Conserved Protein Domain Family
SoxW
?
cd02951: SoxW 
SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide fixation during autotrophic growth and the respiratory electron transport chain. It is unclear what the role of SoxW is, since it has been found to be dispensable in the oxidation of thiosulfate to sulfate. SoxW is specifically kept in the reduced state by SoxV, which is essential in thiosulfate oxidation.
Links
?
Statistics
?
PSSM-Id: 239249
Aligned: 22 rows
Threshold Bit Score: 110.096
Created: 3-Mar-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:based on known function of thioredoxin
  • Comment:CXXC motif
  • Comment:Disulfide bond reduction by thioredoxin is initiated by deprotonation of the solvent-exposed N-terminal cysteine in the CXXC motif to form a thiolate. The pKa of this thiol must be near physiological pH to achieve maximal catalysis.
  • Citation:PMID 9099998
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #  #                                            
AAR98730     41 ESFLDLAEDEAAAka----krKILALQWSQRGCPLCKRLHTDYFADAAIEAYVr---------EHFDVVHLDIYGsrevt 107 Starkeya novella
AAD07445     58 KSYAGLEDVFSDNksis-pndKYMLLVFGRNGCSYCERFKKDLKNVKELRDYIk---------EHFSAYYVNISYskehd 127 Helicobacter pyl...
AAC07319     19 SSGEEKSQVQEAKsii--pknKYALLIVESKSCIYCAQLKKDIKTEKRLQEALkgidiytllyESYEPVKTNIGGkv--- 93  Aquifex aeolicus...
AAP77594     48 ESYAGLEDVFLDTktiqgqegKITLLIFGKNHCTYCDKLKDDIKNNTSLKSILq---------SHFLPYYINISYtknhh 118 Helicobacter hep...
NP_908252    51 ASYAELADLFLDNknid-pkgKYLLLVFGSNGCIYCEKLKQEIKENPEIKAFIq---------ENFSPYYINGSYskphq 120 Wolinella succin...
ZP_00171478  44 PLATDLATHAADAtr----rgEPLLVLVSLPNCGYCETVRKSYLGPQAAAGEIavr----eldMTTDTPLRDTDGt---- 111 Ralstonia eutrop...
ZP_00334477  30 NAKDFQADARTAAkr-----rVPILVLFSSPDCPYCDRVKREYLVPMHKDPAYr---------DRVVIREVTVDAgtplk 95  Thiobacillus den...
ZP_00369225  49 KSYEEIANLFKDNtnik-sddKNILIIFSANHCLYCDKLKEEIKNDKKIQDFIk---------EKYSSYYINISYkkiht 118 Campylobacter la...
AAW56099     47 NSYKEIAEFFKDNqniv-fsdKPVLIIFSANNCVYCDKLKHEIQNDKEVQNILk---------NTYNSYYINTSYhkihn 116 Campylobacter je...
ZP_00508997  41 ASLPRIAMAAAAKd-------QPVVLLVSLPGCPYCELVRRNYLLPARQDIGLhawq---lsiADQTTPLIGFDGk---- 106 Polaromonas sp. ...

Feature 1                                                                                
AAR98730    108 d-------fggqtLSEKALAGRYA---VRATPTFQFFAArdgkvAEVARMPGLLPkPEFLAMFRYVEAGAYES 170 Starkeya novella
AAD07445    128 fkvgdknnekeikMSTEELAQIYA---VQSTPTIVLSDKt---gKTIYELPGYMPsTQFLAVLEFIGDGKYQD 194 Helicobacter pylori 26695
AAC07319     94 -----------evLSEKELARKLK---ATSFPNLIFYDKn---gNLILQIPGYLPpEKFACVINYVKKEEFKK 149 Aquifex aeolicus VF5
AAP77594    119 lqf---qnapestLSTSTLIETYVkspMRPTPTLIFLAPt---gEVIYELPGYLPsKELSALLKYMQSQKWKG 185 Helicobacter hepaticus ...
NP_908252   121 li----taqksveMMTEELVRLYG---VRPTPTLIFATPe---gKTILTYPGYMPkDRLQATLGFITQKSWEG 183 Wolinella succinogenes ...
ZP_00171478 112 ------------mTTARAWARAHQ---VRVAPTVLFLDRdg--kQAAAPLRGLQP-DFYGAYLEQALGQARAA 166 Ralstonia eutropha JMP134
ZP_00334477  96 g-------fkggaTTQGEFSADHK---VFMVPTVKVFDTqg--dPAGDAIVGLLSaDYYFGYLENAIDEGVRK 156 Thiobacillus denitrific...
ZP_00369225 119 fy-----knhksdLSTAELSSIYD---IVATPTIVILNKn---sQTLLNYPGFISaKRLSATMEFLNQKENQN 180 Campylobacter lari RM2100
AAW56099    117 --------ydnkkTSTEELSREFN---IDATPTLVFFTPk---hKTLLIYPGFMSaKRLALTMEILKDEKNQK 175 Campylobacter jejuni su...
ZP_00508997 107 ------------aSTAAAQIKAWK---ATFTPTVLFLGDsg--qELAERLVGVGVpDFYGAYLEQRLAAARKT 162 Polaromonas sp. JS666

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap