Conserved Protein Domain Family
PseudoU_synth_RluE
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cd02566: PseudoU_synth_RluE 
Pseudouridine synthase, Escherichia coli RluE.
This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Links
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Statistics
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PSSM-Id: 211334
Aligned: 8 rows
Threshold Bit Score: 278.111
Created: 18-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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probable active
Feature 1:probable active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              ####                                     
BAB72503      7 YIIFHKPYGVLSQFtqe-spkHITLkdyidv--pdvypVGRLDWDSEGLLLLTnnGRLQHRLSDPRf---------gHER 74  Nostoc sp. PCC 7120
YP_045888     3 IVVFNKPYDVLSQFred--saHLTVssfiad--pelriAGRLDLDSEGLMFLTdhGGLNQYITHPSn---------kKYK 69  Acinetobacter sp...
EAO11335      6 LILFNKPYGVQSQFrdesnndHTTLseyftd--kslriAGRLDATSEGLLILTsdGRINKAITQPPsakgfaqnkqkQGK 83  Psychrobacter cr...
ZP_00063961   2 IVLFNKPYNVLTKFtda--egRPTLadyidi--prvyaAGRLDMDSEGLLLLTdsGKLNHELTDPDn---------kAYK 68  Leuconostoc mese...
AAF41852      4 LIAFNKPYGVICQFsph--ekHKSLkdfinl--pgfypAGRLDTDSEGLLLLTddGRLQAQITDPKf---------kHPK 70  Neisseria mening...
ZP_00268915   4 LILLNKPYDVLSQFtdr-aegRATLaslvpi--pgvyvCGRLDRDSEGLLLLTdnGPLQHHISHPRs---------kVPK 71  Rhodospirillum r...
P75966       41 VILFNKPYDVLPQFtde--agRKTLkefipv--qgvyaAGRLDRDSEGLLVLTnnGALQARLTQPGk---------rTGK 107 Escherichia coli
AAZ24368     21 HFKIFKPYGFLSQFvpe-srkKKHLlgelfnfpdktmaIGRLDHDSEGLLLLTtdGMMSYKVRDKS-----------IVK 88  Colwellia psychr...

Feature 1                                                                                    #  
BAB72503     75 TYWVQVERIPDeeaISKLQTGVEIrdyrtr----pakvglLPEYPPVGDRQPPIRFRKNVPTAWLEMTLTEGKNRQVRRM 150 Nostoc sp. PCC 7120
YP_045888    70 TYLVQVDGDITedaLEKLRKGVELadgltl----paqatkVEEPEWLWERNPPVRFRASIPTSWVEISICEGRNRQVRRM 145 Acinetobacter sp...
EAO11335     84 TYLVQVEGMVTsvqLKALASGVVLkdgktlpa-savlvdeVDLPITLWEREPPIRERKNIPTSWLMLTIYEGKNRQVRRM 162 Psychrobacter cr...
ZP_00063961  69 TYVVQVEGVPTksqLKQLEQGVALkdgltl----pakvkrIPYPKWLWEREKPIRIRKNQPTSFIQLKIKEGRNRQVRRM 144 Leuconostoc mese...
AAF41852     71 TYWAQLEGVPDesrLESLRKGIDLggfvtrp--asirilkHGEADSLWERIPPIRVRKTVPDFWIEITISEGKNRQVRRM 148 Neisseria mening...
ZP_00268915  72 TYRAQVEGVADkaaLDRLRQGVTLrdgpar----avtveaIDEPAGLWPRDPPIRWRANIPTSWIELTIDEGRNRMVRRM 147 Rhodospirillum r...
P75966      108 IYYVQVEGIPTqdaLEALRNGVTLndgptl----pagaelVDEPAWLWPRNPPIRERKSIPTSWLKITLYEGRNRQVRRM 183 Escherichia coli
AAZ24368     89 EYYVQVDGEITtdaISQLQNGVEIginstkyltmpckafkLDCEPQLPARGRKIRDPKHGPTSWISITLCEGKNRQIRKM 168 Colwellia psychr...

Feature 1                               
BAB72503    151 TAAVGFPTLRLVRVSIGHLRLDGL 174 Nostoc sp. PCC 7120
YP_045888   146 TATVGFPTLRLIRTQIGSINLVKL 169 Acinetobacter sp. ADP1
EAO11335    163 TAHVGLPCLRLIRWSVAGFELGEL 186 Psychrobacter cryohalolentis K5
ZP_00063961 145 TAAVGIPTLRLIRTHIGEYHIADL 168 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
AAF41852    149 TAKAGYPCLRLIRVASGRLKLFDL 172 Neisseria meningitidis MC58
ZP_00268915 148 TAAVGLPTLRLIRWSIGDWTLENL 171 Rhodospirillum rubrum
P75966      184 TAHVGFPTLRLIRYAMGDYSLDNL 207 Escherichia coli
AAZ24368    169 TAAVGFATLRLVRVRIGNIGIDNL 192 Colwellia psychrerythraea 34H

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