1JND


Conserved Protein Domain Family
GH18_IDGF

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cd02873: GH18_IDGF 
Click on image for an interactive view with Cn3D
The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are related to the glycosyl hydrolase family 18 (GH18) chitinases, but they have an amino acid substitution known to abolish chitinase catalytic activity. IDGFs may have evolved from chitinases to gain new functions as growth factors, interacting with cell surface glycoproteins involved in growth-promoting processes.
Statistics
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PSSM-Id: 119352
View PSSM: cd02873
Aligned: 15 rows
Threshold Bit Score: 664.013
Threshold Setting Gi: 53830694
Created: 8-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
carbohydrate
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:carbohydrate binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #                                #                                          
1JND_A      3 NLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDiy--khQFSEVTSLKRKYPHLKVL 80  fruit fly
Q9W303     26 HLLCYYDGNSFVREGLSKLILTDLEPALQYCTHLVYGYAGINPSSNKLVSNNEKLDldlgssLFRQVTGLKRKYPALKVL 105 fruit fly
AAV68692   28 KLVCYYDSRAYNRPGNGKFDIPFLEPALQFCTHLIYGYAGIREDNFKISPLNEPLDin--kqNYRHITDLKRKYPGLRVL 105 Diaprepes root weevil
AAT36640   24 KVVCYYDSKSYVRESQARMLPLDLDPALSFCTHLVYGYAGIQPDTYKMVPLNENLDvdrshaNYRAITNFKSKYPGLKVL 103 Pieris rapae
AAS80137   32 KVLCYYDGSNALREGLGKVTVSDIELALPFCTHLMYGYAGVNAETYRLRSLNEDLDldsgksHFRAVTTLKRRYPGLKVF 111 African malaria mo...
AAS80138   27 KVLCYYDAANFLIEGLGKVSLADIDAALPFCTHLVYGYAGIDVETNKAVSRQPNLDldtgkgNYRTVTQLKSKYPSLKVL 106 African malaria mo...
XP_396769  31 KVVCYWNTTAFERQGPGKFQLDDVQSALSLCTHLIYGFAGINAETFEVVPLKPSLDtgvgysYYKLVTQLKRTFPNLKIY 110 honey bee
AAF57703   30 KLVCFYDAQSFVREGPAQMSLAELEPALQFCNFLVYGYAGIDAVTYKIKSLDPSLTnd--rqHYRHITALRKKYPHVRFL 107 fruit fly
AAU95190   21 RVVCYWDGKSFWRDGAAKVTAEDIKPGLQYCSHLIYGYAGIHDDDYVVKSIDEDLVldsgrgQYRAATNLKTFNSGLKVL 100 Oncometopia nigricans
ABM55664   25 KISCFYDSKAYNRKGIAQVTAEELKPAALLCNYIIYSFVGMDSDKYKIKSLDESLDtekgknNFRAVTNLKLLNPQLKVL 104 hibiscus mealybug
Feature 1          #                                           # # #                          
1JND_A     81 LSVGGDHDidpdh--pnkyIDLLEGEKVRQIGFIRSAYELVKTYGFDGLDLAYQFPKNKPRKvhgdlgLAWKSIKKLFtg 158 fruit fly
Q9W303    106 LSVGGDKDtvdp---ennkYLTLLESSNARIPFINSAHSLVKTYGFDGLDLGWQFPKNKPKKvhgsigKFWKGFKKIFsg 182 fruit fly
AAV68692  106 LSVGGNNDvtgegseknlkYRTLLESVESRLAFVNSAHDLVKNYGFDGLDLSWEFPENKPKKirn-avSSWFSKIKHKiv 184 Diaprepes root weevil
AAT36640  104 LSVGGDADkee-----eqkYNLLLESPQARTAFVNSGMLLAEQHGFDGIDLAWQFARIKPKKvrstwgSIWHGIKKTFgt 178 Pieris rapae
AAS80137  112 LSVGNYRDlgeek--pfekYLTLLESGGSRTAFVNSAYSLLKTYEFDGLDLAWQFPQTKPKRirgwtgKVWHGFKKLFtg 189 African malaria mo...
AAS80138  107 LGLGGYKFsep-----sikYLTLLESGAARITFINSVYSLLKTYGFDGVDLEWQFPMNKPKKvrstlgGVWHGFKKVFsg 181 African malaria mo...
