Conserved Protein Domain Family
TRX_DnaJ
?
cd02963: TRX_DnaJ 
TRX domain, DnaJ domain containing protein family; composed of uncharacterized proteins of about 500-800 amino acids, containing an N-terminal DnaJ domain followed by one redox active TRX domain. DnaJ is a member of the 40 kDa heat-shock protein (Hsp40) family of molecular chaperones, which regulate the activity of Hsp70s. TRX is involved in the redox regulation of many protein substrates through the reduction of disulfide bonds. TRX has been implicated to catalyse the reduction of Hsp33, a chaperone holdase that binds to unfolded protein intermediates. The presence of DnaJ and TRX domains in members of this family suggests that they could be involved in a redox-regulated chaperone network.
Links
?
Statistics
?
PSSM-Id: 239261
Aligned: 10 rows
Threshold Bit Score: 161.773
Created: 14-Feb-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
catalytic
Feature 1:catalytic residues [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        #  #                                         
CAI12977  136 DSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVIQELEELGVGIGVVHAGYERRLAHHLGAHST 215 human
AAT94506   96 IAFYQKLSITENYFEKMILSKNAKKVHVVMFYNDWCFKCTRIVDAFKKILELLQPIGINFATVNAVHEESVFRKCGAREV 175 fruit fly
EAA13497  127 ISLYHRLSITTKYYETNIVPKSRHTPQIIMFYADWCFACMKAANSFKKLIDTLEPYGITFATVNAGHEEQLVRKVGVHSL 206 Anopheles gambiae ...
CAG31599  132 DTSDEKYLLHFSHYINEIVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVAQELEALGVGIGVVHAGYERRLAHHLGAHST 211 chicken
CAG01766  129 DFADSKYILHFNQYVNEVVPNSYKRPYLIKITSDWCFSCIHIEPVWKEVVQEMESLGVGIGVVDVGYERRLANHLGAHRT 208 Tetraodon nigrovir...
AAK93843  118 SVFEYKYRMSYQQYQFKILEESNTKPYIVYIYSNYCQMCYRFHPQWKRVIADLEPLGYGIATVNGNREQNLMEKMRISHV 197 nematode
XP_395584 132 ISLFYKMSITYRSFENVIVPKTFRTPYLILFYSDWCFACLQIEPTWRRLIDELEPLGLGLATAHAEKESALARKLGIHSL 211 honey bee
XP_684522 133 DFADSKYTLHFNQYVNEVVPDSFKRPYLIKITSDWCFSCIHIEPVWKETVQELETLGIGIGVVDVGYERRLANHLGAHQT 212 zebrafish
XP_787822  74 SGNNDPRRVTLSRLQDGILPQSTDKPYLIFVTGSFCFNCMNIERMWSDITPEIESWGVGVGSVNIDSDRRLASVLGIRHR 153 purple urchin
XP_607303 136 DSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEAVQELEGLEKSYIDGSIGTCGEDDIKSESVAW 215 cow

Feature 1                                       
CAI12977  216 PSILGIING-KISFFHNAVV---RENLRQFVESL 245 human
AAT94506  176 PQLVLILDN-QYFLYRDHSFt--PQKVVEFIRKK 206 fruit fly
EAA13497  207 PCVIMVLND-HNYVYKDSVFn--PQHVVDFIRQK 237 Anopheles gambiae str. PEST
CAG31599  212 PSILGLING-KITFFHSAVV---RENLRQFVENL 241 chicken
CAG01766  209 PSILGIING-KVTFFHYAVA---KVHLRQFVEGL 238 Tetraodon nigroviridis
AAK93843  198 PALVAIVEGrIIPMRIDSSFs--DRSIVAFAQKV 229 nematode
XP_395584 212 PCLVVTIDG-RTSVYKESLFs--IQKIVDFLRSK 242 honey bee
XP_684522 213 PSILGVVNG-KVSFFHYAVV---KEHLIQFVDDL 242 zebrafish
XP_787822 154 PAIAGIING-QVTDYGQGSVt--LKAMRDFVDRL 184 purple urchin
XP_607303 216 FIPLHVTNK-NYVRFLSGWQqenKPRVLLFDQMP 248 cow

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap