1EU1,1VLE,4DMR,1TMO


Conserved Protein Domain Family
MopB_DMSOR-like
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cd02751: MopB_DMSOR-like 
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The MopB_DMSOR-like CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR catalyzes the reduction of DMSO to dimethylsulfide, but its cellular location and oligomerization state are organism-dependent. For example, in Rhodobacter sphaeriodes and Rhodobacter capsulatus, it is an 82-kDa monomeric soluble protein found in the periplasmic space; in E. coli, it is membrane-bound and exists as a heterotrimer. BSOR catalyzes the reduction of biotin sulfixode to biotin, and is unique among Mo enzymes because no additional auxiliary proteins or cofactors are required. TMAOR is similar to DMSOR, but its only natural substrate is TMAO. Also included in this group is the pyrogallol-phloroglucinol transhydroxylase from Pelobacter acidigallici. Members of the MopB_DMSOR-like CD belong to the molybdopterin_binding (MopB) superfamily of proteins.
Links
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Statistics
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PSSM-Id: 239152
Aligned: 40 rows
Threshold Bit Score: 625.793
Created: 18-Apr-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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molybdopterin
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:molybdopterin cofactor binding site [chemical binding site]
Evidence:
  • Structure:1EU1; Rhodobacter sphaeroides dimethylsulfoxide reductase (DMSOR) binds Mo and two MGD units
  • Structure:4DMR; Rhodobacter capsulatus DMSOR with bound substrate DMS
  • Comment:defined by 3.5 Angstrom contacts
  • Comment:Primary difference between TMAOR and DMSOR is loss of Tyr (Y114 in DMSOR) from TMAOR
  • Citation:PMID 9813128
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1EU1_A        9 MSGCh------wGVFKARvengrAVAFEPWdkd----------------------paPSHQLPGVLDSiysptRIKYPMV 60  Rhodobacter spha...
1VLE_M        8 TNSSt------gGPVFVYvkdgkIIRMTPMdfddavdapswkieargktftpprktsIAPYTAGFKSMiysdlRIPYPMK 81  Pelobacter acidi...
YP_076161    53 WQQCtvncggysCALRLHvkddvIVRVDTDqldrsg----------------fpamrACLRGRATRKFvynpdRLKQPMK 116 Symbiobacterium ...
ZP_00329586  57 PTSCvhnc-ggrCPLYAHvkdgvVTWFSPDqegndsp--------------dfpqvrACLRGRSQRKRlyhpdRLKYPMK 121 Moorella thermoa...
ZP_00097771  29 PSICwhnc-ggrCQLKAYvkdgvVVRFGTDnvgpdtp--------------edlqarACLKGRTQRQRlyhpdRLKYPMK 93  Desulfitobacteri...
NP_717049    45 WSSClvnc-gsnCPIKVFsrdgiITRIETDhetndey--------------gnhqirACARGRSLRSRtyapdRLRTPMK 109 Shewanella oneid...
AAN57326     45 LSACignc-fqtCPLRVYsrngiITRIESEsggdikfvdnw------svdgahheirPCLKGRAQKQKaysadRVKYPMK 117 Shewanella oneid...
ZP_00099477  57 TAACwhnc-ggrCLNKALvvdgvVVRQKTDdthedsp--------------dfpqqrGCARGRSHRKMvmgadRLKYPMK 121 Desulfitobacteri...
ZP_00329589  58 TAACwhnc-ggrCLNKAYvvdgvVVRQKTDdthpdtp--------------dypqqrGCARGRSQRKQafgvdRLKYPMK 122 Moorella thermoa...
YP_074542    59 TAACwhnc-ggrCLNKALvrdgvVIRQKTDdthedsp--------------dfpqqrGCARGRSQRKQvfavdRLRYPMK 123 Symbiobacterium ...

