Conserved Protein Domain Family
GH18_zymocin_alpha

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cd02878: GH18_zymocin_alpha 
Zymocin, alpha subunit. Zymocin is a heterotrimeric enzyme that inhibits yeast cell cycle progression. The zymocin alpha subunit has a chitinase activity that is essential for holoenzyme action from the cell exterior while the gamma subunit contains the intracellular toxin responsible for G1 phase cell cycle arrest. The zymocin alpha and beta subunits are thought to act from the cell's exterior by docking to the cell wall-associated chitin, thus mediating gamma-toxin translocation. The alpha subunit has an eight-stranded TIM barrel fold similar to that of family 18 glycosyl hydrolases such as hevamine, chitolectin, and chitobiase.
Statistics
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PSSM-Id: 119357
View PSSM: cd02878
Aligned: 22 rows
Threshold Bit Score: 485.276
Threshold Setting Gi: 13276769
Created: 21-Jul-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                 #                                         
P09805        384 KKIAYWLda-----kdKLAMDpkni--pngpYDILHYAFVNINSDFSIdd---saFSKSAFLKVTs-SKKIPSFGGWDFS 452  Kluyveromyces...
CAE84954      222 DNIVYWLda-----egPLASDpdni---gsdYSRVHYAFVNINSDFTIdd---snISNSYFLNIK--NNKVASFGGWDFS 288  Debaryomyces ...
EAL91911      440 KTIGYFEafdq--lraCLRMSvdei--paqkYSHVHFAFATVTPGFDVdts-sveDEFRRFVKRTg-FKKILSFGGWAFS 513  Aspergillus f...
XP_001483636  173 KNIGYWLdv-----sgGMALDpttl--ddgsYTAIHYAFVPIKSDMTIdd---skFKISKFLSLKk-TKKVASFGGWDFS 241  Pichia guilli...
XP_001223888   78 HRIAYFEafnf--dwaCLRMDvaqi--dtskYTHVHFAFLDLTEDFDVdvv-ryrEQFIRFTKLKg-VKRIVSFGGWTMS 151  Chaetomium gl...
DAA05858      493 KKVTYYEswnl--drsCMHMDvrtvgdlgqgYTHLHFAFVNITKDLKVsvq-dprGQFEHFKGLSg-IKRIAAFGGWSFS 568  Hypocrea jeco...
XP_001215392  551 RRVTYYEaynm--drdCLNMDvrei--ndddLTHVHFAFAGLTSNIEImfddsykDQFGAFIEMHapWKKILSFGGWAES 626  Aspergillus t...
XP_387745     518 LNVGYFQgynl--grpCLNMDvtklpqlttaYTHIHFAFAGLTSDFSVliepatrEQFIKFKEVKgsWKKIISFGGWAGS 595  Gibberella ze...
CAD91890      868 KNIAYWLdadgpmasdPFNYDdg-------sYDAIHYAFVNINSDFSId-----dSKFSNSKFLNs-NLKNSSFGGWGFS 934  Pichia inosit...
CAP65303      220 KKIGYFEawst--drdCLWMDatsi--detqFTHIHFAFADVTPDFRVdvs-kvqAQFNKFKALKr-SKRIIAFGGWAAS 293  Podospora ans...
Feature 1                                               # # #                                     
P09805        453 TSPSTYTIFRnavktdqNRNTFANNLINFMNKYNLDGIDLDWEYPGAPDIPdipaDDSSSGSNYLTFLKLLKGKMPs-gK 531  Kluyveromyces...
CAE84954      289 TNPSTYKIFRegv-ksqNRDKFTSNLVVFAQKYNLDGIDLDWEYPGAPDIPgipaDDKNNGKNYLEFIKLLKSKLPg-gM 366  Debaryomyces ...
EAL91911      514 TDPSTFQRFRdat-kpeHRDTFVTNLVSFMSRHNLDGFDFDWEYPGAPDIPditpGSPDEGQNYLAFLQRLRSKLPs-gK 591  Aspergillus f...
