1MSZ


Conserved Protein Domain Family
R3H_Smubp-2_like
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cd02641: R3H_Smubp-2_like 
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R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.
Links
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Statistics
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PSSM-Id: 100070
Aligned: 9 rows
Threshold Bit Score: 85.0962
Created: 2-May-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RxxxH motifputative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #   #                         
1MSZ_A         18 VDHFRAMIVEFMASKk-MQLEFPPsLNSHDRLRVHQIAEEHGLRHDSSGEGKRRFITVSK 76   human
AAS38931      776 RLQLESIVNTFMKTSm-ESHSFPStLSSFERLVVHELAEKNKLNHQSVGEGENRVITISK 834  Dictyostelium discoideum
CAG08762      472 YSEIKKQVELFLKDGdrTELQFPPfFNSHDRLLVHQVAEELGLTHESKGEGRDRRITVSR 531  Tetraodon nigroviridis
CAG32761      379 TNKFKAVLEAFLEGDe-PQLDFPSsLSPHDRMLIHLLAEEHGLQHVSTGEGRDRYISVRK 437  chicken
NP_001038365  719 RKEIKEQLLNFLKDPdkTELEFPStLNSHDRLLVHELSEEIGLRHESQGEGKSRHITVSR 778  zebrafish
XP_001117732  726 VDHFRATIAEFMASDk-TQLEFPPsLNSHDRLRVHQIAEELGVRSAQGQPASKEQQASGQ 784  rhesus monkey
XP_001684537   96 VRHYHRLLLAFIEDKskYELELPN-LSSLDRMVVHALAEKCNLSHESTGDRADRVMHLKK 154  Leishmania major strain Friedlin
XP_816495     137 KKNLYAMVKAFVDDPnaEEMSFPPtLSAAERHMVHEIALNFNLHHRSAGCKSERVLTLKK 196  Trypanosoma cruzi strain CL Brener
AAX80478      131 KKHLQSMVKAFVDDPtaHELSFPPtLSAAGRQQVHKFAHTFGLFHKSSGSQNERFLTLRK 190  Trypanosoma brucei

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