Conserved Protein Domain Family
PSSA_1
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cd02555: PSSA_1 
Pseudouridine synthase, a subgroup of the RsuA family.
This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. The TruA family is comprised of proteins related to Escherichia coli RsuA.
Links
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Statistics
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PSSM-Id: 211329
Aligned: 8 rows
Threshold Bit Score: 219.199
Created: 21-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                            ####       
NP_638299    60 QAEPATLLLNKPAGMSCeaaval----------atpqsrSSLDQTEIRVLKRHFL---------RLSAPMPLDDEASGLL 120 Xanthomonas camp...
ZP_00138698  60 TIEPATLLLHKPAGWRHddfegl----------laagrrWSDDPSPLRALKKHFA---------RQRPTLALDSEASGLV 120 Pseudomonas aeru...
AAN66815     60 TLEPVTLLLNQPAGMDSedaras----------mnmgslSEAHREGVRALHGHFA---------RQACVAPLERGASGLQ 120 Pseudomonas puti...
ZP_00503382  59 ALAPVTLLLHKPAGHEAgldapagrgvpsaaellvaanqSPDDRSGIRPLKKHFS---------AAELVTPLATAASGLV 129 Polaromonas sp. ...
NP_793783    60 SPESVTIILHKPASASAesalqm----------itpgtlSAEHSYSKRPLKGHFM---------RLEAISSLQANASGLM 120 Pseudomonas syri...
ZP_00415802  60 PVEPVTLLLHKPAGETLeqalar----------lgpatrAESDRDPRRPLSRHFH---------RLTALLPLEPAASGLQ 120 Azotobacter vine...
ZP_00333342  61 QQQRVTILLHKPVGYVSgqpepgyqpa--valirgetqwRDERRPGPAFLPAHLK---------GLAPAGRLDIDSTGLL 129 Thiobacillus den...
AAK22840     69 LDAVPTYLVHKPRGVVSsqpd--------------pgqvPAARLLTRANLWGDARgvaipqsgdLIPPIGRLDKDSRGLL 134 Caulobacter cres...

Feature 1                                                                                     # 
NP_638299   121 VLSQDGRILRRLTADaatIEQEYLVEVRGELrpyGMARLAs---GLVYQQRSLPACKVSWQNEERLRFAIKHVQPGQLRY 197 Xanthomonas camp...
ZP_00138698 121 VFSQQHGVLRKLVDDgarLEQEYLVEVAGDLaagGLERLRh---GLAYQGRRLSPCKVSWQNESHLRFALKDVLPGQLRF 197 Pseudomonas aeru...
AAN66815    121 VFTQDWRVSRKIEADlrrLEQEFIIEVRGETtpqALERLAr---GAMRNDRELPKAKASWQNETHLRMVLKNPQPGQISE 197 Pseudomonas puti...
ZP_00503382 130 VFTQDWRVARKLREDagvLEHEVIVEVTGEIkpgGLERLNridhGFTFNGVLLPPAKVSWQSEARLRFALKGERPGQIAY 209 Polaromonas sp. ...
NP_793783   121 VFSQDWKILRKLTDDrskIEQEYVVEISGEMvahGLNRLNh---GLTYKGKELPAVKASWQNENRLRFAMKNPQPGIIAL 197 Pseudomonas syri...
ZP_00415802 121 VFSQQRGVLRRLGEEsdaPEQEFVVEIAGEPaadGLARLGh---GLDQRGRPLPPCKVSRQSERHLRFALKAPQAGQIEH 197 Azotobacter vine...
ZP_00333342 130 VLTQDGRVARQLIGDhsdVEKEYLVRVEGRLdarGLALLNh---GLSLDGVRLRPAKVAWQNADQLRFSLKEGRKRQIRR 206 Thiobacillus den...
AAK22840    135 LLSQDGVVAKAVIGPqseLEKEYRVAVMGELteeKLELLRf---GLELDGRELRPAEVEVISDQRLSFVLREGRNRQIRR 211 Caulobacter cres...

Feature 1                                              
NP_638299   198 MCNEVGLDVVTIRRLRVGRISLGKLALGEWRYLPTGERF 236 Xanthomonas campestris pv. campestris str. ATCC 33913
ZP_00138698 198 MCESEGLEVRSIRRLRIGALPLARLPLGEWRYLGLHERF 236 Pseudomonas aeruginosa UCBPP-PA14
AAN66815    198 LCAYLRLELLGMRRIRLGGVSMGKLPLGQWRYLATSERF 236 Pseudomonas putida KT2440
ZP_00503382 210 MCESVGLRVEAMKRLRIGRVPMSNLQSGRWRYLLPHERF 248 Polaromonas sp. JS666
NP_793783   198 LCEAVGLKIVAIRRIRIGGVSMGKLPEGQWRYMTTKEKF 236 Pseudomonas syringae pv. tomato str. DC3000
ZP_00415802 198 MCRSLGLEVLALRRIRIGRLAMAGLPVGQWRYLGERERF 236 Azotobacter vinelandii AvOP
ZP_00333342 207 MCELVGLRVVGLKRVRIGAVRLGDLPLGRWRYLAPGEHF 245 Thiobacillus denitrificans ATCC 25259
AAK22840    212 MCELVDLKVVDLFRVRVGPLDLGDMPEGHWRLLTAAERA 250 Caulobacter crescentus CB15

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