Conserved Protein Domain Family
PDI_a_TMX3
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cd03000: PDI_a_TMX3 
PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at the C-terminus. The TMX3 transcript is found in a variety of tissues with the highest levels detected in skeletal muscle and the heart. In vitro, TMX3 showed oxidase activity albeit slightly lower than that of protein disulfide isomerase.
Links
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Statistics
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PSSM-Id: 239298
Aligned: 7 rows
Threshold Bit Score: 189.202
Created: 16-May-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:CXXC motif
  • Comment:based on known function of the redox active TRX domains of PDI
  • Comment:Studies on PDI show that a conserved arginine affects the pKa value of the active site cysteine and is critical in reoxidation function.
  • Citation:PMID 8639681
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #  #                                                  
NP_061895  27 FVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLemksiGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLK 106 human
AAK93120   27 KVLELSDRFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQal--hATNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIK 104 fruit fly
NP_491361  29 AVLDLSDKFLDVKDEGMWFVEFYAPWCAHCKRLHPVWDQVGHtlsdsNLPIRVGKLDCTRFPAVANKLSIQGYPTILFFR 108 nematode
AAH73549   27 LVEDLDDSFKENRKDDIWLVDFYAPWCGHCKKLEPVWNEVGIeirtsGSPIRVGKIDATVYSSIASEFGVRGFPTIKALK 106 African clawed frog
XP_419113  51 FVEDLDESFKENRKDDIWLVDFYAPWCGHCKKLEPVWNEVGMemknmGSPVKVGKMDATSFSSIASEFGVRGYPTIKLLK 130 chicken
AAH81419   20 LVLDLDDSFKDSRMEDVWLVDFYAPWCGYCKKLEPVWEEVGAelsrsGSPVRVGKMDATAYSGMASEFGVRGYPTIKLLK 99  zebrafish
AAH95139   19 YVEGLDDKFTEFRQNELWLVEFYAPWCAYCHTFEPVWTEVGAelkslGSPVNVGKIDTTAHTSIATEFNIRGYPTIKLFK 98  zebrafish

Feature 1               #             
NP_061895 107 GDLAYNYRGPRTKDDIIEFAHRVS 130 human
AAK93120  105 GNMEFTYNGDRGRDELVDYALRMS 128 fruit fly
NP_491361 109 NGHVIDYRGGREKEALVSFAKRCA 132 nematode
AAH73549  107 GDMAYNYRGPRTKEDIVEFANRVA 130 African clawed frog
XP_419113 131 GDLAYNYRGPRTKDDIIEFANRVA 154 chicken
AAH81419  100 GDLAYNYKGPRTKDDIIEFANRVA 123 zebrafish
AAH95139   99 GDLSFDYKGPRTKDGIIEFTNRVS 122 zebrafish

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