1FDO


Conserved Protein Domain Family
MopB_Formate-Dh-H
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cd02753: MopB_Formate-Dh-H 
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Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is a monomer composed of a single polypeptide chain with a Mo active site region and a [4Fe-4S] center. Members of the MopB_Formate-Dh-H CD belong to the molybdopterin_binding (MopB) superfamily of proteins.
Links
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Statistics
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PSSM-Id: 239154
Aligned: 32 rows
Threshold Bit Score: 655.823
Created: 18-Apr-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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molybdopterin[4Fe-4S]
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:molybdopterin cofactor binding site
Evidence:
  • Structure:1FDO; E. coli formate dehydrogenase H binds Mo and two molybdopterin guanine dinucleotide (MGD) units.
  • Comment:defined by 3.5 Angstrom contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #                                     
1FDO          5 VTVCPYCASGCKINLVVdngkIVRAEAAQg---kTNQGTLCLKGYYGWDFindtqiltpRLKTPMIRrqrg--------- 72   Escherichia coli
AAU37339    224 RTTCPHCAVGCQYDLLVkdnkLVGAEGVDg---pSNGGRLCVKGRFGSYKfvm---sgdRLTDPLIKdrat--------- 288  Mannheimia succ...
NP_769776   252 VTTCAYCGVGCAFKAEMrgeeVVRMVPYKdg--kANRGHSCVKGRFAWGYtnh----keRILKPMIRerie--------- 316  Bradyrhizobium ...
NP_815111   233 PTTCPHCGTGCQMNLLVknnrLVGVEPLDg---pANKNLLCVKGKFASYKfvg---sgdRLTEPLIKrng---------- 296  Enterococcus fa...
ZP_00173197 240 ITTCAYCGVGCSFRAEMkgeqVVRMVPDKng--gANHGHSCVKGRFAWGYath----rdRITTPMIRksih--------- 304  Methylobacillus...
NP_744334   247 ITTCAYCGVGCSFRAEIkgdqLVRMVPDKng--gANHGHACVKGRFAWGYath----pdRITKPMIRkrle--------- 311  Pseudomonas put...
NP_906390     8 DTVCTYCGVGCDIAASVsnnrVQSISAHPeg--vVSEGKLCVKGKYGFGFles----pdRLKTPRIKrrfleenpeilka 81   Wolinella succi...
ZP_00268190   5 LTVCPYCGSGCKINLLVendqVIGAEPAQg---vTNQGELCLKGYYGWDFlndpklltpRLRKPLIRrtrd--------- 72   Rhodospirillum ...
BAD84403      3 KVVCPYCGFGCKLLIDPa---TLKVKPYKg---ePNKGKLCPKGLYSTEIvks----rdRLKRPLKRvgs---------- 62   Thermococcus ko...
AAB94932      3 IITCPYCGAGCRAYVKKelshPFIIEYVTdinvpNDRGKLCPKGNAMFEYlls----keRLKTPLKAierg--------- 69   Thermococcus li...

Feature 1                                                     #                            ##   
1FDO         73 ---------gklePVSWDEALNYVAERLSAikekygpdaIQTTGSSRgtGNETNYVMQKFARAVIgtNNVDCCARVXHGP 143  Escherichia coli
AAU37339    289 ---------gkfrKASWDEALDLVASKFMTlkrqyggdsLAGFACSRs-PNEDIYMVQKMVRTCFgtNNTDNCARVCHSA 358  Mannheimia succ...
NP_769776   317 ---------dpwrEVSWDEAFSFAAARMRGiqkkygrdaIGGITSSRc-TNEETYLVQKLIRAGFgnNNVDTCARVCHSP 386  Bradyrhizobium ...
NP_815111   297 ----------ifePASWEEALTLVSSKFNEikaengpdaLAGFSCSRa-TNEDNYVFQKMVRAAFgtNNVDNCARVCHSA 365  Enterococcus fa...
ZP_00173197 305 ---------dpwqEVSWEEAITYAASELKRiqakhgrnsIGAITSSRc-TNEETYLVQKLVRAAFgnNNVDTCARVCHSP 374  Methylobacillus...
NP_744334   312 ---------dpwqEVSWDEAVTYAASEFRRiqlkygrdsIGGITSSRc-TNEEAYLVQKLVRTAFgnNNVDTCARVCHSP 381  Pseudomonas put...
NP_906390    82 iepdlielderwyECSLEGAIKAAALKLQEirdrhgarsLASIGGARt-SCESAYLLQKFTRETLgsPHVDNCARVCHAP 160  Wolinella succi...
ZP_00268190  73 ---------safeEVSWYEAINFAATRLQEikhkygpdsIMLTGSARgpGNEANYVMQKFARAVVgtNNIDHCARVCHGP 143  Rhodospirillum ...
BAD84403     63 ----------kivPISWGQAMEEISNKLLEvrelygpdaVAFLASSKv-SNEENYLLQKIARLFGt-NNIDNCARLCHEA 130  Thermococcus ko...
AAB94932     70 ----------kfvKISWKEAINEIASFIRGymkd-dpnrLMFIAGGKv-SNESAYLFQKLARNIGt-NNVDNTSHLCHGV 136  Thermococcus li...

