Conserved Protein Domain Family
SSP411
?
cd02955: SSP411 
TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein, called SSP411, is specifically expressed in the testis in an age-dependent manner. The SSP411 mRNA is increased during spermiogenesis and is localized in round and elongated spermatids, suggesting a function in fertility regulation.
Links
?
Statistics
?
PSSM-Id: 239253
Aligned: 38 rows
Threshold Bit Score: 184.718
Created: 23-Feb-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:based on known function of thioredoxin
  • Comment:CXXC motif
  • Comment:Disulfide bond reduction by thioredoxin is initiated by deprotonation of the solvent-exposed N-terminal cysteine in the CXXC motif to form a thiolate. The pKa of this thiol must be near physiological pH to achieve maximal catalysis.
  • Citation:PMID 9099998
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #  #                                                  
NP_073738 100 YPWGQEAFDKARKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREERPDVDKVYMTFvqa------ 173  human
NP_070565  24 FEWGEEAFAKAKKEDKPILLSIGGVWCHWCHVMAKESFENEEIAEMINRNFVAIKVDRDERPDIDKRYQEFvma------ 97   Archaeoglobus ful...
NP_148674   1 MPWGAEAFEKARRLDKPVFVSVGYSSCHWCHVMQRESFSDPMVAEVLNRAFVMVKVDREERPDVDTLLMRYcai------ 74   Aeropyrum pernix K1
NP_343584  39 YTWSNDVFEIAKKENKPILIDVGAAWCHWCNVMDEDTYSNPEIAKIVNENFIPVKVDRDEMPDLDRLLQNAama------ 112  Sulfolobus solfat...
NP_394451  24 RMWSKETLRIATEENRLIFLSIGYSSCHWCHVMHEESFVDPDVAEILNNNYIPVKVDREERPDLDSYFMKVsqv------ 97   Thermoplasma acid...
NP_560207  27 WGWCKEAFEAAEREDKPVLVDVGAVWCHWCHVMDERTYNDEEVAEFINKHFIPVKVDRDERPDVDRRLQEAaql------ 100  Pyrobaculum aerop...
XP_322084 192 QLLNADTLKRAQAENKPIFMHIGFLADHHCRLTTQDSFSNNAVAAFLNSSFIPVIIDRDERPDLDTIYQNYsea------ 265  Neurospora crassa
AAP99027   29 YPWGAEAFHIAAIENKPVFLSIGCKHSRWCQVMLQESYTNPEIAAMLNEYFVNVKVDKEELPYVAKLYGDLaqmlavsgd 108  Chlamydophila pne...
EAA77409   57 QLLDDEAVERSRKENKLIFLNIGYKACHFCRLMSIETFSNPESAAVLNESFVPVIVDREERPDIEAVYMNYaqa------ 130  Gibberella zeae PH-1
YP_132325  80 YAWGKEAFDAARRENKPIFLSIGYSTCHWCHVMEAESFDNEEVARILNKYFISIKVDRDLRPDIDDFYIKAalv------ 153  Photobacterium pr...

Feature 1                                                                       
NP_073738 174 tsSGGGWPMNVWLTPNLQPFVGGTYFPPEd--------gLTRVGFRTVl--------lRIREQWKQ 223  human
NP_070565  98 ttGSGGWPLTVFLTPDGKPFFGGTYFPPEd--------rYHLPGFKTVl--------rKIAEMWRH 147  Archaeoglobus fulgidus DSM 4304
NP_148674  75 asGSCGWPLNVLLTPDGKPFYVATYLPKEsl-------vALAVSLERVwre----rraEVLEVAER 129  Aeropyrum pernix K1
NP_343584 113 itGESGWPLTIFMTPEGKVFFGGTYFPPEd--------rYGRIGFKRLl--------lEILRIWRE 162  Sulfolobus solfataricus P2
NP_394451  98 inGNGGWPLNIILLPDARPVFAMTYVPKEd--------rNGMTGLKTIl--------iQLSQMYLK 147  Thermoplasma acidophilum DSM 1728
NP_560207 101 isGQSGWPLTVFMTPKGQVIWAATYLPPRr--------eMGLPGMLEVl--------eAVLRAYRE 150  Pyrobaculum aerophilum str. IM2
XP_322084 266 vnATGGWPLNLFLTPDLYPIFGGTYWPGPgtehslaaarGGASGVGGVaatp---easSINGGGEE 328  Neurospora crassa
AAP99027  109 hqETVSWPLNVFLTPDLVPFFSVNYLGNEg--------kLGLPSFPQIi--------dKLHFMWED 158  Chlamydophila pneumoniae TW-183
EAA77409  131 vyKVGGWPLNVFLTPNLEPVFGGTYWVGPtg-------rRRHNGDSTDevldsltifkKMRDTWND 189  Gibberella zeae PH-1
YP_132325 154 fsGKAGWPVSSFLTHDSKPFFVASYFSRP----------DFVDLLEQVq--------dKWTNNHQF 201  Photobacterium profundum SS9

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap