Conserved Protein Domain Family
PseudoU_synth_RluB
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cd02556: PseudoU_synth_RluB 
Pseudouridine synthase, Escherichia coli RluB like.
This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluB makes psi2605 in 23S RNA. psi2605 has been detected in eubacteria but, not in eukarya and archea despite the presence of a precursor U at that site.
Links
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Statistics
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PSSM-Id: 211330
Aligned: 11 rows
Threshold Bit Score: 236.436
Created: 14-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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probable active
Feature 1:probable active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 ####                                  
P37765       68 RVLAYYKPEGELCTrnDPEGRPTVFDRLpkl---rgaRWIAVGRLDVNTCGLLLFTTDGELANRLMHPSreVEREYAVRV 144 Escherichia coli
AAL88719    198 IWMHFKNPQVLTSEy-DPDGRDCLLPIIrkvi--gidHLISVGRLDYYTEGLILFTNDGELARYLTLPQnlFFRVYKVRI 274 Dictyostelium di...
Q9ZD06       62 RLWIYYKPVGLITThkDPLSRKTVFEQLig-----lpRVISIGRLDLNSEGLLLLTNSGDLAHQFEMPAskLKRVYNVRA 136 Rickettsia prowa...
ZP_00304167  89 RLFRFHKPSGLITAerDPTGRPTIYTALrnalpqgtpRVMPVGRLDVNTEGLLLMTNDGELKRALELPStgIPRTYRART 168 Novosphingobium ...
EAN28797    131 TAIILHKPKSIICTrsDPQGRRTIFDLIenh---gssRLITVGRLDINSEGLIILTSDGQLAHGLMHPSreVPRVYRVKT 207 Magnetococcus sp...
AAK22217     95 RIFRYHKPTGLMTThnDPKGRPTVFGALpkd----lpRLISVGRLDLNSEGLLLLTNDGELSRALETPSnaWVRRYRARA 170 Caulobacter cres...
P57369       67 KIIIYNKPEGEICTrnDYKKRPIVFDKLpll---nihRWISIGRLDINTRGLLLFTNNGNLANELMHPSnkIEREYYIRV 143 Buchnera aphidic...
YP_160531   117 RVLIYHKPEGEIVSreDPEGRPTVFERLpil---rkgRWIAVGRLDFNTSGLLLFTNDGTLANRLMHPRyeLEREYAVRL 193 Azoarcus sp. EbN1
AAR37917     66 KVLILNKQAGFICStkDPEGRKSVFDLLpe-----nsRWIMIGRLDLNSSGLLLFTNNGELASKLMHPSaqIDREYAVRV 140 uncultured bacte...
Q89AL1       68 KVLLYNKPEGEICTrkDQRNRRTIFEKLpkl---snaRWINIGRLDLNSSGLLLFTTDGELAYRLTHPSfnIERIYKVRV 144 Buchnera aphidic...
YP_095476    67 RVLLYHKPVGEVSSrhDPKFEKTVFDNLphl---rqgRWVQVGRLDLNTSGLLIFTNNGELANQLMHPKygLEREYAVRV 143 Legionella pneum...

Feature 1                                                                    #                  
P37765      145 FGQVdd---aKLRDLSr-GVQLEDgpAAFKTIKFSGgeg-----inqWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRY 215 Escherichia coli
AAL88719    275 FGKFtd---eMKFSLAk-GMVINEvfYRPVSVQVESetd-----sntWLRITLQEGKKREIRTLLEYFNVKVLRLIRVAY 345 Dictyostelium di...
Q9ZD06      137 YGNPnillknNYKNLKidGIFYNPh-SIKLLRQNKSn---------sWFEVVLFEGKNREIRRIFEYFGLQVNKLIRIQY 206 Rickettsia prowa...
ZP_00304167 169 FGDIsq---aRLEELMe-GIEIDGvrYGSINANLERsag-----rnkWIELTLTEGKNREVRRVLEHLGLQVSRLLRTKY 239 Novosphingobium ...
EAN28797    208 HGILla---sQLEQIRtvGVRLEDgpTGPLEIVLDRgreq---gnnsWYTITLREGRNREVRRIFDHFGLQVARLLRVGY 281 Magnetococcus sp...
AAK22217    171 FGDTtq---aKLDKLKd-GVTIEGvtYGAIEAKLDKahekagggknvWITVSLSEGKNREVRKVLESIGLKVNRLIRLSY 246 Caulobacter cres...
P57369      144 FGKInk---nTMNILKn-GVKIKDgnAAFKSIQTIDhacs---kknkWFKGVLCEGRNREIRSMWQAVQCQVSRLIRIRY 216 Buchnera aphidic...
YP_160531   194 LGQLdd---eQLESLKt-GIQLEDglARFTSISDEGgeg-----anhWYRVTLSEGRNREVRRMFEAVGLTVSRLMRVRY 264 Azoarcus sp. EbN1
AAR37917    141 LGKVke---eHIKKLTn-GVELEDgfAKFHKVTQGGgeg-----anrWYRVVIREGRKREVRRLWEFLDFKVSRLIRIRF 211 uncultured bacte...
Q89AL1      145 FGQFte---nILKQLNv-RVKLLDgyANFKSIQFKYgeg-----knkWFNVSLCEGRHRIVRRIWEKLGFQVNKLVRISY 215 Buchnera aphidic...
YP_095476   144 HGQVsq---eSLNNLLk-GVMLDDglAKFTKIQFRGgeg-----tnsWYHVTLNEGRNREVRRLWESQGVEVSRLIRIRY 214 Legionella pneum...

Feature 1                          
P37765      216 GdIPLPKGLPRGGWTELDL 234 Escherichia coli
AAL88719    346 GpYVLPNSLKHGETIEVPI 364 Dictyostelium discoideum
Q9ZD06      207 G-ALKIGNLKPGNYQEISN 224 Rickettsia prowazekii
ZP_00304167 240 G-PFELADLPRGAAEEIPQ 257 Novosphingobium aromaticivorans DSM 12444
EAN28797    282 G-GISLGNLEPGAWRPVTV 299 Magnetococcus sp. MC-1
AAK22217    247 G-PFALGTLAAGQIEEVGP 264 Caulobacter crescentus CB15
P57369      217 GnIFLPKNLKLGDWSELSS 235 Buchnera aphidicola (Acyrthosiphon pisum)
YP_160531   265 GpVTLSSRLKRGMWMEMPE 283 Azoarcus sp. EbN1
AAR37917    212 GdICLPDKLRSNQSEYLKP 230 uncultured bacterium 560
Q89AL1      216 AhLTLPKTLFPGTWITLNK 234 Buchnera aphidicola (Baizongia pistaciae)
YP_095476   215 GmLTMPRFLSRGQFYELTP 233 Legionella pneumophila subsp. pneumophila str. Philadelphia 1

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