Conserved Protein Domain Family
PseudoU_synth_TruB_4
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cd02867: PseudoU_synth_TruB_4 
Pseudouridine synthase homolog 4.
This group consists of Eukaryotic TruB proteins similar to Saccharomyces cerevisiae Pus4. S. cerevisiae Pus4, makes psi55 in the T loop of both cytoplasmic and mitochondrial tRNAs. Psi55 is almost universally conserved. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi).
Links
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Statistics
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PSSM-Id: 211344
Aligned: 10 rows
Threshold Bit Score: 334.405
Created: 1-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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probable active
Feature 1:probable active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           ####      
XP_421776  19 GLFAVYKPKGPTSAAVLNLLKERLLAeagvqtkd-----------------------kkrkrqalKIGHGGTLDSAATGV 75  chicken
NP_631908  70 GVFAVHKPKGPTSAELLNRLKEKLLAeagmpspew----------------------tkrkkqtlKIGHGGTLDSAARGV 127 human
P48567      3 GIFAIEKPSGITSNQFMLKLQHALTKsqvfskeiqrataerkqqy-ekqtgkkaskrklrkvskvKMGHGGTLDPLASGV 81  baker's yeast
AAW42149   14 GLFPIAKPSGKSSMRVIDRITPLLLDsklfddpvkraqpq-----------mkgkrkknltqfglKIGQGGTLDPLADGV 82  Cryptococcus neofo...
CAG81470    6 GVFVVDKPKNIGSTQVVEKLKWTFINaaggkqk-------------------------ggsrnplKIGHGGALDPFATGV 60  Yarrowia lipolytic...
CAC28752    9 GVFAINKPYGMSSAQVIRDCQHHFNPsklfapllaadralreke----gryqkqrrthakreinvKIGHGGTLDPLATGV 84  Neurospora crassa
CAG88073    3 GVFAIEKPSGITSSKFIGDIQALFTQseifkndlneaktkaaqalgtdkkwskerinkrvkslkvKIGHGGTLDPMASGV 82  Debaryomyces hanse...
XP_759204  63 GIFGINKPSGPTSMSLLDDLKPLFATsplfadadgnrvndksrkr-gkfgakgkakwaggvagapKIGQGGTLDPLADGV 141 Ustilago maydis 521
O59721     51 GLIAINKPSGRTSAQCLNELKKIISNselaqyfrpapphpn---------drnrrrrksnrlpdiKIGHGGTLDPLASGV 121 fission yeast
EAA77559    9 GVFAINKPCGQSSAQVIRECQQVFNPseffkpliqsevakrmne----nsgesarrkalkrasqvKIGHGGTLDPLATGV 84  Gibberella zeae PH-1

Feature 1                                                                                     
XP_421776  76 LVVGIGKGTKLLKTILa-GSKKYTAIGLLGRATDTLDATGKVTeekpydqVTKSDLENVLQKFTGDIMQVPPLYSALKRD 154 chicken
NP_631908 128 LVVGIGSGTKMLTSMLs-GSKRYTAIGELGKATDTLDSTGRVTeekpydkITQEDIEGILQKFTGNIMQVPPLYSALKKD 206 human
P48567     82 LVIGIGAGTKKLANYLsgTVKVYESEALFGVSTTSGDVEGEILsqnsvkhLNFDDLKTVEEKFVGQLKQTPPIYAALKMD 161 baker's yeast
AAW42149   83 LVLGVNRGTKHLNQFLe-CSKEYESIGLIGATTTSMDADDPVLstapwehITREDVEKVLDRFRGEIMQVPPIFSALKMD 161 Cryptococcus neofo...
CAG81470   61 LAIGVGAGTKQLGDMThsTDKEYIATVFMGHETTTCDREGHVVksddsshITAEKIEETLAKFRGDIKQFPPVYSSVSVD 140 Yarrowia lipolytic...
CAC28752   85 LILGVGKGTKALHDFLg-CTKTYETVVVFGASTDTYDRVGKLIkkgdystITREQVEEALNSFRGKFQQMPPLYSALKMN 163 Neurospora crassa
CAG88073   83 LVVGVGLGTKKLQYYLseCNKTYETKALLGISTTTGDAEGEIItknqvshITQEMIKETAPKFIGDLKQTPPIFSALKMN 162 Debaryomyces hanse...
XP_759204 142 LVIGVGNGTKHLQKYLd-CTKEYRSTGLLGSATTSYDSCDPILtrkpfdhVTPQMIAHLLPRFTGAVLQIPPLYSAVRMD 220 Ustilago maydis 521
O59721    122 LVVGLGTGTKQLSSLLs-CMKTYRATALFGCSTDTYDSAGKIIkia-vhiPTKEEILSGLDAFRGDISQLPPLYSALHIQ 199 fission yeast
EAA77559   85 LILGIGCATKALPQFLe-CTKTYETTIVFGAATDSYDRVGRILtkrpyehITRELVEKEIASFKGRQIQIPPLFSALKMN 163 Gibberella zeae PH-1

