1Z2Z


Conserved Protein Domain Family
PSTD1
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cd02577: PSTD1 
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Pseudouridine synthase, a subgroup of the TruD family.
This group consists of several hypothetical archeal pseudouridine synthases assigned to the TruD family of psuedouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). The TruD family is comprised of proteins related to Escherichia coli TruD.
Links
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Statistics
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PSSM-Id: 211342
Aligned: 17 rows
Threshold Bit Score: 330.443
Created: 8-Apr-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                ####   
1Z2Z_B       24 GQLRQEIEDFIVKEITnree--------------geeGKYLIVELTKRDWDTHhltRTLSRILQVSQKRISVAGTKDKRA 89  Methanosarcina m...
O59207       20 GKIKVYPEDFIVKEVIpksi--------------frgGRCRIYLLKKKNWETMaaiKEIAKRIGIHYSEIGFAGTKDRHA 85  Pyrococcus horik...
Q58008       16 GIIKKYPEDFIVEEITpegiilevgksiefkdeenwkGNYIHFTLEKRNWTTLdaiREIANRVGKQRKHFGFAGNKDKYA 95  Methanocaldococc...
Q8TXJ7       16 GECPECREYHRGRECPecgqdlrrp---rlrpqfggrGPHTLFYLEKYDWDTMkavRRIAQALRKHHRHFGIAGMKDKRA 92  Methanopyrus kan...
O67616        3 IRIKEKPEEFYVKEIKkldl--------------kekGQYAYFLLKKKDMTTLdavRHISHRFGIPLKNIGFAGLKDKKA 68  Aquifex aeolicus
ZP_00575956   1 MKLKVIPEDFVVRELArlpi--------------rekGPYRLYLFEKKGWNTIdllIRLAKAHRLPYRLFAYGGLKDRHA 66  Moorella thermoa...
Q9HSG5       25 GRLRDSPADFRVRELEafdtqpa--------daptgdYPWLVVRATLHEWDTNdfaRELANTVGMSRERVRWAGTKDRHA 96  Halobacterium sa...
Q6LZL0       17 GTLKKYPEDFIVEEITpegtvlevgkeigfedvekwhGSFIHFTVEKTNWNTMdalKQIVRATKTKRKNFGFAGTKDKFA 96  Methanococcus ma...
YP_074793     1 MRLKTTPEDFVVREAVdlhi-------------rqkpARYRVYLLEKKGWNTAdavAAIARARRLPPGRIQYGGKKDRHA 67  Symbiobacterium ...
Q58759       27 MKLRMKPEDFIVEEIIdfnk--------------iagDRCYLYKLTKRNIESLkafSYIAKKFKIPLKDIGYCGLKDRHA 92  Methanocaldococc...

Feature 1                                                                                       
1Z2Z_B       90 LTTQKISIfdtdase---iekihlkDIELKVLGRSRKSVELGDLWGNDFRITVRnienspeeteallkkttdeilaqgGV 166 Methanosarcina m...
O59207       86 VTYQYISIcrevdl------envaiKDVTLRFVGYGRPLKLGLLLGNFFKIRVRdttpellpn------ilkeakekgGF 153 Pyrococcus horik...
Q58008       96 VTTQRVGCfnvkled---lmkvkikGIILRDFQKTNRKIRLGDLWGNRFTIRVRepelkgkele----ealnklcklkYF 168 Methanocaldococc...
Q8TXJ7       93 VTSQRVTVrgvppgv---larlrirDLKIVPMGRARRKLRPGDLWGNRFVITVRgakvrrlpe------alrtvrelgGV 163 Methanopyrus kan...
O67616       69 VTEQYISVkdlneekirkmdgyrteNLELKFLGFSDKGLELGEIEGNYFEVVVRgvtkyhrrvf----prmkelvenyGC 144 Aquifex aeolicus
ZP_00575956  67 HTFQYVTVkhpadl------tteaeNFSLQSIGYMDRPMGPDLLEGNEFAITIRalgaaevcri----srrvdevrgfGY 136 Moorella thermoa...
Q9HSG5       97 VTTQLFAVrdldaa-----qvpeirNADIEVVGRAGRGLEFGDLAGNAFEIVVRdpdaperaaava-delaafgggtvGT 170 Halobacterium sa...
Q6LZL0       97 VTTQRFGCfglkkeq---leninikDIVIRDVQKTNKKLRMGGLWGNKFTIKIRdlnlsekei------krisdlkldYV 167 Methanococcus ma...
YP_074793    68 HTFQYVTIdhpadh------slstpYYRLKAVGYATEPMAPGRVLANHFEVTVRelrpeeaarl----vdgvrrvaaaGF 137 Symbiobacterium ...
Q58759       93 LTTQYISIpkkygk------lsldePNLKLELIGESKFLLLGDLEGNRFTITVRglkkedipki-----kenlkylefGA 161 Methanocaldococc...

