1EU1,4DMR,1TMO


Conserved Protein Domain Family
MopB_DMSOR-BSOR-TMAOR
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cd02769: MopB_DMSOR-BSOR-TMAOR 
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The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its cellular location and oligomerization state are organism-dependent. For example, in Rhodobacter sphaeriodes and Rhodobacter capsulatus, it is an 82-kDa monomeric soluble protein found in the periplasmic space; in E. coli, it is membrane-bound and exists as a heterotrimer. BSOR catalyzes the reduction of biotin sulfixode to biotin, and is unique among Mo enzymes because no additional auxiliary proteins or cofactors are required. TMAOR is similar to DMSOR, but its only natural substrate is TMAO. Members of this CD belong to the molybdopterin_binding (MopB) superfamily of proteins.
Links
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Statistics
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PSSM-Id: 239170
Aligned: 23 rows
Threshold Bit Score: 930.135
Created: 27-May-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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molybdopterinsubstrate
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:molybdopterin cofactor binding site [chemical binding site]
Evidence:
  • Structure:1EU1; Rhodobacter sphaeroides dimethylsulfoxide reductase (DMSOR) binds Mo and two MGD units
  • Comment:defined by 3.5 Angstrom contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1EU1_A        9 MSGCHWGVFKARvenGRAVAFEPWdkd-paPSHQLPGVLDSIys-ptRIKYPMVRREFLEkgvna-drstRGNGDFVRVT 85  Rhodobacter spha...
4DMR         51 MSGSHWGVFTATvenGRATAFTPWekd-phPSPMLAGVLDSIys-ptRIKYPMVRREFLEkgvna-drstRGNGDFVRVS 127 Rhodobacter caps...
1TMO         42 TTGSHFGAFKMKrknGVIAEVKPFdld-kyPTDMINGIRGMVyn-psRVRYPMVRLDFLLkghks-nthqRGDFRFVRVT 118 Shewanella massilia
P44798       49 VTAAHWGSIGVVvqdGKVVKSGPAiep-avPNELQTVVADQLys-erRVKCPMVRKGFLAnpgks-dttmRGRDEWVRVS 125 Haemophilus infl...
CAB72732     45 ITAAHWGILKLTikdGKIVKSEPWekvtkmDNPLQHYTADMVyk--sRVKYPYVRKSYLEnpdnp-kpelRGKDEFVRVS 121 Campylobacter je...
P33225       54 LTGSHWGAIRATvkdGRFVAAKPFeld-kyPSKMIAGLPDHVhn-aaRIRYPMVRVDWLRkrhls-dtsqRGDNRFVRVS 130 Escherichia coli
CAG21952     29 PHASHWGPFNAIvkdGILIGVQPRkeldamPTEMLTEGLLSRvydktRVKYPMVRQSYLAdpkgdnkphlRGKEPFVRVS 108 Photobacterium p...
ZP_00276637  50 LTGSHWGAFYMRvddGRVTGVRPWekd-pkPSHQLPGVLDSMys-ptRIRHPMVRRAWLErgpga-dpegRGKGDFVRVS 126 Ralstonia metall...
P20099       11 LTAAHWGPMLVEtdgETVFSSRGAlat-gmENSLQSAVRDQVhs-ntRVRFPMVRKGFLAspen--pqgiRGQDEFVRVS 86  Escherichia coli
NP_404419     7 PQLAHWGAYTAVvedGKLIRCEPFadd-pdPSPLLNSIVPMVys-dkRIRKPAIRRSWLKrreks-drtlRGQEDFVEVD 83  Yersinia pestis ...

