Conserved Protein Domain Family
TlpA_like_DipZ_like
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cd03012: TlpA_like_DipZ_like 
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.
Links
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Statistics
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PSSM-Id: 239310
Aligned: 18 rows
Threshold Bit Score: 208.699
Created: 29-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic
Feature 1:catalytic residues [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             #  #                                       
Q10801       401 PDLKGITGWLNtpgnKPIDLKSl-rGKVVLIDFWAYSCINCQRAIPHVVGWYQAYkd-sGLAVIGVHTPEYAFEKVPGNV 478 Mycobacterium t...
NP_001006504  50 PELSRDLQWLNt--eGPISLHKdlcGKVVVLDFFTYCCINCLHLLPDLHELEHQYsdkdGLVIIGVHSAKFPNEKVLDSI 127 chicken
BAB72970       8 PELPQNYPWLNt--eQPLSIKQl-nGRVVILDFWTYCCINCLHVLPDLKYLEQKYk--dSLTVIGVHSAKFDNEQETENI 82  Nostoc sp. PCC ...
NP_940916     55 PEFPEGLEWLNt--eEPISVYKdlcGKIVVLDFFTYCCINCIHLLPDLHALEHTYsdkdGLLIIGVHSAKFPNEKVLDNI 132 human
EAA09865       5 AEFPDGLDWFNv--tEPLTLQGslrGKVVVLDFFTYCCINCMHILPNLKRLEHLYpieeGLAVVGVHSAKFRNEKDSANI 82  Anopheles gambi...
EAA46001      58 VEFESDLEWFNv--sCPLSIKGl-qGKVIILDFFTYCCINCMHVLQELHLLEERFpiesGVVVIGVHSPKFENERNAANI 134 fruit fly
XP_396242     49 ADFQAGLEWFNv--tEELSLYRhlnGKIIILDFFTYCCINCMHILPDLDDLEKRFpitdGLVVIGVHSAKFSNERDSKRL 126 honey bee
XP_685393     50 PDFEEGLEWLNt--dGPLSLRKelsGKVVLLDFFTYCCINCIHILPDLHQLEKNYsiqdGLIVVGVHSAKFPNEKVLQNV 127 zebrafish
ZP_00266749  259 PSLSGAVQWLNs---PELSAESl-rGKVVLVDFWTYDCINCQHTLPYVKEWEKKYgk-dGLVVIGVHTPEYGYERIIDNV 333 Pseudomonas flu...
AAN68017      37 PSLAGASQWLNs---PPLDAPGl-kGKVVLVDFWTWDCINCRRSLPHVNDWARRYad-qGLVVVGVHTPEFDYEHDVATL 111 Pseudomonas put...

Feature 1                                                          
Q10801       479 AKGAANLGISYPIALDNNYATWTNYRNRYWPAEYLIDATGTVRHIKFGEG 528 Mycobacterium tuberculosis
NP_001006504 128 KSAVLRYNIVHPVVNDADATLWHELEVSCWPTLVILGPRGNMLFSLVGEG 177 chicken
BAB72970      83 RQAILRYDIEHPVLVDKDFRVWQEYAVRAWPTLMVIDPKGYVIGYVSGEG 132 Nostoc sp. PCC 7120
NP_940916    133 KSAVLRYNITHPMVNDADASLWQELEVSCWPTLVILGPRGNMLFSLIGEG 182 human
EAA09865      83 RAAVERYEISHPVVNDNVSAMWRKLRVQCWPTLMILGPRANPLFVIMGEG 132 Anopheles gambiae str. PEST
EAA46001     135 LSAVQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTGVPMMLLMGEG 184 fruit fly
XP_396242    127 LSAIQRYNIKHPVVNDKTLSAWRNLGISCWPTLLMIGPTGELLAVFVGEG 176 honey bee
XP_685393    128 QSAVLRYDINHPVVNDSDARLWQELEVSCWPTLLLLGPRGNLLFSLVGEG 177 zebrafish
ZP_00266749  334 KDQVHKLGITYPVAIDNNYAIWRNFDNQYWPAHYLVDAKGQVRYTHFGEG 383 Pseudomonas fluorescens PfO-1
AAN68017     112 RDKVARLGIGYPVAVDNDYKVWNAWGNQFWPAHYFVDRKGQVRHVHFGEG 161 Pseudomonas putida KT2440

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