Conserved Protein Domain Family
GH18_SI-CLP

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cd02876: GH18_SI-CLP 
Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl hydrolase family 18 (GH18) domain but lacks a chitin-binding domain. The catalytic amino acids of the GH18 domain are not conserved in SI-CLP, similar to the chitolectins YKL-39, YKL-40, and YM1/2. Human SI-CLP is sorted to late endosomes and secretory lysosomes in alternatively activated macrophages.
Statistics
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PSSM-Id: 119355
View PSSM: cd02876
Aligned: 19 rows
Threshold Bit Score: 345.447
Threshold Setting Gi: 145522544
Created: 1-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative carbohydrate binding site [chemical binding site]
Evidence:
  • Comment:based on the carbohydrate binding site of the human HCGP-39 and mouse YM1 chitolectins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                         #                                              
AAH13642       3 FAGDVLGYVTPWNSHGYDVTKVFGSKFTQISPVWLQlkrrgr----emfevtGLHDVDQGWMRAVRkha------kgLHI 72  human
NP_192013     99 YDYPVLAYITPWNSKGYDMAKIFNSKFTHLSPVWYDlksqgs-----glvleGRHNADKGWIQELRsr-------gnALI 166 thale cress
NP_508185     57 EGLTQLAYITPWNRHGYELAEKTAHKLTHVSPVWFQakafsengkldgckieGTHEINRDWIEKLRekn------enIAI 130 nematode
NP_609190     81 FNGTTLGYVTPWNSHGYDVAKIFAKKFDIISPVWLQivkqgd-----ryavaGTHDIDAGWLTDVRrkgkqvhnqrtVKV 155 fruit fly
XP_635730     76 EQGNTLVYITPWNGKGYDVATKWAKKFTHISPVWHQvkfenn-----kvmieGDHNIDKKWMEKVKens-----dqkSKI 145 Dictyostelium d...
XP_971647     76 FDGLVLGYVTPWNNEGYDIAKIFGNKFTHISPVWLEikksnn-----rfdfsGTHDIDKKWIIHVKnagr----erkLKI 146 red flour beetle
EAY74993     130 FRNPVLAYVTPWNSKGYDMAKLYSTKFTHISPVWYDlksdgn-----klvleGQHNFDAKWVSELQsn--------gSLV 196 Indian rice
XP_317335     84 FEGKVLGFVTPWNNHGYDVAKLWGPKFDYVSPVWLQilrkgp----kkyevaGVHDIDDGWVKDVKkags----tinNRV 155 Anopheles gambi...
ABK24365     115 FNSMVLAYVTPWNSKGYDMAIKFRAKFTHVSPVWYQlkrigt-----elqlfGKHDADQQWMAQVRkh-------glPLI 182 Sitka spruce
XP_001773378  89 FLNSVLVYVTPWNSLGYDMAKKFRAKFTHVSPVWYQlqrgkd-----rlellGRHDVDKQWIDAVRqd-------gsPMI 156 Physcomitrella ...
Feature 1                                                            # # #                       
AAH13642      73 VPRLLFEDWTYDDfrnvl---------dsedEIEELSKTVVQVAKNQHFDGFVVEVWNQllsq--------krvgLIHML 135 human
NP_192013    167 LPRVVLEAIPGEMlnk-------------kkLREKAISLIVTECKEMEYNGIVLESWSRwaaygvlh-dpdlrkmALKFV 232 thale cress
NP_508185    131 VPRILFDGWSAQEmknll---------mdakVARHCFEDIANFYSRNQFEGAVVELYMQalisvqslevkefiieSIQDL 201 nematode
NP_609190    156 FPRFIFDHFTDRDiklll---------sdaqERTKVNDVLIKCCKDNGFDGLVLEVWSQlagri-------ddkiLYTLV 219 fruit fly
XP_635730    146 LPRFSFEGQQWGSkesf-----------qkyIDPKLIDSLVSTVKKNNYDGLVIEGIVHink-----------qlRDPFL 203 Dictyostelium d...
XP_971647    147 VPRILFSGLNENQmnsl----------fdpkELKSLIKTLITTAKSYNFDGYVIEIWPQlqmdm-------nydpLINLV 209 red flour beetle
EAY74993     197 LPRVVLEAFPGVVlmkkklrdkaidlivnecSYNCQFVIWLSVNRDKGYDGVVLESWSRwavygvld-dselrnrALQFV 275 Indian rice
XP_317335    156 IPRVLFDKFTDRDfsqll---------typeERTIVAKLLLATARKHRFDGLVLEVWSQlaarv-------edsyLIGLV 219 Anopheles gambi...
ABK24365     183 LPRVALEGSPIELltk-------------krERKQAYELIVSECKNMGFDGVVLEAWSQwaaygilk-dpnlrqmALQFV 248 Sitka spruce
XP_001773378 157 VPRVVLEGSPLHMlvd-------------paERKQAIDLIVNECKYMEYDGVVLEAWTAwavynile-npnlrhkALEFV 222 Physcomitrella ...
