2UY2,1CNV,1HVQ,1TE1,2GSJ


Conserved Protein Domain Family
GH18_hevamine_XipI_class_III

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cd02877: GH18_hevamine_XipI_class_III 
Click on image for an interactive view with Cn3D
This conserved domain family includes xylanase inhibitor Xip-I, and the class III plant chitinases such as hevamine, concanavalin B, and PPL2, all of which have a glycosyl hydrolase family 18 (GH18) domain. Hevamine is a class III endochitinase that hydrolyzes the linear polysaccharide chains of chitin and peptidoglycan and is important for defense against pathogenic bacteria and fungi. PPL2 (Parkia platycephala lectin 2) is a class III chitinase from Parkia platycephala seeds that hydrolyzes beta(1-4) glycosidic bonds linking 2-acetoamido-2-deoxy-beta-D-glucopyranose units in chitin.
Statistics
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PSSM-Id: 119356
View PSSM: cd02877
Aligned: 55 rows
Threshold Bit Score: 288.369
Threshold Setting Gi: 19072991
Created: 1-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                    #                                     
2UY2_A          6 TNIAVYWGQNsag--------tqESLATYCESs-dADIFLLSFLNQFp--------TLGLNFANACsdtfsdg------- 61   baker's yeast
CAC07217       29 HKLTVYWGAEdd----------tTTLDDVCNDs-sYDVVNLAFLSHFfsa----ggYPKMSIGNLDgpsqaqkkag--at 91   Metarhizium a...
XP_388763      18 GGLNGYWGQLg-----------sEPLKAYCDSh--PEYITLSFVNQApeqn--psnLPGTNFAGHCaggtygnsn----- 77   Gibberella ze...
EAL85097       31 AQNVVYWGQNgggt------venNDLASYCTStsgIDIIVLSFLYQY---------GNGNTIASGTigqscyisps---g 92   Aspergillus f...
XP_964254      23 AKVNVYWGQRg-----------dARLRDHCDQa-nFDYVTIGAHCDAtyy---tngTTSGHMNGKCsv------------ 75   Neurospora cr...
CAL36995       22 HKIVAYWGQNavynslkprqyweKDLVDFCRDy-nYDIIVLSFLNVFfdrk-nkdrMPGFNFAFHCetpvapeyp----- 94   Hydractinia e...
XP_001222559   20 PAVNVYWGQKgv---------atDRLRTFCDDs-sFEYVTVGFINKSpeqdpsslkYPGSDFAVHCveakykdpnevdsn 89   Chaetomium gl...
DAA05862       32 AQNVVYWGQNgggt------venNDLSAYCTPtsgIDIIVLSFLYQWgqg----ssALGGTIGQSCgittsge------- 94   Hypocrea jeco...
DAA05866       12 GLLNGYWGQYtt----------tEGLRPHCDSg--VDSITLGFVNGApda----sgYPSLNFGPNCwaesypgnlglpsk 75   Hypocrea jeco...
XP_001907459   20 PEVNVYWGQTa-----------gSRLSTFCDAs-gFDYVTVGFLNKSpsqdpsganWPGTNFGSHCdgvyykyngan-tn 86   Podospora ans...
Feature 1                                                                                         
2UY2_A         62 -llhctqiAEDIETCQSLGKKVLLSLGGASGSYlf----sDDSQAETFAQTLWDTFGEGtga-------------seRPF 123  baker's yeast
CAC07217       92 glqdgsslVKSIKNCQSKGKPVILSMGGATDYSdvq--lnSDAQGQQIANTVWNLFLGGtdh------------kelRPF 157  Metarhizium a...
XP_388763      78 llsecytiQEGIPYCKDRGVKILLSIGGVYSDEgsnykvtTDDKGRDFADFLYKSFGPHnehsnpir--pfdsidndGNT 155  Gibberella ze...
EAL85097       93 qpqncdalASAIKTCQSRGVKVILSLGGAVGAYsl----sSQAEAETIGQNLWEAYGNTqgng-----------nvpRPF 157  Aspergillus f...
XP_964254      76 -------vASDIKHCQEKGKKVLLSLDGVEHMGsrf-slsSEAKAEEFASFLWGAFGPYdakwtg-------prpfdFAG 140  Neurospora cr...
CAL36995       95 kmfrcpkiEAGIKECQKNGKQVLMSLGGAVGRVgf----sGVDEAKLFAYRVYHLLLEGtdl------------qaiRPF 158  Hydractinia e...
XP_001222559   90 llarcgqiAADVRYCQKKGKKVLLSIGGQWDPPhtdytisSGPAGEYFADFIWGAFGPYnkdwegkprpfddyygaeEGD 169  Chaetomium gl...
DAA05862       95 -pqncdalTAAITKCKTAGVKIILSLGGASAFSsf----qTADQAAQAGQYLWNAYGGGsg--------------vtRPL 155  Hypocrea jeco...
DAA05866       76 llshcmslQSDIPYCRSKGVKVILSIGGVYNALtsnyfvgDNGTATDFATFLYNAFGPYnasytgp-----rpfddiTTG 150  Hypocrea jeco...
XP_001907459   87 vqsdcgkiAADIRYCQKKGKKVLLSIGGEWKTTany-dlsNEAEGRRFALFVWQAFGPRiagstvprpfddyylnaeEGE 165  Podospora ans...
