1GTE,1H7X


Conserved Protein Domain Family
DHPD_FMN
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cd02940: DHPD_FMN 
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Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and eight [4Fe-4S] clusters, arranged in two electron transfer chains that pass the dimer interface twice. Two of the Fe-S clusters show a hitherto unobserved coordination involving a glutamine residue.
Links
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Statistics
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PSSM-Id: 239244
Aligned: 22 rows
Threshold Bit Score: 415.915
Created: 19-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1GTE_D; Sus scrofa DPD binds FMN and 5-iodouracil
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                ##              #                  # #
1GTE_D     532 DISVEMAGLKFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSldkdiVTNVSPRIVRGTtsgpmygpgqsSFLNIE 611  pig
1H7X_A     532 DISVEMAGLKFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSldkdiVTNVSPRIVRGTtsgpmygpgqsSFLNIE 611  pig
AAB51366   532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSldkdiVTNVSPRIIRGTtsgpmygpgqsSFLNIE 611  human
AAH80003   532 DISVEMVGLKFLNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSlekdiVTNVSPRIIRGTtsgsiygpgqgSFLNIE 611  African clawed frog
XP_426639  685 DISVLMAGLKFPNPFGIASATPATSSSMIRRAFEAGWGFAVTKTFSldkdiVTNVSPRIVRGVtsgpiygpgqgSFLNIE 764  chicken
NP_998058  532 DISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGldkdlVTNVSPRIVRGTtsghifgpgqgSFLNIE 611  zebrafish
XP_647452  530 DISVEMCGMKFPNPFGLASATPATSAAMIRRSFEQGWGFAVTKTFSldkdlVTNVSPRIVRGTtsghhfgpgqgAFLNIE 609  Dictyostelium di...
AAY44826   527 DISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGldkdlVTNVSPRIVRGTtsgykygpqqgCFLNIE 606  fruit fly
NP_508927  546 DISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGldkdlVTNVSPRIVRGStsgplygpnqgSFMNIE 625  nematode
EAS01570   621 DISTEICGVKMENPFGLASAPPTTSYPMIARSFDIGYDFAVVKTAVldkdtVFNVSPRIFKVPdplr----qecSYGNIE 696  Tetrahymena ther...

Feature 1                                                              # ##                    
1GTE_D     612 LISEKTAAYWCQSVTELKADFpdNIVIASIMCsyNKNDWMELSRKAEASGADALELNLSCPHgmgERGMGLACGQDPELV 691  pig
1H7X_A     612 LISEKTAAYWCQSVTELKADFpdNIVIASIMCsyNKNDWMELSRKAEASGADALELNLSAPHgmgERGMGLACGQDPELV 691  pig
AAB51366   612 LISEKTAAYWCQSVTELKADFpdNIVIASIMCsyNKNDWTELAKKSEDSGADALELNLSCPHgmgERGMGLACGQDPELV 691  human
AAH80003   612 LISEKTAAYWCQSITELKADFpkHIIIASIMCsyNKDDWTELSLMAEASGANALELNLSCPHgmgERGMGLACGQDPELV 691  African clawed frog
XP_426639  765 LISEKTAAYWCKSITELKSDFpkQILIASIMCsySKDDWTELSKMAEAAGADALELNLSCPHgmgERGMGLACGQDPELV 844  chicken
NP_998058  612 LISEKTAAYWCKSVAELKADFpkNIIIASIMCsyNQADWTELAKMAQESQADALELNLSCPHgmgERGMGLACGQDPELV 691  zebrafish
XP_647452  610 LISEKTCHYWCKAIGELKRDFpdRIVIASIMCgfNKEDWTQLAKMAEASGADGIELNLSCPHgmgEKGMGLACGQDTELV 689  Dictyostelium di...
AAY44826   607 LISEKRAEYWLKSIGELKRDFpeKIVIASIMCsfNEEDWTELAIKAEQSGADALELNLSCPHgmgERGMGLACGQDPELV 686  fruit fly
NP_508927  626 LISEKSCEYWLQCIRELKRDHptKIVIASIMCvyNKADWIELATKSEEAGADILELNLSCPHgmgEKGMGLACGQSPEIV 705  nematode
EAS01570   697 LVSEKSLKYWVEGAKQIKKDYpnKVLIGSLMAayNQQDWIDIMHQVKDAPFDMIELNLSCPHgmnEKGMGRACGEDPDIV 776  Tetrahymena ther...