Feature 1                                   # ####                            #                 
1EU1_A       86 WDEALDLVARELKRvqesygptgTFGGSY-GWKSPGRLHNCQvlMRRALNLaGGFVNSsGDYSTAAAQIIMPHVMGtlev 164 Rhodobacter spha...
4DMR        128 WDQALDLVAAEVKRveetygpsgVFGGSY-GWKSPGRLHNCTtlLRRMLTLaGGYVNGaGDYSTGAAQVIMPHVVGtlev 206 Rhodobacter caps...
1TMO        119 WDKALTLFKHSLDEvqtqygpsgLHAGQT-GWRATGQLHSSTshMQRAVGMhGNYVKKiGDYSTGAGQTILPYVLGstev 197 Shewanella massilia
P44798      126 WDEALDLVHNQLKRvrdehgstgIFAGSY-GWFSCGSLHASRtlLQRYMNAtGGFVGHkGDYSTGAAQVIMPHVLGtiev 204 Haemophilus infl...
CAB72732    122 YDEAIKLIAKELKKtrdskgasaIFGGSY-GWKSSGNMQNSRilLHRFLNVtGGFVGAtGDYSTGASQVIMPYVVGsiev 200 Campylobacter je...
P33225      131 WDEALDMFYEELERvqkt-hgpsALLTAS-GWQSTGMFHNASgmLAKAIALhGNSVGTgGDYSTGAAQVILPRVVGsmev 208 Escherichia coli
CAG21952    109 WETALSLVADSIQTtakefgneaIFSSSYgGWSHAGLMRPQVl-QGRFFNLiGGQSTTtGDYSGGASQVILPHVIGdmev 187 Photobacterium p...
ZP_00276637 127 WEKALDLVAAELMRvrkkhgptsIFGGSY-GWKSPGKLHNCQtlLARALTVnGGFVSRsGDYSTGAAQVILPYVVGsidv 205 Ralstonia metall...
P20099       87 WDEALDLIHQQHKRireaygpasIFAGSY-GWRSNGVLHKAStlLQRYMALaGGYTGHlGDYSTGAAQAIMPYVVGgsev 165 Escherichia coli
NP_404419    84 WDVALDLVAEENRRvrdqygpagLFTGSY-GWSSAGRLHHARslVRRFYFSgGGGVDQlGNYSWGAAQFFLPYVIGtfsp 162 Yersinia pestis ...

Feature 1                            #    ##                                 ###                
1EU1_A      165 y-eqqtAWPVVVenTDLMVFWAaDPMKTneigwvi-pdhgayaGMKALke----kgTRVIXINPVRTETAdy---fgADV 235 Rhodobacter spha...
4DMR        207 y-eqqtAWPVLAenTEVMVFWAaDPIKTsqigwvi-pehgaypGLEALka----kgTKVIVIDPVRTKTVef---fgAEH 277 Rhodobacter caps...
1TMO        198 y-aqgtSWPLILehSDTIVLWSnDPYKNlqvgwna-ethesfaYLAQLkekvkqgkIRVISIDPVVTKTQay---lgCEQ 272 Shewanella massilia
P44798      205 y-eqqtSWESILesSDIIVLWSaNPLTTmriawms-tdqkgieYFKKFqa----sgKRIICIDPQKSETCqm---lnAEW 275 Haemophilus infl...
CAB72732    201 y-eqqtSWENILsdSKYVVIWGaDPLSTlriawts-neqrglaYFEKLkd----skIKVICIDPVKTTTAkf---lnAKW 271 Campylobacter je...
P33225      209 y-eqqtSWPLVLqnSKTIVLWGsDLLKNqqanwwc-pdhdvyeYYAQLkakvaageIEVISIDPVVTSTHeylgrehVKH 286 Escherichia coli
CAG21952    188 y-spqtAWPVIEkhTEVFVLIGcDPWKNnriefrv-adhqmypRWKQFae----kgIKFISINPQRTRTDde---ldADW 258 Photobacterium p...
ZP_00276637 206 y-eqptAWPVLAehTELMVFWAaDPMVTnqigwqv-pdhgaypGMEALks----kgVKVICIDPVRTDTRry---fdAEW 276 Ralstonia metall...
P20099      166 y-qqqtSWPLVLehSDVVVLWSaNPLNTlkiawna-sdeqglsYFSALrd----sgKKLICIDPMRSETVdff-gdkMEW 238 Escherichia coli
NP_404419   163 ltgrvtSWPSVVehCELFIAFGgLALKNaqvssggsaehslklWLEKLaq----kgTPVINISPMRDDCPaf---vnAEW 235 Yersinia pestis ...