XP_396769 111 LGIGGNADpdde----thkYLVLTETSQSRSKFINSVNRLLNDYDFDGIDLAWQFPPAKVKKergtfgSIWHGIKKTFgy 186 honey bee
AAF57703  108 LSVGGDRDvnsegvadsdkYLRLLEQSEHRKSFQASVLAELNNNGFDGIDLAWQFPKNRPKLqqgvfkRVWGSLRGWFss 187 fruit fly
AAU95190  101 LSIGGFGDtdd-----lekYYEVLENIERRTKFINSVHATLKQFNFDGVDLAWRFPEVKEKKdrnifsSAWQGLKKAVgv 175 Oncometopia nigricans
ABM55664  105 VSVGGFWDdde-----pekYLKSLEKQEHRAKFIESAVKLAKDYNFDGIDLAWQFPIVKEKKdrgtlgSIWHSIKKAVts 179 hibiscus mealybug
Feature 1                                                                     ##              
1JND_A    159 d-fiVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYS 237 fruit fly
Q9W303    183 d-hvVDEKAEEHKEAFTALVRELKNAFRPDGYILGLSVLPNVNSSLFFDVPAIINNLDYVNLHTYDFQTPERNNEVADFP 261 fruit fly
AAV68692  185 gesvVDEKAEEHKEQFTALVRELKNVFRHDGLLLTVSVLPNVNSSVYFDPRQLAPNIDFATLEAFDYRTPQRNPKELDYV 264 Diaprepes root weevil
AAT36640  179 --tlVDEKEAEHREGYTALVRELKQAMTLKQMQLSISVLPNVNSSIYYDVPAIINLVDIVNLHAYDYYTAARNPKEADYS 256 Pieris rapae
AAS80137  190 d-svLDPKADEHREEFTALVRDLKNAFVHDKFQLGYTQLPHVNQTIFLDIPLLKDNIDYVNVAAYDQQTPERNPKEGDYT 268 African malaria mo...
AAS80138  182 d-svLDEKAEEHREEFTALLRELKNAFRSDGYQLGITVLSHVNSSVFMDIPAIINYLDFVNIAAYDQQTPTRNKKEADHA 260 African malaria mo...
XP_396769 187 g-kfKDDKEVEHRDGFTILVRDLKAQLRPRLKDLTIGVLPHVNSTVYYDARLLAPNIDAVHLFTFDQKTPERNPREGDYP 265 honey bee
AAF57703  188 --ssVDEKSEEHREQFATLLEELQSDLRRGGQLLTVSMLPHVSAELFIDVPKVLSNVDFVNLGTYDFQTPERDPKVADLP 265 fruit fly
AAU95190  176 ---gVDEKWAEHRDQFVNLVRELKAALRTDSKLLSLGVLPHINATAYYDVRNLAPQVDFVNLWTFDFRTPKRSKVQADYS 252 Oncometopia nigricans
ABM55664  180 --stKDDKEKEHKEQFTALVRELGAALRGNKQILTLSVLPHVNSKAYFDGNNFKDWIEHIHLMTYDYRTPKRTPEEADFA 257 hibiscus mealybug
Feature 1                                                #                                    
1JND_A    238 APIYhpdgskdrlahlNADFQVEYWLSQGFPSN--KINLGVATYGNAWKLTKDSGLEGVPvvPETSGPAPEGFQSQKPGL 315 fruit fly
Q9W303    262 APIYelner---npefNVNYQVKYWTGNRAPAA--KINVGIATYGRAWKLTKDSGLTGLPpvAEADGVAPAGTQTQIPGL 336 fruit fly
AAV68692  265 APLYelldr---kvdeNADYQVRYWLGGGLPAN--KLILGIPTYGRAWKLNDDSGLTGVPp-LLTDGAADPGPYSNEAGL 338 Diaprepes root weevil
AAT36640  257 APTYkpqnr---nellNVDAAISYWLTGGAPSS--KIVVGIATYARTWKLDSDSEISGVPp-LHTDGPGEAGPYTKTEGL 330 Pieris rapae
AAS80137  269 APIYepter---vvgnNVDDKVKAWHSQGTPLD--KIVVGIATYGRGWRLVGDSGITGVPp-IPADGPSPAGPYTNVPGF 342 African malaria mo...
AAS80138  261 APLYelsdr---vpgnNVDGQVRLWLTNNAPAS--KLIVSIPTFGRGWKMNGDSGITGVPp-LPADGPSNPGPQTQTEGF 334 African malaria mo...
