2PA4,2UX8,2E3D


Conserved Protein Domain Family
UGPase_prokaryotic

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cd02541: UGPase_prokaryotic 
Click on image for an interactive view with Cn3D
Prokaryotic UGPase catalyses the synthesis of UDP-glucose.
Prokaryotic UDP-Glucose Pyrophosphorylase (UGPase) catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans. UGPase is found in both prokaryotes and eukaryotes, although prokaryotic and eukaryotic forms of UGPase catalyze the same reaction, they share low sequence similarity.
Statistics
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PSSM-Id: 133021
View PSSM: cd02541
Aligned: 42 rows
Threshold Bit Score: 328.723
Threshold Setting Gi: 32491118
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitetetramer
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Structure:2pa4_a; Udp-glucose pyrophosphorylase from Corynebacteria glutamicum with bound magnesium and UDP-glucose
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ####             ##                                                        
2PA4_A        13 KTVVVPAAGLGTRFLPATKTVPKELLPVVDTPGIELIAAEAAe-lGATRLAIITApnKAGVLAHFERSSELEETLMergk 91  Corynebacterium...
YP_015814      6 RKAIIPAAGWGTRFLPITKVIHKELLPILKKPAIEILIEEAFe-aGIEEIILVISsrKQELKRYFEVNHDLELELFknkk 84  Mycoplasma mobi...
YP_117988      8 RKAVIPAAGIGSRLLPLTKAIPKEMLPVGDKPVIEHTVRELVa-sGITDITIVVSggKSLIQDHFRPNPALVAQLRadgk 86  Nocardia farcin...
NP_214168      5 RKVVLPVAGWGTRFLPATKAMPKEMLPIIDKPIIQFIVESFIn-iGIENIIFVTGrhKKAIEDHFDHNHELEEHLKkagk 83  Aquifex aeolicu...
YP_828556     13 QSAVVPVAGLGTRLLPATKSQPKEMLPVARKPIVQYVVEELVs-nGIEQILFVTGrsKASIENHFDHDPELFQALTqank 91  Solibacter usit...
ZP_01772070    1 MKAIIPAAGLGTRFLPGTKCTPKEMLPVLDKPVIQYVVEEALdpeEVDDAIIVTSpgKPELLSYFQPDRSLENLLRergk 80  Collinsella aer...
NP_212341      1 MKGIILAAGYGTRFLPITKTIPKEMLPILNKPAIDYIIQEFId-sGIKDILLISSrrKKVLEDYFDREIELENIFLkenk 79  Borrelia burgdo...
YP_001535603  21 VKAVIPAAGLATRFLPATKAVPKELLPVVDRPVLQYIVEEATq-aGITDILLVTGrgKTSMIDHFDRRPDLEERLAkkpd 99  Salinispora are...
NP_975120      4 RKAVIPCAGFGTRFLPFTKSQAKEMLPIIDTPTIEYIVKEAVd-sGIKEILIILNdkKSEIMNYFSRNIQLEGFLYnkgk 82  Mycoplasma myco...
EDZ60379       3 KQAIIPLAGLGTRLLPLTSVFAKELLPINGKPGLEYIINECId-aGIKQIIFIISkrKKMIKKYFYNDKFYKELIKkknd 81  Candidatus Pela...
Feature 1                               #  ####                     # ##                         
2PA4_A        92 tdqve---iirraadliKAVPVTQDKPLGLGHAVGLAESVLdddedVVAVMLPDDLVLPtg---vMERMAQVRae-fgGS 164 Corynebacterium...
YP_015814     85 wdllk---slkttninaKIRIVYQEKQLGLGHAIAVGAQWIdd--ePFAVILGDDLIKSke--paIKQLIREFdd-kqAS 156 Mycoplasma mobi...
YP_117988     87 tafadaveevgelsrlgHITYLDQHGPYGNGTPVLNAARTMgd--ePMLVLWPDDVFVAet--prAQQLIEAYer-tgAP 161 Nocardia farcin...
NP_214168     84 ekllr---evvkissliNPIYVRQKEQLGLGHAVLMAEPAVsq--ePFFVALGDIIVENee--eeLKKMIHLFrk-fgNS 155 Aquifex aeolicu...
YP_828556     92 qdlls---eldvvalkaKFFYTRQRMQRGLGDAIMCAENFAge--ePFLVALGDSILGLnavskaVARMADVFdskraSC 166 Solibacter usit...
ZP_01772070   81 dayad----avahaggmPVDFRYQYEPKGLGHAIRSAADAVag--eNFLVLLGDYVVPNrd---iCDKMLAVSkehggAS 151 Collinsella aer...
