1LVW,1H5R,1MC3


Conserved Protein Domain Family
G1P_TT_short

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cd02538: G1P_TT_short 
Click on image for an interactive view with Cn3D
G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase.
This family is the short form of glucose-1-phosphate thymidylyltransferase. Glucose-1-phosphate thymidylyltransferase catalyses the formation of dTDP-glucose, from dTTP and glucose 1-phosphate. It is the first enzyme in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme.There are two forms of Glucose-1-phosphate thymidylyltransferase in bacteria and archeae; short form and long form. The homotetrameric, feedback inhibited short form is found in numerous bacterial species that produce dTDP-L-rhamnose. The long form, which has an extra 50 amino acids c-terminal, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced.
Statistics
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PSSM-Id: 133019
View PSSM: cd02538
Aligned: 29 rows
Threshold Bit Score: 383.464
Threshold Setting Gi: 168700509
Created: 14-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substratetetramer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:
  • Structure:1h5r_a; E. coli Glucose-1-phosphate thymidylyltransferase binds with dTMP and glucose-1-phosphate
    View structure with Cn3D
  • Structure:1mc3_a; Escherichia coli glucose-1-phosphate thymidylyltransferase (RffH) complexed with dTTP and Mg2+.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # ##                                                                       
1LVW_A         4 MKGIVLAGGSGTRLYPITRAVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTprdLPLYRDLLGDGsqf-gvrFSYRV 82  Methanothermoba...
1H5R_A         4 RKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTpqdTPRFQQLLGDGsqw-glnLQYKV 82  Escherichia coli
EDP75571       1 MKGIILAGGSGTRLYPITKGINKHLLHIYDKPMIYYALSVLMLAKIKDILIITNpeyVENFENLLGNGshi-ginISYAS 79  Hydrogenivirga ...
YP_001097827   1 MKGIILAGGSGTRLYPMTYAGNKHLMPLFNKPMIYYSLSVLMLSKIKEVLIISTpeaLPAYEKLFGNGdql-ginISYAG 79  Methanococcus m...
AAL06018       1 MKGIILAGGSGTRLYPSTLTLCKQLLPIYDKPMIYYPMSVLMLAKIKEVLIISTpkdIDRFKELFKDGsfl-gmqIQYKI 79  Campylobacter j...
YP_827437      1 MKGVVLAGGTGSRLFPLTKITNKHLLPIYDRPMIYYPIQTLVDAGIQEILIVTGgrnSGDFLRLLANGkqfglkhINYTY 80  Solibacter usit...
P39629         1 MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEAGIKDILLISQkehMPQFYKLLGNGeel-gvtITYQV 79  Bacillus subtilis
AAM05580       1 MKGVILAGGTGSRLYPLTKVTNKHLLPIYDKPMIYYPMETLINAGIKDIMIVSGrghAGHFLELLGSGvdf-gvhFTYEI 79  Methanosarcina ...
YP_002250031   6 VKGVILAGGTGSRLRPLTKVTNKHLLPVGRYPMIFYPIYKLKQAGIYEILVVTGrehMGDVIELLGSGrdf-gveFTYKV 84  Dictyoglomus th...
ZP_02732786    3 IRGVILAGGKGTRMGELTRVTNKHLLPVGAWPMVYHPLKKLTGVGLQEILLVSGtehMGDFVELLGSGkdh-gcrLTYRV 81  Gemmata obscuri...
Feature 1        #  ####                     #                                      #            
1LVW_A        83 QEEPRGIADAFIVGKDFigdskVALVLGDNVFYGhrFSEILRRAasl---edGAVIFGYYVRDPRPFGVVEFDseg-rvI 158 Methanothermoba...
