1G8K


Conserved Protein Domain Family
MopB_Arsenite-Ox
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cd02756: MopB_Arsenite-Ox 
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Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin. Arsenite oxidase is a heterodimeric enzyme containing a large and a small subunit. The large catalytic subunit harbors the molybdopterin cofactor and the [3Fe-4S] cluster; and the small subunit belongs to the structural class of the Rieske proteins. The small subunit is not included in this alignment. Members of MopB_Arsenite-Ox CD belong to the molybdopterin_binding (MopB) superfamily of proteins.
Links
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Statistics
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PSSM-Id: 239157
Aligned: 6 rows
Threshold Bit Score: 898.383
Created: 18-Apr-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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molybdopterin[3Fe-4S]
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:molybdopterin cofactor binding site [chemical binding site]
Evidence:
  • Structure:1G8K; Alcaligenes faecalis arsenite oxidase binds Mo and two MGD units
  • Comment:defined by 3.5 Angstrom contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1G8K_A         5 DRITLPPanaqrtNMTCHFCIVGCGYHVYKWPELEEGGRAPEQNALGLDFrkqlpplavtltp----------------- 67   Alcaligenes fa...
AAR05656       8 DRLPIIPadakkhNVTCHFCIVGCGYHAYTWPINKQGGTDPQNNIFGVDLseqqqaesdawys----------------- 70   arsenite-oxidi...
ZP_00356732    8 DRMVLPPvdaekyQTVCHYCIVGCGYHVYKWPEGRSGGLLPDQNALGVDFtkqvaplsgdwia----------------- 70   Chloroflexus a...
YP_145366      8 DRLPIPPknakvyNQVCQYCTVGCGYKVYVWPVGEEGGVKPEQNAFGLDLstpqpplagqsyt----------------- 70   Thermus thermo...
NP_148692      8 GRVPLPPkgaqhyTTMCQFCNVGCGYDVYVWPAGAEGSPEPGGHGIEYKIvdeaygrnlvkqpdftkehtglsaeegepw 87   Aeropyrum pern...
NP_378391     16 NKVPLPPvtaerySVTCRFCNVGCGYDVFVFPVGQEGGPSAGQNAIVYNMvdkvfnrnlqnyqadytsvlpalsan---s 92   Sulfolobus tok...

Feature 1                                                     #                                  
1G8K_A        68 ------------amtnvvtehdgaRYDIMVVPDkACVVNSGLSSTRGGKMASYMYTptg-------dgKERLSAPRLYaa 128  Alcaligenes fa...
AAR05656      71 ------------psmynvvkqdgrDVHVVIKPDhECVVNSGLGSVRGARMAETSFSear------ntqQQRLTDPLVWry 132  arsenite-oxidi...
ZP_00356732   71 -----------pdhhtviterdgrRFHIAIVPDkECVVNKGHHSGRGGTLGSSLYRpdg-------ptHVRLTHPLVYra 132  Chloroflexus a...
YP_145366     71 -----------etmhavtvgrdgrQYNVVIVPAkDSPINRGNYSIRGGTNALTVWSldr-------gtQDRLTYPLLRvg 132  Thermus thermo...
NP_148692     88 iseamvvktirrtwergrgtggwrEVYVAQVPSpECPINWGNHSVRGGTQAERIWSpwn------iagERRLTKPLVRfg 161  Aeropyrum pern...
NP_378391     93 gtpwigegmvsktikynpntqtweEVYILEVPSaECPVNEGNYSTRGGRNAQRIWSpfndvasgfrvyETRIKTPLIRwn 172  Sulfolobus tok...

