Conserved Protein Domain Family
PseudoU_synth_TruA_Archea
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cd02866: PseudoU_synth_TruA_Archea 
Archeal pseudouridine synthases
This group consists of archeal pseudouridine synthases.Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. This group of proteins make Psedouridine in tRNAs.
Links
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Statistics
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PSSM-Id: 211343
Aligned: 8 rows
Threshold Bit Score: 296.21
Created: 9-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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probable active
Feature 1:probable active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                    ####                             
O58941      5 LKIAYDGTKFHGFQRQPNvrTVEGEIIKALNNSGImf----neLKSASRTDKGVSALGNVVAITTEDEri-tNPMILNAK 79  Pyrococcus horikoshii
O26928      6 LKVAYIGTNYHGFQRQPDvpTVEGKLLEALEGAGIiedpkrarFQIAGRTDRGVHALGNFVSFFTEEDi--hVNQINDLL 83  Methanothermobacte...
Q59069      4 LKIAYDGRYSFQQQPHKQ--TVCDILLDALEETGFlak--kkvIYSGGRTDKGVSALGNFVVVELKKEp--iLSYINAKL 77  Methanocaldococcus...
O28544      6 FKIAYFGDNFHGSQFQPDqrTVEGEVINALRRLGVen----prLRSAGRTDAGVHAYGQVISFYSEDKi--fPRMLNAEL 79  Archaeoglobus fulg...
Q8TU65      5 LKLAYIGTEFHGSQIQPNveTVEKELFKALRNLSIiespksadYTCAGRTDAGVHALGQVVAFDTEKPnlaiPRVINSEL 84  Methanosarcina ace...
Q5JI92      5 LRVAYDGSAFYGFQRQPGvrTVEGEIIKVLQKLGIiespekndFKGASRTDRGVSAFFNVVSFVPSERpdlaRPEVLNHH 84  Thermococcus kodak...
Q6M0K2      4 FKIAYDGKLSFQTQPHGE--TVCDKISNALLDCGYldnkdrvpLYHGGRTDRGVAALGNYVVYEMDKKp--vLPRVQSKL 79  Methanococcus mari...
Q8TWZ3      5 LRVAYDGSRYHGFQYQPDvpTIEGALRKALSELGLe------lVGYASRTDAGAHARYQVVVVEGDPEla-qPDPINARL 77  Methanopyrus kandleri

Feature 1                                                                                     
O58941     80 LKDVWVLSAVKVPSDFHPRFWARSKVYRYYLPsfdLDVEKVKECSKLFLGVHDFSAFSRVDgr---eTVRSIDRIEVLDl 156 Pyrococcus horikoshii
O26928     84 PRDIRVLAWASVMYPFKVRYPLERHYRYILHReesMDTYSMAEAAAHFRGTHDFSNFSRRSdr---dPVRRINDVRISEv 160 Methanothermobacte...
Q59069     78 KDKGIWVLGYREIDEIPKVKYRHYRYILPNIG---YDVDAIKEGAKKMIGTHSFHNLSKRDrtkeksPIRTIYDIKISEn 154 Methanocaldococcus...
O28544     80 PEDITAWAWAKVSEDFDPRRAKSRVYTYVMYGs-dYDISAMRKAVKELIGVHDFSNFTKKFgeg-esCVREIISADIRAd 157 Archaeoglobus fulg...
Q8TU65     85 PPAIWAWAHAEVPYYFDARRSAVSRHYHYVMSgedYDISKMREASKLLLGTHDFENFSRSNge--ksTVRTLERINVRVd 162 Methanosarcina ace...
Q5JI92     85 LSDVWVLGIAEVPDDFHPRFWAKFKTYRYYLVnegFDLSAMRECASLFVGRHDFSAFAKLEpg--rdPIREVERVEVIEr 162 Thermococcus kodak...
Q6M0K2     80 KWDGIWVLGCKKIEIFPEIEHRHYQYTLPNKN---HDVELMKKASEKLIGTHYFQNLSKRDktkvkdPVRTLYDIKISSn 156 Methanococcus mari...
Q8TWZ3     78 PKDIRVIAKTEVHEEFDPRRDALRKEYRYFLGp-lNRPEAAARAARKLEGKHDFSAFRREDgr---nPIITVERCELVEi 153 Methanopyrus kandleri

Feature 1                        #                                                  
O58941    157 g-pVLAIEVEAKSFLWEMVRRIVKTLELCGLGKLSSEEVRKMLRGKFE--KSRKvpPAPAEGLLLVEVKY 223 Pyrococcus horikoshii
O26928    161 g-dSIIIDVYGESFLWQMVRKMVRALLMVSEGELAPDDMAGLLDTDRR--VFLE--PMPPENLILMDLKY 225 Methanothermobacter thermaut...
Q59069    155 e-fYLTVDIIGESFLWNMVRKIVGALDLVGRGKKPVEWIDKLLDENHR--EGVP--TFPPEGLILVEAKV 219 Methanocaldococcus jannaschii
O28544    158 r-eFIIFEIEGNAFTWNMVRCIVTAIMEIGKQHRSIEWFRDLLNPEKHk-ERVE--PAPPYGLILKDVKY 223 Archaeoglobus fulgidus
Q8TU65    163 g-eITKIDVVGNSFLWNMVRKIVTALSMIGNGVRDNDWLLQMLNPEIYe-EGIE--PAPPYGLTLMGVNY 228 Methanosarcina acetivorans
Q5JI92    163 q-gYLVIEVQGKSFLWEMVRRIVNALRFCGLGLLEAEEVERMLSGEYG--KKIP--PAPPEGLVLWHIEY 227 Thermococcus kodakarensis KOD1
Q6M0K2    157 d-yFITIDIFGESFLWNMVRRIIRLLSDIGKHKIENPEKFIELILSEDykKGYP--PSPAEGLILVDVKT 223 Methanococcus maripaludis
Q8TWZ3    154 tpnAYVLRVVAPRFLWEMVRRIAGFVWEVGHGLREEGDAEALLSGKFEp-SKKPr-CLPAEGLILWHIEY 221 Methanopyrus kandleri

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