1TZF,1WVC


Conserved Protein Domain Family
G1P_cytidylyltransferase

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cd02524: G1P_cytidylyltransferase 
Click on image for an interactive view with Cn3D
G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose.
Alpha-D-Glucose-1-phosphate Cytidylyltransferase catalyzes the production of CDP-D-Glucose from alpha-D-Glucose-1-phosphate and MgCTP as substrate. CDP-D-Glucose is the precursor for synthesizing four of the five naturally occurring 3,6-dideoxy sugars-abequose (3,6-dideoxy-D-Xylo-hexose), ascarylose (3,6-dideoxy-L-arabino-hexose), paratose (3,6-dideoxy-D-ribohexose), and tyvelose (3,6-dideoxy-D-arabino-hexose. Deoxysugars are ubiquitous in nature where they function in a variety of biological processes, including cell adhesion, immune response, determination of ABO blood groups, fertilization, antibiotic function, and microbial pathogenicity.
Statistics
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PSSM-Id: 133015
View PSSM: cd02524
Aligned: 34 rows
Threshold Bit Score: 355.341
Threshold Setting Gi: 22657445
Created: 6-Jun-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrate
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:
  • Structure:1tzf_a; Alpha-D-Glucose-1-Phosphate Cytidylyltransferase of Salmonella Typhi binds to CDP-Glucose
    View structure with Cn3D
  • Structure:1wvc_a; Alpha-D-Glucose-1-Phosphate Cytidylyltransferase of Salmonella Typhi binds to substrate MgCTP
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####             ##                                                          
1TZF_A         5 AVILAGGLGTRLSEETIVKPKPMVEIGGKPILWHIMKMYSvHGIKDFIICCGYKGYVIKEYFANYFLHMs-DVTFHma-e 82  Salmonella typhi
NP_355866      3 VVLFCGGRGTRIREYSESVPKPLIPLGSQPIMRHVMQYYArYGHEDFILCLGYKAHVIKEFFLNSRPESy-ADCVIss-p 80  Agrobacterium t...
NP_925131      3 VVLFCGGLGTRIRDYSESIPKPLVTIGYRPILWHVMKYYAhYGHRDFILCLGYKADAIKNYFLNYDECLs-NDFTLsegg 81  Gloeobacter vio...
YP_419484     24 VVILCGGFGTRIRDVADDIPKPMIPIGNLPIVWHIMKSYSaAGHKDFVLCLGYKSHAVKQFFLNYDIHGg-DFTIAlgae 102 Magnetospirillu...
ZP_02585021    3 VVILCGGFGTRMQSHKDNIPKPMITIGDKPILWHIMKYYSsWGHNEFILCLGYQGWKIKEYFMNYKLINs-DFSISlnqp 81  Bacillus cereus...
CAO80527       3 VIILAGGMGTRLGSLGELMPKPMIEIGGKPIIWHIMKIFShYGYNDFIVCLGYKGNVIKDYFYHYYTYNs-DFTINla-s 80  Candidatus Cloa...
CAA57667       9 VVLLCGGYGTRIREASERLPKAMVDIGGRPILWHIMKIYShYGFRRFVLCLGYKGWAIKQFFLDYRAQLs-DFTISlsde 87  Streptomyces gl...
ZP_01925206   11 VMILCGGQGTRLRDLTELLPKPMVPIGEQPVLWHIMRGFAaFGCRRFILCLGYKREEFIDYFLNFQARSc-DMTITlgrk 89  Victivallis vad...
YP_467497      3 AVILCGGQGTRIRDASEVLPKPMLPIGNRPILWHIMKGYAqHGVREFVLCLGYKGSVIREFFLNYRAMTt-DVTVTlgrh 81  Anaeromyxobacte...
YP_002300149   3 VVLFCGGLGLRMRDYSDALPKPMVPIGTRPILWHLMRYYAhYGHKDFILCLGHKGHVIKDFFLKYDECVsnDFVLSeg-a 81  Rhodospirillum ...
Feature 1                                #    #                  ###                             
1TZF_A        83 NRMEVHhk-rvEPWNVTLVDTGDSSMTGGRLKRVAEYVkdd-eaFLFTYGDGVADLDI-KATIDFHKAHGKKATLTAtf- 158 Salmonella typhi
NP_355866     81 GRVELLee-lpRDWRVSLIDTGIWRNIGERLWAVRHHLkge-kmFLANYSDGLTDVDLdDMIAQFEKSDKLACFLAVrpp 158 Agrobacterium t...