Feature 1                                                                                   # 
XP_421776 155 GERLSTLMKRGEAVEAKPARPVRVYSLSLRQFqp-----------------------------pLFTLDVECGGGFYVRS 205 chicken
NP_631908 207 GQRLSTLMKRGEVVEAKPARPVTVYSISLQKFqp-----------------------------pFFTLDVECGGGFYIRS 257 human
P48567    162 GKPLHEYAREGKPLPRAIEPRQVTIYDLKVFSdslkr----------------------dhdypLLRPTTEEAVDTVKNL 219 baker's yeast
AAW42149  162 GKPLYEYARESKPLPRPIPARKCQVSIELIDFt-------------------------------PASVTPGDGGHDYHWP 210 Cryptococcus neofo...
CAG81470  141 GVRLWDYARNGLKVPYIPSRECHVSKLELVSPvisthgytplgraneeemavaagvakikkeggDMTREEYEKSKQGQPT 220 Yarrowia lipolytic...
CAC28752  164 GKPLYEYAREGKPIPREIETREVDVTELELTEwye--------------------------pgtHNHRWPTEEAEQAEKN 217 Neurospora crassa
CAG88073  163 GKPLYDYAREGIPLPMPIKVRQVKVFDVKVHDedslrtd-------------------hefqtlKSELDEQGNPKEHELS 223 Debaryomyces hanse...
XP_759204 221 GKRLFEYARENLPLPRPIEARRVTIHELRLVDwlepg----------------------khafkEPQREVPPEDKALVGR 278 Ustilago maydis 521
O59721    200 GKRLYEYAREGIPLPESIKARSMHCEELILKDfip---------------------------keEHTYTDPDEFASKEAI 252 fission yeast
EAA77559  164 GKPLYEYAREGKPIPRQIEGREVDVKEIEMVEwye--------------------------pgeHNHRWPTEEAEAAERN 217 Gibberella zeae PH-1

Feature 1                                                                                     
XP_421776 206 LVSDIGKELSTCASIQELTRTKHGPF-----------------------------TLEEHALHEDRWT------------ 244 chicken
NP_631908 258 LVSDIGKELSSCANVLELTRTKQGPFtlee----------------------halPEDKWTIDDIAQSleh--------- 306 human
P48567    220 NANMLNDVLYFSKEYTEKHGLDSEVAk----------------------------VEEPFPLSEQEEQe----------- 260 baker's yeast
AAW42149  211 EKRLTSEEKETFRRLTEIVHNAQTGPve--------------------------tAKTSGNKDQVEEEklrv-------- 256 Cryptococcus neofo...
CAG81470  221 VSKKQLKKNKKRKYDAEEVAAVVRDPvgev----------------------eetHTHSKSLEEREKEyne--------- 269 Yarrowia lipolytic...
CAC28752  218 VVKSVWQVAKNQQDGTTSTEEAATLIpevvekevkalanhesnkraaeervdelvSEEPAGKKRKTETgaaepmmsgalk 297 Neurospora crassa
CAG88073  224 NNPTLNDSPLYFSEQYLSKAETEGLPkevgkprs--------------laddslpEKLPLIHLTADVS------------ 277 Debaryomyces hanse...
XP_759204 279 VLHMAGRKEGQTDTVKEVDATAPQEPees-----------------------astITTSWQKSPTTADanssaten---- 331 Ustilago maydis 521
O59721    253 ESEELLRPIEGGAERHDLLAKTEQDInpqdgdekinaksp-ttnsvtdvakdqtvTNPKKRKFEVTDLargsrpaigp-- 329 fission yeast
EAA77559  218 LAEQVWRVKKQQESNKPLSPEEKQQDdka-----------------------iaaHETFKRNFEERQDa----------- 263 Gibberella zeae PH-1

