1K8W,1R3E,1SGV


Conserved Protein Domain Family
PseudoU_synth_EcTruB
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cd02573: PseudoU_synth_EcTruB 
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Pseudouridine synthase, Escherichia coli TruB like.
This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). E. coli TruB and M. tuberculosis TruB make psi55 in the T loop of tRNAs. Psi55 is nearly universally conserved. E. coli TruB is not inhibited by RNA containing 5-fluorouridine.
Links
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Statistics
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PSSM-Id: 211339
Aligned: 105 rows
Threshold Bit Score: 248.898
Created: 9-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteRNA binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:1K8W_A, PDB D48 is key conserved residue
  • Structure:1k8w_a, active site residues of E. coli TruB
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     ####                                            
1K8W_A     26 GVLLLDKPQGMSSNDALQKVKRIYNAnRAGHTGALDPLATGMLPICLGEATKFSQYLLdSDKRYRVIARLGQRTDTSDAD 105 Escherichia coli
Q8R5X8      3 GIIVINKPKGITSFDVIRKLKKFLKTkKIGHTGTLDPLAIGVMLVCVGKATKLASDLEaKDKVYIADFDIGYATDTYDIE 82  Fusobacterium nucl...
Q6F1I4      5 GIIILNKPKGLTTNHLIQKLKRKLNVkKIGHAGTLDPLATGVVICLINNGTKLSDYFLnENKAYEVTMKLFQATDTYDSD 84  Mesoplasma florum
Q6MTR0      5 GIFILNKPSNISTYQLINQVKKKLNIkKVGHCGTLDLLATGVVICLVNNATKISDYLLnANKAYQVKIKLFTLTDSFDAE 84  Mycoplasma mycoide...
O51743      4 GFLLINKEQGKTSFETLFPIKKYFNTnRVGHAGTLDKFASGILVCLVGKYTKLSGYFTsLDKEYVAEFRFGLETDTLDPN 83  Lyme disease spiro...
Q6YQY6      3 GFFLVNKPEKMTSHDVVFQIKKKFHFdKVGHTGTLDPLASGLLIICVGKATKLAFLFDkLPKTYQGTFLFNKHYDTLDVT 82  Onion yellows phyt...
Q6KHH8      3 MILLLRKTKNISSFNFINNFKKTKGFkKIGHCGTLDPLATGLLIVATDEDTKLIDYLDqKDKTYVARAKLGFETTTYDSE 82  Mycoplasma mobile
Q601U7     48 MITFLYKPKKISSAKFLRQWSKTNLIkKAGHAGTLDPLASGLLLVATEDDTKLLQYLDqKTKTYLAKIQFGFWSTTYDAE 127 Mycoplasma hyopneu...
Q7M9J1     21 ALFVGYKPMFMSSNHYLQRLKRRFGVkKAGYSGTLDPFAKGVLVVAFGHYTRLFDHLNqEPKVYRATLWLGLHSDSLDIE 100 Wolinella succinog...
Q98Q19      1 MFYLIYKEKGISSFKAIKDFAWQNNIkKIGHSGTLDPEATGLLLLASDEDTKLLDYVDkKFKSYRATMILGLQSQSFDSQ 80  Mycoplasma pulmonis

Feature 1                                                                                     
1K8W_A    106 GQIVeer--pvtFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEg--nEL 181 Escherichia coli
Q8R5X8     83 GKKIaen--iieVSKENLEQSLKKFIGNIKQVPPMYSAIKIDGNKLYHLARKGIEVERPERDITIEYINLLDFKd--nKA 158 Fusobacterium nucl...
Q6F1I4     85 GSIIeeqepfkiEQEQVEKVIAKFNGLAYEQEPPMYSAIKIDGKKLYEYARENQVVKVNKRLIKINSLSLDKYEn--nEI 162 Mesoplasma florum
Q6MTR0     85 GNIIqtqtpfniSLDQINKVISKYNNYTYNQYPPIYSSIKVDGKKLYEYALTNQNVEIKSRKVTIYKTSLLSYDqknyEI 164 Mycoplasma mycoide...
O51743     84 GRIVskt--dyiPNVEDIDLKLKDFVGEIYQSPPRFSSVHIDGSRAYKLALNGKFFEIKKRKVTVYNIQRLSYDfsssLL 161 Lyme disease spiro...
Q6YQY6     83 GKLLdtkn-tplTDCNIQKSFASFHQKKYLQIPPMFSAVKIKGKKMYRLARKNQVVDIPPREVFIHHFEKTSLFcr-dQV 160 Onion yellows phyt...
Q6KHH8     83 GEIInqss-nvkFTKEKLIEVLNSFIGLTKQMPPKYSAKKLNGIRAYDLARQNIDFELNEVEINITKIKLLSYNedenYF 161 Mycoplasma mobile
Q601U7    128 GQIYgveq-pikVTKDNLEQALNRLSESQKQVPPVFSSKKVSGKSAYHYARQGKQIELKPISIKISKTILINFDeklqNC 206 Mycoplasma hyopneu...
Q7M9J1    101 NILGvev--ippYSKERVEEIMGALEGEISYTPPKYCAKRIGGRRAYDMARNKEEVELPILTMRVGRLSLLHYTh--pFV 176 Wolinella succinog...
Q98Q19     81 GKIInss--nlkVDNLTIEKTIKNFVGPFVQIPPIFSAKKINGKRAYEYARQGSEISMKAQEVFVKSIEIEKIDf--pKV 156 Mycoplasma pulmonis

Feature 1                 #                                            
1K8W_A    182 ELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYp---VERMVTLEHLREL 235 Escherichia coli
Q8R5X8    159 KIETKVSKGCYIRSLIYDIGQDLGTYATMTALQRKQVGEYs---LENSYSLEQIEEM 212 Fusobacterium nucleatum subsp. nucleatum
Q6F1I4    163 SMTVYCSKGTYIRSLIVDIAKELNTIAHVTSLNRIESGNFi---IKNSVNIENCEES 216 Mesoplasma florum
Q6MTR0    165 FLDVKCSKGTYIRSLAVDICKDLNTIGYVVYLNRTLSGNFk---LENAIDLNNISWD 218 Mycoplasma mycoides subsp. mycoides SC
O51743    162 SLKISCSKGTYIRSIARDLAYSLNSCAYVSNLKRTKVGMFr---LKDSTLCENLSKA 215 Lyme disease spirochete
Q6YQY6    161 DFLAHVSKGTYIRSLARDLALQLNTYGALLRLQRTAIGTHl---LQNAKTIENLELN 214 Onion yellows phytoplasma
Q6KHH8    162 DFEVVVSRGTYIRSLIYDIGIKLNSLAYMESLERTKIGNL----FLEKNQDDKILNA 214 Mycoplasma mobile
Q601U7    207 VIMWQVSRGCYIRSLADDLGKMLKTRAYLSDLERTKIGNFdkkfLNQSLKPQDLFDL 263 Mycoplasma hyopneumoniae
Q7M9J1    177 HFEAEVSKGSYIRSLGGMIASRLGCYGALSSLERLSEGEMr---FEGYRELEPLEIL 230 Wolinella succinogenes
Q98Q19    157 IFKAKVSRGTYIRSLINQIGLELKTYALMDDLERIELSGLs---KNDLGVVSDLDII 210 Mycoplasma pulmonis

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