Feature 1                                                                     ##                 
AAH13642     136 THLAEALhqa----------rlLALLVIPPaitpgtdqlgmFTHKEFEQLAPVLDGFSLMTYDYstahqPGPNAPLSWVR 205 human
NP_192013    233 KQLGDALhstsspr-nnqqhmqFMYVVGPPrsekl--qmydFGPEDLQFLKDSVDGFSLMTYDFsnpqnPGPNAPVKWID 309 thale cress
NP_508185    202 SRQMKKLh-------------mQVILTVPAplewnnqpnnlVTPDDFKKITAVSDFVQIMTYDYrg-nkPAGVAPYDWFE 267 nematode
NP_609190    220 LQMAKELqkq----------qlRLILVIPPfrke---tghlFGEKHMDKLFKHIYAFSLMTYDFssvqrPGANAPLYFVR 286 fruit fly
XP_635730    204 ISLSEKLhsi----------gkEIILVIYPfrqkg--qetgFGAKDFELLSNHIDGVSLMTYDFgp--sGGMNAPKVWVE 269 Dictyostelium d...
XP_971647    210 RTIGDSLale----------slDTILVIPPkrgr----nlpFSEDHFNALYDHVTAFSLMTYDYsnprrPGPNAPLTWVE 275 red flour beetle
EAY74993     276 KHLGKTLhltssnl--sthhhlKLIYVVPAprmke-lnnqeFRPEDLLQLADSVDGFSLMTYDFsgpqnPGPSAPLSWIQ 352 Indian rice
XP_317335    220 EEICNTLtaa----------syDCILVIPParke---tydlFSRKHFEALEPSVTAFSLMTYDFssvqrPGANAPLYWVR 286 Anopheles gambi...
ABK24365     249 QELGSMLhtaktvd--gldrnlQLVFVIPPlnsie-nnpdmFTSTDMARVSNNVDGFSLMTYDFsstyrPGPNAPIGWVH 325 Sitka spruce
XP_001773378 223 LALGETLhsmkasksgsekrnmQLHFVIPPpsdyk-kdprvFTRADMTMLGNSIDGLSVMTYDFsgpnhPGPNAPAPWID 301 Physcomitrella ...
Feature 1                                                                                        
AAH13642     206 ACVQVLdpks-----------------kwrsKILLGLNFYGMDYatskd--arepVVGARYIQTLKDHRPQMVWDsq--v 264 human
NP_192013    310 LTLKLLlgssnni------------dsniarKVLLGINFYGNDFvisgdsggggaITGRDYLALLQKHKPTFRWDke--s 375 thale cress
NP_508185    268 SCIFYLgg---------------------ghKTLAGLNFYGYEFskgn----veaITADRYLTLLKSEKSKLEFDek--s 320 nematode
NP_609190    287 KAVETIapegcad------------mtakraKILLGLNMYGNDYtpdg----ggpITFSQYLDLVRHVKKHLTYDer--d 348 fruit fly
XP_635730    270 DNLKFLlpnge---------------nknskKIFMGIPFYGYKIgend---qsdaIVGSEFISVLKQNKSKKLKFdqn-t 330 Dictyostelium d...
XP_971647    276 DCIKTVssqe-----------------skrgKILTGFNFYGNHYsevg----gkpILGHEFIRKLEEKLKTARMIydpqi 334 red flour beetle
EAY74993     353 YSLKTLlaakgsa------------shghshMIFLGINFYGNDFllskg-dggnaITGRDFIYLLDKYKPTLQWDek--s 417 Indian rice
XP_317335    287 NAVQHVcpdgadr------------mrekraKILVGLNMYGSDFtpng----gqpIVAHEYLALLKHLKGHLTYDeh--d 348 Anopheles gambi...
ABK24365     326 ACLQYLlpvsaakrqrdtkidmktvsyqlagKILMGINFYGNDFvlpr---ggapILGHEYLSLLRTHKPKLFWDeq--s 400 Sitka spruce
XP_001773378 302 STLASLrrmsed--------------sdaapEVLLGLNFYGNDYtlpq---gggaIVGHQCVALLEKYKPSITWDkk--s 362 Physcomitrella ...
Feature 1                                                 #             
AAH13642     265 sEHFFEYkksrsgrhvVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL 319 human
NP_192013    376 gEHLFMYrddknikhaVFYPTLMSILLRLENARLWGIGISIWEIGQGLDYFFDLL 430 thale cress
NP_508185    321 mEHRVKTsn-----siAYFPSLTSLELRINMAHRYDVGIAIWDYGQGLDYFTNLL 370 nematode
NP_609190    349 vENFFEIkndd-grhiVFYPTLYSINERIKLAQELGTGISIWELGQGLNYFYDLF 402 fruit fly
XP_635730    331 hEHIFTYknkknqqvsMTYPSLLFIEDRIQLANKYKVSISIWEIGQGLDYFMDLL 385 Dictyostelium discoideum AX4
XP_971647    335 aEHYVEYeesn-gkhlLFYPTLYSIHKRIELCKKLGTGISIWELGQGLKYFYDLL 388 red flour beetle
EAY74993     418 sEHFFVYsdkg-lrhaVFYPTLMSLSLRLDEAQDWGTGLSIWEIGQGLDYFFDVL 471 Indian rice
XP_317335    349 vENFFEVktsn-grhmVFYPTLFSIDERLKLARELGTGISIWELGQGLDYFYDLF 402 Anopheles gambiae str. PEST
ABK24365     401 mEHYFDYeerl-nrhrVFYPSLKSISLRLEEAQTWGVGLSIWEIGQGLEYFFDLL 454 Sitka spruce
XP_001773378 363 eEHYFMYdged-akhvVFYPTLASVSARLNTANKVGSGISIWEIGQGLEYFFDLL 416 Physcomitrella patens subsp. patens

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