1J9B,1RW1,1JZW


Conserved Protein Domain Family
ArsC_family
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cd02977: ArsC_family 
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Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.
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Statistics
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PSSM-Id: 239275
Aligned: 144 rows
Threshold Bit Score: 79.0731
Created: 31-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:Based on the known function of arsenate reductase, ArsC.
  • Comment:The catalytic cysteine is conserved throughout the family, however the arginine triad is not.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                                       
1J9B_A        4 ITIYHNPAXGTSRNTLEMIRnSGTEPTIILYLenppSRDELVKLIADMgisvRALLRknvepYEQLGla---edKFTDDQ 80  Escherichia coli
NP_267001     2 IKIYTVASCSSCKKAKEWLEkQNLAYQEINLVtsriCKEDILEILALTeegtGDIISrrsqaYQRLNid---feTIKLND 78  Lactococcus lact...
P60375        2 ITIYTAPSCTSCKKAKTWLSyHHIPFNERNLIadplSTTEISQILQKCddgvEGLISsrnrfVKTLGvd---feDISLSQ 78  Lactococcus lact...
NP_267217     2 IKIYLSGSCSSCRKAKKWLRkHHIEFEEINLSkdfmEKDDLIKILSLTengfEDIIAtrgktYASLNyn---fdELGLEK 78  Lactococcus lact...
YP_140493     2 IKIYTISSCTSCKKAKTWLNkHQLPYKEQNLGkeplTKEEILTILSKTengvESIVSkknryAKALNcd---idELSVSE 78  Streptococcus th...
P54503        5 LTFYSYPSCTSCRKTKHWLKaHQIEFNERHLFretpTREELKYILSLTtegiDEILAtrsqtFKNLNln---ieEITVNE 81  Bacillus subtilis
ZP_00538587   5 LIFFTYPSCTSCRKTKSWLKeEHVDVEERHLFrnapTVDELMELLKLStdgiESLLAtrsqaFKDLGid---vdDMKLSE 81  Exiguobacterium ...
AAP56896     45 IVLFITASCIGCTRVRRFFReYNIQHKEINFYktaiEEKYFNDILSLTengvFDIIStrskyLQNNKvn---idELTISQ 121 Mycoplasma galli...
NP_072789    14 TFILISSSCSSCQKAIEFFDqNKISYVVENFYkkpiSDKRFKDILSLSedgtESLFSkradqIKATNsvs--veELSISE 91  Mycoplasma genit...
Q9PQW7        2 IYVLYSPNCAVCKKVVRFFRnNQIEITKIIIGedkiERSMLLDILSLCedgfGTIISfktesSKRLNitsktflDLSTKE 81  Ureaplasma parvum

Feature 1                                        
1J9B_A       81 LIDFMLQHPILINRPIVVTPl------GTRLCR 107 Escherichia coli
NP_267001    79 LIQIIEENPTLLRRPLIVDHk------RLQVGY 105 Lactococcus lactis subsp. lactis Il1403
P60375       79 AIKIISENPQIMRRPIIMDEk------RLHVGY 105 Lactococcus lactis subsp. lactis
NP_267217    79 AFGLIQENPRLLKRPLIFDEd------CLLIGF 105 Lactococcus lactis subsp. lactis Il1403
YP_140493    79 VIDLIQENPRILKSPILIDDk------RLQVGY 105 Streptococcus thermophilus CNRZ1066
P54503       82 VLELLIEKPKLLRRPILVDNk------KLVIGY 108 Bacillus subtilis
ZP_00538587  82 LLRLMSDNPKLLRRPIITDGk------QLVIGY 108 Exiguobacterium sp. 255-15
AAP56896    122 LITLVNEHPSILKRPIILQYdksgipkRLMVGY 154 Mycoplasma gallisepticum R
NP_072789    92 LIKLVRERPSLLRRPIIIQYnssgipkRMRIGY 124 Mycoplasma genitalium G-37
Q9PQW7       82 LLNLIQNDLNLIRRPLIYQTknn-rpyRLQIGY 113 Ureaplasma parvum

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