Conserved Protein Domain Family
PseudoU_synth_RluF
?
cd02554: PseudoU_synth_RluF 
Pseudouridine synthase, Escherichia coli RluF like.
This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluF makes psi2604 in 23S RNA. psi2604 has only been detected in E. coli. It is absent from other eubacteria despite a precursor U at that site and from eukarya and archea which lack a precursor U at that site.
Links
?
Statistics
?
PSSM-Id: 211328
Aligned: 12 rows
Threshold Bit Score: 259.549
Created: 3-Mar-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
probable active
Feature 1:probable active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             ####                                      
P32684       68 VLIALNKPVGIVSTTe-DGERDNIVDFVNHs-kRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPI 145 Escherichia coli
ZP_00310582 118 TYYAYYKPRGIECTL--NAAIENNLLHTLPfgeHVYPVGRLDKESEGLLLLTNDGKLYKDIAFSDNFKEKEYLVEVDKPL 195 Cytophaga hutchi...
NP_980967    61 VYIAFHKPVGITCTAa-DHIEDNIIDYINYp-eRIFPVGRLDKASEGLILLTNDGAIANQILHGDHEHEKEYVVTVDKPF 138 Bacillus cereus ...
BAB82019    122 VYIALNKPVGITCTTe-SKIKGNIVDFINHe-kRIFPIGRLDKDSQGLIFMTNDGDIVNKILRAGNNHEKEYIVTVNKPI 199 Clostridium perf...
NP_892776    64 IYLVFNKPVGIVCTTdrRVESDNIIDFIKYp-tRIFPIGRLDKPSEGLIFLTNDGDIVNKILRARNNHEKEYIVSVNRPI 142 Prochlorococcus ...
AAK38326     66 VYLAFNKPVGIECTTn-LEVKNNIVDYINYp-kRIFPIGRLDKASEGLIFMTNDGDIVNKILRARNNHEKEYTVTVNKPI 143 Flavobacterium j...
NP_637988    69 VYIALNKPVGITSTTe-SSVKGNIVEFVGHe-qRIFPIGRLDKDSEGLILMTSNGNIVNEILRAENRHQKEYLVAVNKPV 146 Xanthomonas camp...
ZP_00634349  64 AYWLYNKPIGIDCRLl-AQDPASLIHQLPSa-pRLYPAGRLDKDSRGLLLLTNDGDLTHKLMHPDFYHPKTYHVQVNQPL 141 Shewanella denit...
ZP_00637727  65 QYWLYHKPVGIDCRL--LVDDPHSLLHVLPelpRLYPAGRLDKDSRGLLLLTNDGQLTQALMHPDYYHPKTYVVQVDKPI 142 Shewanella frigi...
ZP_00582418  66 AYWILNKAVGTDCRLl-EQDETSLIRLLPKa-pRLYPVGRLDKDSRGLLLLTNDGELTHKLMHPSFAHSKTYHVRLNRPF 143 Shewanella balti...
ZP_00538676  60 EYLILNKPVGITCTTe-RDIEGNIIDFVNHp-nRIFPIGRLDKDSDGLIILTNDGDIVNRILRAENNHDKEYIVTVDAPI 137 Exiguobacterium ...
ZP_00585266 102 AYFLYHKPVGIDCRL--RAEDPHSLIHCLPgdlRLFPAGRLDKDSRGLLLLTNDGELTQRLMHPDFHHQKGYLITLNKAP 179 Shewanella amazo...

Feature 1                                                                 #                     
P32684      146 TeeFIRGMSa----GVPILGTVTKKCKVKKEAp----------fVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNV 211 Escherichia coli
ZP_00310582 196 TdeAVEQLSs----GIVIMGQKTRPARVSMVTe----------hSFRIILTQGLNRQIRRMCYKLRYEVTMLKRIRITSI 261 Cytophaga hutchi...
NP_980967   139 TdwFIDEMSs----GVKIKDGMTKPCKVTRVDq----------sTFRIVLTQGMNRQIRRMSRAFGFTVTKLKRERIMNI 204 Bacillus cereus ...
BAB82019    200 TdeFIKGMSn----GVPILGTVTKKCLVKKESk----------nSFRIILTQGLNRQIRRMCEYFGYEVKKLERIRIMNV 265 Clostridium perf...
NP_892776   143 NrdFIQSMSn----GVEILGTITKNCFVKQLGp----------kKFRIILTQGLNRQIRRMCESLGFRVKSLKRVRIMNI 208 Prochlorococcus ...
AAK38326    144 TerFIQRMGn----GVPILDTVTKKCKVEQISk----------yTFKIILTQGLNRQIRRMSEYLGYEVTALKRIRIINI 209 Flavobacterium j...
NP_637988   147 TdeFLRGMAr----GVRLHDETTLPCRTARIAk----------fGFRIVLEQGLNRQIRLMAAAFGFRVTQLRRVRIDNI 212 Xanthomonas camp...
ZP_00634349 142 KdeDIMALSt----GVAYPGVLTRRCEVRRLAd----------dKFEMILTQGLNRQIRRMCKALGYKVIDLQRTAIMKL 207 Shewanella denit...
ZP_00637727 143 StsFLSMMAngvsyGDVQTRSCDIRPLSLTAEe----------dRFEIVLTQGLNRQIRRMCQTLGYKVIDLMRTQLLDI 212 Shewanella frigi...
ZP_00582418 144 TdeFVEQMAs----GVRYKDLQTLPCQVRRLSs----------dSFEIVLTQGLNRQIRRMSSALGYKVIDLQRVALMTL 209 Shewanella balti...
ZP_00538676 138 TetFIEGMAg----GVDILGTTTKECVVEQLEs----------rTFRIVLTQGLNRQIRRMCKEFGYRVKRLQRVRIMNI 203 Exiguobacterium ...
ZP_00585266 180 QpdDIAAIAa----GFDYGEGPTRPCVVEAAIdcgyatedgnprKLRMRLTEGKKRQIRRLWRARGYRVLDLLRESIQQL 255 Shewanella amazo...

Feature 1                                
P32684      212 SLSg-----IPLGEWRDLTDDELID 231 Escherichia coli
ZP_00310582 262 ELGd-----LKPGAYRVLTRAEIFD 281 Cytophaga hutchinsonii
NP_980967   205 ELDd-----LEVGKWRNITDGELEI 224 Bacillus cereus ATCC 10987
BAB82019    266 SLGn-----LKMGSWRYLTKKELAE 285 Clostridium perfringens str. 13
NP_892776   209 KLD------VSIGEYREFTKEELFE 227 Prochlorococcus marinus subsp. pastoris str. CCMP1986
AAK38326    210 SLD------VPVGRYRDLTDAEIKE 228 Flavobacterium johnsoniae
NP_637988   213 KLAa-----LKPGQWRNLTDQELQG 232 Xanthomonas campestris pv. campestris str. ATCC 33913
ZP_00634349 208 ELNskefeqLADNKMRPLEAAELIS 232 Shewanella denitrificans OS-217
ZP_00637727 213 RIDe-----LAEKTMRPLTAAELLS 232 Shewanella frigidimarina NCIMB 400
ZP_00582418 210 TLKs-----LAEGAMRPLTPKEVAV 229 Shewanella baltica OS155
ZP_00538676 204 ELGd-----LPIGEWRDLTESEMKT 223 Exiguobacterium sp. 255-15
ZP_00585266 256 NIGk-----LEQGEIRSLTASELRQ 275 Shewanella amazonensis SB2B

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap