1EIY,1B70


Conserved Protein Domain Family
tRNA_bind_bactPheRS
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cd02796: tRNA_bind_bactPheRS 
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tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.
Links
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Statistics
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PSSM-Id: 239196
Aligned: 102 rows
Threshold Bit Score: 86.7934
Created: 17-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative tRNA-binding site [nucleic acid binding site]
Evidence:
  • Comment:These residues were identified by mutational analysis as important for interaction with tRNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #            #                    #             #      #  #     
1EIY_B       45 VVFARVLEAHPIPGT-RLKRLVLDAGr--TVEVVSGAENaRKGIGVALALPGTELPGLgqkVGERVIQGVRSFGMALSPR 121 Thermus thermoph...
Q9WZS9       45 IITARVIERFDHPASeKLIVCKVDTGk-rIYTVITADKTvNEGDYVILALEGATLNNGl-kIEPREFKGVISEGMLCSLE 122 Thermotoga maritima
O67620       45 VVFGKVVEVKEHPTKkKLAVVKVQVQehiFIDVVTVDKSvREGDGVIVALPNAKVGNMc--VTEREFDGVVSKGLLLSAQ 122 Aquifex aeolicus
YP_115619    45 IKFGQILEIRKNPEAdNLWICKVQFAd-kIREIQTAAKNvIENKQVLAFIPGSKSGNTt--FLAKKLRGHISEGMLISAV 121 Mycoplasma hyopn...
CAC13520     46 IKFGLIKKVYKNPNAsNLNVCEIEFEd-kMRIIQTTAQNvEQNKYIVAFVENSTFGKIk--IEAKEIKGTFSQGMLCSLE 122 Mycoplasma pulmonis
YP_016213    45 IKYGKVLKIYKNENSdNLTVCEIQFKd-kIRIIQTTAKNvEINKYVMAFIPGSKLANNl--IESKLLKGIISEGMLVGFD 121 Mycoplasma mobil...
ZP_00884841  45 VVVGKILDVFLHPENpNLFVCKVDVRe-cVLTIITAAKNiYKGAFVPVAKPGASLANGk-vIDKLEFKGVVSEGMLCSLD 122 Caldicellulosiru...
YP_278739    95 FTFAKVLEVEKHPKSdSLFVLKLDAKrdkEVQIVTNSTLvKKDMIILIANPGSVTAKGd-vILKSSVMGIESQGMIMSYK 173 Mycoplasma synov...
YP_278430    37 LLFAKVLNVFDNPNStKLQVVELDTKl-gELTIQTTNKVlSKGDLTICYPVGSSYQGKe--FQEVTMQGYKSQGMLASFS 113 Mycoplasma synov...
YP_277867    45 VVIGEIVECKMHPNLhNVWITKVNNGdnkLLNIVCNAPNcRKNIRVAVAQIGAMLPDGr-kIKLKTIQGKQSEGILCTFS 123 Candidatus Bloch...

Feature 1                                        
1EIY_B      122 ELGVge-------ygGGLLEFPEda-lpPGTPL 146 Thermus thermophilus
Q9WZS9      123 ELGLee-------ksDRVYRFPDpv--eLGVNV 146 Thermotoga maritima
O67620      123 ELGLee-------ksEGVLKIHEdf--kPGTDA 146 Aquifex aeolicus
YP_115619   122 ELGFnkhll-nseldQGVLVFDPif-dlESNPL 152 Mycoplasma hyopneumoniae 232
CAC13520    123 ELGFdksli-rdefqDKIFLLDKad--lKQDPI 152 Mycoplasma pulmonis
YP_016213   122 EMLGfeiklvpkelsKNVIVLDEan--lNEDPI 152 Mycoplasma mobile 163K
ZP_00884841 123 ELGLtsaef-pyadeDGIFIIEGiddnkLGVDI 154 Caldicellulosiruptor saccharolyticus DSM 8903
YP_278739   174 NAAVd---------kDGVFTTKDek--lIGTEY 195 Mycoplasma synoviae 53
YP_278430   114 EIGYdnsl---ltdkDQILVLPKnf-asLNDDA 142 Mycoplasma synoviae 53
YP_277867   124 ALGIts-------htVGIIELPIna--pIGENF 147 Candidatus Blochmannia pennsylvanicus str. BPEN

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