Feature 1                   # #                                        #                          
2UY2_A        124 DSAVVDGFDFDIENNne----vgYSALATKLRTLFaegt-----kqyYLSAAPQCPYPDa----sVGDLLEn--aDIDFA 188  baker's yeast
CAC07217      158 GDVKLDGVDLDNETNdg----tgYLAMTKQFKANFqkdt----skkyYITAAPQCPYPDq----sEPLDVCq---LLDWV 222  Metarhizium a...
XP_388763     156 VHAAVDGFDFDIEHDlpn---gpYIAMINRLRELDeg---------lTITGAPQCPTSDey--fyMKDMIKs--aKFDAL 219  Gibberella ze...
EAL85097      158 GSTFVNGWDFDIESYsgn---eyYQYLINKLRSNFasdp----snqyYITGAPQCPIPEp----nMQVIVTk--aQFDYL 224  Aspergillus f...
XP_964254     141 HRVSVDGFNLDGELKlngagegaYAAMAKKLRELYngn------aelLLTAAPGCSLDDv----kMKAIFDn--aQFDAL 208  Neurospora cr...
CAL36995      159 GSAIMDGIDLDIENGyy----syYTDFVKELRRLEkags-----qkiLIGAAPQCPFPDrllgpsAGRVLGdvpkLVDEI 229  Hydractinia e...
XP_001222559  170 EHFVFDGFDFDIEHKfed--qtgYVAMVRRLRGLTsldt----srkyLITAAPECPLEDky--fkMKTIINe--cQFDAL 239  Chaetomium gl...
DAA05862      156 GNNVMDGFDLDIESNpgt--nenYAALVSALRSNFasdp----srqyVISGAPQCPLPEp----nMGVIIQn--aQFDYL 223  Hypocrea jeco...
DAA05866      151 LPTSVDGFDFDIEADfpn---gpYIKMIETFRSLDss---------mLITGAPQCPTNPqy--fvMKDMIQq--aAFDKL 214  Hypocrea jeco...
XP_001907459  166 ENFVFDGFDFDIEKSydanqskgYIAMISSLRQFMatpqlnpnnrqfLITAAPECPLNDpy--ykMKHIIKn--sKFDLL 241  Podospora ans...
Feature 1           # #                                                                           
2UY2_A        189 FIQFYNNyc----------svSGQFNWDTWLTYAqtvspnknikLFLGLPGSAsa------agSGYISDTSLLESTIADI 252  baker's yeast
CAC07217      223 QVQFYNNgncn------iaqrGFAKAVKNWSKGIgsg-----vqLYIGALASGad------gdEGYVHAATLNRAVNQVK 285  Metarhizium a...
XP_388763     220 FVQFYNNpwcdav---sqgheGESFNYDKWVEIIeesdcskdakLYVGLPASEeaa-----pgGGYLEPEDLKDLVCELT 291  Gibberella ze...
EAL85097      225 WVQFYNNpgc---------svNGPINYDQWVSNLantps-anakIFIGVPASPlgatgtssgaQYYLQPSALASLVAEYK 294  Aspergillus f...
XP_964254     209 FIQFYNNpsce-------aasASGFNYLQWEKAIaagms-keakLFIGLAGASda------agSGYIEPLEAAALINTYK 274  Neurospora cr...
CAL36995      230 YIQFYNNwcht------gnerVFYGHVKKWVDYSkktd---gpmIFVGVPGNKkas----gnpLHYRTPSELAKIYQNLK 296  Hydractinia e...
XP_001222559  240 FIQFYNNdmc---------agVNNNNFDAWASYLkntas-knakIFLGLPGSKaa------agSGYLQPSQAHALINKHK 303  Chaetomium gl...
DAA05862      224 WVQFYNNneypgdpcslglpgDAPFNFNNWTTFIqstps-kdakVFVGVPAAPlaangapsgeVYYATPSQLADIVNDVK 302  Hypocrea jeco...
DAA05866      215 FIQFYNNpvcdai---pgntaGDKFNYDDWEAVIagsaksksakLYIGLPAIQep------neSGYIDPIAMKNLVCQYK 285  Hypocrea jeco...
XP_001907459  242 FVQFYNNpgc---------hgVTNNNFDTWASHLqstas-sgakIFIGLPGSTnavq--ngeaSGYLTPTNLRTVINKFK 309  Podospora ans...
Feature 1                     #                          
2UY2_A        253 ASss-sFGGIALWDASQAfsne-----lngePYVEILKN 285  baker's yeast
CAC07217      286 AMnlpnFGGAMLWEAHSAvk---------ngNYQKKIKA 315  Metarhizium anisopliae var. acridum
XP_388763     292 TKp--hFGGVSLWDLTRGagni-----iegkSYNEHVMD 323  Gibberella zeae PH-1
EAL85097      295 DNp--aFGGVMMWSAGFSdanv-----nngcTYAQEAKR 326  Aspergillus fumigatus Af293
XP_964254     275 TRs--sFGGAMVLDAFRGqtla------ngmTFLDVINT 305  Neurospora crassa OR74A
CAL36995      297 DEp--rFGGIMFWDASFDqnnv-----idgkHYSEHIAA 328  Hydractinia echinata
XP_001222559  304 NKp--aFGGVMVWDAVYGsekf------sgtRYYDLMHE 334  Chaetomium globosum CBS 148.51
DAA05862      303 SNp--aFGGIMMWSAGFSdtnv-----ndgcNYAQEAKN 334  Hypocrea jecorina
DAA05866      286 DRp--hFGGLSLWDLSRGlvnn-----ingtSFNQWALD 317  Hypocrea jecorina
XP_001907459  310 GRa--aFGGVMIYDATYGasnivsgsspaglNYYQYARS 346  Podospora anserina DSM 980

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