Feature 1                                     ####  ##                    ## #                  
1FDO        144 SVAGLHQsvGNGAMSNAINEId-NTDLVFVFGYNPADSHPIVAnHVINakrnGAKIIVCDPRKiet----ariADMHIAl 218  Escherichia coli
AAU37339    359 SVEGLARtlGSGAMTNPIYDIthDVDAILLVGSNPEEAHPVIGmQIREavrnGTKLIVVDPRDigl----tkqADIHLKl 434  Mannheimia succ...
NP_769776   387 TGYGLSQtfGTSAGTQDFDSVe-NTDVAVVIGANPASAHPVFAsRLKKrlrqGAKLIVIDPRRtemve-sphvKALHLPl 464  Bradyrhizobium ...
NP_815111   366 SVHGLAQtlGSGAMTNPIADIteDVDMILLVGSNPEEAHPVIGaQIRQaiqrGTQVVVVDPRKinl----vkdSALHLQv 441  Enterococcus fa...
ZP_00173197 375 TGYGLKQtlGESAGTQTFDSIm-KSDVIMVIGANPTDGHPVFGsQMKRrlreGAKLIIADPRAidlvsgphvkADYHLKl 453  Methylobacillus...
NP_744334   382 TGYGLKQtlGESAGTQSFDSVm-QADVVLVIGANPTDAHPVFGsQLKRrlrqGARLIVIDPRRidlvdspharADLHLQl 460  Pseudomonas put...
NP_906390   161 SLKGMRTtiGEGAATNPYNDIy-NTEFMIVLGSNTTEAHPIISnRIVDmaskHDNLAVFDVREitl----hrfAKYKGIi 235  Wolinella succi...
ZP_00268190 144 SVAGLQVtlGNGAMSNSVEEIe-NTKCVFVFGYNAAVSHPIVArRILKakekGAKIIVCDPRFiet----ariADLWLPl 218  Rhodospirillum ...
BAD84403    131 SVHALKLavGTGAQTNPYEDIp-KFKSVLIWGYNPAETHPVVMdYILRakksGAKIIVVDVREtrt----mafADHRLIi 205  Thermococcus ko...
AAB94932    137 SVRAILDa-NFERNWATYDDIe-ESNVIILWGANLAETAPLIFrRVLKaknrSAKIIVIDPRKtkt----tkfASIHVRp 210  Thermococcus li...

Feature 1         # #                                                                           
1FDO        219 knGSNIALLNAMGHVIIEENLYDkafvasrteg----feeyrkivegYTPESVEDITG--VSASEIRQAARMYAqaksaA 292  Escherichia coli
AAU37339    435 rpGTNIAFANGMCHIFIKEGLIDekfiaehteg----fkelkkivkdYTPEYVAEICG--IDADDLRAAARIYAtakkaP 508  Mannheimia succ...
NP_769776   465 mpGTNVAVVTALAHVIVTEGLVNeafvrercdwtefeewaafvaqpnNSPEATAILTG--VDPKALREAARIYAtggngA 542  Bradyrhizobium ...
NP_815111   442 qaGTNVAFANGMMHVILKEGLADrhfieerteg----fldlekmvadYTPEKVAEICH--IHPEDLIQAARMYAkaekaP 515  Enterococcus fa...
ZP_00173197 454 rpGTNVALITALAHVVVTEGLVDeafvrercewdsyqywsefvaqpeHSPEAMQDVIG--VPAQDLRAAARLYAtggnaA 531  Methylobacillus...
NP_744334   461 rpGTNVAMLNALAHVIVTEGLLAqsfidarcetgdfarwrdfvslpdNAPEVLGPVCG--VPAEQIRAAARLYAtggnaA 538  Pseudomonas put...
NP_906390   236 phECNLLILNMMAYVIITEELFSesfiqnrtagfe-efkaqilsdplANPRYFEEIEGyeYLSKLIPKVAREYAlk-ksM 313  Wolinella succi...
ZP_00268190 219 knGTNMALVNAFAHVLLEENLYDkdfvakyteg----lddykatvakYTPEYAEKITG--VPAQQIREAMRMYAgaetaT 292  Rhodospirillum ...
BAD84403    206 rpGTDIVLANALAHVIIEEELYNeefirsrttg----fsevrmavkkYTPEYAERATG--VPAEKIKEVARDFSlagsgA 279  Thermococcus ko...
AAB94932    211 fpGTDIVLINALINLLLKRRNIKsahfkas----------dleiiskNTPEYAERITG--VPVRDIEEIAREIGlarrgI 278  Thermococcus li...

