1UG8


Conserved Protein Domain Family
R3H_PARN
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cd02637: R3H_PARN 
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R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.
Links
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Statistics
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PSSM-Id: 100066
Aligned: 15 rows
Threshold Bit Score: 56.1787
Created: 28-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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degenerate
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:degenerate RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name. In this sub-family, a RxxxY motif is more typical
  • Citation:PMID 9787637
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #   #                                    
1UG8_A         13 IDQVIEKIEDFLQSee-kRSLELDPCTGFQRKLIYQTLSWK-YPKG--IHVETL-ETDKKERHIVISKVDE 78   house mouse
XP_392167     166 IEEICSRIDEFVTSe--tEELLIEKCNAFIRRLVYQEVKLR-WPNK--LKVESK-MNNFGCILVVQRLGTK 230  honey bee
XP_001622538  186 VSGACSKIEEMVKDpd-gKRTSLPPCNGYLRKLIYQTVKHR-FRSG--IHLEKN-MNEKKECFIVATKVDD 251  starlet sea anemone
EDS26303      143 MAEIEERIGVFLASe--eKDFTITNCNGFQRKLVYQMIEAK-FRKQ--ISTSSV-ELENKHKGILVERKRT 207  southern house mosquito
Q7ZU92        180 IRSVEEKVEALLKNt--dQTLDLEPCTGFQRKLIYQTLNSK-YSKG--LHVEAL-ETEKKERFIQISKVDD 244  zebrafish
XP_001607788  166 IDEICSGIEDYVNSeddgKELRIERCNAFIRRLVHQEARLR-WPNK--IRLETR-NENGNQFIIVSKIGTK 232  jewel wasp
XP_001454910  166 IRELIDKLEKFNKSd--eKQITIETTNGYQRKVIYTYLEAY-QKNM--IGESLLkGEMKITKLTNAEKQAK 231  Paramecium tetraurelia...
XP_967921     173 VDDFMKRLSDFLESd--dDELELPKCNAFVRRLIYQTTGQK-FTNK--IVLHTK-QNKNKDRILVASKCKT 237  red flour beetle
XP_001324087  572 MDKVDEKLLEFAESv--eQDLECIGITAIEDKLQEGVPETIeWLRRagIHVWVL-TGDKLETAIEIGKTSK 639  Trichomonas vaginalis G3
XP_785661     228 IDDVSKRVGAFAAGt--aDELKLEPCTGYPSGLHLDTHTTE-DKKGrfIVVRRV-TEEEKKKLAQDKLQAE 294  purple urchin

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