1PYB,1PYB


Conserved Protein Domain Family
tRNA_bind_EcMetRS_like
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cd02800: tRNA_bind_EcMetRS_like 
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tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine transfer RNAs (tRNAmet). AaTrbp111 is structure-specific molecular chaperone recognizing the L-shape of the tRNA fold. AaTrbp111 plays a role in nuclear trafficking of tRNAs. The functional unit of EcMetRs and AaTrbp111 is a homodimer, this domain acts as the dimerization domain.
Links
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Statistics
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PSSM-Id: 239199
Aligned: 48 rows
Threshold Bit Score: 125.692
Created: 22-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative tRNA-binding site [nucleic acid binding site]
Evidence:
  • Comment:These residues were identified by mutational analysis as important for interaction with tRNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #            #                          #   #      #  
1PYB_A        7 IGIEDFLKVDLRVAKVLSAERVEGSEKLLKLTLSLGd-EERTVVAGIAKYYt-PEELVGKKIVIVANLKPRKIFGIESQG 84  Aquifex aeolicus
P37465      560 ITIDQFMDVELRVAEVIEAEPVKKADRLLKLQLDLGf-EKRQVVSGIAKHYt-PEELVGKKLVCVTNLKPVKLRGELSQG 637 Bacillus subtilis
CAB83583    578 ASFDDFMKIDMRVAKVLNCEAVEGSTKLLKFDLDFGf-EKRIIFSGIAASYpnPAELNGRMVIAVANFAPRKMAKFGVSE 656 Neisseria mening...
P59077      598 ITFDDFQKIDLRVAKVVACEPVKKANKLLKLQLQVGs-EQRQVLSGIAQYFt-PEQMVGKNVVLVANLADRTMRGELSQG 675 Chlorobaculum te...
Q8XHG1      540 ITIDDFDKIDLRVVKVLECEPVKKAKKLLKLKVDLGg-EERQVISGIAQYYk-PEELVGKYVVLVANLKPVKLRGELSQG 617 Clostridium perf...
Q9RUF3      576 ISIDDFAKIDLRIAEVVACEAVEKADKLLKLTVKLGd-ETRTVVSGIRKWYe-PEALVGRKVVLVANLKPAKLRGIESQG 653 Deinococcus radi...
AAQ65408    575 IAFEDFLKLDIRVGTVLECEKVPKADKLLRFRIDDGl-SGRTIVSGIAKHYa-PEELVGKQVCFIANLPPRKLKGIESEG 652 Porphyromonas gi...
ZP_00145502 594 IGIEDFAKVEMKVAHVIACSYVEGADKLLQFTLDVGeaQPRNVFSGIRKFYe-PEQLLDKKVICVTNLAPRKMKFGISEG 672 Psychrobacter sp...
YP_077078   545 IEYDDFAKVELKVAEVVEAERIPKADRLLRLVLQVGe-ERRQIVSGIAQHYa-PEELVGKRIILVANLKPKKLRGVESHG 622 Symbiobacterium ...
ZP_00399700 588 IQYDDFAKVELRVGLVKAAEKVEKADKLLKLSVDVGepEPRTIVAGIAQAYpePQALVGRRIVVVANLAPRPLRGITSHG 667 Anaeromyxobacter...

Feature 1       #                             
1PYB_A       85 MILAASDg--eNLSVIVPDr-dVKEGAKLS 111 Aquifex aeolicus
P37465      638 MILAGEAd--gVLKVVSIDq-sLPKGTRIK 664 Bacillus subtilis
CAB83583    657 GMILSAAtadgKLKLLDVDa-gAQPGDKVG 685 Neisseria meningitidis Z2491
P59077      676 MILTVEGad-gRLFLLEPQg-eGINGNSVS 703 Chlorobaculum tepidum
Q8XHG1      618 MILAAAPsddsELLLVNPGe--MLTGSQVR 645 Clostridium perfringens
Q9RUF3      654 MILAAEDda-gNLDLVGTEl-dLPSGTKVR 681 Deinococcus radiodurans
AAQ65408    653 MILSAEDad-gSLRVIMPAa-eVAAGSQVK 680 Porphyromonas gingivalis W83
ZP_00145502 673 MILSSGDpk-tQLTVVTLPd-nCVIGDLLA 700 Psychrobacter sp. 273-4
YP_077078   623 MLLAATAed-gSLSLVTLDkpdFPTGMRVK 651 Symbiobacterium thermophilum IAM 14863
ZP_00399700 668 MLLAAGEp--pNLQVVTVGe-gIAPGTRVK 694 Anaeromyxobacter dehalogenans 2CP-C

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