Conserved Protein Domain Family
R3H_NF-X1

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cd02643: R3H_NF-X1 
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system and, the yeast homolog FAP1 encodes a dosage suppressor of rapamycin toxicity. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Statistics
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PSSM-Id: 100072
View PSSM: cd02643
Aligned: 11 rows
Threshold Bit Score: 114.377
Threshold Setting Gi: 17552206
Created: 28-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
RxxxH motif
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                       #   #                         
CAG10245      857 KDDARKDLKFVAEVEEEMKNLVELtnkg--kqpkRSHCFPPmNREHRKMVHELAEAYaLESVSYDsePKRNVVITA 930  Tetraodon nigrovi...
Q12986        971 KEDARKDLKFVSDVEKEMETLVEAvnkg--knskKSHSFPPmNRDHRRIIHDLAQVYgLESVSYDsePKRNVVVTA 1044 human
XP_418890    1081 KEDARKDLKFVSDVEKEMRMLVEAvnkg--kytkKSHCYPPmNRDHRRIIHELAQVYgIESVSYDnePKRNVVITA 1154 chicken
XP_787841     865 KDMYRKSPPFVADVEKDFANLISSvntes-qqptQIYTFPPmARDQRAFVHEMANLYcLSSDSTGqeTTRHVIITA 939  purple urchin
XP_970597     818 RNWAKKDPQFCQKVHEKLTELVQLakqs--kqksRSYSFESmNRDKRHFVHEYCEHFgCESAAYDaePNRNIVATA 891  red flour beetle
P40798        996 RGFAKKNPALTKSVYETLTDLVKLakes--kqrsRSHSFPTmNREKRQLVHELCEVFgIESVSYDkePNRNVVATA 1069 fruit fly
NP_001071774  890 MNMAKTDLAFIRTVEKDLINLVESvswl--dttkQSHPFPSmKRDKRQAVHELAEAFqCKSESLDeePNRNVVATA 963  Ciona intestinalis
EDP30406      852 KNKLKTNYKDILDVEDTLIELLHDlnaqp-nvtsVSHSFPPmHSELRRIIHEYSEHFgIETVSYGqePQRNVVATA 926  agent of lymphati...
XP_001637933  899 LAEAKFNFPFIKSIEEVFYGLIESttkg--sltqKSHAFNPmNSHQRRIIHELASHYnLCSRSYDqePKRNTVVTA 972  starlet sea anemone
EDS44970      882 RTYAKKDPALIKMIHDRLSELVKLakesk-hqksRSFSFPVmNREKRHVVHEMCGMFgIESVAYDaePNRNVVATA 956  southern house mo...
NP_498394     860 KEMVRTNIDFVKSVEKILIDLVIQilsgeayhdtFRAHLPAmSIEKRRFVHEYANFFnIASESVDspPKRSIVLTA 935  nematode

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