Conserved Protein Domain Family
GH18_chitobiase

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cd02875: GH18_chitobiase 
Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. Chitobiase can only do so if the asparagine that joins the oligosaccharide to protein is previously removed by a glycosylasparaginase. Chitobiase is therefore the final step in the lysosomal degradation of the protein/carbohydrate linkage component of asparagine-linked glycoproteins. The catalytic domain of chitobiase is an eight-stranded alpha/beta barrel fold similar to that of other family 18 glycosyl hydrolases such as hevamine and chitotriosidase.
Statistics
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PSSM-Id: 119354
View PSSM: cd02875
Aligned: 8 rows
Threshold Bit Score: 511.978
Threshold Setting Gi: 66819083
Created: 1-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #                                 #              
Q01459        21 GLALLALLALLALrlaa----gtdCPCPEPELCRPIRHHPDFEVFVFDVGq-------KTWKSYDWSQITTVATF----G 85  human
XP_422372      9 LVLLLGLLQLLGRta--------aCPCQDPRLCQPIAGTDRFEVFVFDVGk-------EAWKSYDWSKITTVAAF----G 69  chicken
XP_643201      3 VIFLLILLILLKIvks------yeCNCILKEYCKPLEVGERIEFIGFSFNs------tGNYLNYDYYSVTTIAISyqsnY 70  Dictyostelium d...
XP_642876      5 IIISLILTILIIQsks------keCPCSNVELCKPLEIGPRKEFIGFSVNs-------TFYPYYNWDHLTTIGIFy--sE 69  Dictyostelium d...
XP_644238      2 RIILLLFLIVFVVaqssssssssgCPCDSSYLCEPLQIAPRQEFLGFSLNs-------TQYPNYYWNQLTTLAIFy---E 71  Dictyostelium d...
AAH53782       7 GYWALSPLFIMLIcvsl---csagCPCTDPSLCEPINSTRDSEVLVFYTRg-------ENWKFYDWSQVTTIALF----G 72  African clawed ...
NP_001018565   5 LSILVLTFCVQVWsk--------vCPCERKELCQPISSQPAFEVFVFDVGe-------KAWKFYDWTKVTTIAAF----G 65  zebrafish
XP_001627848   6 RWLAVICVFSFAIsltl----crkCPCKEESLCEPITRPPGKECLVWTTTpnvwrktdFNAPGYDWSKITTIGMF----R 77  starlet sea ane...
Feature 1                                                             # # #                      
Q01459        86 KYDSELMCYAHSKGARVVLKGDVSLKDIIDPAFRASWIAQKLNLAKTQYMDGINIDIEQEVnclSPEYDALTALVKETTD 165 human
XP_422372     70 KYDPELLCFAHSKGARVVLKGDVPLKEVVDPAKRAAWISQQVDLAKKQYMDGINIDIEQEVnetSPEYYALTELVKETTD 149 chicken
XP_643201     71 DIPEELVCKSHENRVRLVWSAIISNNQISNETYRNQFIDSIVETIQKENMDGVIYELDNPNdltIENSDYFTEIIKKTYQ 150 Dictyostelium d...
XP_642876     70 DIEDELLCMAKTNGVRLVYSAFYPVEQLSNETYIDQWINEKLELVQNTFTDGLNFDVEYPIt-dPIVAQQYTQLVAATNN 148 Dictyostelium d...
XP_644238     72 TIEDELLCIAHENDVRLVWGTTFPIENLGNSSYIEEWIQEQIEKVQSTFTDGLNFDVESPIt-dPTIAQQYTELVSATNK 150 Dictyostelium d...
AAH53782      73 KYDPQLLCFAHLKGARLVLKGDVPLQDIVDPNNRTSWIAQKVELAKSQFMDGINLDIEQSVlkgSPEYYGLTALVQETTE 152 African clawed ...
NP_001018565  66 QYDAELMCYAHSKGVRLVLKGDIRLPEIVDPVNRTAWIQGNVKLAKSQFMDGINIDIEQAVetgSPEYYALTDLVKETTE 145 zebrafish
XP_001627848  78 EWDDELFCTAHSKGVRVVLVSGFPVEKLSNSQVRKDWIKNKTTEAKENFADGINIDIEGPIekgSKEVTLLTKLVNNVAK 157 starlet sea ane...
Feature 1                                                    ##                                  
Q01459       166 SFHREIEGSQVTFDVAWSPk-NIDRRcYNYTGIADACDFLFVMSYDEQSQIws---eCIAAANAPYNQTLTGYNDYIKMS 241 human
XP_422372    150 AFHKEIPGSQVTFDVAWSPa-CIDKRcYNYTGIAAACDFLFVMSYDEQSQIwt---dCIAKANAPYLQTLFGYEEYITMG 225 chicken
XP_643201    151 KLKLINWNYQISAKFPFSP--NIDFS-YNYPEISYYSDYLVIMDYNIGSRVsndgnyCLAGSNSPNPLIEQGVHNFTSMG 227 Dictyostelium d...
