Conserved Protein Domain Family
TRX_NTR
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cd02949: TRX_NTR 
TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible oxidation of an active center dithiol present in a CXXC motif, while the NTR domain functions as a reductant to oxidized TRX. The fusion protein is bifunctional, showing both TRX and NTR activities, but it is not an independent NTR/TRX system. In plants, the protein is found exclusively in shoots and mature leaves and is localized in the chloroplast. It is involved in plant protection against oxidative stress.
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Statistics
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PSSM-Id: 239247
Aligned: 5 rows
Threshold Bit Score: 191.945
Created: 5-Nov-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:based on known function of thioredoxin
  • Comment:CXXC motif
  • Comment:Disulfide bond reduction by thioredoxin is initiated by deprotonation of the solvent-exposed N-terminal cysteine in the CXXC motif to form a thiolate. The pKa of this thiol must be near physiological pH to achieve maximal catalysis.
  • Citation:PMID 9099998
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             #  #                                                    
CAE46765  389 GQYALRKVYHESPRLVCVLYTSPTCGPCRTLKPILSKVIDEYNEHVHFVEIDIEEDPEIAEAAGIMGTPCVQFFKNKEML 468 Japanese rice
AAB84351  430 GQYALRKLYHESPRVILVLYTSPTCGPCRTLKPILNKVVDEYNHDVHFVEIDIEEDQEIAEAAGIMGTPCVQFFKNKEML 509 thale cress
BAB72694  384 GGYALRKLFHESDRLLIVKYVSPGCGPCHTLKPILNKVVDEFDSKIHFVEIDIDQDRDIAENAGVTGTPTVQFFKDKELV 463 Nostoc sp. PCC 7120
YP_171611 355 GSYALRKLYHESDRLLAVLYTAPTCGPCRTLKPILRKVAEEFSDRLHYVLIDIDADPEIAQSAGVVGTPTLQLFKDKAKV 434 Synechococcus elon...
NP_893267 359 GSYALRKLYHESNKPILVIFSSPSCGPCHVLKPQLKRVIKEFDGAVQGIEIDIDKDQEIAKQAGINGTPTIQLFKDKLLK 438 Prochlorococcus ma...

Feature 1                      
CAE46765  469 RTVSGVKMKKEYREFIE 485 Japanese rice
AAB84351  510 RTISGVKMKKEYREFIE 526 thale cress
BAB72694  464 KEVKGVKQKSEYRLLIE 480 Nostoc sp. PCC 7120
YP_171611 435 DEIRGVKMKSDYRARFE 451 Synechococcus elongatus PCC 6301
NP_893267 439 KQWQGVKQRSEFKEAIQ 455 Prochlorococcus marinus subsp. pastoris str. CCMP1986

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