NP_925131     82 RKLQLSns-diHDWNITFVDTGFNANIGQRLMAIEPYLegd-kyFLANYSDGLTNLHL-PDLIAFSQRQERIATFLSvk- 157 Gloeobacter vio...
YP_419484    103 KQITHHgevrhDDWSVTLAETGLNAMTGARIRRIRKYLgdd-enFLLTYGDGVSDVDL-DALLEFHKSHGKILTVTGvh- 179 Magnetospirillu...
ZP_02585021   82 NDIQYHnrlseEDWKITMVETGLDSMTGSRIKQIQKYIgdd-stFMLTYGDGVCNLNI-NRQLDFHHSHGKILTVTGis- 158 Bacillus cereus...
CAO80527      81 DEIIFHns-ndDNFNVTLVDTGLKNLKGSRLKQVERYLed--nlNFITYGDGVADINI-SSLVEFHKSHNKLLTITGvk- 155 Candidatus Cloa...
CAA57667      88 HRIRFHddradENCEITFAETGLDTATGARLRRVRRYVdt--ddFMMGYGDGVGNIDL-AALEKEHRAAGRIGTVTGih- 163 Streptomyces gl...
ZP_01925206   90 NGIVYHgssaeADWEVTLADTGIDTMTGGRVLRASRYLkpqdreFFLTYGDGVADIDV-AALLEFHRRNGKQLTVSAvh- 167 Victivallis vad...
YP_467497     82 DRIEFHgqhgeEDWKVTLAETGEATMTGGRVAAVRRYVegd-dlFCLTYGDGVSDLDV-AASIEAHRRHGKVATVAAvr- 158 Anaeromyxobacte...
YP_002300149  82 KRLELLrr-diDDWRITFVDTGTASNIGQRLLAVRRFLrde-emFLANYSDGLTDCPL-PEITDRLAASNATAAFMAar- 157 Rhodospirillum ...
Feature 1                                      #                       #                         
1TZF_A       159 ppGRFGALDIQag-qVRSFQEKPKgdgaMINGGFFVLNPSVIDLIDnd--aTTWEQEPLMTLAQQGELMAFEHPGFWQPM 235 Salmonella typhi
NP_355866    159 ltYHLAEIDESg--kVREFRSSETsd-mWINGGYFLMRPEIFDYMRe---gEELVLEPFSRLISEDKLMAYKHEGFWRSM 232 Agrobacterium t...
NP_925131    158 psQSFHLVAMDeqglVRDICDTRRsd-vWINGGYFVFKRQIFDYMRy---gEELVCEPFRRLIAAQELLTYPYQGFWACM 233 Gloeobacter vio...
YP_419484    180 ppGRFGEIEHAng-qVQGFNEKSQttsgMISGGYFVCRREIFDYLDdr-edLVFEVGPVRALVAAGEMMVYEHHGFWQCM 257 Magnetospirillu...
ZP_02585021  159 rtGQYGELQCDseghVTEFQEKPQvadaKISGGYFICNRGIFEYLDnd-keLVFEKEPLQKLMGNKQMMVYNHSDFWGSM 237 Bacillus cereus...
CAO80527     156 ppSMFGEMIEKdg-lVLSFEEKPQtskgLINGGFMVFHRDLMNYLSed-pqCDFEFGPLEDLAKKEEIMTYKHKGFWECA 233 Candidatus Cloa...
CAA57667     164 ptSKFGEMDVEdd-qVLEFNEKPTrvtgFVSGGFFMFRREFLDDYLdddpkLWLESAPLQRLARDRQLTLHPHHDFWCAM 242 Streptomyces gl...
ZP_01925206  168 peGRFGEMQLDdrggIIGFTEKKVrsegRVNGGFMVLERDFVARYLerredCYFEQRPMAEALRDGEMAAYRHEGFWQCM 247 Victivallis vad...
YP_467497    159 ppGRFGEMRLDga-rVTEFNEKPNasegFINGGFFVLDARRIWPYIgddarTVLEQEPLRKLARDGELVAFPHTGFWQPM 237 Anaeromyxobacte...
YP_002300149 158 pnTSFHFVRHDtagrVTRVDNVEDad-lWVNAGYFAFRQEIFDYIVp---gEELVEEPFQRLIDARRLLVHEHTGFWRGC 233 Rhodospirillum ...
Feature 1        #                    
1TZF_A       236 DTLRDKVYLEglWEKGKAPWK 256 Salmonella typhi
NP_355866    233 DTLRDWQTLEamVERGDMPWI 253 Agrobacterium tumefaciens str. C58
NP_925131    234 DTFKEKQQLDelYARQEAPWE 254 Gloeobacter violaceus PCC 7421
YP_419484    258 DTYRDWSLLRdlWDSGKAPWK 278 Magnetospirillum magneticum AMB-1
ZP_02585021  238 DTYKDQLTLNqmYENMEAPWK 258 Bacillus cereus G9842
CAO80527     234 DTVRDLEHLNklWNENKAFWK 254 Candidatus Cloacamonas acidaminovorans
CAA57667     243 DTFKDYQHLNelWAAGDAPWK 263 Streptomyces glaucescens
ZP_01925206  248 DTPREHRILNelWESGNAPWC 268 Victivallis vadensis ATCC BAA-548
YP_467497    238 DTAREYGLLNdlWTRGVAPWK 258 Anaeromyxobacter dehalogenans 2CP-C
YP_002300149 234 DTFKDLQTLEaaLSPGPAPWE 254 Rhodospirillum centenum SW

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