Feature 1                                                                                       
1Z2Z_B      167 PNFFGIQRFGSvrpvTHLVGKAIVEGNFEKAAllyi--------------aepfPEEPEETKNARQFVKDTLDFKEGLkt 232 Methanosarcina m...
O59207      154 PNYFGIQRFGEkrsvNHIVGKLLLLGKYEEAAevflgypgng---megdearkkFLETKNVDLALEEFPKFLRYERAMly 230 Pyrococcus horik...
Q58008      169 LNYYGVQRFGTtrpiTHIVGRFIIERDWEGAFhaycgtplpy--ddkksklareLVDEENFKEAYKKFPKAFFYERRMik 246 Methanocaldococc...
Q8TXJ7      164 PNYYGLQRFGSrrpvTHVVGKYVVLEDWEKAVktfltleyprespealearrwlKEHWGEFKEALRRFPKFLDYERHIle 243 Methanopyrus kan...
O67616      145 ENYFGEQRFGSvkhaEEFIVKYLLRHEYEEAMke-------------------yLTSLGDKRLKRLLRKAWRDWDRFLsl 205 Aquifex aeolicus
ZP_00575956 137 PNYYDNQRFGSmdrqMGLMAERLLKKHYNGSLqiylt-------------giypEEKKEARERKLFFREHWGDWSTCLar 203 Moorella thermoa...
Q9HSG5      171 PNYFGQQRFGSkrpvTHEVGLAILRDDWEAAAmaylgaptehe-padsqrareyVAETRDWTGALAEFPQRLRYERTMlh 249 Halobacterium sa...
Q6LZL0      168 LNYYGIQRFGLirpiTHIVGKFIYERDFESAFytycgtpine---tgdslearqLVDMGEFKKALKLFNRGHDYEKRLiq 244 Methanococcus ma...
YP_074793   138 PNYFDDQRFGSfdprRGFIAEQMAQGRWEQALqialt-------------hvypGEKSRAKARKRRLLEAWGDWATCLdl 204 Symbiobacterium ...
Q58759      162 PNYFDSQRFGSvf-dKKFIAKEVIKGNYEEAVkillt-------------kykkSEKKLIKDLKRFIDKNWGDWDKIWey 227 Methanocaldococc...

Feature 1                                                                                       
1Z2Z_B      233 yplrlgh--eraxxnhlIANPEDYSGSFRVLPQNLy-RXFVHGYQSYIYNIILCRRIeagip----------------ln 293 Methanosarcina m...
O59207      231 ----------------kYRETGSWKRSFLALPRPIl-RIFIHAFQSYLFNLYISRRIeegfp----------------ln 277 Pyrococcus horik...
Q58008      247 ----------------aYIETGSYQKAFMILPPYLr-CMFINAYQSYLFNEIINRRFeyg-------------------f 290 Methanocaldococc...
Q8TXJ7      244 ---------------hlARHPHDYINAFRRLPMWIr-RMFVHAYQSYLFNRILSERIarglp----------------vh 291 Methanopyrus kan...
O67616      206 mpkgak---pelevvkaLRRGESFKNAFMVLPKNIr-LMFVFAYQSYLWNRYLYTFVvrylkycktpflkwelaffndms 281 Aquifex aeolicus
ZP_00575956 204 akttme----srifsllVEKPKAYIEALQMIPREEl-SLLFSAYQSFLFNELLRRILqefgl----------------dl 262 Moorella thermoa...
Q9HSG5      250 ----------------eLADGGSFRDAVETFPSNLq-QLFVHAAQSYVFNRIVSERMarglp----------------fg 296 Halobacterium sa...
Q6LZL0      245 ----------------qYLKYKDFKMAFTALPPQLn-SMFVNAYQAYLFNEMINKRFdyg-------------------f 288 Methanococcus ma...
YP_074793   205 aetaf-----errcfalLAEQPGGFRAALATARREeqEMWLSAWQAFLWNEVLRRLVaa--------------------- 258 Symbiobacterium ...
Q58759      228 ikenniksrlyvnmvkeLKKSNDYKKALSYVDDRLk-KIFVAAYQSYLWNECVKELLrkyvpee-----------drvyy 295 Methanocaldococc...