Feature 1                                                                                     
XP_421776 245 -------------------IDEIARSL----------------------EHCMS------------------LFPGEQSH 265 chicken
NP_631908 307 ----------------cssLFPAELALk--------------------kSKPESn-----------------EQVLSCEY 333 human
P48567    261 -------------------IQKEGDSYr--------------------aPKLHFk-----------------ANVSSGTY 284 baker's yeast
AAW42149  257 ----------------vepLVPDLDAPeypeisp---------nnglrpPTFTVrmtvssgtyvrsivndigLALGCGAH 311 Cryptococcus neofo...
CAG81470  270 -----------------klAQQEVNVFnkfakeq--------aekgsfqPKTPVfq--------------irAAVSSGTY 310 Yarrowia lipolytic...
CAC28752  298 dkkgkdkkqdkyaknrgldLAPPPPSPdtpfpw-----------egkgpPAAKIrmtvtsgfyvrslchdlgEKLGCGAM 366 Neurospora crassa
CAG88073  278 -------------------SGTYIRSLvsdyg------------ralesSAYMVe----------------lIRVRQSEW 310 Debaryomyces hanse...
XP_759204 332 ------------sesqadpAGPPAFVLemtvssgtyvrsivhdlalaagSAAHVqt---------------lTRTRQGEW 384 Ustilago maydis 521
O59721    330 ----------iavldmtvsSGFYVRSLihdlg------------rqvnsEAHMVd----------------lVRLKQGSF 371 fission yeast
EAA77559  264 -------------------LIKDAPSKksrk---------------skePRMMSga---------------lGKLPQPTY 294 Gibberella zeae PH-1

Feature 1                                                                            
XP_421776 266 Kk---------------------------FKTEl---------------------------pGETAVSCED 282 chicken
NP_631908 334 I----------------------------TLNEp----------------------------KREDDVIKT 348 human
P48567    285 Irslvsdigk-----------smrsscymVKLIrlqqqd------------------wslekNNVFQLTDF 326 baker's yeast
AAW42149  312 V----------------------------VKLTrt-------------------------rqGEFSLYGDE 329 Cryptococcus neoformans var...
CAG81470  311 Irq-------------------------lANDIceel----------------------gvsGHLVELRRL 334 Yarrowia lipolytica CLIB99
CAC28752  367 Maelvrsr--------------qgefvlgTDNCm---------------------------eYSDLALGEE 396 Neurospora crassa
CAG88073  311 Qlgk-----------------------nvFKISdfenrderiw---------gpvlkkvldsDHDIDVLKE 349 Debaryomyces hansenii CBS767
XP_759204 385 Sintp---------------------ssdDKPSingncidwsvfadaiaemkreatdaqfksARDAEGLRA 434 Ustilago maydis 521
O59721    372 Al--------------------------dDENCfd--------------------------fSEFSAPGWE 390 fission yeast
EAA77559  295 StkgqnlvpdapdsstpppwsdqgppackVRLTvtsgfyvrsfc--------hdlgakldsaGLMAELSRT 357 Gibberella zeae PH-1

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