1B9Y,1A0R,1B9X,2TRC


Conserved Protein Domain Family
Phd_like
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cd02957: Phd_like 
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Phosducin (Phd)-like family; composed of Phd and Phd-like proteins (PhLP), characterized as cytosolic regulators of G protein functions. Phd and PhLPs specifically bind G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane and impeding G protein-mediated signal transduction by inhibiting the formation of a functional G protein trimer (G protein alphabetagamma). Phd also inhibits the GTPase activity of G protein alpha. Phd can be phosphorylated by protein kinase A and G protein-coupled receptor kinase 2, leading to its inactivation. Phd was originally isolated from the retina, where it is highly expressed and has been implicated to play an important role in light adaptation. It is also found in the pineal gland, liver, spleen, striated muscle and the brain. The C-terminal domain of Phd adopts a thioredoxin fold, but it does not contain a CXXC motif. Phd interacts with G protein beta mostly through the N-terminal helical domain. Also included in this family is a PhLP characterized as a viral inhibitor of apoptosis (IAP)-associated factor, named VIAF, that functions in caspase activation during apoptosis.
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Statistics
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PSSM-Id: 239255
Aligned: 72 rows
Threshold Bit Score: 63.7276
Created: 4-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1B9Y_C    109 PRYGFVYELEtgEQFLETIEkeqk-------------------------------------------vttIVVNIYEDGv 145 Norway rat
AAQ11192  173 KVFGYFKQIDs-SQYIHEIDnepp-------------------------------------------nvfVIIHLFQNYi 208 Dictyostelium disc...
EAK95347   94 KKFGHVLPISk-NEYENEVTkask-------------------------------------------esyVLVHLSLQSs 129 Candida albicans S...
XP_324797  97 SVHGSVYPLSk-PEYSREVTdasq-------------------------------------------ngpVFVLLTSSLg 132 Neurospora crassa
CAB39851   84 AKFGSVYPISk-PEYTAEVTdask-------------------------------------------evfVVVHMFQDSl 119 fission yeast
Q12017     94 SKFGEVFHINk-PEYNKEVTlasqgkkyegaqt-------------------------ndngeeddggvyVFVHLSLQSk 147 baker's yeast
CAG80963   89 EQYGSVVKISk-PEYVEEITeaskrdpknphlkkatkqqpeeeae-hadarnaivasgdprdqdesegtfVFVHISHGGv 166 Yarrowia lipolytic...
AAW44281  105 GRFGSMEPLAr-EDFVREVTegsk-------------------------------------------gtgVVVFLFKDSv 140 Cryptococcus neofo...
NP_703508  91 DIYGEVFEISk-ENFLTDINeaskknplnnnnnddddnnnddnnnnynsdnynsdnynnkqskrkpkgthVLLHLYSENv 169 Plasmodium falcipa...
EAK90451   91 SRFGELYFIRk-PDFVKEVTeask------------------------------------------dnttVVVHLYKESn 127 Cryptosporidium pa...

1B9Y_C    146 --rGCDALNSSLECLAAE-YPMVKFCKIRAsntgaGDRFSSdVLPTLLVYKGGELISNFI-SVAEQFa--eDFFAADVES 219 Norway rat
AAQ11192  209 --pECVLLNQQLGQLAVK-YRYIKFLKILSke-akENYHDE-ALPSLLVYIGGKLLVSFV-PLTEELg--rNFDQEDLEL 280 Dictyostelium disc...
EAK95347  130 --lQSRLLSSILIDLASK-FPELKICDIPAqr-ciENYPES-NCPTLIIYHDTNVVKQFI-TLTQLGg--nATTLKDVET 201 Candida albicans S...
XP_324797 133 tnvESRVLSELWRQAARE-YGDIKFCEMRAsq-aiENYPER-NCPTILVYNKGDIVKQVV-TLMTMHg--vKTNMLDIDK 206 Neurospora crassa
CAB39851  120 --pACKLLAAILERLAPM-YPQIKFVKIPGkq-avENYPEA-MMPTLLIYGHGDLQQQIL-TLATLGg--mNTSVVDVAE 191 fission yeast
Q12017    148 --lQSRILSHLFQSAACK-FREIKFVEIPAnr-aiENYPES-NCPTLIVYYRGEVIKNMI-TLLELGg--nNSKMEDFED 219 baker's yeast
CAG80963  167 --pESRLLSGLFDRAAQK-FPDVKFVDIDSkq-inEKYSLA-SVPTILVYYKGNPVNQVV-ALEGIGg--kSTNMEDIEA 238 Yarrowia lipolytic...
AAW44281  141 --pLSQHLQPLLNQAAAA-HPSTKFLSIPAgl-ciPNYPDK-NVPTLLIYRNGEMVGNVV-AGMGLKg--mKTTVRDLEG 212 Cryptococcus neofo...
NP_703508 170 --iSCKVLNNILKELAQK-HKYIKFTKGIYnr-iiENYPEN-KLPTILIYYNGTCIHQICnVLDHIKgglnNLNMPTFEK 244 Plasmodium falcipa...
EAK90451  128 --eDCQIINRLLSETIAKeYGKIKFVKGISsd-ivPNYPDK-SLPTMIIYRNGTSISQIT-GSSSFKdknrKITIKSILK 202 Cryptosporidium pa...

1B9Y_C    220 FLN 222 Norway rat
AAQ11192  281 LLS 283 Dictyostelium discoideum
EAK95347  202 ALA 204 Candida albicans SC5314
XP_324797 207 LLV 209 Neurospora crassa
CAB39851  192 ALV 194 fission yeast
Q12017    220 FMV 222 baker's yeast
CAG80963  239 FLV 241 Yarrowia lipolytica CLIB99
AAW44281  213 LLL 215 Cryptococcus neoformans var. neoformans JEC21
NP_703508 245 FIN 247 Plasmodium falciparum 3D7
EAK90451  203 LFV 205 Cryptosporidium parvum
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