Conserved Protein Domain Family
PDI_a_ERp44
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cd02996: PDI_a_ERp44 
PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by two redox inactive TRX-like domains, homologous to the b and b' domains of PDI. The CXFS motif in the N-terminal domain allows ERp44 to form stable reversible mixed disulfides with its substrates. Through this activity, ERp44 mediates the ER localization of Ero1alpha, a protein that oxidizes protein disulfide isomerases into their active form. ERp44 also prevents the secretion of unassembled cargo protein with unpaired cysteines. It also modulates the activity of inositol 1,4,5-triphosphate type I receptor (IP3R1), an intracellular channel protein that mediates calcium release from the ER to the cytosol.
Links
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Statistics
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PSSM-Id: 239294
Aligned: 10 rows
Threshold Bit Score: 181.434
Created: 15-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:Substitution of the active site cysteine to serine prevented the formation of mixed disulfides with Ero1alpha and other endogenous partners.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  #                                                  
Q9BS26     29 TEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNenQVVFARVDCDQHSDIAQRYRISKYP 108 human
AAH66767   60 GEITSLDSGNIDDILNGAGVALVNFYADWCRFSQMLHPIFEEASNIVREEYPDatQVVFGRVDCDQHSDLAQRYRISKYP 139 zebrafish
XP_419079  29 SEITSLDSGNIDDILNNADVALVNFYADWCRFSQMLHPIFEEASNVIKEEYPDknQVVFARVDCDQHSDIAQRYRISKYP 108 chicken
NP_491589  17 AEVVSLTSQNFEQTIQANELVFVNFYADWCRFSQMLKPIFLEASEKFKDAAPG--KIMWASVDADKNNDIATKYHVNKYP 94  nematode
EAL28915    3 GNSVTVGQHNIDQILESTELVLLNFYTDWCPFSIRLAPIFEEAARQINNTFWEsgRVTIGKVNCDKEENVALKFEIIKYP 82  Drosophila pseudoo...
AAL13926   33 AGAVPMTSDNIDMTLASNELVFLNFYAEWCRFSNILAPIFAEAADKIKEEFPEagKVVLGKVDCDKETAIASRFHINKYP 112 fruit fly
AAF54029   27 SSVVAVTHENLQGIIDSNELVLLSFYTDWCRFSQILQPIFEEAAAKVIQKFPEngRVILGKVNCDTEDILADQFDILKYP 106 fruit fly
NP_501303  25 KEAIELSMANHDHVLGSAQVVFVAFCADWCPFSRRLKPIFEESARVFHQENPQa-SAVWAIVDSQRQADIGDKYFVNKYP 103 nematode
CAE58415   18 CDLVSITSVNHDDIMQNSRLAFVAFTASWCPYSQELLGSFTQAAAKYKEKYPDr-KTVWGNVDCVSEMKLGDDYNIVKYP 96  Caenorhabditis bri...
AAH89277   49 SEIITLESGNIDDILRNADVALVNFYADWCRFSQMLHPIFEEASNIIQEEYPDknKVVFARVDCDQHSEIAQRYRISKYP 128 African clawed frog

Feature 1                                 
Q9BS26    109 TLKLFRNGmmMKREYRGQRSVKALADYI 136 human
AAH66767  140 TLKLFRNGmmMKREYRGQRSVTAIADFI 167 zebrafish
XP_419079 109 TLKLFRNGmmMKREYRGQRSVTAIADYI 136 chicken
NP_491589  95 TLKLFRNGeaAKREYRSSRSVEALSEFI 122 nematode
EAL28915   83 TLKILRNGmvVNSEYRGQRSVEAFYQFV 110 Drosophila pseudoobscura
AAL13926  113 TLKIVRNGqlSKREYRGQRSAEAFLEFV 140 fruit fly
AAF54029  107 TIKIVRNGliGNQEYRGQRSVEALFQFV 134 fruit fly
NP_501303 104 TMKVFVNGelITKEYRSTRSVEALTNFV 131 nematode
CAE58415   97 TMKVFFYGh-PMVEHRGSRQVNGLIEFV 123 Caenorhabditis briggsae
AAH89277  129 TLKLFRNGmmMKREYRGQRSVTAIADYI 156 African clawed frog

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