Feature 1                                                                                       
1EU1_A       61 RREflekgvnad-------rstrgngdFVRVTWDEALDLVARELKRvqesygptgTFGGSygwkspgr------------ 121 Rhodobacter spha...
1VLE_M       82 RKSfdpngernpqlrgaglskqdpwsdYERISWDEATDIVVAEINRikhaygpsaILSTPsshhmwgn------------ 149 Pelobacter acidi...
YP_076161   117 RVGkrg------------------egkFEPITWDEAYTLIAENLDRiiktygnqaVFNHYasgtdg-------------- 164 Symbiobacterium ...
ZP_00329586 122 RVGkrg------------------egkFERISWDEALDTIARELQRiksnygneaIYINYatgvygqvsq---------- 173 Moorella thermoa...
ZP_00097771  94 RVGerg------------------sgeWARISWEEAFDTTAKELRRiidqygnesVYFNYacgaygll------------ 143 Desulfitobacteri...
NP_717049   110 RVGkrg------------------eakFVPISWDEAASTIASEIQRiassygnksILKHYgtgayyg------------- 158 Shewanella oneid...
AAN57326    118 RVGprg------------------sgqYVRISWDEAINTVAQELSTkittygaqsIYLPVatgdydyqvdgmyaammflh 179 Shewanella oneid...
ZP_00099477 122 RKNwapgggnk---------elrgqdeWVRISWDEALDIMASELTRikdaygnraIFAPVggsd---------------- 176 Desulfitobacteri...
ZP_00329589 123 RKHwepgggnk---------elrgrdeWVRISWEEALDIVASEIKRikekygnraIFVGGgn------------------ 175 Moorella thermoa...
YP_074542   124 RKHwepgggrk---------dlrgrdeWVRISWDEALDIVASEIKRivekygnraILSTGgs------------------ 176 Symbiobacterium ...

Feature 1                                       #                                          #    
1EU1_A      122 ------lhncqvlMRRALNLa-GGFVNSsGDYSTAAAQIIMPHVMGtlevy---eqqtAWPVVVe--nTDLMVFWAaDPM 189 Rhodobacter spha...
1VLE_M      150 ------vgyrhstYFRFMNMm-GFTYADhNPDSWEGWHWGGMHMWGfswrlgnpeqydLLEDGLk--hAEMIVFWSsDPE 220 Pelobacter acidi...
YP_076161   165 --------tsrtpIPRLLNMl-GGYLGYyGTYSSACYTWAAPYTYGsag-------cnSADDLVn---SRLIVLFAsNPG 225 Symbiobacterium ...
ZP_00329586 174 ---switpafggaLPRFLNMf-GGYLGYyNTYSSACFSYAAPYTFGtve-------gnSPDDLLn---SKLIVLFAdNPG 239 Moorella thermoa...
ZP_00097771 144 -----nqtnsnnsLRRLLNIm-GGYLQSyGNYSQANYMYAVPYMFGnpy------sgsSPTTFPd---AKLIVMFGdNPA 208 Desulfitobacteri...
NP_717049   159 -------fassacFDRVLNLn-GGFLKIyGNYSWAQQNEAAAATGFast------sgsSLTALYd---SDLFLGIGyNPS 221 Shewanella oneid...
AAN57326    180 eitkkkiplyipeMDFTMELdaSGYLMYhDSYSAAQMKDAVKSTFGwddlw---gtgnTLLDVKn--gTDLMICFGyNPM 254 Shewanella oneid...
ZP_00099477 177 ---------slqaVPRLLSAf-GGYTARwGSVSWGSWPTVYSKVTGqphn-----gasDGNDRFrlreSKLIILWGaNPA 241 Desulfitobacteri...
ZP_00329589 176 ------------eISNILALy-GGYVSHwGTTSWGSWRYAGDIIGLadgy-----ykfSHNDRFdlrnSQLIVLWGaNPA 237 Moorella thermoa...
YP_074542   177 ------------eIGRTLALy-GGYVGTwGTTSWGSWRWGPAKFGMaegy-----ndtSINDRLdlrnSNLIVIWGgNPA 238 Symbiobacterium ...