Feature 1                                                          #                         ##  
1G8K_A       129 dEWVDTTWDHAMALYAGLIKKTLDKDGp---------qGVFFSCFDHGGAGGGFe-nTWGTGKLMFsaiqtpmVRIHNRP 198  Alcaligenes fa...
AAR05656     133 gQMQPTSWDDALDLVARVTAKIVKEKGe---------dALIVSAFDHGGAGGGYe-nTWGTGKLYFeamkvknIRIHNRP 202  arsenite-oxidi...
ZP_00356732  133 tEQSPTTWDDAIDLAARVIYGSILRDGn---------nSIFMKIFDHGGGGGGFe-nNWAVGKFFFnavqtinCSIHNRP 202  Chloroflexus a...
YP_145366    133 dQFQAITWQDALTLMGLLIKGIRDRDGnd--------dNIAVKCFDHGGSGQGFe-dNYAAGKLFFaalsvkhIAIHNRP 203  Thermus thermo...
NP_148692    162 gRLEPVSWEYAIDLVARVVKGVIDKWGierpgwgkeghAVFAHRMDHGGGGGGGmifNTVVGLFFFygvrtafARIHNRP 241  Aeropyrum pern...
NP_378391    173 gTLQAVGWSYVIEAIAQILYYYLTNETtdypv-gpaatEVMAIRSDHGGGEGGGvfsNLMPGLFLHmglatpfVRFHYQV 251  Sulfolobus tok...

Feature 1                                           ###  ###                                     
1G8K_A       199 AYNSECHATREMGIg--eLNNAYEDAqLADVIWSIGNNPYESQTNYFLNHWLPNLQGattSKKKERFPnen-fpqARIIF 275  Alcaligenes fa...
AAR05656     203 AYNSEVHGTRDMGVg--eLNNCYEDAeLADTIVAVGTNALETQTNYFLNHWIPNLRGeslGKKKELMPeep-heaGRIII 279  arsenite-oxidi...
ZP_00356732  203 AYNSEVHASRDMGVp--eLNFAYVDAeLSDTIVLWGANSYETQTNFYLVHMLPNLQGttvKAKQDARPgeq-vgpGRIIV 279  Chloroflexus a...
YP_145366    204 AYNSEVWGSRERGVh--eLNYTYEDArLADTIVLWGANSYETATVFYVEHMLPNIQGatvAEKQQAFDpgepaepGYLIV 281  Thermus thermo...
NP_148692    242 FFGPENPAAGDAGPg--aMNTSYHDLrLADTIILWGNNPYSTATVMFVKHVLDNLRGatkAEKQRWFNpgepvidSRIII 319  Aeropyrum pern...
NP_378391    252 AFSLTEDALMEATNgkgtDTSSMLDIsITDVMVMWGINEYVTSTVNLIQHIFDNLRGatvSRKQQWFEpgeptppGMAIV 331  Sulfolobus tok...

Feature 1        ####                                           # #                              
1G8K_A       276 VDPRETPSVAIArhva-------------------gndRVLHLAIePGTDTALFNGLFTYVVEqgwidkpfiea------ 330  Alcaligenes fa...
AAR05656     280 VDPRRTVTVNACeqta-------------------gadNVLHLAInSGTDLALFNALFTYIADkgwvdrdfidkstlreg 340  arsenite-oxidi...
ZP_00356732  280 IDPRRTATVVVSeraa-------------------gkdRVLHLQLnPGTDIALANAIARVVYErgwhdkdfvanrvea-- 338  Chloroflexus a...
YP_145366    282 IDPRKTSSYTVAaqv--------------------apdRVMLLRPnLGTDYILANAIARAVWEkgyydmaylqartdm-- 339  Thermus thermo...
NP_148692    320 VDPRRTETVEAAeaaa-------------------gkdRVLHLQVkPGTDIVLANAIARVIYErygdvveefvnhyrsaa 380  Aeropyrum pern...
NP_378391    332 VEARPSETAHAVaaavgctveqamngtcnvgksqeglpQVLVVQVnPGTDTELINAVAAYIYYtygsttvqnfinmyqqa 411  Sulfolobus tok...