Feature 1          ###  ##                               ##                                     
1FDO        293 ILWGMGVTQFYqGVETVRSLTSLAMLTgnlgkphaGVNPVRGQNNVQGACDMGALPdtYPGYqyvkdpanrekfakawgv 372  Escherichia coli
AAU37339    509 IIYCLGVTEHStGTEGVMSMSNMAMMVgkigregcGVNPLRGQNNVQGACDMGASPnqYPGYqsvkdpeirakfekawgv 588  Mannheimia succ...
NP_769776   543 IYYGLGVTEHSqGSTTVIAIANLAMATgnigrpgvGVNPLRGQNNVQGSCDMGSFPheLPGYrhisgnavrdqfealwnv 622  Bradyrhizobium ...
NP_815111   516 IIYCLGVTEHStGTEGVMSMSNLAMLVgkvgkpgcGVNPLRGQNNVQGACDMGCMPydFPGYqkvnnpevidkfekawhv 595  Enterococcus fa...
ZP_00173197 532 IYYGLGVTEHSqGSTMVMGIANLAMATgnigregvGVNPLRGQNNVQGACDMGSFPheFPGYrhvsddttralfeaawgr 611  Methylobacillus...
NP_744334   539 IYYGLGVTEHSqGSTAVMGIANLAMATgnigregvGVNPLRGQNNVQGSCDMGSFPheLPGYrhvsnegvraefeqawgv 618  Pseudomonas put...
NP_906390   314 IFWGLGVTEHVdGSYSVMAIVHLALMTgnvgksgaGLMPLRGQNNVQGACDMGMLPyyAPDYqspkeeglatp------- 386  Wolinella succi...
ZP_00268190 293 VMWGMGVTQWSqAVDVVKGLSGLALLTgnlgkpscGVAPVRGQNNVQGACDHGALPnmLPGYqpvtdaaarakfekawgv 372  Rhodospirillum ...
BAD84403    280 EMWGMGLTQHVsGVENVLALINLALLLgyig-ergGLYPMRGQNNVQGAAYMGALSefLPGYvpltdgkfrkrvaglwgv 358  Thermococcus ko...
AAB94932    279 ILWGSGIAMHSnGYDVIRSIITLASIVd------fKVLPLAGQNNSQGVMDMGVVPnfLPGYrtydnvyifreawkneel 352  Thermococcus li...

Feature 1                                    # #   #                   #### #           ##      
1FDO        373 eslpahtgyriselphraahgeVRAAYIMGEDPLQTdaelsavrkaFEDLELVIVQDIFMTKTASAADVILPSTSWGEHE 452  Escherichia coli
AAU37339    589 kl-pahiglhatdvfpaaikgkIKGLYICGEDPVVTdpdtnhvinaLKSLDFLVVQELFMTETALLADVVLPGRSYAEKD 667  Mannheimia succ...
NP_769776   623 kl-npepglripnmfdaaiegtFMGIYVQGEDILQSdpntshvvaaLAAMECVIVHDLFLNETANYAHVFLPGSSFLEKD 701  Bradyrhizobium ...
NP_815111   596 pl-nrntgltstkvlpaatagsVKGLYIFGEDPIVTdpdtghvrqaLESLDFLVVQELFMTETAAYADVVLPGISYAEKD 674  Enterococcus fa...
ZP_00173197 612 pl-dkepglripnmldfaihgsFKALYCEGEDIAQSdpntqhvtqaLSSMECVIVQDLFLNETAMYAHVFLPGCSFLEKN 690  Methylobacillus...
NP_744334   619 tl-qpdpglripnmfeaaldgsFKALYCQGEDIAQSdpntqhvtaaLLAMECVVVQDIFLNETAKFAHVFLPGSSFLEKD 697  Pseudomonas put...
NP_906390   387 ------------elidemlegrVKGVLNMGEDLMHIhpnlnkmeraLGNLELLVVQELFETEIAKRADILIGVKSAYEKT 454  Wolinella succi...
ZP_00268190 373 snlpdkpgvcltevpkmvkagkLKAYYIFGEDPAQTdpdlhevresMRDLEFVICQEIFMTKTAMMADVVFPATSWGEHE 452  Rhodospirillum ...
BAD84403    359 ddlpterglyltelwdaiekgdVRALYIVGENPAVSeadfmrvrraLRNLDLLVVQDIFPTRTARYAHYLLPASAFCEKA 438  Thermococcus ko...
AAB94932    353 p---tevgldipksikeaqkrnVSAFYVMGANIALSfpea---ekaLRRAEFVIVQDIFPTQTTELADIVLPAAAFLESN 426  Thermococcus li...