Feature 1       ##                              ###                 ## #                        
1EU1_A      190 KTneigwvipdhgayaGMKALke--kgTRVIXINPVRtetadyfgADVVSprPQTDVALMLGMAh------tLYSEDLHD 261 Rhodobacter spha...
1VLE_M      221 TNsgiyag---fesniRRQWLkd--lgVDFVFIDPHMnhtarlvaDKWFSpkIGTDHALSFAIAy------tWLKEDSYD 289 Pelobacter acidi...
YP_076161   226 ETqpggg-----nefhWLMQAkr--agVKIIVVDPRLsdtakalaDEWIPirPTTDNALIDAMAy------vMITENLHD 292 Symbiobacterium ...
ZP_00329586 240 ETrlgga-----nghyYLRLAke--kgARVIVVDPRYtdtavtlaDEWIPirPTTDNALIDALAy------vMINENLHD 306 Moorella thermoa...
ZP_00097771 209 CTrvggf-----nstyYLKLAkq--ngARIIVIDPRHsdtvstfaDQWIPirPTTDSALVAGMAy------vMISEGLHD 275 Desulfitobacteri...
NP_717049   222 EMrqsgs-----gegyDFLKAleananLEVIMVDPRYtdsmagkeSQWLPirPGTDAAFAEAIAyem---isSGWVDTHS 293 Shewanella oneid...
AAN57326    255 ESrmgga-----gsayDYTNLkrq-fgFKTIYIEPRYtdtmvvcdDQWVPirPGTDAALAEAIAyvw---iaEMDEAPLD 325 Shewanella oneid...
ZP_00099477 242 QSsqgl-------payNYLQAkk--agVKFIVIDPIYsesarvlaDEWIPirPATDTALILGMAy------yIIKNNLLD 306 Desulfitobacteri...
ZP_00329589 238 WSslgn-------ptyNYLQAkk--agAKFIFIDPIYteaarvlgGEWIPirPATDHAMLLGMAytlikeddPVTNPLID 308 Moorella thermoa...
YP_074542   239 WSaggs-------ptyHYLQAkk--agAKFIFIDPIYhqsaellaDEWIPirPGTDHAMMLGMAytliteddPVNNPLID 309 Symbiobacterium ...

Feature 1                                                                                       
1EU1_A      262 KDFLENCTTGFDlf------------------------------aAYLTGE---SDGTPKTAEWAAEICGLPAEQIRELA 308 Rhodobacter spha...
1VLE_M      290 KEYVAANAHGFEew------------------------------aDYVLGK---TDGTPKTCEWAEEESGVPACEIRALA 336 Pelobacter acidi...
YP_076161   293 QAFLDKYCVGFDdahlpaga------------------ppkssykSYVLGE---ADGVPKTPEWAEAITGVPRQTIVRLA 351 Symbiobacterium ...
ZP_00329586 307 QAFLDKYCLGFDeehmppgi------------------ppgnsykSYVLGQg--EDKTPKTPEWAEAITGVPRDTIIKLA 366 Moorella thermoa...
ZP_00097771 276 QAFLDKYCLGFDeehmpeg-------------------ipagnsyKSYILGe--SDGKPKTPEWASEITGIPVETIKQLA 334 Desulfitobacteri...
NP_717049   294 KAFLDKYCVGFDkasleklvaeftasgdpkktqylpyidvednyrNYILGEgkfADNGPRTPAWAAKICGISEANIKSVA 373 Shewanella oneid...
AAN57326    326 MAFLQSKVYGYGaeaafdhyp---------------elplaksykGHILGL---DDGQAKTPEWAAAITGIPVDTIRALA 387 Shewanella oneid...
ZP_00099477 307 QNFLDNCTIGFDadhlpega------------------dpkdnfkDYVLGT---YDNTPKTPEWASEICGVPAVKIAEFA 365 Desulfitobacteri...
ZP_00329589 309 WDFLNRCTIGFDadhmpaga------------------dpkenfkDYVLGT---YDGVPKTPEWAAEICGVDPEKIRSLA 367 Moorella thermoa...
YP_074542   310 WDFLNRCTVGFDadhmpega------------------dpkenfkDYVLGT---YDGQPKTPEWASEICGVDPHTIRRLA 368 Symbiobacterium ...

