1JYL


Conserved Protein Domain Family
PC_cytidylyltransferase

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cd02523: PC_cytidylyltransferase 
Click on image for an interactive view with Cn3D
Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline.
This family contains proteins similar to prokaryotic phosphocholine (P-cho) cytidylyltransferases. Phosphocholine (PC) cytidylyltransferases catalyze the transfer of a cytidine monophosphate from CTP to phosphocholine to form CDP-choline. PC is the most abundant phospholipid in eukaryotic membranes and it is also important in prokaryotic membranes. For pathogenic prokaryotes, the cell surface PC facilitates the interaction with host surface and induces attachment and invasion. In addition cell wall PC serves as scaffold for a group of choline-binding proteins that are secreted from the cells. Phosphocholine (PC) cytidylyltransferase is a key enzyme in the prokaryotic choline metabolism pathway. It has been hypothesized to consist of a choline transport system, a choline kinase, CTP:phosphocholine cytidylyltransferase, and a choline phosphotransferase that transfers P-Cho from CDP-Cho to either lipoteichoic acid or lipopolysaccharide.
Statistics
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PSSM-Id: 133014
View PSSM: cd02523
Aligned: 55 rows
Threshold Bit Score: 155.083
Threshold Setting Gi: 91792522
Created: 8-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitemetal binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Structure:1jyl_a; CTP:Phosphocholine Cytidylyltransferse binds to CDP-choline.Mg+, defined by 3.5 A distance.
    View structure with Cn3D
  • Citation:PMID 9370319
  • Comment:Multivalent coordination of Mg2+ drives the conformation change of the enzyme which is pivotal to the reaction.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####                                                                        #
1JYL_A        28 AIILAAGLGTRLRPLTentPKALVQVNQKPLIEYQIEFLKekgiNDIIIIVGylKEQFDYLKek-ygVRLVFNDkyadyN 106 Streptococcus p...
ABA57815     312 AIVLGATRGKGLESLTqdrPKVMLPVAGIPLLRRLVDEFKrqhvNRITVVTGykPEAIDVKA-----ISLIHNPdyghsS 386 Nitrosococcus o...
YP_583956    307 AVVLAAGRGKGLEALTedkPKIMLPVAGKPLLRWLVDGFKnqgiNDITVVGGykAEAIDAAG-----IKLVRNErhaatG 381 Ralstonia metal...
AAR01900       3 AIILAAGFGSRLMPLTkdqPKCMVEYKNKKIIDYEIEALKsagiNEIAVVGGylNDVLKNYLnkydiEHFFINSkydktN 82  Campylobacter j...
YP_326630      2 AVHLAAGQGTRLRPLTddrPKPLVELGGQSLLEQNVETLKeagvRDHVVVTGyeGDQIVDRG-----FETVHNDvydetE 76  Natronomonas ph...
YP_001617954 297 AVILAAGQSQGLLPLTeelPKPMLDLKGKSILERQIDVLNacgvKDVAVVRGykKEAIKVPN-----ARFYDNDeyattN 371 Sorangium cellu...
YP_001581996   4 LIILGAGEGTRLRPLTqncPKCMVNIFGKSLLEHQINTAKncgiDEIIIVKGflGYMIQIPN-----IRYYENKyydstN 78  Nitrosopumilus ...
YP_001002353   3 AIILAAGQGTRLRPLTddkPKCLVELAGKSLLDHQLDVLRaagvDDIHVVAGyrADQLERPG-----FTRHINEryaetN 77  Halorhodospira ...
YP_858575      3 AIILAAGRGSRLGSMTenqPKPLAKLAGKSLIEWQLASLAaagvDSVHVVCGycSEALQGYG-----DSRIMNTnwassN 77  Aeromonas hydro...
AAN66351       3 AVILAAGRGSRLQALTderPKALVPFNGVPLLQRAIETLRrcdvSEVGIVAGyrSEMLAPFA-----DTLFYNHrwhssG 77  Pseudomonas put...
Feature 1        #  #                      ##                                      #             
1JYL_A       107 NFYSLYLVKeel-------anSYVIDADNYLFknMFRNDltRSTYFSVYred----------ctnEWFLVygdd------ 163 Streptococcus p...
