Conserved Protein Domain Family
Succinoglycan_BP_ExoA

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cd02525: Succinoglycan_BP_ExoA 
ExoA is involved in the biosynthesis of succinoglycan.
Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.
Statistics
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PSSM-Id: 133016
View PSSM: cd02525
Aligned: 26 rows
Threshold Bit Score: 228.27
Threshold Setting Gi: 10640362
Created: 10-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Ligand binding
Feature 1:Ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # #                                                                       
CAJ74006      15 FVTIIMPIRNEASFINRSLGSVLAQdyphnlVEVIIVDGMSDDGTMEIvqsiinnysqtkdnnvpspihspitliDNPSR 94  Candidatus Kuen...
NP_126870      2 RISLITTVKNEENSIRAFLESILQQsr--ppDEFIIVDGGSTDKTVEIlqeytplfk---------rkniiykiiVKKGA 70  Pyrococcus abys...
CAC12176       5 GASIVVTVKNEGKNLRELLESIEKNdf--tnFETVVVDDLSTDDTEDIvksyr------------------ftvyKRIAC 64  Thermoplasma ac...
NP_633163      5 FVSVVVGIRNEERYIEECIESLLRLdypqdsYEIIIVDGMSTDRTRELvqkyp------------------vrllLNERK 66  Methanosarcina ...
YP_001409752   5 KVSIVLPVRNEAKTIQKVLDGLLRQey--edIEIIVIDGMSTDETRNIvqryvgrf------------pekvkliENEKV 70  Fervidobacteriu...
EDK35182       6 TVSIIIPVYNEELYIEKCLKSIIDQtye-niIEILVIDGMSTDSTRDIlksfen---------------ekialiDNEKK 69  Clostridium klu...
CAI64282      15 FISIIVAVKNEEKYVRECIDSLLNQsypadkYEIIVVDGLSTDGTWEIlqelkkr-------------npelrlfKNLKE 81  uncultured arch...
YP_001471506   5 KVSVIIPARNEEKFIEECIRSLMNTsypeekIEILVVDGVSEDGTRSVvekmmek-------------nkcvkliENLKK 71  Thermotoga lett...
NP_344649      9 LVSIVISAYNEEKYLPGLIEDLKNQtypkedIEILFINAMSTDGTTAIiqqfikedt----------efnsirlyNNPKK 78  Streptococcus p...
YP_695362      2 LVSFIIIAHNEEKNLKNLLEDLNGQtypkklIEVILIDSISSDNTKNVmnefrnsnk----------efnkiiikSNVKK 71  Clostridium per...
Feature 1                               #                                                        
CAJ74006      95 IVPTGLNSAIRharGDIIIRVDGHAIIDTDYvqqcvk---vlkdtGAECVGGPmvtvgetwlac--vislaqssffgVGG 169 Candidatus Kuen...
NP_126870     71 NIAKGRNIAISnssGDIIACTDAGCVLSKAWleeiar--sfeqdpSVDIVSGWyeplatskfe----eivaeitypkLKK 144 Pyrococcus abys...
CAC12176      65 SRGEGRNIGVDlsrYGYILFTDGDAKVSEHWisgmv----salaaGNDAVIGNtl---------------------yTGK 119 Thermoplasma ac...
NP_633163     67 NVAAARNLGVQnsmGDFVAFTDGDCKADPLWlktlvte-mknapeDVVCVGGPnlifdtdpvfgr-vvghaqetflgSGG 144 Methanosarcina ...
YP_001409752  71 YTPSGLNIGIRnssGEYVMIASGHASYSKNYikecvk---aiessECDIAGGVvevlprseskkalaiaeilkhpfgIGG 147 Fervidobacteriu...
EDK35182      70 IQSAALNKGIKmskGDIVVRVDAHALYDKNYvrecvntlnkfkedSVVNVGGPtylltsksyven-civflheskfgIGV 148 Clostridium klu...
CAI64282      82 NAAAGRNIGVRnakGEYVAFIDGDAVADTNWlenisk---tfgnvDAVGVGGPdllppdsayisr-vigmimasplaSGG 157 uncultured arch...
YP_001471506  72 RKSPGLNIGIKhaaGDVILIADAHSTYPKDYilknvq---nllnsDAHCVGGMinvkprsdtvkakaiayvlshpfgTGG 148 Thermotoga lett...
