Conserved Protein Domain Family
GH18_plant_chitinase_class_V

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cd02879: GH18_plant_chitinase_class_V 
The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic activity in others. Included in this family is a lectin found in black locust (Robinia pseudoacacia) bark, which binds chitin but lacks chitinase activity. Also included is a chitinase-related receptor-like kinase (CHRK1) from tobacco (Nicotiana tabacum), with an N-terminal GH18 domain and a C-terminal kinase domain, which is thought to be part of a plant signaling pathway. The GH18 domain of CHRK1 is expressed extracellularly where it binds chitin but lacks chitinase activity.
Statistics
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PSSM-Id: 119358
View PSSM: cd02879
Aligned: 13 rows
Threshold Bit Score: 344.733
Threshold Setting Gi: 125590096
Created: 18-Jul-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                  #                                     
CAB78982       4 SDVVKASYWFpat-----------dfPATDIDSSLFTHLFCTFADLEAESYeitiat---wnqapFHAFTETVQQRNPHV 69  thale cress
CAD56465      34 TTRVKGIYWDrnp-----------lfPPASIDTSLFTHIFYAFVSPNKFTYkleeeedsttvatsLTTFTNTFKTKTPPI 102 barrel medic
BAD98525      24 QNALKVGFWPaysv---------sefPPSKINSRLFTHLYYAFAELNAPTFevrvpp---gsektAEDFTPTVRRLNPSV 91  Cycas revoluta
AAM18075       4 PTIVNGGYWLssta---------gklPASNIDATLYTHLFCGYGEIDATSHevti------psteVSHFSEKVKVSNPSV 68  balsam pear
CAB78978      11 NSIVKASYWFpdgksqsp-eclsqgtPSSFIDSTLFTHLFCAFADVDSSTHevtisa---ansyqFSSFTETVKEKNTDV 86  thale cress
CAN60685      26 SPPVKGAYWPswd----------esfPPSAIDTSLFTHVYYAFASPNNVTFkfdisn---stgisLLDFTSTLHRKKPSL 92  wine grape
CAN60686     269 SSGIKGAYWPswla---------eslPPVGIPTSYFTHLFYAFVQLDASAYqlsitq---pdeqwMGNFTATLHAKNPLA 336 wine grape
AAD52097      24 TAWIKSGFWYags-----------efPVPEIPSTMFTHIHFAFAYINASSFelyvsh---sdepyISTFSNTVKQKNPSV 89  common tobacco
EAZ30446      38 REAVRAGYYLaada---------hlrPLAALDASLYTHLYYYAVAVHPARRtlllppd-paaaslLGDFSRAVKAKNAAV 107 Japanese rice
CAO67701      23 ETWIKAGYWYags-----------esPIPDIKSGLFTHLLCAFADINPTTYqlsiss---seehyFSTFTDVVKRRNPSV 88  wine grape
XP_001771980  30 GAVVRGGYWLqd-------------lPLVNINFNYETHVYYAFAGLDPSSYqvvapt---tdngqYATFVATAKSSNPSV 93  Physcomitrella ...
XP_001784103  20 SKIVKSGYWPyw------------atDTSNLNFEFQTHVFFAFAQIDPVTYevvpppp-sdgvsiFPTFTKLARKSNKCV 86  Physcomitrella ...
NP_193707      3 TEVVKASYWFpdgasspttgsvvpqsSAVLIDSTLFTHLFCAFADLDPQTNsvvvsg---aheqeFSNFTKIVKKKNPHV 79  thale cress
Feature 1                                                                # # #                   
CAB78982      70 KTLLSIGGGnad-----------kdaFASMASNPDSRASFIQSTITVARSYGFHGLDLDWEYPRNEEEMYDFGKLLEEWR 138 thale cress
CAD56465     103 PTLLSIGGAtsn-----------stlFAFIASDPTARATFTNSTIQVARTFGFDGIDFDWEFPTTTKEMNDLGELLFQWR 171 barrel medic
BAD98525      92 KTLISIGGGgsev----------rdnFAKLNSDASARQRFVKSSIALARRYGFHGLDLDYEYPEPQLEMENFVKLVSELT 161 Cycas revoluta
AAM18075      69 KTLLSIRGDsk--------------vFSDIAKVPTARDTFVNSSIKAAVDCGFDGLDLQWLYPSSPTDMQNFKTLIVKWR 134 balsam pear
CAB78978      87 QTLLSIGGKdad-----------kavLASMASNSKNRKAFIDSSIDIARKKDFYGLDLAWEYPSNDVEMTNFGKLLEEWR 155 thale cress
CAN60685      93 KALLSIGGGggd-----------qqlFARMASKASTRASFIKSTVEVARKYGFDGLDLDWEFPESPKEMEDWGLLLQEWR 161 wine grape
CAN60686     337 KAFXSIGGGass-----------pytFSKMAGDPDNRAAFINSTIDVARKYGFDGLDLDWEFPTNPQDMSNLAILYSEWH 405 wine grape
AAD52097      90 ITLLSIWGGrde-----------spnFFAMTSQFSRRKSFITTSIKTARQYGFQGLDLIGVNPNTDANMTNMRSFIEEWR 158 common tobacco
EAZ30446     108 KTVLSIGRGggaggaaavagsgsdpaFAAMAADPASRAAFIGAAVKVARENGFDGLDVAWRFPASAVEMAEFGFLVAEWR 187 Japanese rice
CAO67701      89 VTLLSIWGGkgptglsilgervnssmVSLMVRQPSYRKSFIESAMKTARLYGFHGLDLFWLWPNTESDMKNMGALLDELR 168 wine grape
XP_001771980  94 VTLLSIGGGaan-----------fttFGEMVSTSTRRQAFIDSSISLARQYSYEGLDLDWESPQSQTEMENLALLLQEWR 162 Physcomitrella ...