XP_001483636  242 TSPSTYQIFRngv-qvaNRDKLATNLVNFMTKYNLDGIDLDWEYPGAQDIPgipsDDLNNGQNYLELVKSIKSKLPs-gK 319  Pichia guilli...
XP_001223888  152 TSLATYNIFRdav-kpeNRQTFARNLADFANEWHLDGIDIDWEYPGAQVLPeipkGSLDDGKNLASCLVLLRDLLGp-dQ 229  Chaetomium gl...
DAA05858      569 VGVDTYATLRqai-kpeHREFFATQVVDFLKQHKLDGVDFDWEYPGATDLPip-aGSPEDPANYLRFLQLLRKKLPa-eM 645  Hypocrea jeco...
XP_001215392  627 TDAATFQRYKdvv-kpeNRERFANNVVAFVNKHKLDGIDFDWEYPGATDIPgv-pGGQGETDHYLNFLKLMREKLGd--K 702  Aspergillus t...
XP_387745     596 TDASSFQIYRdai-kpaNRNKFAYNVMTVLNNHKLDGVDFDWEYPGSASSD----GSSTDTANYVEFLKIMRSKIGksgK 670  Gibberella ze...
CAD91890      935 TSPSTYQIIRkgv-qigNVVKFANNVVNFLNKYNLDGLDFDWEYPGAPDILgipaDDPKNGNNYLNFLILVKAMLPa-gK 1012 Pichia inosit...
CAP65303      294 TSPTTFQIFRagv-nsaNRATLANNIANFVREHGLDGADIDWEYPAAPDLPdippADPIDGPNYLAFLRLLRAGLPt-gK 371  Podospora ans...
Feature 1                                         ##                                              
P09805        532 TLSIAIPSSYWYLKNFPISDIQnTVDYMVYMTYDIHGIWEygka--------nsyINCHTPRKEIEDAIKMLDKAGVKFN 603  Kluyveromyces...
CAE84954      367 SLSIAIPSSYWYLKNFPLKDIQqYLDYMVYMTYDIYGVWDmdk---------dsrIKCHTNKTAVIDALKMLDKAQIEIG 437  Debaryomyces ...
EAL91911      592 SLSIALPASYWYLKQYPVKQMAkYVDYFIYMTYDLHGQWDvdnqwaipgcpagncLRSHVNKTETHDALVMITKAGVEAR 671  Aspergillus f...
XP_001483636  320 TLSVALPNTYYYLSNFPVKAMQdYVNYFIFMTYDYPGATQn-------------tLFCHTDKDQVVQSLEMLDKAGVKMW 386  Pichia guilli...
XP_001223888  230 SLSIATPASYWYLKGFPIAKMSaALDYIVYMTYDLHGQWDfgsrwadpgcpdgncLRSHVNLTETLNALSMITKAGVPSN 309  Chaetomium gl...
DAA05858      646 SLSIAAPASFWYLKAFPIADIAkTVDYIVYMTYDLHGQWDfnsrwasdgcpkgscLRSHVNMTETLNALAMITKAGVEAR 725  Hypocrea jeco...
XP_001215392  703 SLSIALPASYWYLKPFPVEKMAkYLDYFIYMTYDLHGQWDfgnknaspgcangncLRSHVNKTETHDALAMITKAGVPAN 782  Aspergillus t...
XP_387745     671 TMSVALPAAYWYLKPFPVTQIApLVDYMVYMTYDLHGQWDygnptinsgcpdgncLRSHVNKTETLDSLAMITKAGVDPA 750  Gibberella ze...
CAD91890     1013 TLSVALPASYWYLKAFPIYQMHnYVDYFIYMTYDIHGTWDlsk---------dnaVKCHTNKTEIVDALKMLNKAGLNLS 1083 Pichia inosit...