NP_344649     79 NQASGFNLGVKhsvGDLILKIDAHSKVTETFvmnnv----aiiqqGEFVCGGPrptivegkgkwaetlhlveenmfgSSI 154 Streptococcus p...
YP_695362     72 ILPCGWNIAISeskGDILLRVDAHSRIPKNFieenv----nciksGEKICGGYreniilnknnwketlllaeksifgSSI 147 Clostridium per...
Feature 1                                                                                        
CAJ74006     170 VAFRtgrrqg------cyvdtVAFGAYRRnvfnrIGGFDEELvrnQDDEFNFRLTQSGGkirmdpsIRSVYYSRSSLRGL 243 Candidatus Kuen...
NP_126870    145 VLRNpskf----------lpsSRSIAFKKkcwkkVGGYPEWLytaEDTLYDILLKRAGCkfvfnpnAVVYWKVRENLRKL 214 Pyrococcus abys...
CAC12176     120 RRYMqervkifl-egievtapSVNLAYRKdrfrqLGGFDPKFvtaEDIDLNIRAVKAGFrfatcdsCVVYAKVRENLASF 198 Thermoplasma ac...
NP_633163    145 SAQSknslkkh----yvsslpNCNAMYKKntiieAGYFDERFvvgQDGDLNYRINKKGYkflyipeAIVLHHRRGTLKSF 220 Methanosarcina ...
YP_001409752 148 ARYKlgavek------tyvdtVAYGVYKRevfekVGLFNENLirnQDIEFNLRLKGSGYrimlipqARAYYFARDKYKEL 221 Fervidobacteriu...
EDK35182     149 AKFRqkdyd-------gfvdtVWNGAFYRwifdeIGFYNENFtrsEDNDLNNRILKRGYkiyqnknIIAYYKPRSSIKKI 221 Clostridium klu...
CAI64282     158 KLNPsvqhimssqagyvkhipTCNLCLRKdvierIGYFDEDFvkgQDLELNTRLVMAGYklyhspmIRVTHYRKQHIRDF 237 uncultured arch...
YP_001471506 149 AKYRlkiekp------eyvdtVPFGCYRKevfdkLEGFNENLhrnMDIEFNLRMIRNGYkiklfpdIVIDYYARDNYRDL 222 Thermotoga lett...
NP_344649    155 ANYRnssed-------ryvssIFHGMYKRevfqkVGLVNEQLgrtEDNDIHYRIREYGYkiryspsILSYQYIRPTFKKM 227 Streptococcus p...
YP_695362    148 APYRrnigk-------ryvssIFHGAYSRevfenTGLFNENLartEDNEMNYRIRKNGYkicfnpnIKSYQYTRNNLLKM 220 Clostridium per...
Feature 1                                                     
CAJ74006     244 WKQYFQYGFykvrvi------------qkrgavPSWRHLIPAVFV 276 Candidatus Kuenenia stuttgartiensis
NP_126870    215 FRQYYNYAKgdge-----------------anlFFWRYFLVCYFP 242 Pyrococcus abyssi GE5
CAC12176     199 LRQAYWNGYgryqlemkhpgitrntrvrlghnfFDFLHMVSGAAG 243 Thermoplasma acidophilum
NP_633163    221 SVRMFKYGMwmgelf------------kkhgelVRWYAILPSVAI 253 Methanosarcina mazei Go1
YP_001409752 222 WKNNFSNGFwvtysk------------kfaenpYRLRHLIPLFFV 254 Fervidobacterium nodosum Rt17-B1
EDK35182     222 LSQNYGNGRaigesl------------innrdiVRMRHLVPLIFF 254 Clostridium kluyveri DSM 555
CAI64282     238 TMQIYKWAKakaai--------------ikkhgMTNPSYLSPVFG 268 uncultured archaeon
YP_001471506 223 WNNNFANGYwvmmsn------------lyskrpFSLRHTVPMAFL 255 Thermotoga lettingae TMO
NP_344649    228 LHQKYSNGLwiglts------------hvqfkcLSLFHYVPCLFV 260 Streptococcus pneumoniae TIGR4
YP_695362    221 LEQKFLNGYwigltl------------gvcpkcISIYHLIPFLFV 253 Clostridium perfringens ATCC 13124

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