XP_001784103  87 KTLLSIGGGgsm------------spFSAMASSAANRKAFIQSSIQLALNNSFDGLDLDWEFPDTQVDMDNLAILLKEWR 154 Physcomitrella ...
NP_193707     80 QTLLSIGGRnad-----------ksaFASMASNPTSRKSFIWSAISSARYYRFDGLDLVWKYPKDDVEMRNFGQLLEQWR 148 thale cress
Feature 1                                                               ##                       
CAB78982     139 SAVeaesnssgttALILTAAVYYssny-------qgvpYPVLAISNSLDWINLMAYDFygpgwstvtgpp----aslylp 207 thale cress
CAD56465     172 RAIsdeaastsrpPLLLTAAVYFavnffl---sgerrmYPVDSINKNLDWVNVMSYDLrgsgsnvtgaps-----gmfds 243 barrel medic
BAD98525     162 AAIreeartsgkpRLLLTEAVYFhqklfp---wevvteYPVQFIAAGLDWVNVMAYDFhgswenftgapa-----alrdp 233 Cycas revoluta
AAM18075     135 QAAvddarnnnrpERILVASVPNlpyie------knveYPGEAIKQNLDWVNLVCYDFytpaegsspdytgpssalfnrr 208 balsam pear
CAB78978     156 AAVveesdktnqlPLLLTAAVYYspqy-------dgveYPVKAIADNLDFVNIMAYDFygpgwspvtgppaa-lfhdpsn 227 thale cress
CAN60685     162 AEVkkeaklkgraPLLITAATYFsvdffa---ygdyrkYQVGSAGKNLDLINLMCYDYrgswdtsatgaq----aalfdp 234 wine grape
CAN60686     406 AAVkkeahysgqyKLLLSSAVYFasdffl---sdvprsYPADAIKKYVDFVSPMCFDYhgswdtsvtgah----allydk 478 wine grape
AAD52097     159 TAInseskssgtrTLILTMGAYYspml-------dsmsYPIDTIIRNFDWVHLKAYAAlydpt----------------- 214 common tobacco
EAZ30446     188 AAVp--------rGFLLTATVYFsnhvfda--pfagvdYPSETVARSLDWVNVMAFGLrppgaananataf--daplydr 255 Japanese rice
CAO67701     169 AAVklesrnsgkaPLILTMAVHYvptl-------ysvsYHIEAIQRNLDWAHIPAYDYylpsrvnfthah----aalydp 237 wine grape
XP_001771980 163 AAAhteaqssgntELLLTAAVSYqsillyt--gvgnqvWPITAFNTYLDWVNVMTYDYhgsweptttgeh----talydp 236 Physcomitrella ...
XP_001784103 155 AEAq--------kKLLLTAAVYFrnilyfwqpadqqrrYPIASINKNLDWINVMCFDYrgswesntgeht----alydpn 222 Physcomitrella ...
