Conserved Protein Domain Family
ArsC_15kD
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cd03033: ArsC_15kD 
Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also encodes dinitrogenase reductase ADP-ribosyltransferase (DRAT) and dinitrogenase reductase activating glycohydrolase (DRAG). ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via glutaredoxin, through a single catalytic cysteine.
Links
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Statistics
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PSSM-Id: 239331
Aligned: 19 rows
Threshold Bit Score: 187.488
Created: 2-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative catalytic residues [active site]
Evidence:
  • Comment:Based on the known function of arsenate reductase, ArsC.
  • Comment:The catalytic cysteine and the second arginine of the triad is conserved in this subfamily. The first arginine is replaced by an asparagine while the third arginine is replaced by a phenylalanine, similar to Yffb proteins.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #                                             #                        
NP_946351     3 KVVFYEKPGCVGNARQKALLTASGHELEVRNLLAEPWTRETLRPFFGDKPLIEWFNQSSPKVKAGAIDFAALGVEAALAL 82  Rhodopseudomonas...
ZP_00054391   9 LIVFYEKPGCMNNTRQKQLLSKSGHDVVALDIRAQGWSPETLRPFFEGLPVAQWFNRAAPRVKSGAVVPETVGAEEALAE 88  Magnetospirillum...
CAC42522      3 CIIFYEKPGCATNRLQKELLRSAGIELEVRDLLREAWTPERLRPFFGRLPVAEWFNPSAPAIKYGELDVSELSAEQALEL 82  Pseudomonas stut...
EAN30051     18 HIIFYEKPGCLNGRLQKAMLEASGHTLEVRNLLTETWQAATLRPYFGKKPVKEWFNRSAPKIKSGEVVPYSFTEKSALQA 97  Magnetococcus sp...
ZP_00516416   3 NVTFYEKPGCRNNTKQKNLLLAAGHNLEEKSLLTEPWKPENLRLFFGDLPINLWFNPSAPRIKSGEVIPDNLNEEQALEL 82  Crocosphaera wat...
ZP_00417314   9 TVIFYEKPGCGGNRRQKTLLQEHGIELQVRDLLSTPWTRERLEPFFAGLEKDAMVNAAAPKIKSGEVDVAALSRDELIEK 88  Azotobacter vine...
ZP_00550292   3 KIIFWEKPGCKGNAKQKEILEASGHELDVRDLLTTGWSEETLRPFFGDLPVAEWFNPTNPLVKTGEIKPSEISETKALAL 82  Desulfuromonas a...
ZP_00590706   3 TILFYEKPGCRNNNRQKAMLELSGHTLETVNLLEYAWSKEELAAYLGDKPVADCFNPAAPMIKSGELNPQSFTREEAIAM 82  Pelodictyon phae...
ZP_00513138  58 AILFFEKPGCRNNAKQKSLLELSGHHVEAVNLLDYPWTKEELSCFLGEKPLAACFNPAAPSVKSGETEPHAYSRNEAIDA 137 Chlorobium limic...
ZP_00528410   3 SILFFEKPGCQNNTRQKAWLELSGHTVDAVNILEYAWTKEELSLYLGENPISACFNPAAPEVKTGSMKPELLNKEDALDA 82  Chlorobium phaeo...

Feature 1                #            #          
NP_946351    83 MIEDPLLIRRPLMQSGDRREVGFDQATVHAWLG 115 Rhodopseudomonas palustris CGA009
ZP_00054391  89 MCLDPLLIRRPLMESGGRRMAGFDETLVNDWLG 121 Magnetospirillum magnetotacticum MS-1
CAC42522     83 MVAQPLLIRRPLIRCGMHYMVDFDLVGINAWLP 115 Pseudomonas stutzeri
EAN30051     98 MLSDPLLIRRPLMKSGGGYMSGFEPEEVDHWIG 130 Magnetococcus sp. MC-1
ZP_00516416  83 MIADPLLIRRPLIHVDGVFRVGFDPEKIDAWIG 115 Crocosphaera watsonii WH 8501
ZP_00417314  89 MLAEPLLIKRPLLEVGETRICGFDIPRLNALLE 121 Azotobacter vinelandii AvOP
ZP_00550292  83 MVHEPLLIVRPLMQIGNYKMAGFDVARVEECIA 115 Desulfuromonas acetoxidans DSM 684
ZP_00590706  83 MIQQPLLIKRPLMKIGGHHLQGFDTTILKKLIH 115 Pelodictyon phaeoclathratiforme BU-1
ZP_00513138 138 MIRNPILIKRPLMKIGTRCIQGFDTAVLRNFIS 170 Chlorobium limicola DSM 245
ZP_00528410  83 MIKKPLLIRRPLLKIGNHYLQGFDTAVLRTIIS 115 Chlorobium phaeobacteroides DSM 266

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