Feature 1           ## #                                                                        
1EU1_A      236 VSprPQTDVALMLGMAhtLYSEDLHDKDFLENCTTGFDLFAAYLTGESDGTPKTAEWAAEICGLPAEQIRELARSFvagR 315 Rhodobacter spha...
4DMR        278 ITpkPQTDVAIMLGMAhtLVAEDLYDKDFIANYTSGFDKFLPYLDGETDSTPKTAEWAEGISGVPAETIKELARLFeskR 357 Rhodobacter caps...
1TMO        273 LYvnPQTDVTLMLAIAheMISKKLYDDKFIQGYSLGFEEFVPYVMGTKDGVAKTPEWAAPICGVEAHVIRDLAKTLvkgR 352 Shewanella massilia
P44798      276 IPvnTATDVPLMLGIAhtLVEQGKHDKDFLKKYTSGYAKFEEYLLGKTDGQPKTAEWAAKICGVPAETIKQLAADFaskR 355 Haemophilus infl...
CAB72732    272 IAprPNTDVALMMGMAshLIAKKKVNYEFLDTYTTGFDKFKDYLEGKEDGVKKDTKWASKICGIDEKTIKNLAETFydnS 351 Campylobacter je...
P33225      287 IAvnPQTDVPLQLALAhtLYSENLYDKNFLANYCVGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLARQMaanR 366 Escherichia coli
CAG21952    259 VKivPNTDTALFLAMAqyAYEKELYDPTYLARYTVGADKYIDHLMGKNDGVVKSPQWAEKITGISAEKIREMAELFankK 338 Photobacterium p...
ZP_00276637 277 LAprPHTDVAMMLGIAhtLYTEKLHDAKFLARYTTGFDRFVPYLTGESDGVAKNAEWAAGICEIPADTIRDLARRFaskR 356 Ralstonia metall...
P20099      239 VAphMGTDVALMLGIAhtLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVGAAKIRELAAIFhqnT 318 Escherichia coli
NP_404419   236 IPirPNTDVALMLALAyeIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIPAARIAQLAQQLigvR 315 Yersinia pestis ...

Feature 1             ##  #                                                                     
1EU1_A      316 TMLAAGWSIQRMhHGEQAHWMLVTLASMIGqIGLPGGGFGLsyhysnggsptsdgpalggi----------------sdg 379 Rhodobacter spha...
4DMR        358 TMLAAGWSMQRMhHGEQAHWMLVTLASMLGqIGLPGGGFGLsyhysgggtpstsgpalagi----------------tdg 421 Rhodobacter caps...
1TMO        353 TQFMMGWCIQRQqHGEQPYWMAAVLATMIGqIGLPGGGISYghhyssigvpssgaaapgafp-------------rnlde 419 Shewanella massilia
P44798      356 TMLMGGWGMQRQrHGEQTHWMLVTLASMLGqIGLPGGGFGLsyhysnggvptatggiigsi---------------tasp 420 Haemophilus infl...
CAB72732    352 TMIMSGWGMQRAhHGEQPHWMLVTLCAMLGqIGTKGGGFGLsyhysnggvptckggviggmtagslgiwkngkfkglska 431 Campylobacter je...
P33225      367 TQIIAGWCVQRMqHGEQWAWMIVVLAAMLGqIGLPGGGFGFgwhyngagtpgrkgvilsgf---------------sgst 431 Escherichia coli
CAG21952    339 AQFAAGWSLQRAdHGEMVHWAIINFAAMLGkIGKPGEGVGFswhygnggmpqsgka------------------------ 394 Photobacterium p...
ZP_00276637 357 TMLAAGWSIQRQhHGEQSHWMLVTLASMLGqIGLPGGGYGFtyhyanggsptatgpvlpgi----------------vgg 420 Ralstonia metall...
P20099      319 TMLMAGWGMQRQqFGEQKHWMIVTLAAMLGqIGTPGGGFGLsyhfanggnptrrsav----------------------- 375 Escherichia coli
NP_404419   316 SFMTCSYSVQRAhRGEQPYWMVIALSAMLGqVGLPGGGFSFghgsmngvgnpridt------------------------ 371 Yersinia pestis ...

