1G97,1HV9


Conserved Protein Domain Family
GT2_GlmU_N_bac

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cd02540: GT2_GlmU_N_bac 
Click on image for an interactive view with Cn3D
N-terminal domain of bacterial GlmU.
The N-terminal domain of N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU). GlmU is an essential bacterial enzyme with both an acetyltransferase and an uridyltransferase activity which have been mapped to the C-terminal and N-terminal domains, respectively. This family represents the N-terminal uridyltransferase. GlmU performs the last two steps in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), which is an essential precursor in both the peptidoglycan and the lipopolysaccharide metabolic pathways in Gram-positive and Gram-negative bacteria, respectively.
Statistics
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PSSM-Id: 133020
View PSSM: cd02540
Aligned: 80 rows
Threshold Bit Score: 236.643
Threshold Setting Gi: 42520463
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
SubstrateMg++ binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate binding site
Evidence:
  • Structure:1g97_a; N-Acetylglucosamine-1-phosphate Uridyltransferase binds to UDP-N-Glucosamine
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###                                        #                                 
1G97_A      5 AIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAiqpeKTVTVVGHk-AELVEEVLag---------qTEFVTQSE 74  Streptococcus pneu...
AAY82768    4 SVILGAGKSTRMKANKSKLLFSIAGKPVINHIVSSLKDakakHIICVINNs-SAELKKILea--------enISFTYQKT 74  uncultured bacteri...
Q30RT9      8 IVILAAGKGSRMKSSKAKVLHPICGKEMLYYIIKTSRAis-dDVSVVVAHq-RDAVVESMsry------fndINFVTQDA 79  Thiomicrospira den...
NP_223342   4 VIILAAGKGTRMHSSLPKTLHTICGEPMLFYILEVAFSis-nDVHLVLHHq-QERIKEAVskr------fkgVIFHAQIV 75  Helicobacter pylor...
Q7VIB6      5 VVILAAGAGTRMKSHIPKVLHKICGKEMLFYSIDEALKis-dDVHIVLFHq-ENVIKERLlcaykqayadgaLHFHLQDH 82  Helicobacter hepat...
A7ZCS8      7 IIILAAGLGTRMKSKRPKVLFELCGEPMIIHILKQAYAit-nDVSVVLHYe-KELISKKIkei------fpqTKIFEQDL 78  Campylobacter conc...
YP_891928   6 IIILAAGNGTRMKSNKSKVLHTLCGEPMISHILKKSYEis-nDVRIVLSYq-FEEVKNSVlse------fkdVKIYKQDT 77  Campylobacter fetu...
AAP34258    5 ILILAAGLGTRIKSQKPKVLQELCQKSMILHILKKAFAls-dDVSVVLSHq-KERVEKEIley------fpkTQILEQDL 76  Campylobacter jeju...
Q5GTJ4      2 FIILAAGHGKRMNSGLPKVLHKIGNFSMLQHIIYNARQlnpeNISVVANLplIERLKCLEd-----------IQLITQES 70  Wolbachia endosymb...
NP_966378   5 LIILAAGKSSRMNSQYSKTLHLVGNFTLLEHIIHNAKPlslkSLSIVINKpfLKELERFStlkdi--idkynIKLIIQEN 82  Wolbachia endosymb...
Feature 1          #  #                         # #                                           
1G97_A     75 Q--LGTGHAVMMTEPileg-------lsghTLVIAGDTPLITGESLKNLIDFHinhknVATILTAETDNPFGYGRIVRnd 145 Streptococcus pneu...
AAY82768   75 L--DGTAGAVKAALKvkkt-------snekLLIICGDIPFITSSSIKKLISKLkn--yDAVVGTVELESPKGYGRIIRvn 143 uncultured bacteri...