XP_642876    149 AFKSVNLYYQISVDVAWDAsnCIDYRcYDYLGLSKASDFLVVMDYDMKLDGyyf-ktCLASANSPPSSVLSGMVNFTKLG 227 Dictyostelium d...
XP_644238    151 AFKAINPFYQISIDVAWSPs-CIDKRcYDYAGLASNSDFLVAMDYDERSQVfge-kvCTAGANSSPSNALAGINNFTDLG 228 Dictyostelium d...
AAH53782     153 AFHREIPGSQVTFDVAWCPd-CVDGRcYNYTGIAESCDFIFVMSYDEQSQIwt---eCEAGANSPLNKTISGYEKFIQLG 228 African clawed ...
NP_001018565 146 SFHTEIPGSQVSFDVAWSPk-CIDKRcYDYITIADSCDLLFVMSYDEQSQIwg---dCIAMANAPYDQTLTAYDQYISMN 221 zebrafish
XP_001627848 158 AFRKEFKHTQISFDAAWSPd-CIDGRcYDLKAIVDIVDFMVIMAYDQQSQIke--gpCIAKANSPYSQTLEGVQQYLKLN 234 starlet sea ane...
Feature 1                    #                                                                   
Q01459       242 INPKKLVMGVPWYGYDYt-CLNls----eDHVCTIAKVPFRGAPCSDAAGRQVPYkt-----iMKQINSSi---sGNLWD 308 human
XP_422372    226 IDPKKLVMGVPWYGYDYv-CLNls----eDHVCSLPKVPFRGAPCSDAAGHQVPYge-----iMKQVNSSi---sGALWD 292 chicken
XP_643201    228 IPGERLVLTYPWFGLDFi-CFNgn---lsSVDCLVTKSENVSCNDINSISNQISYge-----iLKILNDDniingGINWN 298 Dictyostelium d...
XP_642876    228 IDESSLVMGLPWYGYNYp-CIGsny-tlqTFECIIPPSSYLGYNCTDASGIEINYsi-----iMNMLNDTaiqngGVQWD 300 Dictyostelium d...
XP_644238    229 ISTDQLVMGLPWYGYIYknCLNgdeagleTVVCQIESVPFRGANCSDAAGSEYDYsylvqllqDQTINSS-----AVQWN 303 Dictyostelium d...
AAH53782     229 IEPKKLVMGVPWYGYDYp-CLElf----qDNKCTIKEVPFRGAPCSDAAGRQIPYsk-----iMKQVNSSl---tGRLWD 295 African clawed ...
NP_001018565 222 IDPKKLVMGVPWYGYDYs-CLNfs----kDGVCTIPKVPFRGAPCSDASGRQIPYsi-----mMKQINSSi---sGRLWD 288 zebrafish
XP_001627848 235 ISNNKLVLGLPWYGYDYp-CEEid---ekNDICFIKKVPFRGVNCSDAAGTQIPYatv--ndlLMTRTDT-----GRKWS 303 starlet sea ane...
Feature 1                                                      #                        
Q01459       309 kd-qrAPYYNYKDPAGHFHQVWYDNPQSISLKATYIQNYRLRGIGMWNANCLDYSgdavakqQTEEMWEVL 378 human
XP_422372    293 ev-qnSPFYEYKDSLGHFHQVWYDDPRSISLKAAYVKNRGLKGIGMWNGNSLDYSreavaekQTEAMWQAL 362 chicken
XP_643201    299 sq-skSVFFNYYDKQGILHQIHFDNPKSLFIKVFLTKRLKAKGIAAQSMDNLDFNdlvnsynMFDTMAYFF 368 Dictyostelium discoideum...
XP_642876    301 sesesPYFNFIDLFSGTQHQMWFDNPDSLTIKVNIARTMNLRGVGVWNIDQLWDDh-----sLSSGMWGAL 366 Dictyostelium discoideum...
XP_644238    304 tewqsPYFNYIDPITGNVDQVWFDNPQSLSIKVQLAQKLNLRGVAVWNIDFLDFSdq----yNSRPMWDAL 370 Dictyostelium discoideum...
AAH53782     296 dv-qkSPFYNYKDAKGQLHQVWYDDPVSISLKSAYVKIHGLRGIGMWNGDLLDYSrnpiaetQTKSMWNAL 365 African clawed frog
NP_001018565 289 ee-qrAPYYNYKDTEGMVHQVWYDDPESIALKAAYVMQHGLKGIGMWNGNLLDYNgdpiaqkQTVDMWNAL 358 zebrafish
XP_001627848 304 lk-slSPYFWYSDHVGNPHQVWYDDPSSLTFKYRIANMLDLKGVAIWNADLLDYSglmranvQTPDMWNKL 373 starlet sea anemone

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