Feature 1                                                           # #   # #                  #
1EU1_A      380 gkavegaawlsesgatSIPCARVVDMLLNPGGEFQFNGATATYPDVKLAYWaGGNPFaHHQDRNRMLKAWEKl-ETFIVQ 458 Rhodobacter spha...
4DMR        422 gaatkgpewlaasgasVIPVARVVDMLENPGAEFDFNGTRSKFPDVKMAYWvGGNPFvHHQDRNRMVKAWEKl-ETFVVH 500 Rhodobacter caps...
1TMO        420 nqkplfdssdfkgassTIPVARWIDAILEPGKTIDANGSKVVYPDIKMMIFsGNNPWnHHQDRNRMKQAFHKl-ECVVTV 498 Shewanella massilia
P44798      421 sgkagaktwlddtsksAFPLARIADVLLHPGKKIQYNGTEITYPDIKAVYWaGGNPFvHHQDTNTLVKAFQKp-DVVIVN 499 Haemophilus infl...
CAB72732    432 eassegaewlqnaasySFPVARIADALLHPGKTIDHNGAKITYPDIDFIYWvGGNPLvHHQNTNTNVKAWRKp-RTVVVN 510 Campylobacter je...
P33225      432 sippvhdnsdykgyssTIPIARFIDAILEPGKVINWNGKSVKLPPLKMCIFaGTNPFhRHQQINRIIEGLRKl-ETVIAI 510 Escherichia coli
CAG21952    395 --lpvglsqgknpvdkVCPASRISEMLNNPGKRFTRDGIEYTYPDIKVIYNaGNNLLsHQQNTNELIAALNQkvDTFICQ 472 Photobacterium p...
ZP_00276637 421 akpppgsewleaggteTIPVSRIVEMLENPGKPYDFNGKRSKYPDIRLAYWvGGNPFmHHQDRNRMIKAWRKl-DTFIVQ 499 Ralstonia metall...
P20099      376 lssmqgslpggcdavdKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWaGGANFtHHQDTNRLIRAWQKp-ELVVIS 454 Escherichia coli
NP_404419   372 --pgpampvgknpaglAIPVARICDMLLQPGQPYQFQGETHTYPDIHLVHWaGGNPFhHHQQLNRLVEGWQKp-DTVIVQ 448 Yersinia pestis ...

Feature 1       #   #                 #                             #                           
1EU1_A      459 DFQWTATARHADIVLPATTSYERNDIEsvgdysnraILAMKKVVDPlYEARsDYDIFAALAERLGKGAEFTEGrdeMGWI 538 Rhodobacter spha...
4DMR        501 DFQWTPTARHADIVLPATTSYERNDIEtigdysntgILAMKKIVEPlYEARsDYDIFAAVAERLGKGAEFTEGkdeMGWI 580 Rhodobacter caps...
1TMO        499 DVNWTATCRFSDIVLPACTTYERNDIDvygayanrgILAMQKMVEPlFDSLsDFEIFTRFAAVLGKEKEYTRNmgeMEWL 578 Shewanella massilia
P44798      500 EVNWTPTARMADIVLPATTSYERNDLTmagdysmmsVYPMKQVVPPqFEAKnDYDIFVELAKRAGVEEQYTEGkteMEWL 579 Haemophilus infl...
CAB72732    511 EIYWTPTAKMADIVMPVTSSYERDDITmtgdysnmhIAPMKQAVEPvGESKdDYVIFSDICKIYGKDVFNAYTe-nGKKA 589 Campylobacter je...
P33225      511 DNQWTSTCRFADIVLPATTQFERNDLDqygnhsnrgIIAMKQVVPPqFEARnDFDIFRELCRRFNREEAFTEGldeMGWL 590 Escherichia coli
CAG21952    473 DPWWCASSRYADIVLPATSSLERDDLSsggtysndkIYAMRQVIQPyGESLdDFEIFRQLSKIFGVEEQFTDGlafNDIL 552 Photobacterium p...
ZP_00276637 500 DFQWTATARHADIVLPCTTTYERNDIEgigdysmshILAMRKVVDPlFEARdDYDIFAAICERMGTGKAFTEGrddMAWI 579 Ralstonia metall...
P20099      455 ECFWTAAAKHADIVLPATTSFERNDLTmtgdysnqhLVPMKQVVPPrYEARnDFDVFAELSERWEKGGYARFTegkSELQ 534 Escherichia coli
NP_404419   449 DIWWTPVAKMADIVLPVTSSLERNDIGgssr--dryVLAMHQAIAPqHQARhDFDIFADLADRLGYRETFTEGrdeMAWI 526 Yersinia pestis ...