NP_193707    149 EAIeddaertermPLLLTAAVYYspvy-------dsvsYPIREIKKKLDWVNLIAYDFysssttigppaa----lfdpsn 217 thale cress
Feature 1                                      #                                                 
CAB78982     208 tdgrsgDSGVRDWTEAGl-PAKKAVLGFPYYGWAWTLadpdvngydanttgpaisdd----------geisyrqlqtwiv 276 thale cress
CAD56465     244 ksnvsvVGGLFSWIRGGv-APEKIVMGMPLYGKSWKLqdpnvhgigapnvgpgpgvd----------ggmayfqvvdfnk 312 barrel medic
BAD98525     234 nskftaSVGIESFLAAGm-PPEKLVLGIPLFGRSWLLknnnevgigapavgagpvd------------galsfseiqnfi 300 Cycas revoluta
AAM18075     209 snslsaHFGIESWTKYV--PAKKIVFGIPFHGWAWTLanaaehdmfskatgscvwpm-----------dysevkshrrar 275 balsam pear
CAB78978     228 pagrsgNSGLRKWLDEAklPPKKAVLGFPYCGWAWTLedaenngydaatdgaaispd----------gsityakirnyiv 297 thale cress
CAN60685     235 nsnistSYGVKSWIKAGv-PRSKLVMGLPLYGRTWKLkdptqhgigapavdvgpgde----------gvlsfsqveafnk 303 wine grape
CAN60686     479 asnistSYGISSWIEAGv-PPEKLVMGLPLYGRTWELkdqnkhgigdpavgtgpgdg-----------imaytnivdfns 546 wine grape
AAD52097     215 -sklntDYGIKEWIKRGl-PANKIVLGLAYHGYAWTLvnpkhntvrtparglaitqd----------gsisyryikqymk 282 common tobacco
EAZ30446     256 ashysaSYGVVSWLDAGv-PASKVVMGIPLYGRSWFLrnkansgvgapvvaagpkqrgsnatgamsyaevqwlaatatrg 334 Japanese rice
CAO67701     238 lsnvstDFGIREWISKGf-PASKLVLGLPYHGYAWTLvnpnhngigapasgiamtad----------gsmsykyikwflr 306 wine grape
XP_001771980 237 nsdvdtDYGINNWLSAGm-QADKMCLGLAFYGKQWVLaslantgvgapatsggdpi-------------tyadivtynna 302 Physcomitrella ...
XP_001784103 223 lpvvstDDAVTDWITAGl-YPHKLVMGLAFYGKQWTLqslantgigaptqtdisskyt---------pvwseivvylqnd 292 Physcomitrella ...
NP_193707    218 pkgpcgDYGLKEWIKAGl-PAKKAVLGFPYVGWTWSLgsgndaatsrvatsaegs--------------inydqikrliv 282 thale cress
Feature 1                                                          #           
CAB78982     277 dngatkvHDDMMVGDYCYAGTTWIGYDSEKSIVTKVIYAKQ-KGLLGYFSWHVGGDDNSELS 337 thale cress
CAD56465     313 qmgakvvYDKETGSVYSYSGSTWIGYDDPFTVSVKVGFAQA-LKLGGYFFWAAGYDTSDWKV 373 barrel medic
BAD98525     301 rggarevFDTTTVSAYAYKDNVWVGYDNQQSVALKVQYAKE-KRLGGYFFWSVNQDIDAILP 361 Cycas revoluta
AAM18075     276 qceynipNDPRFGIAYAYVETTWIGYESESTIPVKIKFAKQ-NQLLGYFAWNISGDDDVNTL 336 balsam pear
CAB78978     298 dngaatfHDPAVIGFYCYVGNTWIGYDDNQSIVYKVKYAKF-TGLLGYFSWHVGADYNCGLS 358 thale cress
CAN60685     304 enxatvvYDARTVSTYSYAGTSWIGYDDTRSTTVKIGFARA-LGLRGYFFWAVNDDSKWKIS 364 wine grape
CAN60686     547 ekgatvvYDEETVSTYSYAGTNWIGYDGPISTENKVKFAWE-QGLGGYFLWALGDDKNWTLS 607 wine grape
AAD52097     283 sygvtpvYNSTFVVNYVTIGSFWIGYDDVEAIRTKVSYAKD-KGLLGFAAFQIPSDDVNWEL 343 common tobacco
EAZ30446     335 sravitaYDNASVASYVSVGDVWVAFDGVAVVAEKLAFAAR-CGLLGYFLWPVNYDDANLTV 395 Japanese rice
CAO67701     307 sygatsmYNATYVVNYVTIGTTWIGFDDVQAIRAKISYAKE-KKLLGYNVFQVSNDDNWALS 367 wine grape
XP_001771980 303 ggatveqDSTTVSMYSYKSDLTWIGYDNPDTIAAKVQYAQS-KSLLGYFAWALHQDDANFSL 363 Physcomitrella patens subsp. patens
XP_001784103 293 gwttvldDATVSMYSYNTQSLQWVGYDNEVTIKKKVEYAIRiKKLKGVFVWSLNHDDSNWSL 354 Physcomitrella patens subsp. patens
NP_193707    283 dhkarpvFDSTVVGDYCFAGTSLIGYDDHQSVVAKVKYAKQ-KGLLGYFSWHVGADDNFGLS 343 thale cress

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