Conserved Protein Domain Family
GT2_RfbF_like

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cd02526: GT2_RfbF_like 
RfbF is a putative dTDP-rhamnosyl transferase.
Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.
Statistics
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PSSM-Id: 133017
View PSSM: cd02526
Aligned: 34 rows
Threshold Bit Score: 190.187
Threshold Setting Gi: 13541700
Created: 11-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Ligand binding
Feature 1:Ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # #                                                                          
BAC08567    7 AYITAYNDy-fALNRCIDGLInqtykidYLLIVDNSSRpipiqklgn--------nlsievqhHPENIGVAGGLTLGIQy 77  Thermosynechococcu...
EDP65407  349 AVVVSYQPd-eALDRVLDAGLaq---adRVVLVENGSApdiqerlatra---adsggrltliaNPSNVGLATAQNQGLAa 421 alpha proteobacter...
AAM93398    5 SIVVLYEPn-nKEIENILDYYds---vdKAYILDNSVEsreaivndvlskrsrhvkekaeyihFHKNIGLCKALNHGMKl 80  Streptococcus ther...
ABI98987    6 AVLVAYNPehnDLKNAVELLLrq---vtKVVVCNNSTNgykyaens---------sgdvkifnFNDNLGIAEAQSIGMKw 73  Escherichia coli
ABM21405   10 AGVVTYNPelsRLKENLATLVnq---vdELYIFDNGSDnvveienlld-----qyarkivlhkEGKNAGIAFALKNIMKf 81  Lactobacillus john...
NP_951691  13 GVVVLYRPd-sSVLDAIASYRhq---vhELIVVDNSEEqdhklhsrlr------drfgativgEGRNLGIAAALNRAARe 82  Geobacter sulfurre...
ABD99795    5 GVVVWYNPa-tDVLDNINSYIte---ieKLYIIDNSKYshinlladyk------yhnkceyipLHKNLGLVYALNVGCKk 74  Lactobacillus sali...
AAM93399    5 AGIVLFNPdikRLKENIDAVIiq---ctHLYLVDNGSGnvdevkgllnq----ynqskisilwNRENQGIAKALNQLTSa 77  Streptococcus ther...
AAW22492    7 AVCVVYKPnvsQLIKTIKHYDsf---fdELVIVDNSGGnnielteqvk------lirnvtyipLHANKGIGKAQNIGLAa 77  Lactobacillus rham...
NP_111388   9 ALIVTYNPd-kRLIESLTKLEkl---vdFVVIVDNNSNkspvldyisn-----nifndryliqLEDNLGIAYALNTGIKy 79  Thermoplasma volca...
Feature 1                    #                                                                
BAC08567   78 aihk-kfdfIWLFDQDSTPyenalenli-yfydkyinkSEIGILSCAVQDRetgqincgfiyknyrf-yqqqidsrkavy 154 Thermosynechococcu...
EDP65407  422 alad-gadwILLQDDDSVPgdsmvatmi-etwrglpdrRRVGLLTPRLTDPegtlrarlltargrfdlartpllpgtiar 499 alpha proteobacter...
AAM93398   81 aade-gfewALIMDADSTFntnvvkvyk--dyiqknncSKIGVLAPVHLHDrnleskfe------------------gqr 139 Streptococcus ther...
ABI98987   74 afen-gadfILQMDQDSIPdpkmveqlltcykkllkqnVNVGLVGSQDFDKvtgelnkarvkkg--------kpltevyy 144 Escherichia coli
ABM21405   82 akec-kfdwVLSVDQDSVLdshlvdkyk--teiskhknDDIGMLTCLIKDRnfedasvekq--------------eedvk 144 Lactobacillus john...
NP_951691  83 alae-gfdlLLTMDQDSRAepgmveqml--aclgsdwrERVGLIAPFHLTGarpapggt-----------------tpcs 142 Geobacter sulfurre...
ABD99795   75 aikd-rfdyILTMDQDSIFeptavskl----kvatqkdERYGIICPNVKSIyhdektnldkvay-------lkwkkeefk 142 Lactobacillus sali...