ABA57815     387 ELSSLACALesl------sedTIITYGDLLFRsyILNDLrhVPGNIVVVvdsal-------spgmKDDIRdvafcsqpdd 453 Nitrosococcus o...
YP_583956    382 ELASLACAAdsl------etdTVVSYGDLMFRsyILRDLleTDAPFSVVvdssesapsnqsvrdfAWCSAaddrdlfgq- 454 Ralstonia metal...
AAR01900      83 MVHTFFCAKdfmlkcieekqdLIISYADIVYFqdCVQKLinAKEELAIVvdks---------wrkLWSKRfanpledaet 153 Campylobacter j...
YP_326630     77 MIYSLFCAAeafpd--sgegdLLISYGDIVYErdVVEALldCSAPLCVAvdrq---------wrkLWEERfedplsdaet 145 Natronomonas ph...
YP_001617954 372 EVVSLFRASkel------sgpFLFLYGDIVFErgHLEKLlkSPADISIVidr----------ayaEGQRPkdargvpdlv 435 Sorangium cellu...
YP_001581996  79 MVETLFCAEkel------nesVIVSYGDIIYQknILKKLidSPDDFSVVidkn---------wknYWQIRfsnilddves 143 Nitrosopumilus ...
YP_001002353  78 MVGTLFAAEsvmt----gesdLIISYGDIVYEprVLAALqaVDAPIGLAvdre---------wrrYWAARmddpladaet 144 Halorhodospira ...
YP_858575     78 MVRSLMCADavls-----aapTLVCYGDIVYRpgIIRTLisSDAPLAISydke---------wwsLWSARfedplsdaes 143 Aeromonas hydro...
AAN66351      78 IFSSLNCASdwls-----aepCLVSYGDIFYDstLVSELinHPADIVLGydpa---------avrLWQQRfndplpdlen 143 Pseudomonas put...
Feature 1                                                                                      # 
1JYL_A       164 ---------------------ykvQDIIVDSkagRILSGVSFWDaptAEKIVSFIDKAyvsg-----------efvdLYW 211 Streptococcus p...
ABA57815     454 rsl---------frqdvdllrietQKKQLSKqphGRWIGMARVAgegRQWLLDALQALrqqe-----------nfsqLAM 513 Nitrosococcus o...
YP_583956    455 ---------------kvllrkisdTPAATDGephGRWIGLLNVRgegRARLQKLLAELrqrp-----------dfdsLDM 508 Ralstonia metal...
AAR01900     154 l------------kmtngyiielgKKANAYDeieAQYIGLFKFSyqfLSEVIAFYEMLdrdilyd------nknfenMYM 215 Campylobacter j...
YP_326630    146 ld-----------iddkgriheigETPEGYDtidAQYVGLLKVRndhIDRFVDAYTELdaqtd----------gyvsIDT 204 Natronomonas ph...
YP_001617954 436 alkdaqeagyrfvgaeaphrvarvGRAIPAGeahGEFVGMAMFTakgARLLTDCYHQLqesrakggf--heaeslrnATF 513 Sorangium cellu...
YP_001581996 144 l------------rlkdgyimdigQKPNSLDnidGQYIGLMKFQhnaLSTLKTFYHNSkeqsklgtnplnpkipftkSYM 211 Nitrosopumilus ...
YP_001002353 145 lk-----------ltdgdrvvelgKKPEGYAdiqGQYTGLIKVRadhVRRLPEVWRAMdrhatyd------gkdydnMYM 207 Halorhodospira ...
YP_858575    144 f------------rqqggqlltigEQVQTREeieGQYMGLLKFTpegWQRVSAVLAGLsaeq------------inkLDM 199 Aeromonas hydro...
AAN66351     144 f------------rlvdgwvsaigQTATSLEviqGQYMGLFKVTpagWQALKKQLQGLtpqa------------rdqTDM 199 Pseudomonas put...
Feature 1        #                        # #         
1JYL_A       212 DNMVKDNikeldVYVEELeg-nSIYEIDSVQDYRKLE 247 Streptococcus pneumoniae
ABA57815     514 PDLFNHLva-ngHPIKVLyingHWLDVNDMEDLTRAG 549 Nitrosococcus oceani ATCC 19707
YP_583956    509 PDLINALve-agEKVEVRyvhgHWRGVNDLEDFRRAG 544 Ralstonia metallidurans CH34
AAR01900     216 TSFLQALie-kyNNAKAVeidgNWCEIDFMSDLEVQI 251 Campylobacter jejuni
YP_326630    205 TAFLQQLid-dgWHLQAVsidrGWLEVDTLEDLERYR 240 Natronomonas pharaonis DSM 2160
YP_001617954 514 TDLLQELid-rgADVQAIdvykGWLEIDTFEDYRRAW 549 Sorangium cellulosum 'So ce 56'
YP_001581996 212 TDLLQGLih-ngQNIKAIeingGWLELDTLNDFEIYQ 247 Nitrosopumilus maritimus SCM1
YP_001002353 208 TSFIQHLid-mgWEARAAfidnGWAEVDCEADLAAAT 243 Halorhodospira halophila SL1
YP_858575    200 TSLLRLLls-hgVPIASIaisgGWVEVDNPSDITLYE 235 Aeromonas hydrophila subsp. hydrophila ATCC 7966
AAN66351     200 TSLLGTLvs-egFPVAGVathaPWGEIDCPSDVALYE 235 Pseudomonas putida KT2440

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