XP_396769 266 APIYesygr---vpqdNVDSTARYWLEHGTPGS--KIVVGIPTYARTWKLTSESQISGVPp-IVTDGPGAEGPHTNTPGL 339 honey bee
AAF57703  266 TPLYamydr---dpshNVQYQVQYWMNQTSEISvhKLHVGVTSYGRAWNMTRNSGITGYPpiPAANGAAPPGRQTVTPGL 342 fruit fly
AAU95190  253 APLYymydr---npqqNADAHVTWWISNGCDPS--KLNLGIPTFGRSWELTTDSPISGVPp-LLADGAGDEGTYSKIKGT 326 Oncometopia nigricans
ABM55664  258 APTQflvgr---nesyNIEATVKWWLEQKMPAN--KLLITIPTFGRTWKLTTDSGKTGVPpvKKADEEGEEGAYLKEKGR 332 hibiscus mealybug
Feature 1                                                                                     
1JND_A    316 LSYAEICgklsnpqnqflkgnespLRRVSDPTKRFGGIAYRPVDgqi--teGIWVSYDDPDSASNKAAYARVKNLGGVAL 393 fruit fly
Q9W303    337 LSWPEVCaklpnpanqhlkgadgpLRKVGDPTKRFGSYAYRSADdsg--enGVWVGYEDPDTAAIKAEYVKREGLGGIAV 414 fruit fly
AAV68692  339 LSYPEICskiatpke-iqagylgkLRKTNDPTKRYGSYAYRLPDsng--enGIWVGFEDPDTVGNKAAYSKAKGLGGIAI 415 Diaprepes root weevil
AAT36640  331 LSYPEVCaklinpnh--qkgmrphLRKVTDPSKRFGTYAFRLPDdng--dpGLWVSYEDPDTAGQKASYVKSKNLGGVSI 406 Pieris rapae
AAS80137  343 YSFGEVCaklpnpgnanlkgaeypLRKINDPTKRFGPYAFRIPDend--ehGIWLSYEDPESAGNKAAYVKAKGLGGISI 420 African malaria mo...
AAS80138  335 YSWAEVCamlpnpsntalkgadapLRKVGDPTKRFGSYAFRLPDsng--ehGVWVSYEDPDTAGNKAGYVKAKNLGGIAI 412 African malaria mo...
XP_396769 340 LSYAEVCsrlte-------savgrLRRVGDPSKKYGSYAYQPYNent-gadGIWVGYEDPDTAGNKAAYAKAKGLGGVAI 411 honey bee
AAF57703  343 LSWPEICdllqqqp---qdrevphLRKVGDPTKRFGIYAYRAADdqg--enGLWVGYEDPLTAAIKAGFVHAQGLGGVAF 417 fruit fly
AAU95190  327 LAYYETCtrvvsptn--arapstlLRRVTDPTKRLGTYAYRLPQkdkdeeeGFWLSYEEPETAAYKAGYAKAKGLGGVVL 404 Oncometopia nigricans
ABM55664  333 MAYYEICpilstda----nppstlLKKVTDSTYRTGSYAFRPADsk---kkGIWVSYEDPDVAAKKAYYAKLKGLGGVAI 405 hibiscus mealybug
Feature 1     #                            
1JND_A    394 FDLSYDDFRGQCsg--dKYPILRAIKYRL 420 fruit fly
Q9W303    415 VDLSFDDFRGGCtg-hdKFPILRQVKSKL 442 fruit fly
AAV68692  416 VDLTLDDFRGTCsq--dHFPLLRAAKFRL 442 Diaprepes root weevil
AAT36640  407 VDLSMDDFRGLCtg--dKYPILRAAKYRL 433 Pieris rapae
AAS80137  421 NDLGLDDFRGTCsg--dKFPILRAAKYRL 447 African malaria mosquito
AAS80138  413 NDLSYDDFRGSCag--eKFPILRAAKYRL 439 African malaria mosquito
XP_396769 412 YDLSLDDFRGVCtg--dKYPIIRAAKYKL 438 honey bee
AAF57703  418 HDLSMDDFRGQCag--eKFPILRSIKFKL 444 fruit fly
AAU95190  405 VDLSLDDARGACdg--tKFPILRSAKMNL 431 Oncometopia nigricans
ABM55664  406 MDLSLDDFKGSCdktgvKFPITTQAKINL 434 hibiscus mealybug

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