1H5R_A        83 QPSPDGLAQAFIIGEEFiggddCALVLGDNIFYGhdLPKLMEAAvnk---esGATVFAYHVNDPERYGVVEFDkng-taI 158 Escherichia coli
EDP75571      80 QEKPKGIAEAFIIGEKFirdsnVALILGDNLFYGqgFSDILVKAfqn---keGATIFAYPVKDPERFGIAEFDenf-nvI 155 Hydrogenivirga ...
YP_001097827  80 QAEPKGLAEAFIIGEEFigddsVCLILGDNIVYGsgLTGILEKSyenienngGAIVFGQYVNDPHRYGVLEFDknk-kvT 158 Methanococcus m...
AAL06018      80 QERPEGLAQGLILAQDFiqnddIALILGDNIFYGqgFSDILENAkddl-kkgFASIFSYHVKDPERFGVVEMDqng-nvL 157 Campylobacter j...
YP_827437     81 QEGEGGIADALALAEHFadghqICVVLGDNIIEGn-IKAAADRFraq---paGAHILLKEVQDAERFGVAEVAgd--riV 154 Solibacter usit...
P39629        80 QPAASGISDGLSYAKRFtkkesFILLLGDNIFEDs-LKPYTERFeqq---gkGAKVLLKEVDDPERFGIAEIDeknkriR 155 Bacillus subtilis
AAM05580      80 QEKAGGIAQALSLAEDFvdgdsVTVILGDNIFQDn-IKEDVANFn------sGAKIFLKEVTDAHRFGVAELKgk--kvI 150 Methanosarcina ...
YP_002250031  85 QDEAGGIAQALGLARHFvgddkCVVILGDNIFEDd-ITPYVKKFeeq---keGAKILLKEVPDPQRFGVPVFEng--riI 158 Dictyoglomus th...
ZP_02732786   82 QDEAGGIAQALGLAEHFcmgsrSLVLLGDNIFRDp-LIGLLEKAntr---pdWAWIGLKEVHDPGRYGVAELDgd--kvL 155 Gemmata obscuri...
Feature 1           ##         #                           #                                     
1LVW_A       159 SIEEKPSRPKSNYVVPGLYFYDNQVVEIARriEPSDRGELEITSVNEEYLRmgkLRVELMgrgmAWLDTGTHDGLLEASS 238 Methanothermoba...
1H5R_A       159 SLEEKPLEPKSNYAVTGLYFYDNDVVQMAKnlKPSARGELEITDINRIYLEqgrLSVAMMgrgyAWLDTGTHQSLIEASN 238 Escherichia coli
EDP75571     156 SLEEKPKKPKSNWAVTGLYFYDNEVVDIAKkiNPSERGELEITSINSEYLKrnkLKVQLLgrgfAWFDAGTHESLLEASL 235 Hydrogenivirga ...
YP_001097827 159 KVIEKPENPPSNYAVIGLYYYDNDVINISKsiKPSGRGELEITDVNNVYLDknkLDVELFprgiAWFDAGTHESFLDASN 238 Methanococcus m...
AAL06018     158 SLEEKPKNPKSNYVATGLYFYNNDAIDIAKniKPSARGELEITDVNIEYLRlnkLKSQHLgrgfAWIDTGTHDSLIEASS 237 Campylobacter j...
YP_827437    155 GIEEKPNNPKSNYAVTGIYMYDASVFQKIKtlVPSGRGELEITDVNNAYIRegnMSFSYLd--gWWTDAGTFDSLLRATN 232 Solibacter usit...
P39629       156 SIIEKPEQPPTNLCVTGIYMYDAEVFSYIEqiSPSKRGELEITDVNNLYIEnsqLTYDVLs--gWWVDAGTHESLYLASQ 233 Bacillus subtilis
AAM05580     151 GIEEKPKNPKSDFAVTGLYIYDSDVFNAIKtlKPSGRGELEITDVNNYYINkgmMEYGILd--gFWSDAGTFESLLRAGM 228 Methanosarcina ...
YP_002250031 159 AIEEKPKEPKSNFAVTGIYMYDSYVFEIIKtlKPSARGELEITDVNNTYLKmgkLTYDILk--gWWTDAGTPESLFRANE 236 Dictyoglomus th...
ZP_02732786  156 GIEEKPEKPKSPMAVVGIYIYPPDVFGLIKtlKPSRRGELEITDVNNHYIQqgrMGCFNLd--gYWTDAGTLDSLDYANE 233 Gemmata obscuri...
Feature 1             
1LVW_A       239 FIETI 243 Methanothermobacter thermautotrophicus
1H5R_A       239 FIATI 243 Escherichia coli
EDP75571     236 FVSTI 240 Hydrogenivirga sp. 128-5-R1-1
YP_001097827 239 YIHAI 243 Methanococcus maripaludis C5
AAL06018     238 FVQTI 242 Campylobacter jejuni
YP_827437    233 LVAQS 237 Solibacter usitatus Ellin6076
P39629       234 LVHQA 238 Bacillus subtilis
AAM05580     229 LVKQN 233 Methanosarcina acetivorans C2A
YP_002250031 237 LARNI 241 Dictyoglomus thermophilum H-6-12
ZP_02732786  234 LVRKE 238 Gemmata obscuriglobus UQM 2246

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