Feature 1                                                                                       
1Z2Z_B      294 raVEGDIVcfrnevglpdssktekvtsetvnaxnrllklgrafitaplpgyntefasgipgeiengvlkelgvslegfni 373 Methanosarcina m...
O59207      278 eaLPGDIVvqvkkgiplrdrtyrvtesnldfvnekimqgeamvsgpifg----ysyrrshgipgrledeileeagvslen 353 Pyrococcus horik...
Q58008      291 epMEGDILidnvpsgalfgykt---------------------------------------------------------r 313 Methanocaldococc...
Q8TXJ7      292 rpVEGDVTqdglptvplpgfrtelsdgpqgei--------------------------------------erevleeegv 333 Methanopyrus kan...
O67616      282 evIWEEIKdleipylgveykprnkkaeivmkev------------------------------------lqdegitpkml 325 Aquifex aeolicus
ZP_00575956 263 taVPGTAGpylfyrrlerkelgylralslplaasrmefpda-------------------mserlfaaileergikrssf 323 Moorella thermoa...
Q9HSG5      297 epVAGDVVwfadsdadaavaqpdaarqqrvtdsrvdvmarhce---------------rgrafvtaplvgtdtefadgdp 361 Halobacterium sa...
Q6LZL0      289 deLEGDILedntptgtligydtkfsggiqgeie-----------------------------------keiverenldlk 333 Methanococcus ma...
YP_074793   259 -aAGGDEPpaeaagvagpyrfarstpelqqmviplpgrgmrfs---------------dpragliledvlrerrlrpaql 322 Symbiobacterium ...
Q58759      296 eyECGTLMfykkmdeevfnilkdkkfptiapdieysgee------------------------keiieeilkregltmee 351 Methanocaldococc...

Feature 1                                                                          #       
1Z2Z_B      374 ekfpexsskgtrrEVLLEVKPKFEAGEDelnp------------------gkskAVLEFXLPKGSYATTVLREYX 430 Methanosarcina mazei
O59207      354 fkrlpkpmrepggRRELLIKPRGFRYKTeg----------------------rdVLFKFFLPKGVYATSVLREII 406 Pyrococcus horikoshii
Q58008      314 fasgiqgeiereiYERENLSPEDFKIGEfgsfigdrramigkiynmkywieddsYVLQFCLKKGNYATSVLREFI 388 Methanocaldococcus ja...
Q8TXJ7      334 rledfeiksmpelSAGGDRKPALLRVYGlraea----------------igddtVRFTFSLPRGGYATTVLRELL 392 Methanopyrus kandleri
O67616      326 maerigiklfsdgVRKAFFKPQGLKVIEerk---------------------nsLKLSFTLPPGSYATILLRKLF 379 Aquifex aeolicus
ZP_00575956 324 nlrkvrqaffkstPREAIVFPGNFRIQPaepddl--------------ypgrqkIRLFFKLPRGSYGTMLIKRLT 384 Moorella thermoacetic...
Q9HSG5      362 geitrgvlddlglSRADFDLPGEFDSAGsrraillrp---------dltvshdpLAFEFALPSGSYATVVLREFL 427 Halobacterium salinarum
Q6LZL0      334 kfkiedfgnfygtRRKMVTPIYDFKSRFen----------------------eiFELSFKLERGNYATIVTREFT 386 Methanococcus maripal...
YP_074793   323 eaellpglwlrssPREAWVMPRSVRVDPpqpder--------------ypgferVSLRFTLPRGAYATMLIKAAA 383 Symbiobacterium therm...
Q58759      352 lnnigelgkfiysERKILSIPKNLKIGEfeedel--------------nkgkykITLSYELEKGSYATIIIKRAF 412 Methanocaldococcus ja...

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