Feature 1                                                                                   ###  
1G8K_A       331 ------------------htkgfddavkTNRLSLDECSNITGVPVDMLKRAAEWSYKPKasg----qapRTMHAYEKGII 388  Alcaligenes fa...
AAR05656     341 tarpplypargvseanpghlssfedaveGCRMSIEEAAEITGLDAAQIIKAAEWIGMPKegg----krrRVMFGYEKGLI 416  arsenite-oxidi...
ZP_00356732  339 -------------etvqpfleqslqigkSLDEVLAEAEQITGLSRAQIEQAASWIAETKsdg----srpRSIFLYEKGVI 401  Chloroflexus a...
YP_145366    340 -------------tlfeeykakslklsvPYDEFMAQAERITGVSRAEIEKAADWIAKPKagr----fkrRTLTIYEKGII 402  Thermus thermo...
NP_148692    381 gwgf----kwdeegfqkyvsealqvgeeTLDEVLAEAESITGVPRDKIELAAKWIAERKegg----ypkRVWLMYEKGII 452  Aeropyrum pern...
NP_378391    412 qsns---nnaftfnntnyqyylqylqskSLSDWLSEAEQITGVPQNIIQMMGDMLAKPKvgsngqnyykRVVIEFEKGII 488  Sulfolobus tok...

Feature 1        #                                   #                                           
1G8K_A       389 WgndNYVIQSALLDLVIAThn-vGRRGt--GCVRMGGHQEGYTRPpypgdkk---------------------------- 437  Alcaligenes fa...
AAR05656     417 WgndNYRTNGALVNLALATgn-iGRPGg--GVVRLGGHQEGYVRPsdahvgrp--------------------------- 466  arsenite-oxidi...
ZP_00356732  402 WgmkNYQNIGSIVNLALLTgn-fGKPGt--GCGRLGGHQEGYVRPgypgprp---------------------------- 450  Chloroflexus a...
YP_145366    403 WnmkNYDQVAAIVQLAVLThn-iGRPGt--GCGRQGGHQEGYVRPpaptpgsiyr------------------------- 454  Thermus thermo...
NP_148692    453 Wn-qNYRSIYSLFDLCMIAg--aTRGLpgcGCQRQGGHQEGFASPapppppwtderhhiaypdksly------------- 516  Aeropyrum pern...
NP_378391    489 Ws-gNYTPIYSLANLAIIIgalsGRPGc--GMSTGFGHQRGAAFPlpppppwypqiglslnqgrmlwiqmsqyvpqqlqk 565  Sulfolobus tok...

Feature 1                                                           ###   #                      
1G8K_A       438 ---------------------------------iyidqeLIKGKGRIMTWWGCNNFQTSNNAQALREAILQRsaivkqam 484  Alcaligenes fa...
AAR05656     467 --------------------------------aayvdqlLIGGQGGVHHIWGCDHYKTTLNAHEFKRVYKKRtdmvkdam 514  arsenite-oxidi...
ZP_00356732  451 --------------------------------apyiddlLSQGQGNVFYVVGCNPAVTTLNAQRMRETLQTRgklvrdai 498  Chloroflexus a...
YP_145366    455 -----------------------------ggppvnvdkfLIEGKGKFYWVIANDPYLSTPNNQVFRKRIHERtekltkal 505  Thermus thermo...
NP_148692    517 ------------------deyyntkypradfympttdfrLANGEGKVLWVIDMDNYRLAPNSQRLKAVVGDRawrvtryv 578  Aeropyrum pern...
NP_378391    566 qgmtvngpniaefiknfysqytsslvpqiyqynpiidylIYSGYGKVLWVFTAVPYKLTMAGGKLAQTINHRskllqecv 645  Sulfolobus tok...

Feature 1                                                                       ###              
1G8K_A       485 qkarga-----------------------------------tteemvdviyeatQNGGLFVTSINLYp--TKLAEa-AHL 526  Alcaligenes fa...
AAR05656     515 saapyg-----------------------------------dreamvnaivdaiNQGGLFAVNVDIIp--TKIGEa-CHV 556  arsenite-oxidi...
ZP_00356732  499 dasfga-----------------------------------dnatkaqaildaiSQGGLFIIVQDIYp--IETARy-AHV 540  Chloroflexus a...
YP_145366    506 gaggepg--------------------------------tiqeraqkildilyqDPDALFLVVQDIYm--TETARd-AHL 550  Thermus thermo...
NP_148692    579 faeayanvggkesepnyd----------pnalepvittppssreyaekvlqaleETGGLFVIVEDIYp--TFMVEd-AHV 645  Aeropyrum pern...
NP_378391    646 entlsagvpsgstssiissspyyntnavsstipqfpdpdtyaqavisclsgsnkQPGALFIVGNDIIlnqNGLLEtaAHI 725  Sulfolobus tok...