Q30RT9     80 InfPGTGGAMKGVNIkn-----------erVLVLNGDMPLVEKSSLDGFLEAQg----DVVMSIFNLQNPSGYGRVIIed 144 Thiomicrospira den...
NP_223342  76 EkySGTGGAIMQENKtpipt------qherVLILNADMPLITKDALTPLLESH-----NNAIGLLHLADPKGYGRVILen 144 Helicobacter pylor...
Q7VIB6     83 AhyPGTGGALMQGQNaganakkpfcyqydeILILNGDMPLVCSQTLKSLCQNKa----QIVMSVLHLQNPDGYGRVVMes 158 Helicobacter hepat...
A7ZCS8     79 AnfPGTAGAIKGVNLsg-----------ekVLVTCGDMPLVRSTDLMRLANAEa----DVVMSSFEAANPFGYGRVIIkn 143 Campylobacter conc...
YP_891928  78 InrPGTAGAAEAALEnln---------skkTLVICGDMPLVEVNELKSLCDNTa----DISLSAFRAKNPFGYGRVVLnq 144 Campylobacter fetu...
AAP34258   77 QnyPGTAGALSGFEPkn-----------erVLILCGDMPLVEQTSLEALLSNNa----KLNLAVFKARDPKSYGRVVIkn 141 Campylobacter jeju...
Q5GTJ4     71 T--LGTGDAVKTAVRnmkel-----sdsniIVVQYGDTPLIKNSTITQMVSCLe---gKALVCLGFKTSNKEYGRLIIen 140 Wolbachia endosymb...
NP_966378  83 I--TGTGTAVKIALEslerl-----sdqdiVLIQYGDTPFISSDTVMRMTDCLkc-nnKNLVLLGFNSQDKQYGRLVIdd 154 Wolbachia endosymb...
Feature 1                                                                                     
1G97_A    146 naeVLRIVEQKDatdfekqikEINTGTYVFDnERLFEALKNINTNnaqGEYYITDVIGIFretGEKVGAYTlkdfdESLG 225 Streptococcus pneu...
AAY82768  144 -nkFHSIVEEKEttptqrlirEVNTGIIAIQeKVLRQYISLITNNnqkKEYYLTDIIKILidnKKKVTTFKfsnetEVKG 222 uncultured bacteri...
Q30RT9    145 -aeVKKIVEQKDatlqelkvqSVNAGIYAFSkKIIEKYIPLLQNNnaqEEYYLTDIISMArndGIKITPLLvn-enEYKG 222 Thiomicrospira den...
NP_223342 145 -hqVKKIVEEKDandeektikSVNAGVYFFErKFLERYLPKLHDQnaqKEYYLTDLIALGikgNEKIDAIFle-eeCFLG 222 Helicobacter pylor...
Q7VIB6    159 -gvVQRIIEQKDakesellikDVNAGVYKIHkSILDLYLPQVGNAnnqQEFYLTDVVFYAkenGIEIAALEvk-eeEFMG 236 Helicobacter hepat...
A7ZCS8    144 -gkVEAIVEQKDaseaqlaikSVNAGCYCFKrEALEQILPLINNQnaqKEYYLTDAIKIAnekGLKCVAVNvn-eqNFMG 221 Campylobacter conc...
YP_891928 145 -qnVIKIVEQKDanddekkidLCNAGAYCFDtNLLKNIIPLIKNEnasREFYLTDAIELAlkqGFMVKSVLvd-etNFMG 222 Campylobacter fetu...
AAP34258  142 -dsVEKIVEFKDantqekeinTCNAGVYVIDsRLLKELLPLIDNNnaaKEYYLTDIVKLAkekDVMIKAVFvd-edEFMG 219 Campylobacter jeju...
Q5GTJ4    141 -gsLREIVETQDdens-deefLANAGIMVAYaKNLRELVEKIECNgstYEYYLTDIVSIAvksNLNVGYVTtd-eeEATG 217 Wolbachia endosymb...
NP_966378 155 ndnVQKVLKSEDei------lLANSGIMVSYaKDLYTLIKEVKFNdstNECCLNDIIPIAasnNLRAGYVVad-ekEAMG 227 Wolbachia endosymb...
Feature 1            
1G97_A    226 VNDRVAL 232 Streptococcus pneumoniae
AAY82768  223 VNSKVDL 229 uncultured bacterium eBACred22E04
Q30RT9    223 VNSKKDL 229 Thiomicrospira denitrificans ATCC 33889
NP_223342 223 VNSQTER 229 Helicobacter pylori J99
Q7VIB6    237 VNSKIQL 243 Helicobacter hepaticus ATCC 51449
A7ZCS8    222 INDKFQL 228 Campylobacter concisus 13826
YP_891928 223 INDKFAL 229 Campylobacter fetus subsp. fetus 82-40
AAP34258  220 INDKFEL 226 Campylobacter jejuni subsp. jejuni 81-176
Q5GTJ4    218 INSRNDL 224 Wolbachia endosymbiont strain TRS of Brugia malayi
NP_966378 228 VNNKEDL 234 Wolbachia endosymbiont of Drosophila melanogaster

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