Feature 1                          ##  #                                                        
1EU1_A      309 RSFva-gRTMLAAG-----WSIQRMhHGEQAHWMLVTLASMIGqIGLPGGGFGLsyhysnggsptsdgpalggi------ 376 Rhodobacter spha...
1VLE_M      337 RQWak-kNTYLAAGglggwGGACRAsHGIEWARGMIALATMQG-MGKPGSNMWSttqgvpldyefyfpgyaeggisgdce 414 Pelobacter acidi...
YP_076161   352 REIaitkPCALLQH-----YGWQRNaYGEQPVRGLPVLMAMTGnIGRSGGGTGLtpsrkgapsps--------------- 411 Symbiobacterium ...
ZP_00329586 367 RQIasikPCCLLQG-----FGWQRHaYGEQPVRGLPVLAAMTGnIGIRGGGPGLrngghgvvvgw--------------- 426 Moorella thermoa...
ZP_00097771 335 RDIagtkPGFILQG-----RGIQRHgNGEFQSLAVPVLSFMTGnVGILGSNPGLyeggpsvktgn--------------- 394 Desulfitobacteri...
NP_717049   374 SKImnakAPFIVTG-----AGVNRHaNGEQAMRACYMLSFLTGkVGQPGVSNGAlpyqgslnrag--------------- 433 Shewanella oneid...
AAN57326    388 SEIaaakTPFFIQG-----WGIQRAqNGENAARSLFMLPILLGkVGDKGTNFCSvpgaktyakpivagmea--------- 453 Shewanella oneid...
ZP_00099477 366 QEYattkPAAIISG-----GAPARInNGEHLPHAMMTLAYMVGnVGIPGAGVSPnmhnsatnagpalvk----------- 429 Desulfitobacteri...
ZP_00329589 368 REIattkRVALLTG-----WAPARVhNSDSWPQMFMTLGCMTGhIGQPGRMTGVschqsasnggpplvv----------- 431 Moorella thermoa...
YP_074542   369 REIattpRVALLTA-----WAPARTrNSDSWPQMFMTFGAMTGhMGQPGRMTGVschrhtanggpnlvt----------- 432 Symbiobacterium ...

Feature 1                                                                                       
1EU1_A      377 ------------sdggkavegaawlsesgatSIPCARVVDMLlnpggEFQfngat----------------atypDVKLA 428 Rhodobacter spha...
1VLE_M      415 nsaagfkfawrmfdgkttfpspsnlntsagqHIPRLKIPECImggkfQWSgkgfaggdishq-lhqyeypapgysKIKMF 493 Pelobacter acidi...
YP_076161   412 ---------------------iptgtnpvkaQIPVFMWTEAIvr-gkELTakdgvlg------------adkldaNIKFI 457 Symbiobacterium ...
ZP_00329586 427 ---------------------mpagqnpvkaSIPCFMWPEAIer-ghELTaadgvkg------------vdklstDIKMI 472 Moorella thermoa...
ZP_00097771 395 ---------------------ypigtnpiktKISIFMWTDAIe---rILTkeqdrie-----------gadktksTIKMI 439 Desulfitobacteri...
NP_717049   434 ---------------------msggsnpvkeSISFFTWAEAIer-ghEMTarkdgirgt-------adldtplgaDIKAV 484 Shewanella oneid...
AAN57326    454 --------------dsvgnsvgsavingtefTIPGYKWLEGVqr--pLNSrddglrhmlgeeqkkdhdnilelknPIKFI 517 Shewanella oneid...
ZP_00099477 430 ----------------aggnglpkivnpiddSINSGEMYDAIln-gkYIKqkge-----------------irdiNIQMI 475 Desulfitobacteri...
ZP_00329589 432 ----------------pgsnglpsiknpvadSINDSEIWDAIlk--gKYTagynd----------------ireiNIQMI 477 Moorella thermoa...
YP_074542   433 ----------------sggaglpgiknpineSINDSELWNAVlt--gKYTagynd----------------vrdiNIQMI 478 Symbiobacterium ...