AAM93399   78 aqke-gfdwILTLDQDSVVpsnivge-----fekyinnSSVGILCPIICDRnkdeeikin----------------edct 135 Streptococcus ther...
AAW22492   78 lsd--qiatVCFFDQDSWAsekdlqtlf--tlfsvkakENYGMLALSVHQSsekevk---------------------vd 132 Lactobacillus rham...
NP_111388  80 ilekghydyILTLDQDTVPliddikel---ikransiySNIGIIALISKMDpkipef----------------------t 134 Thermoplasma volca...
Feature 1                                                                                     
BAC08567  155 ecdaVITSGTLLNChaAKEIGLPNESLFMDAVDFDYCMKLRKQDYKIFtvcnaKINHRFGNSKSiqlfnrtkfiylYSSL 234 Thermosynechococcu...
EDP65407  500 nglfAIASGSLIRArvLEVVGRMDDRFFIDYVDVEFSLRLRRAGFEIVgvgdaTLHHRLGEVKTarllgrtktlstHEAW 579 alpha proteobacter...
AAM93398  140 dvswAMTSGCFYNIsvFETANGFKEELFVDGLDIDYCYKMHRYGYRVVeladaRINHLPAETRMfnlggfkvkygvASPW 219 Streptococcus ther...
ABI98987  145 evdsTLSSGSLIPKnsWLIVGGMKDELFIDAVDHEYCWRLRAAGFKVIrnknaLLAHRLGDGRFkilni--lsvglPSPF 222 Escherichia coli
ABM21405  145 evpiCITSAALTNVknYFLTSGYDSELFIDLVDTDICLSLREKGFKILrinylGIYHEIGHGVNkkilwknvivhnSNIF 224 Lactobacillus john...
NP_951691 143 dvmtPMTSGCLVNLaaFREVGPFRDDFFIDFVDNEYCLRLRKKGFQVVranraLLHHRVGDLRRygpf----vathHSPL 218 Geobacter sulfurre...
ABD99795  143 eipwTMTSGSLTSLkaYTDVGGFDDDLFIAHIDIDFCIRLKQNNWKILmvgsaVIKQRFGNSKPvrilwkkvhpsfASPV 222 Lactobacillus sali...
AAM93399  136 eideCITSGSLLNIkaWSEIGGFDERMFIDGVDFDICYRLRQRGYKIYcihsvVLLHELGHIEYhrflfwkvlvknHSAF 215 Streptococcus ther...
AAW22492  133 dvdeVISSGSAVLKsvFDKLGGFDENLFIDFVDYEFCWRMRSSGYRIGviegtHLHHQIDSETIhnh-------trSAPF 205 Lactobacillus rham...
NP_111388 135 dvkfPMTSGNIVKSe-IFKYIKYREEFFIDSVDFDFDYNVRMHGYRIIqynyrAIDHNVGITKNgf--------pyESSE 205 Thermoplasma volca...
Feature 1                  
BAC08567  235 RYFYVHRNHTYLE 247 Thermosynechococcus elongatus BP-1
EDP65407  580 RRRTIHRNRVRVW 592 alpha proteobacterium BAL199
AAM93398  220 RYYMQARAIVWLV 232 Streptococcus thermophilus
ABI98987  223 RHYYATRNIFLLL 235 Escherichia coli
ABM21405  225 REYYMARNTIILQ 237 Lactobacillus johnsonii
NP_951691 219 RRYYKTRNRCAVF 231 Geobacter sulfurreducens PCA
ABD99795  223 RTYYLFRNQKYLE 235 Lactobacillus salivarius subsp. salivarius UCC118
AAM93399  216 RKYYIARNIIYTA 228 Streptococcus thermophilus
AAW22492  206 RNYYVFRNAILLL 218 Lactobacillus rhamnosus
NP_111388 206 RLYYIIRNSTVLF 218 Thermoplasma volcanium GSS1

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