CAP65303      372 SLAIAAPASYWYLKGFPIREMGsVLDYIVYMTYDLHGQWDagsrwsqdgcpsgmcLRSHVNMTETYNALVMVTKAGVPAN 451  Podospora ans...
Feature 1                 #                                                                       
P09805        604 KVFGGVANYGRSYKMVNTNCYNYGCGFQReggnsrdmtntpgvls----------dseiididssdkkndrWVDTNTDCI 673  Kluyveromyces...
CAE84954      438 KTYGGISNYGRSYKASSTSCMSENCPFSGpgnkrditntpgvlae-----------selnaiasssaknkrWTNNEIMCD 506  Debaryomyces ...
EAL91911      672 QLVVGVTSYGRSFRMNDASCSGPFCTYAGdrthsmasaapctatggyia---naeihdilqshgnysivkaYVDKESDSN 748  Aspergillus f...
XP_001483636  387 KTYGGLANYGHTYTLKSTSCTAIGCEGSGpgkagpvsgeagtltd-----------feinaiakssrknkrWTDSTSMCD 455  Pichia guilli...
XP_001223888  310 KIAVGISSYGRSFQMTTPGCTGPMCTYTGpasgakpgrctntagyl--------anaeineiiarksnvqtFHDASSDSD 381  Chaetomium gl...
DAA05858      726 QVVVGVASYGRSFEMNDPKCKGPMCTFTGpqslaapggctnssgyis------naeildimedrksypvqaWYDEKTDSD 799  Hypocrea jeco...
XP_001215392  783 QVVVGVSSYGRSFGMADPNCTGPMCKFTGsfnctntsgyisnaelm--------llsdnallgydgyharsWHDDDSDSD 854  Aspergillus t...
XP_387745     751 KVVVGISSYGRSFRMKDPKCTGVTCQFTGsfsvseaepgvctgepgylsdaeirliaydakkgkagvtaktWYDKASDSD 830  Gibberella ze...
CAD91890     1084 KVRGGLANYGRSYKLANPSCYAVGCPFTGggekgpitntdgilad-----------seiinidasksknqrWTDSTSECI 1152 Pichia inosit...
CAP65303      452 KIIVGVSSYGRSFKMKDPNCRGPMCEYTGtasvshatagpctgvqgyi-----snaeiqeyknvndinvatHYDQATRSN 526  Podospora ans...
Feature 1                                                 #     
P09805        674 FMKYDg-------NSVVSWPKSRYDLEDMFKNYGFAGTSLWAANYF 712  Kluyveromyces lactis
CAE84954      507 FMIYDgd-----sVVGWPKPEQRNSMQDFFRTHWLKGSFFWVDNYF 547  Debaryomyces robertsiae
EAL91911      749 ILLYGnpg--avdWVAYMDGAVKARRIDWIKSLNFGGSTDWAIDLQ 792  Aspergillus fumigatus Af293
XP_001483636  456 VMVYDnn-----nWVAWPKAGQRDAMREFFRGAGLGGSSLWLTNYA 496  Pichia guilliermondii ATCC 6260
XP_001223888  382 ILVYDtv-----hWVAYMDNVTKADRIARYQRLNMWGVSDWAVDLE 422  Chaetomium globosum CBS 148.51
DAA05858      800 YLIYNqt-----qWVAYMSKSVKEARIKKYQALNFGGISNWAIDLE 840  Hypocrea jecorina
XP_001215392  855 IMVYGedeh-ahsWVAYMSEDTKAGRIEWVKGLNFGGVSDWAIDLG 899  Aspergillus terreus NIH2624
XP_387745     831 IMTYGtqgkgmtdWVAYMGPTTKLKRTQWVQGLNFGGVVDWAVDLE 876  Gibberella zeae PH-1
CAD91890     1153 FMVYDt-------NNVVGWTANRNNLQNYYQQNGLRGSSLWLTNYF 1191 Pichia inositovora
CAP65303      527 IAIINg------tWIAYMDTAEKNARSNMYRGWNFGGTSDWAIDLD 566  Podospora anserina

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