Feature 1                                #                                                      
1FDO        453 GVFTAADRGFQRFFkavepkWDLKTDWQIISEIATRMGYPMHYnn-tqEIWDELRh-LCPDFYGATYEKMge--lGFIQW 528  Escherichia coli
AAU37339    668 GTFSNTERRVQRVRkaitlpGNSRLDTDIICELMRRMGYNQPNlt-asEIFDEMAs-VTPSFRGISYERLekeptQSLQW 745  Mannheimia succ...
NP_769776   702 GTFTNAERRIQRVRkvm-tpKNGMADWEVTIGLAKAMGFEMNYsh-psEIMDEIAa-LTPTFTGVSYAKLde--lGSVQW 776  Bradyrhizobium ...
NP_815111   675 GTFTNTERRVQRVRkaveprGQAREDYEIFCEVMTRMGYPCAYes-akEIMEEISa-VTPSFGGINYERLe---kESLQW 749  Enterococcus fa...
ZP_00173197 691 GTFTNAERRISPVRrvm-tpKNGYEDWQITAMLSEALGYPMPYrh-asEILDEIAr-LTPTFHGVSFKKLee--mGSIQW 765  Methylobacillus...
NP_744334   698 GTFTNAERRISRVRkvm-epLAGKADWEATVALANALGYPMNYrh-psEIMDEIAr-LTPTFRRISYAELdr--hGSLQW 772  Pseudomonas put...
NP_906390   455 GVYINAMRRLHLSQpl--vqSELPDDWEVISRLGRELGGSYEYgd-skAIWDEVRevAYRRFSGASYQRLerhrvRGLQW 531  Wolinella succi...
ZP_00268190 453 GVYSSCDRGFQRFYkaiepqGDVKPDWEIISLMATAMGYPMKYsn-tqEIWDELRe-LCPIYYGATYEKMag--lGYIQW 528  Rhodospirillum ...
BAD84403    439 GSYMNSERRIQWSEkvcepaYDSKPDWEILTMLGKALGLPGFNytsveEITAEYFr-LFPELEEKSVEELkn--sDGIFL 515  Thermococcus ko...
AAB94932    427 GSTTNAERRIQWSSrvkwppGDAKPDWAILCELGNALGLRGFDfyfpeEILREISt-LVPQYANANPRTLmr-tpEGVMW 504  Thermococcus li...

Feature 1                                                 
1FDO        529 Pcrdts-----dadqGTSYLFke-kFDTPNGLAQFftCDWVA 564  Escherichia coli
AAU37339    746 Pctdq-------yhpGTPIMHv---GKFARGLGLFypTVYTP 777  Mannheimia succiniciproducens MBEL55E
NP_769776   777 Pcnek-------apeGTPVMHi---DGFVRGKGKFivTEYVA 808  Bradyrhizobium japonicum USDA 110
NP_815111   750 Pcrsl-------tdpGTPIMHv---GSFARGKGLFkaIPYKQ 781  Enterococcus faecalis V583
ZP_00173197 766 Pcnee-------hpnGTPIMHv---DEFVRGKGRFmiTEYVP 797  Methylobacillus flagellatus KT
NP_744334   773 Pcnda-------apdGTPTMHi---DQFVRGKGRFmlTGYVP 804  Pseudomonas putida KT2440
NP_906390   532 Pvh----------teDTPILHql-dFRTEDGCGHFfyHAYKP 562  Wolinella succinogenes DSM 1740
ZP_00268190 529 Pcpdl-------dhpGTPYLYadkkFQTPSGKGLLfaCEWRP 563  Rhodospirillum rubrum
BAD84403    516 Pk-------------KRLHTWe---FATPDGKARFmaVEWIP 541  Thermococcus kodakaraensis KOD1
AAB94932    505 NivpdsqptkvyvsnKMPLLEpp-vMITVRYVGQFqtGTMTK 545  Thermococcus litoralis

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