Conserved Protein Domain Family
PDI_a_PDIR
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cd02997: PDI_a_PDIR 
PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved in oxidative protein folding in the endoplasmic reticulum (ER) through its isomerase and chaperone activities. These activities are lower compared to PDI, probably due to PDIR acting only on a subset of proteins. PDIR is preferentially expressed in cells actively secreting proteins and its expression is induced by stress. Similar to PDI, the isomerase and chaperone activities of PDIR are independent; CXXC mutants lacking isomerase activity retain chaperone activity.
Links
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Statistics
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PSSM-Id: 239295
Aligned: 25 rows
Threshold Bit Score: 132.827
Created: 15-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:CXXC motif
  • Comment:The TRX domains of human PDIR contribute to its isomerase activity with the rank order of CGHC > CPHC > CSMC.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #  #                                                
CAG08268  387 EVSHLGSeDFRDALKKKkHALVMFYAPWCPHCKSSIPHFTTAAEVFke--dRKIIYAAVDCtkgqnhELCKQEGVe-GYP 463 Tetraodon nigrovir...
EAA14324  271 EIVHLTAgSFEPALKDEkSVLVMFYAPWCGHCKKMKPEYEKAAEIMka-knIPGVLAALDAtk---eASVGQQYGvkGYP 346 Anopheles gambiae ...
EAA14324  394 EVVHLNEeTFKPFLKKKkHVLVMFYAPWCGHCKRAKPEFARAAEHFke--dPKTELAAVDCtr---hSAVCSSYEvrGYP 468 Anopheles gambiae ...
NP_609645 272 EIVHLTSqGFEPALKDEkSALVMFYAPWCGHCKRMKPEYEKAALEMkq-kkIPGLLAALDAtk---ePSIAEKYKvkGYP 347 fruit fly
XP_782086 610 AVNHLTGqTFGQFIQDNtHVLTMFYAPWCGHCKKAKPSFQQAAEIFkd--tPGRKLAAVDCtv---eKGLCEQYEvkGFP 684 purple urchin
AAH76861  282 AVYHLTDaDFDQFLSEHpSVLVMFYAPWCGHCKKMKPDYEKAAVTLqq--sGVGVLAAVDStv---hRAVSEKFHvtGFP 356 African clawed frog
XP_683991 487 AVFHLTDdSFDSFLEEHpSALIMFYAPWCGHCKKMKPEYDDAAETLnkdpnSPGVLAAVDTti---hKSTGERFKisGFP 563 zebrafish
XP_422097 288 VVYHLTDeDFDKFIKDHsSVLVMFHAPWCGHCKKMKPEYEKAAEFLhagsdSPGVLAAVDAtv---nKALAERYHisGFP 364 chicken
CAG08268  265 SVFHLTDeSFDGFLEEHpAVLVMFYAPWCGHCKKMKPEYDEAAEILnkgvdSPGVLAAVDAte---hKAVGERFKisGFP 341 Tetraodon nigrovir...
Q14554    277 SVYHLTDeDFDQFVKEHsSVLVMFHAPWCGHCKKMKPEFEKAAEALhgeadSSGVLAAVDAtv---nKALAERFHisEFP 353 human

Feature 1                                  
CAG08268  464 TFNHYNYGkfVEKYNGERg--EEGFKGFM 490 Tetraodon nigroviridis
EAA14324  347 TVKYFSNG--EFKFDVNVr-eADKIVKFM 372 Anopheles gambiae str. PEST
EAA14324  469 TIKYFSYLktVRDYNGGRt--ETDFIAYL 495 Anopheles gambiae str. PEST
NP_609645 348 TVKFFSNG--VFKFEVNVr-eASKIVEFM 373 fruit fly
XP_782086 685 TLNLYSNGqfVEKYTGGRm--AEDFEAYM 711 purple urchin
AAH76861  357 TVKYFENG--EEKYTVPHlrtEQKIVEWM 383 African clawed frog
XP_683991 564 TVKYFEKG--EEKYTLPHlrsKDKIIEWL 590 zebrafish
XP_422097 365 TVKYFKDG--EEKYTLPHlrtKKKIIDWL 391 chicken
CAG08268  342 SLKYFVNG--EEKYTLSQlrsKDKIIEFM 368 Tetraodon nigroviridis
Q14554    354 TLKYFKNGe-KYAVPVLRt--KKKFLEWM 379 human

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