGTe--- 515 Salmonella typhimu...
2H4L_X    387 aiiealqrdaq-------------------------------------wgegnittldgvrvdypkGWGLVRASNTt--- 426 Pseudomonas aerugi...
P31120    385 plehesv---------------------------------------------kavtaeveaalgnrGRVLLRKSGTe--- 416 Escherichia coli K12
AAH10087  487 qetikklfenlrnydgknnypkacgkfeisairdlttgyddsqpdkkavlptskssqmitftfangGVATMRTSGTe--- 563 human
BAB74060  762 almrylvethp-------------------------------------aqnlelidgvkirqpfddSWLLVLPDASe--- 801 Nostoc sp. PCC 7120
AAV74380  394 qqiiknaisspnnffns-------------------------lgyeslscssidetdgarftlnngDIIHLRPSGNa--- 445 Escherichia coli
XP_640645 398 silaeytsqfin------------------------------------kpgvvinqedglkidsqdWWVHLRKSNTe--- 438 Dictyostelium disc...
Feature 1        #                              
2DKC_A    518 DAVRVYAEAdtq--------nnVEELSKAVSELV 543 Candida albicans
1KFQ_B    524 ATIRIYFEQfeqqqiqhetataLANIIKLGLEIS 557 Paramecium tetraurelia
1TUO_A    437 PVVRIYVEAqsp--------elVRALLEEARKLV 462 Thermus thermophilus
1WQA_A    425 PIIRIFSEAksk--------ekAQEYLNLGIELL 450 Pyrococcus horikoshii
2DKD_A    518 DAVRVYAEAdtq--------nnVEELSKAVSELV 543 Candida albicans
2FKM_X    426 PVLVLRFEAdte--------eeLERIKTVFRNQL 451 Pseudomonas aeruginosa
2FUV_A    516 DAYKIYCESflg-------eehRKQIEKEAVEIV 542 Salmonella typhimurium
2H4L_X    427 PVLVLRFEAdte--------eeLERIKTVFRNQL 452 Pseudomonas aeruginosa
P31120    417 PLIRVMVEGe-----------dEAQVTEFAHRIA 439 Escherichia coli K12
AAH10087  564 PKIKYYAELcapp-----gnsdPEQLKKELNELV 592 human
BAB74060  802 PLVHLYANSh-----------eRDWVDETVRDYR 824 Nostoc sp. PCC 7120
AAV74380  446 PELRCYAEAs-----------dENQAKQYVTNVL 468 Escherichia coli
XP_640645 439 HIIRVIAEAk-----------sVKEATDIATKFI 461 Dictyostelium discoideum AX4

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