Feature 1           ##                                 #                                         
1G8K_A       527 MLPAAHp-GEMNLTSMNG-ERRIRLSEkFMDPPGTAMADCLIAARIANALrDMYQKDGkaemaa-----qfegfDWKTEE 599  Alcaligenes fa...
AAR05656     557 ILPAATs-GEMNLTSMNG-ERRMRLTErYMDPPGQSMPDCLIAARLANTMeRVLTEMGdvgyaa-----qfkgfDWQTEE 629  arsenite-oxidi...
ZP_00356732  541 VFPAAAw-GESPITSING-ERRLRLYEkFMDPPGIAEPDWKIFGMLAQRIkALAQADGnadiaq-----rfsgfEWQTAE 613  Chloroflexus a...
YP_145366    551 ILPAAGw-GEANETSINCnSRLLRLYEkFMDPPGEAKPDWEIFKWVGLRIaELYRAEGkfeeak----kfefgkNWKTDE 625  Thermus thermo...
NP_148692    646 VLPAAFnnGEWPDVRMGVhERRFRIADaWLDPPGEAKPDWWILANVAKRIvELYEEEGrggdpvaerfrkafkpIWDAME 725  Aeropyrum pern...
NP_378391    726 ILPSAAnhGETYEIRWNGhDRRLRLDEpFHSPPGMAMPDVWIYAMIAYRLyQLFQQNGmgsspqaqriyqafnqIWTSLK 805  Sulfolobus tok...

Feature 1                                                                                        
1G8K_A       600 DAFNDGfrragqpgapaids------------------------------------------------------------ 619  Alcaligenes fa...
AAR05656     630 DAFMDGynknahgg------------------------------------------------------------------ 643  arsenite-oxidi...
ZP_00356732  614 EVFLEGgqsfadgvkas--------------------------------------------------------------- 630  Chloroflexus a...
YP_145366    626 DVFLAGaeefrdntvseedea----------------------------------------------------------- 646  Thermus thermo...
NP_148692    726 ANARDPtveveneifktyianadeayarlgvhwevqywt----------------------------------------- 764  Aeropyrum pern...
NP_378391    806 NNMMQNsqplslipefsefyydynwfniysdiwdyyvangptnfsswpygyfvphwapgwsqmslsdlqatrtigvqlpi 885  Sulfolobus tok...

Feature 1                                                                                        
1G8K_A       620 ----------------------------qggstghlvtydrLRKSGNNGVQLPVvswdeskglvg-----temlytegkf 666  Alcaligenes fa...
AAR05656     644 ----------------------------------efvtyerLSAMGTNGFQEPAtgftdgkieg------tqrlytdgvf 683  arsenite-oxidi...
ZP_00356732  631 ------------------------------terykgvdyafLKAAGNNGIQTPVtivngqpqgr------vryfengepf 674  Chloroflexus a...
YP_145366    647 ---------------------------vleaenykgvtyklLKELGQKGIQTPVrrdpktgklv------gtvrrytyrf 693  Thermus thermo...
NP_148692    765 --------pefkkldlnilrklrtigtvlpitkldvkpdgtIEVRGVVNIMEPAlndtyreevvvvkpdgtivrrievvp 836  Aeropyrum pern...
NP_378391    886 lgkttnpdgsftlwglvnyaepgiqgaingqfraeavtvnpNQSVTVGNTQLPLitrevtyini-------ndlqsmfgy 958  Sulfolobus tok...

Feature 1                           
1G8K_A       667 DTDDGKAHFkp--aPWNGL 683  Alcaligenes faecalis
AAR05656     684 STDDGKARFmd--aPWRGL 700  arsenite-oxidising bacterium NT-26
ZP_00356732  675 YTESGKAKMlp--tPWPGF 691  Chloroflexus aurantiacus
YP_145366    694 GTEDGKFKWyg-tdDWEGY 711  Thermus thermophilus HB8
NP_148692    837 SNETVRSYVpghlkPWPAV 855  Aeropyrum pernix K1
NP_378391    959 DYNTLMQYVidglnPFPMP 977  Sulfolobus tokodaii str. 7

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