Feature 1          # #   # #                       ##   #                 #                     
1EU1_A      429 YWaGGNPFaHHQD-RNRMLKAWEKl-----ETFIVQDFQWTATARHADIVLPATTSYERNDIEsvgdy-----------s 491 Rhodobacter spha...
1VLE_M      494 WKyGGPHLgTMTA-TNRYAKMYTHds---lEFVVSQSIWFEGEVPFADIILPACTNFERWDISefancsgyipdnyqlcn 569 Pelobacter acidi...
YP_076161   458 WNyGGNTLiNQHS-DAGATHRILQdes-lcEFIVVHDVMMTPSARYADLLLPDRTSYERLHLGrgstn----------vm 525 Symbiobacterium ...
ZP_00329586 473 WNyGGNTLiNQHS-DINKTAKILAdek-kcEFILVHDVFMTPSARFADILLPDVTHFEREDIVtfas------------g 538 Moorella thermoa...
ZP_00097771 440 INyGGNTLiNQHS-DSGRTAALLKdds-kcEFILGMDNFMTPSMRYCDIVLPGVTQFEVNDMItrsm------------g 505 Desulfitobacteri...
NP_717049   485 FAiNSNALiNQHSdCNGTAKILEDdt--kcELIVVCDCWMTASARYADILLPDTTWLESNDLVndsyas---------gi 553 Shewanella oneid...
AAN57326    518 FGnACGTTlNQTAdINHTLDILNNapeaqdLFILAIDHMFSPSAKMADIILPCITNLENSDIVtnkldhd-------sgm 590 Shewanella oneid...
ZP_00099477 476 WTwFSHNL-NQRAgSSQGIDAYRKv-----EFVVAQNMFLTADAQYADLVLPVTSEWERLGGLltgn------------- 536 Desulfitobacteri...
ZP_00329589 478 YHgGGATL-QTRDgMTKGIEAHRKv-----EFVVSHSQFLTTNSRYADVVLPVTTEWEREGGLltgn------------- 538 Moorella thermoa...
YP_074542   479 YHgGGAIL-QTRDgMTKGIEAHRHv-----EFVVSHSQFLTTNSKYADIVLPVTTPWERLGGLltgn------------- 539 Symbiobacterium ...

Feature 1                          #                                                            
1EU1_A      492 nraILAMKKVVDPlYEARsDYDIFAALAERLGKGAEFTEGrd-eMGWISSFYEAAvkqaef------------------- 551 Rhodobacter spha...
1VLE_M      570 hrvISLQAKCIEPvGESMsDYEIYRLFAKKLNIEEMFSEGkd-eLAWCEQYFNATdmp---------------------- 626 Pelobacter acidi...
YP_076161   526 gdrFYLGVPAITPlFDAKtNYEVCAGVAAKLGIYDQFTEGkt-wEDWCREAIAALgekn--------------------- 583 Symbiobacterium ...
ZP_00329586 539 igyAIYHQKVVDPmYECRsLYDVCSELAKRLGFGDQYTEGks-eQDWLREAVNVArqkd--------------------- 596 Moorella thermoa...
ZP_00097771 506 hgvAYYGQKLVEPmFECKtINEVGRALAERLGVLAQFDDGks-eEDYLREFVGVSqash--------------------- 563 Desulfitobacteri...
NP_717049   554 mgyLVAMKAAVKPmWESIsMFEMGRLIAAKMGKEAEYTEGkd-eAAWLEELYQKTrtnsant------------------ 614 Shewanella oneid...
AAN57326    591 mvySYVFERAIEPmYEAKsTWEICRLLAARMGVEHSYARLkt-qDEWVKWSFEHYakkvpn------------------- 650 Shewanella oneid...
ZP_00099477 537 reiLIHYRQIVEPqYEAKsDLWIVKEIGKKLGIDPTKVCPvseeQQMYNQLAGAEvikedgsgyeklltltaedikvlga 616 Desulfitobacteri...
ZP_00329589 539 reiLIYYTRITEPlYEARdDQWIAIELAKRLGLDPRQAYPispkQQLFNQLAGAKvmkedgsgfeklltitaadiaawgv 618 Moorella thermoa...
YP_074542   540 reiLIYYTNVTQPlFEAKdDAWIATEIAKRLGFKEEDIYPisekQQLFNQLAGSKvmkedgsgyeplltiteediaewgv 619 Symbiobacterium ...