NP_212341     80 kdel-----ekirskkiNISFIRQKEMLGTGNALLYAKPWInr--ePVVVAYPDDLCIGnp--plSLQLIKLYek-tgKN 149 Borrelia burgdo...
YP_001535603 100 llaa-----vkqtedlaAIYSCRQPEQLGLGHAVGCAESHVge--qPFAVLLGDEFVKPte--plLPAMLELQar-tgGV 169 Salinispora are...
NP_975120     83 iaele----qiktkydaSIHYIIQDEPLGLGHAISLCKGFInn--eSFAVLLGDDLFKCqt--paIKQLMDLYee-kqST 153 Mycoplasma myco...
EDZ60379      82 prvike--ykkilkyrkMIKFVYQNKPKGTGDAVLKTKKYIkd--kYFLMLLPDDLIIKkn---cSKSMIQTHnk-fkSS 153 Candidatus Pela...
Feature 1                      ##                               ##           #                   
2PA4_A       165 VLCAVEvseadvSKYGIFEIeadt-----------kdsdVKKVKGMVEKPAieDAPSRLAATGRYLLDRKIFDALRr--- 230 Corynebacterium...
YP_015814    157 ILGVQAveerdlNKYGVVVPfkgyd----------pkdkSFKIIGAVEKPKieNAPSNKAILGRYIFTPRIIDILTnl-- 224 Mycoplasma mobi...
YP_117988    162 VLALMPmdpaesQRYGVPVVaddh------------gegLLRITGLREKPKpeDAPSSYAAIGGYVVTPGIIEELRrqta 229 Nocardia farcin...
NP_214168    156 IVALMEvpkeevSKYGIAKVkkl-------------deeTYIIVDLVEKPSpeEAPSNLAIVGRYIFTPTIFEKLKv--- 219 Aquifex aeolicu...
YP_828556    167 VIAVEEvpaeetRHYGIVQPeag-------------addVFRVVNLVEKPApkDAPSNLAIAGRYIFSPVLFDMIRr--- 230 Solibacter usit...
ZP_01772070  152 VIAVAAcapeevSRYGVIAGdrvgslegfenaaddepgaVWRIGGLVEKPApeAAPSNLYIVGRYLLSPLVMDLLAd--- 228 Collinsella aer...
NP_212341    150 IISIIEnpe-niNRYGVIDLyk----------------dEIHVKNIIEKPKigSEPSNKASIGRFLYNYEFFEHLEeg-- 210 Borrelia burgdo...
YP_001535603 170 VLAFFEvdpaetTRYGIASVapaepe-------fadiadVVRVTGMVEKPKpeDAPSNLAVLGRYVLPGRIFNAIHr--- 239 Salinispora are...
NP_975120    154 ILGTILidkkdcKKYGICKIess-------------ddnVYKVCSVIEKPDeqNAPSNVAIAGRYILTPEIFNYLDl--- 217 Mycoplasma myco...
EDZ60379     154 VMASMSvnkktvSRWGIYKInkkl------------nitDYSIKGVIEKPKikEAPSNKAVIGRYILPKKIFTKLRk--- 218 Candidatus Pela...
Feature 1                    #                                           
2PA4_A       231 -iTPGAGGELQLTDAIDLLIDeghpVHIVIHQ--GKRHDLGNPGGYIPACVDFGLS 283 Corynebacterium glutamicum
YP_015814    225 -kPSKTSNEIDVIDAFSKLLKee-dIYAYQFS--GTRYDIGNIEGFVKATIDYALD 276 Mycoplasma mobile 163K
YP_117988    230 awYEHRTGEVYLTDAINVHAAdn-pVFGQVIR--GRWYDTGNPADYLVAQFASALA 282 Nocardia farcinica IFM 10152
NP_214168    220 -tKPGKGGEIQLTDAMRLLLEee-aIYACKVN--NTVYDTGNPKDYLKTVISFALR 271 Aquifex aeolicus VF5
YP_828556    231 -vKPDKRGEIQLTDAIQFMCEegrrVMAVKLTpeEKRYDIGNFPSYFESFVEFALA 285 Solibacter usitatus Ellin6076
ZP_01772070  229 -qQAGKGGEIQLTDAMARSLDre-aMYAVVIDp-LSGYDTGTPSGWMATNALMAAS 281 Collinsella aerofaciens ATCC 25986
NP_212341    211 -fKLHKKGEYYHIYALKKLMDqk-kVLYKNIE--GKRIDIGTLEGYLEAIINSAKK 262 Borrelia burgdorferi B31
YP_001535603 240 -tEPGSGGEIQLTDAMEILRTegvpVHAIVYR--GTRYDTGMPLGYLQTVVQIAAE 292 Salinispora arenicola CNS-205
NP_975120    218 -qLKGETGEIELTDSILKTISdv-dCYAKVID--GKRYDIGNKLGYLEAFVDFALN 269 Mycoplasma mycoides subsp. mycoides SC ...
EDZ60379     219 -lKPSKGGEIHITDAIQLLINdkekFIAHNFT--GKYLDCGTMDGYINSSKEIAKL 271 Candidatus Pelagibacter sp. HTCC7211

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