Feature 1                       #                         ###                                  
1GTE_D     692 RNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGlmglkadgtpwpavgagkrtTYGGVSGTAIR 771  pig
1H7X_A     692 RNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGlmglkadgtpwpavgagkrtTYGGVSGTAIR 771  pig
AAB51366   692 RNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGlmglksdgtpwpavgiakrtTYGGVSGTAIR 771  human
AAH80003   692 RNICRWVRQAVKIPFFAKLTPNVTDVVKIAMAAQEGGADGVTATNTVSGlmglkadatpwpavgsgsrtTYGGVSGNAIR 771  African clawed frog
XP_426639  845 RNICRWVRQAVQIPFFAKLTPNVTDIVNIAVAAQEGGADGVTATNTVSGlmglkadgtpwpavgaglrtTYGGVSGNAIR 924  chicken
NP_998058  692 RNICRWVRKATSIPFFAKLTPNVTNIVDIATAAYEGGADGVTATNTVSGlmalkadatpwpgigrgartTYGGVSGNAIR 771  zebrafish
XP_647452  690 FHICQWVRAATRLPFFAKLTPNVTEIKEIAKAAHDGGADGVTAINTVSGlmglkgdsnawpaigdekrtTYGGVSGNATR 769  Dictyostelium di...
AAY44826   687 EQISRWVRKAVKLPFFIKLTPNITDIVSIAAAAKRGGADGGSAINTVQGlmglkadstawpaigkeqrtTYGGVSGNATR 766  fruit fly
NP_508927  706 KEICRWVRACVKIPFFPKMTPNITDVREIARAARDGGASGVTATNTVSSlmhmkadgnawpaigstkrtTYGGMSGSAIR 785  nematode
EAS01570   777 RDITSWVTSQTKIPIIVKITPNYGQAEILAKAAYEGGAKAVTLTNTMPGlvdpypdgesfngvgveknvAPGGSTGSILR 856  Tetrahymena ther...

Feature 1                                                                      
1GTE_D     772 PIALRAVTTIARAlpGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQ-DFTVIQDYCTGL 834  pig
1H7X_A     772 PIALRAVTTIARAlpGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQ-DFTVIQDYCTGL 834  pig
AAB51366   772 PIALRAVTSIARAlpGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQ-DFTVIEDYCTGL 834  human
AAH80003   772 PIALRAVSAIARAlpGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQ-DFTVIEDYCTGL 834  African clawed frog
XP_426639  925 PIALRAVSAIARAlpGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQ-DFTVIDDYCTGL 987  chicken
NP_998058  772 PIALRAVSAIARAlpGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQ-DFTVIEDYCLGL 834  zebrafish
XP_647452  770 PIALRAVSSIRKSlpDYPIMATGGADSADATIQFLHCGASVVQICSSVQNQ-DFTVVQDYITGL 832  Dictyostelium discoideum AX4
AAY44826   767 PMALKAISDIANRvpGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQ-DFTVIEDYCTAL 829  fruit fly
NP_508927  786 PIAMKAVSSIANEldGFPIMATGGIESAETGLGFLMAGASVLQVCSAVQNQ-DFTVVDDYCTGL 848  nematode
EAS01570   857 PFAMRKCVDVAKFvpEIDIFASGGIISGDHGINYLHYGAKALQICSAVQNLdAATVFYDLKTSL 920  Tetrahymena thermophila SB210

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