Feature 1                                                                                       
1EU1_A      539 SSFYEAAvkqaef--------knvamPSFEDFWSEGIVEFPIteg--anfVRYADFRedplfnPLGTPSGLIEIYSKNIE 608 Rhodobacter spha...
4DMR        581 KSFYDDAakqgka--------agvqmPAFDAFWAEGIVEFPVtdg--adfVRYASFRedpllnPLGTPTGLIEIYSKNIE 650 Rhodobacter caps...
1TMO        579 ETLYNECkaana---------gkfemPDFATFWKQGYVHFGDge----vwTRHADFRndpeinPLGTPSGLIEIFSRKID 645 Shewanella massilia
P44798      580 EEFYNAAfsaara--------nrvamPRFDKFWAENKPLSFEageaakkwVRYGEFRedpllnPLGTPSGKIEIFSDVVE 651 Haemophilus infl...
CAB72732    590 KDFIKEYynsalkqtqsfgeafatpmPSFEEFWAKNEPITFEptaeslewTRFSEFIedpilnALGTDSGLIEIYSETIK 669 Campylobacter je...
P33225      591 KRIWQEGvqqgkg--------rgvhlPAFDDFWNNKEYVEFDhpq---mfVRHQAFRedpdlePLGTPSGLIEIYSKTIA 659 Escherichia coli
CAG21952    553 KRAYKASsa----------------tLPFEDFWQQGVAHLPIaesa-ndwVRHGDFYqdpeqfPLHTTSGKIELFCQDIA 615 Photobacterium p...
ZP_00276637 580 RTFYEAArvqarg--------krmemPVFDVFWNSNKPLAFPigeeakgyIRHKEFRddpllnALGTPSGRIEIYSSNIA 651 Ralstonia metall...
P20099      535 WLETFYNvarqrga------sqqvelPPFAEFWQANQLIEMPenpdserfIRFADFCrdplahPLKTASGKIEIFSQRIA 608 Escherichia coli
NP_404419   527 RHIYQECgaaqrs--------hdvewPDFETFWQQGYVGLPApsk---afVFFDSFRedpqanPLQTPSGKIELFSEKIA 595 Yersinia pestis ...

Feature 1                           
1EU1_A      609 KMgYDDCPAHPTWMEPAERL 628 Rhodobacter sphaeroides
4DMR        651 KMgYDDCPAHPTWMEPLERL 670 Rhodobacter capsulatus
1TMO        646 QFgYDDCKGHPTWMEKTERS 665 Shewanella massilia
P44798      652 KMnYNDCKGHPSWMEPEEFA 671 Haemophilus influenzae
CAB72732    670 NYnYDDCKAHPTWFEPIEWL 689 Campylobacter jejuni subsp. jejuni NCTC 11168
P33225      660 DMnYDDCQGHPMWFEKIERS 679 Escherichia coli
CAG21952    616 DFeVKDCPPMPTFIEPFEYL 635 Photobacterium profundum SS9
ZP_00276637 652 RMkYDDCPPHPTWMEPLERL 671 Ralstonia metallidurans CH34
P20099      609 DYgYPDCPGHPMWLEPDEWQ 628 Escherichia coli
NP_404419   596 SYqYNDFAPHAEWKPPVEWL 615 Yersinia pestis CO92

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