Feature 1                                                                                       
1EU1_A      552 ---knvamPSFEDFWSEGIVEFpite--ganfVRYADFRedp---------------lfnPLGTPSGLIEIYSKNIEKMg 611 Rhodobacter spha...
1VLE_M      627 ------kyMTWDEFFKKGYFVVpdnpn-rkktVALRWFAegrekdtpdwgprlnnqvcrkGLQTTTGKVEFIATSLKNFe 699 Pelobacter acidi...
YP_076161   584 -----pgfPTWEKLLEDPIVRGtqe----kpvIAFASFIadp---------------esnPLKTPSGKIEIYSEQLARLg 639 Symbiobacterium ...
ZP_00329586 597 -----pnfPSFEEFRRKGIYKIapk----dpiVAYEKQIkdp---------------annPFQTPSGKIEIFSTRLWAMn 652 Moorella thermoa...
ZP_00097771 564 -----pdfPSYEEFREKGIYKTkat-----kvVAYEKFIkdp---------------eanPLTTPSGKFEIFSKDLYDIq 618 Desulfitobacteri...
NP_717049   615 -daqpafpNSYAEAQKIGVFRAfsk----tpvLALDSYIng-----------------gkAVSTPSGKVEIYSLSMAQKg 672 Shewanella oneid...
AAN57326    651 ---lynpeDTYESVLGRSPVRRias-----enPLFKGLRefky--------------ggvTLNTPSKKIEAYSLTLLNRt 708 Shewanella oneid...
ZP_00099477 617 egepqtgrITYQEFKEKGIYQVprhkgdklefTSFEDFVadp---------------anhKVNTPSGKFEIYCKSLADNi 681 Desulfitobacteri...
ZP_00329589 619 qgapqqgrITLQEFQEKGIYQVprkpgdklgfIALKDFRedp---------------qghPLKTATGKLEIYSQALAKMv 683 Moorella thermoa...
YP_074542   620 egkpqqgrITLKEFEERGIYQVprrpgdklgfIAYEAFRkdp---------------ennPLNTASGKLEIHCQALADLi 684 Symbiobacterium ...

Feature 1                                  
1EU1_A      612 ----------YDDCPAHPTWMEPAERL 628 Rhodobacter sphaeroides
1VLE_M      700 eq-----gyiDEHRPSMHTYVPAWESQ 721 Pelobacter acidigallici
YP_076161   640 ae-----rgnADELPPIPKYVPAWEGP 661 Symbiobacterium thermophilum IAM 14863
ZP_00329586 653 ---------nPKEIPAIPKYIPAWEGP 670 Moorella thermoacetica ATCC 39073
ZP_00097771 619 ----------NPQIPAIPKYMPAEEGP 635 Desulfitobacterium hafniense DCB-2
NP_717049   673 kdwifnpnvkGDYITAIPMYQPTWEGY 699 Shewanella oneidensis MR-1
AAN57326    709 rfe----kfeETETSFIGKYIPATEGA 731 Shewanella oneidensis MR-1
ZP_00099477 682 ek------vgFTSKSPIPKYEPSVEGY 702 Desulfitobacterium hafniense DCB-2
ZP_00329589 684 kd------kgWTQIRPIPTYNPPREGY 704 Moorella thermoacetica ATCC 39073
YP_074542   685 kg------ygFTEIDPIPTYQPRKEGY 705 Symbiobacterium thermophilum IAM 14863

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